Clinical trials: Demyelinating Disorder
Neuromyelitis Optica Spectrum Disorder
CorEvitas SPHERES (Synergy of Prospective Health & Experimental Research for Emerging Solutions) Registry for Neuromyelitis Optica Spectrum Disorder (NMOSD)
This is a Prospective, observational research study for patients with NMOSD under the care of a licensed neurologist. Approximately 800 patients and 35 clinical sites in North America will be recruited to participate with no…
- Trial name
- NCT04886492
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- CorEvitas
Multiple Sclerosis
Immunogenicity and Safety of Subcutaneously-administered Avonex (Interferon Beta-1a) in Multiple Sclerosis (MS) Patients
The primary objective of the study was to evaluate the immunogenicity of Avonex® (interferon beta-1a) 30 mcg when administered subcutaneously (SC) to interferon-naïve participants with relapsing multiple sclerosis.
- Trial name
- NCT00784836
- Testing
- BG9418 (interferon beta 1-a)
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Biogen
Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting
Discontinuing Disease-modifying Therapies in Stable Relapsing - Onset Multiple Sclerosis (DOT-MS).
The aim of this study is to identify whether it is possible to safely discontinue treatment in relapsing-onset MS patients who have shown no evidence of active inflammation in the years prior to inclusion clinically and/or…
- Conditions
- Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Secondary Progressive
- Trial name
- DOT-MS (NCT04260711)
- Testing
- DMT
- Where
- Netherlands
- Volunteers
- 130 people
- Sponsor
- Amsterdam UMC, location VUmc
Multiple Sclerosis
Effect of Combined Exercise Training in Patients With Multiple Sclerosis
The aim of this clinical trial is exercise in sarcopenic MS patients to demonstrate the effectiveness of education. The main questions it aims to answer are: -Can exercise training make a change in muscle thickness in sarcopenic…
- Trial name
- NCT06595394
- Testing
- Exercise, Home program
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Uskudar University
Multiple Sclerosis
Prospective, Multicenter Non Interventional Study to Evaluate Adherence to Betaferon Over a 2 Years Period
The aim of the SEPLUS study is to evaluate the patients characteristics associated with adherence to Betaferon over a 24-month follow up period after the initiation of Betaferon in the BetaPlus program
- Trial name
- SEPLUS (NCT01076595)
- Testing
- Interferon beta-1b (Betaseron, BAY86-5046)
- Where
- France
- Volunteers
- 73 people
- Sponsor
- Bayer
Multiple Sclerosis, Back Pain
A Pilot Project for Multifidus Muscle Evaluation in Patients With Multiple Sclerosis
This research study plans to evaluate if multifidus muscle dysfunction is associated with back pain in patients with Multiple Sclerosis (MS).
- Trial name
- NCT05427045
- Testing
- home - exercise program
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Arkansas
Multiple Sclerosis
Assessment of Walking-related Fatigability in Patients With Multiple Sclerosis.
The primary goal of this interventional study is to objectively examine the prevalence of walking-related performance fatigability, together with the psychometric properties of its measuring parameters.
- Trial name
- NCT03860675
- Testing
- Assessment of walking-related fatigability
- Where
- 3 sites in Belgium
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Multiple Sclerosis (ICD10-G35)
The Effect of a Series of Systemic Cryotherapy Treatments on the Functional State of Patients With Multiple Sclerosis
Multiple sclerosis (Latin: Sclerosis multiplex; MS) is a chronic, inflammatory and degenerative disease of the central nervous system (CNS) characterised by a varied course and symptomatology.
- Trial name
- NCT04533971
- Testing
- Whole body cryotherapy
- Volunteers
- 114 people
- Sponsor
- Pomeranian Medical University Szczecin
Multiple Sclerosis (MS), Multiple Sclerosis, Relapsing-Remitting
Assessing Changes in Multi-parametric MRI in MS Patients Taking Clemastine Fumarate as a Myelin Repair Therapy
The clinical trial is intended to assess for clinical evidence of Clemastine Fumarate as a myelin repair therapy in patients with chronic inflammatory injury-causing demyelination as measured by multi-parametric MRI assessments.
- Conditions
- Multiple Sclerosis (MS), Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Chronic Progressive
- Trial name
- ReVIVE (NCT05359653)
- Testing
- Clemastine Fumarate
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of California, San Francisco
Multiple Sclerosis
The Effect of Aerobic Exercise on Cognitive Function and Sleep Quality in Individuals With Multiple Sclerosis
In addition to the typical motor and sensory impairments, individuals with multiple sclerosis (MS) often experience cognitive dysfunction and sleep disturbances. Cognitive impairment occurs in 40 % - 70% of patients with MS.
