Clinical trials: Demyelinating Disorder
Clinically Isolated Syndrome, Multiple Sclerosis
Clinical Monitoring, MRI and Neuro-Ophthalmology of a Cohort of Patients With a Clinically Isolated Syndrome (CIS)
The purpose of this study is to develop tools to detect, measure, monitor and predict axonal damage in the course of CIS and during Multiple sclerosis (MS), in order to be able to consider as early as possible an adaptation of…
- Trial name
- cinocis (NCT03541226)
- Where
- France
- Volunteers
- 134 people
- Sponsor
- University Hospital, Lille
Clinically Isolated Syndrome, Relapsing Remitting Multiple Sclerosis
Implementation of a Novel Functional Eye-Tracking Biomarker for Multiple Sclerosis
This study aims to develop and validate a sensitive and non-invasive eye-tracking software application. This study will obtain participant responses to brief cognitive tests designed to evaluate several key functions known to be…
- Trial name
- NCT05277740
- Testing
- Eye-tracking
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- McGill University
Relapsing-remitting Multiple Sclerosis, Secondary Progressive Multiple Sclerosis
Patient Research Cohort: Rapidly Evolving Multiple Sclerosis
The primary goal of the research cohort is to facilitate patient access to clinical trials testing new therapeutic interventions, or access to second- line treatments.
- Trial name
- PRC-REMS (NCT01044576)
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Imperial College London
Multiple Sclerosis
Pilot Study Evaluating Functional and Wellness Outcomes of the Shepherd CAN DO MS Program
The study evaluates the efficacy of the CAN DO Program for improving health, wellness, and quality of life in people with MS, and compares outcomes between people with MS who participate in the CAN DO Program to a control group…
- Trial name
- NCT03954717
- Testing
- Shepherd CAN DO Program
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Shepherd Center, Atlanta GA
Carpal Tunnel Syndrome, Diabetic Neuropathies
Neuromuscular Ultrasound in Correlation to Neurophysiological Findings
1. Study the neuromuscular ultrasound findings in different types of neuropathies 2. correlation between ultrasound and neurophysiological findings in peripheral nerve diseases 3.
- Conditions
- Carpal Tunnel Syndrome, Diabetic Neuropathies, Guillain-Barre Syndrome
- Trial name
- NCT04092140
- Testing
- ultrasound
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Multiple Sclerosis
Re-training to Effort (RE) According to the Severity of Multiple Sclerosis: Preliminary Assessments Based on Fatigue and Quality of Life
Regular physical activity promotes physical and mental well-being in the general population. Patients with multiple sclerosis (MS patients) tend them, to limit their physical activity or because of deficiencies related to the…
- Trial name
- RE-SEP (NCT02848976)
- Testing
- Re-training to effort (RE)
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Nantes University Hospital
Relapsing Remitting Multiple Sclerosis
Exploratory Study on the Timing of Multiple Sclerosis (MS) Symptoms
The investigators' overall hypothesis is that appearance or worsening of relapsing-remitting multiple sclerosis (RR-MS) symptoms are affected by various factors including stress, hormonal cycles, illness and missed medications.
- Trial name
- NCT00919217
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Louisville
Krabbe Disease
Biomarker for Krabbe Disease (BioKrabbe)
Development of a new MS-based biomarker for the early and sensitive diagnosis of Krabbe Disease from blood
- Trial name
- BIOKRABBE (NCT01425489)
- Where
- 5 sites in Egypt, Germany and 2 more
- Sponsor
- CENTOGENE GmbH Rostock
Multiple Sclerosis
Unraveling Early Walking Dysfunction in Non-disabled MS People: Assessment and Potential Therapeutic Interventions
The aim of the study is to set up a pilot study to investigate the effects of treadmill training in preventing the onset and worsening of walking impairments, balance deficits and fatigue.
- Trial name
- NCT03492450
- Testing
- Treadmill training
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Multiple Sclerosis
Oral FMT (Fecal Microbial Transplant) in Subjects With Multiple Sclerosis
The goal of this pilot study is to determine whether fecal microbial transplant (FMT) has the potential to be an effective, safe and tolerable therapy for the treatment of multiple sclerosis (MS).
