Clinical trials: Demyelinating Disorder
Multiple Sclerosis
Clinical Pilates for Balance and Function in Multiple Sclerosis
This randomized controlled trial evaluated the effects of an 8-week Clinical Pilates program on balance and physical function in individuals with multiple sclerosis (MS).
- Trial name
- MS-PILATES (NCT07800039)
- Testing
- Clinical Pilates-Based Rehabilitation, Conventional Exercise-Based Physiotherapy
- Where
- Greece
- Volunteers
- 21 people
- Sponsor
- University of Patras
Electrode Site Reaction, Therapy
Functional Electrostimulation on the Upper Lip in Multiple Sclerosis
Multiple sclerosis (MS) is an autoimmune disease where immune cells attack the body, triggering an inflammatory response. A study comparing multifield FES and conventional FES on upper extremity motor skills and functional…
- Conditions
- Electrode Site Reaction, Therapy, Directly Observed Therapy
- Trial name
- EM/2024 (NCT06638775)
- Testing
- Fesia Grasp, GLOBUS ELITE
- Volunteers
- 30 people
- Sponsor
- Universidad de Burgos
Multiple Sclerosis
Effectiveness of the EXOPULSE Mollii Ⓡ Suit in Patients With Multiple Sclerosis
Abstract: Background: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system with unknown etiology, causing a variety of symptoms including impaired balance, coordination, and…
- Trial name
- NCT06384729
- Testing
- EXOPULSE Mollii Ⓡ
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Universidad Europea de Madrid
Multiple Sclerosis (MS) - Relapsing-remitting, Upper Extremity Dysfunction
Wearable Focal Vibration Therapy on Upper Extremity Function of People With Multiple Sclerosis: A Pilot Study
This pilot mixed-method study will evaluate the feasibility, preliminary efficacy, and user experience of a home-based wearable Focal Vibration Therapy (FVT) intervention for improving upper extremity (UEx) function in people…
- Trial name
- NCT07376772
- Testing
- wearable focal vibration therapy
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- University of Florida
Multiple Sclerosis
Costs, Quality of Life and Functional Outcomes in Veterans Treated for Multiple Sclerosis With Beta-Interferon l-B (Betaseron)
The treatment of multiple sclerosis was evolving in light of specific drug therapies to treat the disease, refinements and acceptance of imaging with MRI to diagnose and monitor the disease process, and progress in understanding…
- Trial name
- NCT00439257
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- US Department of Veterans Affairs
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)
A Study of TAK-411 in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)
CIDP is an autoimmune disease. This means that the body's germ fighting (immune) system attacks itself. In CIDP, the immune system attacks the protective covering around the nerves called myelin.
- Trial name
- CASCA (NCT06798012)
- Testing
- TAK-411
- Where
- 22 sites in United States, Canada and 1 more
- Volunteers
- 36 people
- Sponsor
- Takeda
Multiple Sclerosis, Inflammatory Demyelinating Disease
A Study of Imaging in Demyelinating Diseases
This purpose of this study is research the usefulness of MRI with PET/CT imaging for measuring brain inflammation and its relation to Multiple Sclerosis (MS).
- Trial name
- NCT05805839
- Testing
- C-11 ER176 Radiotracer, C11 Pittsburgh Compound B, PET/CT scan
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Multiple Sclerosis, Relapsing-Remitting
ITAKOS - Italian Observation, Multicenter, Prospective Study of Ofatumumab in RRMS Patients
Study to evaluate the effectiveness of ofatumumab in Italian RRMS patients in the real-life setting.
- Trial name
- NCT06345157
- Testing
- Ofatumumab
- Where
- 31 sites in Italy
- Volunteers
- 379 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis
Modafinil in Multiple Sclerosis
Deficits in new learning and memory in MS are a major complaint of patients, and have been noted to be a significant contributor to disability by numerous researchers.
- Trial name
- NCT00142402
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kessler Foundation
Multiple Sclerosis
Safety and Tolerability of Quetiapine in Multiple Sclerosis
Study Purpose: The purpose of this clinical trial is to determine if extended-release quetiapine in a dose of 300 mg daily is tolerable to people with relapsing remitting and progressive MS.