- Trial name
- NCT01783665
- Testing
- aerobic exercise, home exercise program
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Catherine Siengsukon, PT, PhD
Multiple Sclerosis
Study on Cognitive Disorders of Multiple Sclerosis
The purpose of this study is to determine if memantine is effective in the treatment on cognitive disorders of Relapsing - Remitting multiple sclerosis. m
- Trial name
- NCT01074619
- Testing
- Memantine
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Caen
Multiple Sclerosis (MS)
Enhancing Quality of Life in MS Patients Through Tailored Therapeutic Education
Within the framework of improving the quality of life for patients with Multiple Sclerosis (MS), this prospective and descriptive study aims to evaluate the effectiveness of a therapeutic education program.
- Trial name
- MS (NCT06450600)
- Testing
- Multiple Sclerosis Therapeutic Education Program
- Volunteers
- 50 people
- Sponsor
- Akhrif Iman
Multiple Sclerosis
MEsenchymal StEm Cells for Multiple Sclerosis
A double-blind, randomized, cross-over phase I/II study to evaluate the safety and the efficacy of the intravenous administration of autologous Mesenchymal Stem Cells (MSC) to patients with active multiple sclerosis (MS)…
- Trial name
- MESEMS (NCT01854957)
- Testing
- Autologous Mesenchymal Stem Cells
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Antonio Uccelli
Multiple Sclerosis
Improving Memory in Patients With Multiple Sclerosis
People with multiple sclerosis (MS) suffer from cognitive and other brain problems. This study will examine the effectiveness of the drug donepezil and of sugar water for enhancing memory in individuals with MS.
- Trial name
- NCT00062972
- Testing
- donepezil, glucose
- Where
- United States
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Multiple Sclerosis, Exercise (EX)
Immersive Virtual Reality and Exercise Programs in Multiple Sclerosis
TITLE: Immersive Virtual Reality and Exercise Programs in Multiple Sclerosis INTRODUCTION: Multiple sclerosis (MS) is a chronic neuroimmunological and degenerative disease characterized by demyelination within the central nervous…
- Conditions
- Multiple Sclerosis, Exercise (EX), Physical Therapy, Virtual Reality Exposure Therapy
- Trial name
- ExeRVIEM II (NCT07543900)
- Testing
- Virtual exercise based program
- Where
- Spain
- Volunteers
- 5 people
- Sponsor
- University of Vigo
Multiple Sclerosis
Famciclovir in Multiple Sclerosis
This is a proof-of-concept study in 30 patients with established Relapsing Remitting Multiple Sclerosis (RRMS). IMP is Famciclovir. It is a phase II type A open label study.
- Trial name
- NCT05283551
- Testing
- Famciclovir
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Queen Mary University of London
Progressive Multiple Sclerosis
Efficacy of Early Harvest Olive Oil in Cognition of Primary (PPMS) or Secondary (SPMS) Progressive Multiple Sclerosis
To date, no drug therapy has been approved for primary (PPMS) \& secondary (SPMS) progressive multiple sclerosis. The urgent need to find new therapies - if possible with minimal side effects - led us to the search for the…
- Trial name
- NCT04120675
- Testing
- Early Harvest Extra Virgin Olive Oil
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- Aristotle University Of Thessaloniki
Multiple Sclerosis
Comparison Between Clinical and MRI Multiple Sclerosis Activity and Expression of Human Endogenous Retrovirus Type W and Herpesvirus
Multiple sclerosis is the most common autoimmune inflammatory disease of the central nervous system. It is known that your etiology has genetic and environmental causes.
- Trial name
- NCT02489877
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Faculdade de Ciências Médicas da Santa Casa de São Paulo
Multiple Sclerosis, Relapsing-remitting
Peer Support Impact on Therapeutic Adherence in Patients With Multiple Sclerosis
A mixed methods randomized controlled trial pilot study to assess peer support impact on relapsing-remitting multiple sclerosis patients' therapeutic adherence.
- Trial name
- PAIR-SEP (NCT05519553)
- Testing
- Peer support
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Nantes University Hospital
Guillain-Barré Syndrome
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Crovalimab in Participants With Guillain-Barré Syndrome (GBS)
The purpose of this study is to evaluate the efficacy, safety, pharmacokinetics, and pharmacodynamics of crovalimab compared with placebo as an add-on therapy to intravenous immunoglobulin (IVIg) in participants with severe GBS.
- Trial name
- NCT05494619
- Testing
- Crovalimab, Intravenous immunoglobulin therapy
- Sponsor
- Hoffmann-La Roche
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