Clinical trials: Demyelinating Disorder
Multiple Sclerosis, Relapsing-Remitting
Zenapax (Daclizumab) to Treat Relapsing Remitting Multiple Sclerosis
This study will examine the safety of Zenapax (daclizumab) in patients with multiple sclerosis (MS). MS is thought to be caused by an over-reactive immune response.
- Trial name
- NCT00071838
- Testing
- Daclizumab
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Multiple Sclerosis
Clinical Study to Investigate the Long-term Safety, Tolerability, and Efficacy of Ponesimod in Patients With Relapsing-remitting Multiple Sclerosis
This study is an extension to the study AC-058B201 and will investigate the long-term safety, tolerability and efficacy of ponesimod in patients with relapsing-remitting multiple sclerosis.
- Trial name
- NCT01093326
- Testing
- Ponesimod 10 mg, Ponesimod 20 mg, Ponesimod 40 mg
- Where
- 71 sites in United States, Austria and 18 more
- Volunteers
- 353 people
- Sponsor
- Actelion
Neuromyelitis Optica
Safety and Tolerability of Rituximab in Neuromyelitis Optica
The goal of this research study is to investigate whether Rituximab is safe to use in patients suffering from NMO, or who are at high risk for developing NMO.
- Trial name
- NCT00501748
- Testing
- Rituximab
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Rehabilitation, Multiple Sclerosis
Isolated Versus Combined Cognitive and Motor High-tech Rehabilitation
The first aim of this project is to investigate the effects of different high-tech neurorehabilitation interventions (cognitive, motor, and combined cognitive-motor) on both cognitive and motor disability outcomes in people with…
- Conditions
- Rehabilitation, Multiple Sclerosis, Cognitive Deficit, Motor Deficits
- Trial name
- NCT06820125
- Testing
- Cognitive rehabilitation: CG group, Motor rehabilitation: MG group, Combined rehabilitation: CbG group
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- Universita di Verona
Multiple Sclerosis
FAME - Fampyra Outcome Measures Study: a Study of Different Outcome Measures on the Effect of Fampyra
Fampridine-SR is registered for the treatment of walking incapacity in MS patients. Two pivotal trials show that app. 40% of MS patients with walking incapacity can improve walking speed averagely 25% when recieving the drug.
- Trial name
- FAME (NCT01656148)
- Testing
- Fampridine-SR
- Where
- 4 sites in Denmark
- Volunteers
- 108 people
- Sponsor
- University of Southern Denmark
Multiple Sclerosis
Theory Based Intervention Program to Support Physical Activity for Individuals With Multiple Sclerosis: a Case Series
This study evaluates the effectiveness of personalized physical activity coaching combined with the use of a physical activity monitor to support increased levels of daily physical activity in individuals with multiple sclerosis.
- Trial name
- NCT02335450
- Testing
- Motivational Interviewing, Wristband physical activity monitor
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Oakland University
Multiple Sclerosis
Validation of the French Adaptation of the MSWDQ-23 Questionnaire
MS is an autoimmune disease of the central nervous system that affects more than 120,000 people in France. The average age of onset of the disease is between 25 and 35 years.
- Trial name
- WORKSEP (NCT04860791)
- Testing
- questionnaires
- Where
- 16 sites in France
- Volunteers
- 206 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Neuromyelitis Optica
Autologous Hematopoietic Stem Cell Transplant in Neuromyelitis Optica
Neuromyelitis Optica (NMO) is a demyelinating and degenerative disorder of the CNS affecting vision and spinal cord function. This disease is rare compared to Multiple Sclerosis (MS), but it is devastating and often leads to…
- Trial name
- SCT-NMO (NCT01339455)
- Testing
- AHSCT
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- University of Calgary
Multiple Sclerosis
Retrospective Observational Study About Long-term Effect of Fampridine in Patients With Multiple Sclerosis
Mobility problems in multiple sclerosis (MS) is a frequent symptom. It might appear in almost 93% of patients in the first 15 years of the disease, being a clear problem for their normal living.
- Trial name
- RETROFAM (NCT02966808)
- Testing
- cognitive and behavioural questionnaires
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Multiple Sclerosis
Role of Neuromuscular Junction Function in Motor Fatigue in Multiple Sclerosis
This pilot study will evaluate for the presence of neuromuscular junction (NMJ) defect in women with motor fatigue in multiple sclerosis by Single Fiber Electromyography (SFEMG) using the concentric needle electrode.