- Trial name
- NCT04096443
- Testing
- Fecal microbial transplant (FMT)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Griffin Hospital
Multiple Sclerosis
Detection of Pattern of Some Unusual Signs and Symptoms of Multiple Sclerosis
Each Multiple Sclerosis patient will be submitted to Cognitive Abilities Screening Instrument (CASI), Expanded Disability Status Scale, Epowrth Sleeping Scale(ESS),Fatigue Severity Scale(FSS), Hamilton Depression Rating Scale…
- Trial name
- NCT04100343
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Multiple Sclerosis
SPINCOMS Biomarker Study
To determine if biomarker-based CSF testing is reliably detecting differences between patients with Multiple Sclerosis (MS), different MS-subtypes, and other central nervous system (CNS) diseases.
- Trial name
- SPINCOMS (NCT04496830)
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- Washington University School of Medicine
Multiple Sclerosis
Intensity Depended Impacts on Cognitive Functions in Persons With Multiple Sclerosis - a Pilot Study
Multiple Sclerosis (MS) is a chronic autoimmune disease where lymphocytes inflict damage to the axons and myelin sheaths of the central nervous system.
- Trial name
- NCT02408367
- Testing
- Exercise, Relaxation
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Jens Bansi
Multiple Sclerosis
The Effect of Levetiracetam (Keppra) on the Treatment of Tremor in Multiple Sclerosis
We are carrying out this study to determine whether Keppra (a drug usually used to treat epilepsy) is an effective treatment for tremor in patients with Multiple Sclerosis.
- Trial name
- NCT00430599
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Multiple Sclerosis, Autologous Hematopoietic Stem Cell Transplant
ATLG Levels in Autologous HSCT for Multiple Sclerosis
This is a prospective, observational, biological, multicenter study to investigate IR profile, ATLG dynamics, main HSCT and disease outcomes in MS.
- Conditions
- Multiple Sclerosis, Autologous Hematopoietic Stem Cell Transplant, ATLG
- Trial name
- ATLG-MS (NCT07635693)
- Testing
- ATLG administration
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Ciceri Fabio
Multiple Sclerosis, Optic Neuritis
Longitudinal Optic Neuritis Study (LONS)
To assess the beneficial and adverse effects of corticosteroid treatment for optic neuritis. To determine the natural history of vision in patients who suffer optic neuritis.
- Trial name
- NCT00000147
- Testing
- Methylprednisolone, Prednisone
- Where
- 15 sites in United States
- Sponsor
- National Eye Institute (NEI)
Adrenoleukodystrophy, Metachromatic Leukodystrophy
HSCT for High Risk Inherited Inborn Errors
Hematopoietic stem cell transplantation has proven effective therapy for individuals with adrenoleukodystrophy (ALD), metachromatic leukodystrophy (MLD) or globoid cell leukodystrophy (GLD, or Krabbe disease).
- Conditions
- Adrenoleukodystrophy, Metachromatic Leukodystrophy, Globoid Cell Leukodystrophy, Tay Sachs Disease
- Trial name
- NCT00383448
- Testing
- Clofarabine, Total body Irradiation, Melphalan
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Multiple Sclerosis, Treatment Adherence
Semi-inmersive Virtual Reality on Upper Limb in Multiple Sclerosis
Video games based on VR technology are emerging as valid tools used in neurorehabilitation for patients with neurological disorders, and as a low cost and easily accepted adjunct to traditional therapy.
- Conditions
- Multiple Sclerosis, Treatment Adherence, Upper Extremity Paresis
- Trial name
- NCT04171908
- Testing
- Conventional therapy, semi-inversive tech
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad Rey Juan Carlos
Neuromyelitis Optica Spectrum Disorder
A Study of MIL62 in Patients With Neuromyelitis Optica Spectrum Disorder (NMOSD)
This study will evaluate the safety and efficacy of MIL62 in patients with Neuromyelitis Optica Spectrum Disorder.
- Trial name
- NCT05314010
- Testing
- MIL62
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Beijing Mabworks Biotech Co., Ltd.
Trigeminal Neuralgia, Multiple Sclerosis
A Personalised Radiosurgery Procedure for People With Trigeminal Neuralgia to Improve Pain, Quality of Life and Reduce Complications
The aim of this study is to evaluate prospectively the feasibility and impact of personalised gamma knife radiosurgery treatment protocol versus current standard protocol for people with idiopathic or Multiple Sclerosis-related…
- Conditions
- Trigeminal Neuralgia, Multiple Sclerosis, Pain
- Trial name
- NCT04117035
- Testing
- Gamma Knife Radiosurgery (GKRS) personalised procedure, GKRS standard care
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Leeds
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