- Trial name
- NCT02087631
- Testing
- Extended-release quetiapine fumarate
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- University of Calgary
Multiple Sclerosis
Eye-tracking Investigation of Clinical Measures in Multiple Sclerosis
The overarching goal of this research protocol is to acquire eye-tracking, cognitive, and disease-severity metrics in MS patients to train machine learning algorithms that will support the development and performance assessment…
- Trial name
- NCT06283524
- Testing
- Eye-Tracking
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Innodem Neurosciences
Neuromyelitis Optica (NMO), Neuromyelitis Optica Spectrum Disorders (NMOSD)
Slow vs. Rapid Glucocorticoids Tapering With Inebilizumab in NMOSD
Neuromyelitis optica spectrum disorder (NMOSD) is a central nervous system autoimmune condition mainly involving the spinal cord, optic nerves, and area postrema.
- Trial name
- STARGlu-NMO (NCT07132398)
- Testing
- Slow-tapering glucocorticoids + Inebilizumab, Rapid-tapering glucocorticoids + Inebilizumab
- Volunteers
- 170 people
- Sponsor
- Tianjin Medical University General Hospital
Chronic Inflammatory Demyelinating Polyneuropathy
To Assess Efficacy and Safety of Batoclimab in Adult Participants With Active CIDP
This is a multi-center, randomized, quadruple-blind, placebo-controlled study to evaluate the efficacy and safety of batoclimab in adult participants with active CIDP.
- Trial name
- NCT05581199
- Testing
- Batoclimab 680 milligrams (mg) subcutaneous (SC) weekly, Batoclimab 340 mg SC weekly
- Where
- 98 sites in United States, Argentina and 19 more
- Volunteers
- 94 people
- Sponsor
- Immunovant Sciences GmbH
Multiple Sclerosis (Relapsing Remitting)
Multiple Sclerosis and Progressive Resistance Training
The purpose of this study is to investigate underlying mechanisms possibly explaining the beneficial effects of progressive resistance training for people with multiple sclerosis.
- Trial name
- NCT01518660
- Testing
- Training
- Where
- 2 sites in Denmark
- Volunteers
- 35 people
- Sponsor
- University of Aarhus
Multiple Sclerosis
Safety and Tolerability of Fingolimod in Patients With Relapsing-remitting Multiple Sclerosis
This 4 month, open-label study will evaluate the safety and tolerability of fingolimod 0.5 mg in patients with relapsing-remitting multiple sclerosis (RRMS) and generate additional data in Multiple Sclerosis (MS) patient…
- Trial name
- NCT01497262
- Testing
- Fingolimod
- Where
- 29 sites in Argentina, Brazil and 6 more
- Volunteers
- 162 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis
A Safety and Efficacy Study of CNTO1275 in Patients With Multiple Sclerosis
The purpose of the study is to evaluate the effectiveness and safety of CNTO 1275 in patients with Multiple Sclerosis
- Trial name
- NCT00207727
- Testing
- CNTO 1275
- Volunteers
- 249 people
- Sponsor
- Centocor, Inc.
Multiple Sclerosis
E-Support Groups in Multiple Sclerosis
Primary objectives: To determine the feasibility of program (80% retained with 75% overall attendance, and completed immediate follow-up questionnaires from 75% of participants).
- Trial name
- eSupport (NCT03574961)
- Testing
- e-Support group
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Columbia University
Multiple Sclerosis, Relapsing-Remitting
Treatment of Cognitive Deficits in Multiple Sclerosis With High-Definition Transcranial Direct Current Stimulation
The purpose of the study is to test whether low level electric stimulation, called transcranial Direct Current Stimulation (tDCS), on the part of the brain (i.e., presupplementary motor area) thought to aid in memory will improve…
- Trial name
- MS-HDtDCS (NCT05958381)
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The University of Texas at Dallas
Multiple Sclerosis
Effectiveness of Dry Needling for Improving Gait in the Patient With Multiple Sclerosis
Multiple sclerosis (MS) is a chronic, inflammatory, autoimmune disease characterized by the appearance of lesions, characterized by heterogeneity in its pathological, clinical and radiological presentation.
- Trial name
- DRYNEEDEM (NCT05956119)
- Testing
- dry needling + physiotherapy (standard/usual care)
- Where
- Spain
- Volunteers
- 18 people
- Sponsor
- Hospital Universitario de Canarias
Multiple Sclerosis
A Multicenter, Open-label, RebiSmart™ Autoinjector Ease of Use Study
The purpose of this study is to test the RebiSmart™ for ease of use multiple domains related to subject's acceptability and satisfaction reliability of the correct function for self-injection of Rebif® 44 mcg sc tiw in subjects…
- Trial name
- Performs (NCT01036165)
- Testing
- RebiSmart™
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- EMD Serono
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