Clinical trials: Demyelinating Disorder
Multiple Sclerosis, Overactive Bladder
PTNS for Female Patients Suffering From Multiple Sclerosis
This is a pilot, single blind, randomized, sham-controlled trial to assess the benefit of Percutaneous Tibial Nerve Stimulation (PTNS) in treating bladder overactivity (OAB) symptoms in multiple sclerosis (MS) patients.
- Trial name
- PTNS-MS (NCT05422625)
- Testing
- PTNS Treatment
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Corewell Health East
Multiple Sclerosis (MS)
Efficacy and Safety of Ofatumumab and Siponimod Compared to Fingolimod in Pediatric Patients With Multiple Sclerosis
Efficacy and safety of ofatumumab and siponimod compared to fingolimod in pediatric patients with multiple sclerosis
- Trial name
- NEOS (NCT04926818)
- Testing
- Fingolimod, Ofatumumab, Siponimod
- Where
- 51 sites in United States, Argentina and 23 more
- Volunteers
- 129 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis
Expanded Access to Intrathecal Administration of Autologous Mesenchymal Stem Cell-derived Neural Progenitors (MSC-NP) in Progressive Multiple Sclerosis
To give expanded access to intrathecal autologous MSC-NP treatment to patients with progressive MS who do not meet the inclusion/exclusion criteria of our Phase II stem cell trial.
- Trial name
- NCT03822858
- Testing
- Intrathecal MSC-NP injection
- Where
- United States
- Sponsor
- Tisch Multiple Sclerosis Research Center of New York
Multiple Sclerosis
Teriflunomide Male Transmission Study
It is known that teriflunomide, a treatment for relapsing forms of multiple sclerosis, can be found in low concentrations in semen.
- Trial name
- NCT02679885
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Griffin Hospital
Multiple Sclerosis
An Extension Study of the Efficacy and Safety of Fingolimod (FTY720) in Patients With Relapsing Multiple Sclerosis
This study was an extension study of NCT00537082. This study was designed to evaluate the efficacy and safety of long-term administration of 0.5 mg or 1.25 mg of fingolimod (FTY720) to relapsing multiple sclerosis.
- Trial name
- NCT00670449
- Testing
- Fingolimod
- Where
- 20 sites in Japan
- Volunteers
- 143 people
- Sponsor
- Novartis
Multiple Sclerosis
A Multi-Site, Open-Label Extension Trial of Oral RPC1063 in Relapsing Multiple Sclerosis
The purpose of the trial is to determine the safety and efficacy of RPC1063 in patients with relapsing multiple sclerosis.
- Trial name
- NCT02576717
- Testing
- RPC1063
- Where
- 175 sites in United States, Belarus and 24 more
- Volunteers
- 2,494 people
- Sponsor
- Celgene
Multiple Sclerosis
Phase II Study of Teriflunomide as Adjunctive Therapy to Interferon-beta in Subjects With Multiple Sclerosis
The primary objective was to estimate the tolerability and safety of 2 doses of teriflunomide administered once daily for 24 weeks, compared with placebo, in patients with multiple sclerosis [MS] with relapses who were on a…
- Trial name
- NCT00489489
- Testing
- Teriflunomide, Interferon-β
- Where
- 5 sites in United States, Canada and 3 more
- Volunteers
- 118 people
- Sponsor
- Sanofi
Multiple Sclerosis
Effect of Active-Passive Trainer Cycling on Multiple Sclerosis
This randomised controlled trial aims to explore the effectiveness of a four week programme of exercise using lower limb Active Passive trainer (APT) (MOTOmed trainer) in terms of spasticity in people with moderate to severe…
- Trial name
- NCT02737904
- Testing
- APT, Usual care
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- NHS Greater Glasgow and Clyde
Multiple Sclerosis, Fatigue
The Effect of Music and Progressive Relaxation Exercise on Fatigue and Sleep in Multiple Sclerosis
Multiple Sclerosis (MS) is a chronic complex neurodegenerative disease that targets the central nervous system and is autoimmune. The prevalence of fatigue in individuals diagnosed with MS varies between 50% and 81%.
- Conditions
- Multiple Sclerosis, Fatigue, Sleep
- Trial name
- NCT06468241
- Testing
- Progressive relaxation exercise, Listening to music
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ondokuz Mayıs University
Multiple Sclerosis
Rolipram to Treat Multiple Sclerosis
This study will evaluate the safety, tolerability, and effect of the drug Rolipram on multiple sclerosis (MS). It will examine whether Rolipram can dampen the part of the immune response believed to lead to MS and reduce disease…
- Trial name
- NCT00011375
- Testing
- Rolipram
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Trigeminal Neuralgia, Multiple Sclerosis
Symptomatic Trigeminal Neuralgia Attributed to Multiple Sclerosis - a Prospective Study in 60 Patients
Clinical characteristics, neuroanatomical findings and efficacy of medical and surgical treatment of symptomatic trigeminal neuralgia - a systematic prospective study of 60 consecutive patients
- Conditions
- Trigeminal Neuralgia, Multiple Sclerosis, Pain, Neuropathic
- Trial name
- NCT04371575
- Testing
- Carbamazepine
- Volunteers
- 60 people
- Sponsor
- Stine Maarbjerg, MD PhD
Multiple Sclerosis, Relapsing-Remitting
Study Assessing Cognition in Relapsing Remitting Multiple Sclerosis (RRMS) Patients Treated With BG00012
The primary objective(s) of the study are to assess the BG00012 (dimethyl fumarate) treatment effect on cognition over 2 year period in RRMS patients.
