Clinical trials: Demyelinating Disorder
Multiple Sclerosis
Combined Effects of Balance and Cognitive Training in Patients With Multiple Sclerosis
Multiple sclerosis is a potentially disabling disease of the brain and spinal cord involving the central nervous system. Multiple Sclerosis can cause balance and cognitive impairment in patients, affecting overall quality of…
- Trial name
- NCT06845722
- Testing
- Balance training, Cognitive Rehabilitation:
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Healthy Individuals (Controls), Parkinson Disease
Motor Learning in Health and Movement Disorders: Role of Physical Activity and Advanced Devices
The goal of this clinical trial is to investigate motor responses in healthy subjects and patients with movement disorders, brain and spinal cord injury, neuromuscular diseases, or cardiovascular diseases.
- Conditions
- Healthy Individuals (Controls), Parkinson Disease, Multiple Sclerosis, Alzheimer Disease
- Trial name
- Allena-mente (NCT07066137)
- Testing
- CAREN, Control group
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Multiple Sclerosis
FlexToBa for People With Multiple Sclerosis
The purpose of this study is to test the effectiveness of a DVD-delivered, home-based six-month physical activity intervention for people with Multiple Sclerosis.
- Trial name
- NCT01993095
- Testing
- Home-based, DVD-delivered physical activity, Behavioral: Usual care/Wait list
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Illinois at Urbana-Champaign
Multiple Sclerosis
Role of Microglial Activation and Norepinephrine Transporter Abnormalities in Pathogenesis of MS-related Fatigue
The overarching aim is to assess the role of microglial activation and norepinephrine transporter binding in pathogenesis of MS-related fatigue, using novel Positron Emission Tomography (PET) radiotracers, [F-18]PBR06 and…
- Trial name
- NCT04144257
- Testing
- [F-18]PBR06, [C-11]Methylreboxetine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Brigham and Women's Hospital
Multiple Sclerosis
MRI Guided Focused Ultrasound for Tremor in Multiple Sclerosis
This project goal is to explore the option of (MRgFUS) as a treatment for tremor in MS patients with disabling refractory tremor.
- Trial name
- NCT02614989
- Testing
- MRI guided focused ultrasound thalamotomy
- Volunteers
- 15 people
- Sponsor
- Rambam Health Care Campus
Krabbe Disease
Long-term Follow-up Study to Evaluate Safety and Efficacy of FBX-101 in Krabbe Patients
This is an observational study that will enroll any patients with Krabbe disease that have participated in prior interventional clinical trials involving the administration of FBX-101.
- Trial name
- NCT06308718
- Testing
- FBX-101
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Duke University
Multiple Sclerosis
Physical Activity Intervention for Individuals Newly Diagnosed With MS
The proposed study is a parallel-group randomized controlled trial (RCT) designed to establish the behavioral mechanism underlying a 16-week physical activity (PA) behavioral intervention through its effects on the…
- Trial name
- ActivNMS (NCT07731659)
- Testing
- COM-B-based Physical Activity Behavior Change Intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Illinois Chicago
Multiple Sclerosis
Effects Of Motor Imagery and Sensorimotor Training
Many types of pain can occur in Multiple Sclerosis (MS), one of the most common types is neuropathic pain. Neuropathic pain is directly related to the disease's demyelination process and is associated with dysesthetic pain…
- Trial name
- MS-MI-SM (NCT07710742)
- Testing
- Motor imagery, Sensorimotor Training, Conventional therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Uludag University
Multiple Sclerosis
Neurofilaments for NEDA Assessing in MS
Goal is to evaluate the achievement of biological NEDA as demonstrated by a drop in neurofilament levels in MS patients commencing Alemtuzumab therapy as part of their MS management.
- Trial name
- NCT03250169
- Testing
- Alemtuzumab
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- Queen Mary University of London
Multiple Sclerosis
Feasibility and Safety of the 360-degree Turn Test Delivered Via Telehealth
Walking, balance problems and falls are common in patients with multiple sclerosis. The 360-degree turn test is a test used to evaluate balance.
- Trial name
- NCT05809505
- Testing
- 360-degree Turn Test, Expanded Disability Status Scale, Perceived Exertion
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Uskudar State Hospital
Multiple Sclerosis
TENS in Persons With MS
Persons with multiple sclerosis (pwMS) often have an increased sense of fatigue. Furthermore, they present walking difficulties which negatively affects their mobility and results in an additional increase of fatigue.