- Trial name
- NCT02418897
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Relapsing-Remitting Multiple Sclerosis
BG00012 Monotherapy Safety and Efficacy Extension Study in Multiple Sclerosis (MS)
The primary objective of this study is to evaluate the long-term safety profile of BG00012 (dimethyl fumarate). Secondary objectives of this study are to evaluate the long-term efficacy of BG00012 using clinical endpoints and…
- Trial name
- ENDORSE (NCT00835770)
- Testing
- dimethyl fumarate
- Where
- 246 sites in United States, Australia and 32 more
- Volunteers
- 1,736 people
- Sponsor
- Biogen
Multiple Sclerosis, Relapsing Remitting
BETAEVAL Global - The New BETACONNECT Auto-injector : Adherence and EVALuation of Multiple Sclerosis Patients Treated With Betaferon
Considering the significance of an early and consequent Multiple Sclerosis (MS) treatment as well as the challenge to achieve high adherence to treatment, evaluating the benefits of any new measure to improve adherence is…
- Trial name
- NCT02247310
- Testing
- Interferon beta-1b (Betaferon®, BAY 86-5046), BETACONNECT
- Where
- 11 sites in Austria, Belgium and 9 more
- Volunteers
- 498 people
- Sponsor
- Bayer
Multiple Sclerosis, Optic Neuritis, Demyelinating Disease
Visual (Path)Ways in Multiple Sclerosis - Part II
Multiple sclerosis (MS) is an inflammatory demyelinating and degenerative disease of the central nervous system. The mechanisms of neuro-axonal loss remain incompletely elucidated.
- Trial name
- VWIMS - II (NCT06776224)
- Testing
- Measurement of retinal vascular density and visual cognition
- Where
- France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Lille
Multiple Sclerosis, Postural Balance
Motor-cognitive Performance in People With Multiple Sclerosis
Having a neurological disease such as multiple sclerosis (MS) leads to difficulties in balance and gait with or without concurrent performance of cognitive tasks, hindering activity performance and influencing the possibilities…
- Trial name
- HiBalance-MS (NCT06312046)
- Testing
- HiBalance-MS
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Karolinska Institutet
Multiple Sclerosis, Stroke
A Comprehensive Assessment of Trunk, Scapula and Upper Limb in Neurological Patients. Reliability, Validity and Interrelatedness
The study aimed to provide insights in the coordination between trunk, shoulder and upper limb while reaching. Two main phases are present in this study: In phase A: the psychometric properties of two tests: Clinical Scapular…
- Trial name
- NCT04908891
- Testing
- Clinical Scapular protocol (ClinScaP), the prevalence of trunk, scapula and upper limb impairments., the interaction between trunk, scapula and upper limb impairments.
- Where
- 4 sites in Belgium
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Multiple Sclerosis
Assistive Device Training in Multiple Sclerosis
The purpose of this study is to determine whether a training program in the use of ambulatory assistive devices (such as canes, walkers, etc) can reduce falls and increase functional mobility and neural connectivity in people…
- Trial name
- ADT (NCT02408718)
- Testing
- Assistive Device Training
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Portland VA Medical Center
Guillain-Barré Syndrome (GBS)
A Study of Empasiprubart as Add-On Therapy to IVIg in Adult Participants With Guillain-Barré Syndrome
The main purpose of this study is to learn whether empasiprubart, when given in addition to intravenous immunoglobulin (IVIg), helps adults with Guillain-Barré syndrome (GBS) recover and whether it is safe.
- Trial name
- embridge (NCT07821762)
- Testing
- Empasiprubart IV, Intravenous immunoglobulin (IVIg)
- Volunteers
- 63 people
- Sponsor
- argenx
Optic Neuritis, Myelitis
Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX)
The purpose of this research is to evaluate if early vs rescue Therapeutic Plasma Exchange (PLEX) treatment algorithm leads to better visual outcomes in severe Optic Neuritis and leads to better neurological disability outcomes…
- Conditions
- Optic Neuritis, Myelitis, Myelitis, Transverse
- Trial name
- TIMELY-PLEX (NCT07100990)
- Testing
- High-dose corticosteroids (HDCS), High-dose corticosteroids (HDCS) and PLEX
- Where
- 35 sites in United States
- Volunteers
- 382 people
- Sponsor
- Mayo Clinic
Multiple Sclerosis
Blood Flow Restriction And Veterans With MS
There currently is a lack of evidence to support exercise interventions in people with advanced disability due to MS (i.e., need assistance to walk or use a wheelchair).
- Trial name
- BRAVe-MS (NCT05433103)
- Testing
- Low-Load Exercise with Blood Flow Restriction, Low-Load Exercise Control Group
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- VA Office of Research and Development
Multiple Sclerosis
TENS in Persons With MS
Persons with multiple sclerosis (pwMS) often have an increased sense of fatigue. Furthermore, they present walking difficulties which negatively affects their mobility and results in an additional increase of fatigue.
- Trial name
- NCT05321927
- Testing
- Trancutaneous Electrical Nerve Stimulation, Strength training
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- University Medical Center Groningen
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