- Trial name
- StarTec (NCT02579681)
- Testing
- dimethyl fumarate
- Where
- 18 sites in Italy
- Volunteers
- 221 people
- Sponsor
- Biogen
Multiple Sclerosis
Allogenic Mesenchymal Stem Cells And Physical Therapy for MS Treatment
This study aims at expanding Umbilical Cord derived Mesenchymal Stem Cells (MSCs) to a clinical scale according to Good Laboratory Practice and study its efficacy when compared to a Supervised Physical Therapy Program alone.
- Trial name
- NCT03326505
- Testing
- Umbilical cord derived Mesenchymal Stem Cells, Supervised physical therapy
- Where
- 2 sites in Jordan
- Volunteers
- 60 people
- Sponsor
- University of Jordan
Multiple Sclerosis (MS), Myasthenia Gravis (MG)
A Study of C-CAR168 in the Treatment of Autoimmune Diseases Refractory to Standard Therapy
This is an investigator-initiated, single-center, open-label study of C-CAR168, an autologous bi-specific CAR-T therapy targeting CD20 and BCMA, for the treatment of adult patients with autoimmune diseases refractory to standard…
- Conditions
- Multiple Sclerosis (MS), Myasthenia Gravis (MG), Neuromyelitis Optica Spectrum Disorder, Systemic Lupus Erythematosus
- Trial name
- NCT07676266
- Testing
- CD20/BCMA-directed CAR-T cells Autologous 2nd generation
- Where
- China
- Volunteers
- 18 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Dementia, Parkinson
Autologous Stem/Stromal Cells in Neurological Disorders and Disease
The study deals with evaluation of safety and efficacy of use of stem/stromal cell isolates from autologous microvasculature in neurological, non-neoplastic disease.
- Conditions
- Dementia, Parkinson, Altered Behavior in Alzheimer Disease, Demyelinating Autoimmune Diseases, CNS
- Trial name
- NDD (NCT03297177)
- Testing
- Microcannula Harvest Adipose, Centricyte 1000, Sterile Normal Saline Infusion
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Regeneris Medical
Magnetic Resonance Imaging, Central Nervous System
Contrast-enhanced 3D T1-weighted Gradient-echo Versus Spin-echo 3 Tesla MR Sequences in the Detection of Active Multiple Sclerosis Lesions
Gadolinium-enhanced magnetic resonance imaging (MRI) is currently the imaging gold standard to detect active inflammatory lesions in multiple sclerosis (MS) patients.
- Conditions
- Magnetic Resonance Imaging, Central Nervous System, Brain, Multiple Sclerosis
- Trial name
- COGITE (NCT03268239)
- Testing
- Additional MRI sequences
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Parkinson Disease, Stroke
Smart Wearable Device (gaitQ): Walk Better Project
This study will be underpinned by the new MRC guidelines for developing a complex intervention with a participatory design methodology that uses evidence-based research and behaviour change models alongside COSMIN methodology for…
- Conditions
- Parkinson Disease, Stroke, Multiple Sclerosis, Osteoporosis
- Trial name
- NCT05913219
- Where
- United Kingdom
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Multiple Sclerosis
Step it Up: An Exercise and Behaviour Change Programme for People With Multiple Sclerosis
Exercise has consistently yielded short-term, positive effects on health outcomes in people with multiple sclerosis (MS). However, these effects have not been maintained in the long-term.
- Trial name
- NCT02301442
- Testing
- Exercise + behaviour change intervention, Exercise + control education
- Where
- Ireland
- Volunteers
- 65 people
- Sponsor
- University of Limerick
Multiple Sclerosis, Optic Neuritis
Ampyra for Optic Neuritis in Multiple Sclerosis
Fifty subjects will be enrolled in this Phase II, investigator-initiated, randomized and blinded cross-over trial of dalfampridine of 8 weeks duration The study will test the hypothesis that dalfampridine, when administered to…
- Trial name
- NCT01337986
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Washington University School of Medicine
Multiple Sclerosis
Assessment of Subject Use of the Rebiject II Injection Device According to Nurse Examination of Subject Accuracy in 10 Steps as a Dummy Demonstration
Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system (CNS) and is one of the most common causes of neurological disability in young adults.
- Trial name
- NCT01195857
- Volunteers
- 100 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
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