- Trial name
- NCT05321927
- Testing
- Trancutaneous Electrical Nerve Stimulation, Strength training
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- University Medical Center Groningen
Multiple Sclerosis
Meningeal Inflammation on 7T MRI as a Tool for Measuring and Predicting Ocrelizumab Response in Multiple Sclerosis
Multiple Sclerosis (MS) is an autoimmune disorder of the central nervous system. In MS, inflammation is known to attack areas of the brain, spinal cord, and optic nerves; resulting in disability.
- Trial name
- NCT03396822
- Testing
- Gadoteridol
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Maryland, Baltimore
Multiple Sclerosis (MS) - Relapsing-remitting
Educational Programs Based on Healthy Habits to Improve Quality of Life and Psychosocial Profile in Women With Neurodegenerative Diseases: the ADVICE Protocol Study (Phase 2)
This phase of the project aims to compare in-person, supervised educational programs (EP) with online self-guided EPs in individuals with relapsing-remitting multiple sclerosis.
- Trial name
- ADVICE Phase 2 (NCT06884579)
- Testing
- Strength training, nutrition, and behavioral training, Self-Guided and Unsupervised Program with General Recommendations
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad de Almeria
Multiple Sclerosis
Hesperidin RCT in MS
This study is a randomised, double-blind, placebo-controlled trial investigating the effects of Hesperidin supplementation on cognitive function, fatigue, and stress.
- Trial name
- NECTAR-MS (NCT07452562)
- Testing
- Hesperidin
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Swansea University
Multiple Sclerosis
Clinical Investigation to Validate the Safety and Performance of the ABLE Exoskeleton Device for Individuals With Multiple Sclerosis in a Clinical Setting
The primary objective of the study is to validate the safety and performance of the ABLE Exoskeleton device in people with multiple sclerosis during a 10-session gait training program in a clinical setting.
- Trial name
- NCT06261541
- Testing
- ABLE Exoskeleton
- Where
- Spain
- Volunteers
- 33 people
- Sponsor
- ABLE Human Motion S.L.
Neuromyelitis Optica Spectrum Disorder
Efficacy and Safety Study of Ravulizumab IV in Pediatric Participants With NMOSD
The primary purpose of this study is to evaluate the safety and efficacy of ravulizumab in pediatric participants with Neuromyelitis Optica Spectrum Disorder (NMOSD).
- Trial name
- NCT05346354
- Testing
- Ravulizumab
- Where
- 16 sites in United States, Canada and 5 more
- Volunteers
- 12 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Chronic Inflammatory Demyelinating Polyneuropathy
Hematopoietic Stem Cell Transplantation in Chronic Inflammatory Demyelinating Polyneuropathy
Chronic inflammatory demyelinating polyneuropathy is disease believed to be due to immune cells, cells which normally protect the body, but are now attacking the nerves in the body.
- Trial name
- NCT00278629
- Testing
- hematopoietic stem cell transplantation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Northwestern University
CIDP, Chronic Inflammation
Ultrasound-driven Stratification in CIDP
Chronic inflammatory demyelinating polyradiculoneuritis (CIDP) is a rare autoimmune neuropathy characterized by significant clinical and therapeutic heterogeneity.
- Conditions
- CIDP, Chronic Inflammation, Demyelinating Polyneuropathy
- Trial name
- TAILOR-CIDP (NCT07719153)
- Testing
- Refractory CIDP, Standard-of-care treatment for CIDP
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP), Multifocal Motor Neuropathy (MMN)
A Study of TAK-771 in Japanese Participants With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) and Multifocal Motor Neuropathy (MMN)
The main aim of the study is to check for side effects from TAK-771, and to check how well TAK-771 controls symptoms in Japanese participants with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal…
- Trial name
- NCT05084053
- Testing
- TAK-771
- Where
- 23 sites in Japan
- Volunteers
- 26 people
- Sponsor
- Takeda
Multiple Sclerosis
Understanding the Impact of Meal Timing on Neurological Health in Adults With Multiple Sclerosis
The goal of this clinical trial is to learn if the time an individual eats each day impacts neurological health in people with multiple sclerosis. The main questions the investigators are asking are: 1.
- Trial name
- Meal Time MS (NCT07475377)
- Testing
- Time Restricted Eating, Unrestricted eating
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Alabama at Birmingham
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