Clinical trials: Demyelinating Disorder
Multiple Sclerosis
Extension to the MAGNIFY MS Trial on Mavenclad® (Magnify MS Extension)
The primary purpose of this study was to evaluate the long-term effectiveness of Mavenclad® tablets, in terms of disease activity and safety, in participants with highly-active relapsing multiple sclerosis (RMS) previously…
- Trial name
- NCT04783935
- Testing
- Mavenclad®
- Where
- 46 sites in Australia, Austria and 12 more
- Volunteers
- 219 people
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Multiple Sclerosis, Relapsing-Remitting
Natalizumab in Combination With Glatiramer Acetate (GA) in Patients With Relapsing-Remitting Multiple Sclerosis
The purpose of this study is to determine if natalizumab in combination with Glatiramer Acetate (GA) is safe and effective in delaying progression of individuals diagnosed with relapsing-remitting Multiple Sclerosis (MS).
- Trial name
- NCT00097760
- Testing
- Natalizumab
- Volunteers
- 110 people
- Sponsor
- Biogen
Multiple Sclerosis
Exercise in Severely Disabled Patients With MS
In the last decade physical exercise has become an accepted and integrated part of rehabilitation in patients with multiple sclerosis (MS).
- Trial name
- NCT01752660
- Testing
- Endurance training, Standard care
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- University of Aarhus
Spinal Cord Injury, Spinal Cord Involvement
Clinical Trial of a Serious Game for Individuals With SCI/D
This study will evaluate the efficacy of a newly developed serious game, SCI HARD, to enhance self-management skills, self-reported health behaviors, and quality of life among adolescents and young adults with spinal cord injury…
- Conditions
- Spinal Cord Injury, Spinal Cord Involvement, Spina Bifida, Transverse Myelitis
- Trial name
- NCT02341950
- Testing
- SCI Hard
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- University of Michigan
Relapsing-remitting Multiple Sclerosis, Secondary Progressive Multiple Sclerosis
Patient Research Cohort: Rapidly Evolving Multiple Sclerosis
The primary goal of the research cohort is to facilitate patient access to clinical trials testing new therapeutic interventions, or access to second- line treatments.
- Trial name
- PRC-REMS (NCT01044576)
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Imperial College London
Multiple Sclerosis
Effects of Torso Weighting on Muscle Activation During Balance Tests in Individuals With and Without Multiple Sclerosis
Rationale: The Balance-Based Torso-Weighting (BBTW) is a patented evaluation system that uses strategic placement of small or lightweight weights on the trunk to improve balance and stability.
- Trial name
- BBTW-MS (NCT06981013)
- Testing
- balance based torso weighting
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of St. Augustine for Health Sciences
Multiple Sclerosis
Motivation of Patients Diagnosed With Multiple Sclerosis to Become Citizen Researchers
The study will based on qualitative methods investigate motivational factors among patients diagnosed with multiple sclerosis for registering nutrition, environmental factors, stress provoking factors and physical activity…
- Trial name
- NCT02760082
- Testing
- Qualitative evaluation
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- University of Copenhagen
Multiple Sclerosis
Retrospective Study on Registry Data to Evaluate the Impact of Ocrelizumab Used in Routine Care in Patients With RRMS
Multiple Sclerosis (MS) is a chronic, autoimmune, neurodegenerative disease; clinical events are mainly attributed to myelin destruction and inflammatory of the central nervous system.
- Trial name
- SEP-RR (NCT04838015)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Strasbourg, France
Multiple Sclerosis
iConquerMS™ - A Patient-Powered Research Network for Multiple Sclerosis
iConquerMS™ is a research initiative developed by and for people with multiple sclerosis (MS) to contribute their health data and ideas to advance and accelerate research into MS.
- Trial name
- iCMS (NCT02486562)
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Accelerated Cure Project for Multiple Sclerosis
Multiple Sclerosis
Brain and Behavioral Influences on Motor Skill Learning in Multiple Sclerosis
Multiple Sclerosis (MS) is characterized by episodic attacks in which there are sharp declines in physical function. Although neurorehabilitation is the most promising clinical strategy for motor recovery in patients with MS…
- Trial name
- NCT03404388
- Testing
- Balance Training
- Where
- United States
- Sponsor
- Wayne State University
Multiple Sclerosis
Psychometric Properties Mobility Measures MS
Current study will investigate the quality (psychometric properties) and clinical utility of several mobility measures, according to disability level.
- Trial name
- MCS-III-MOB (NCT02339688)
- Testing
- conventional MS rehabilitation
- Where
- Belgium
- Volunteers
- 254 people
- Sponsor
- Hasselt University
Secondary Progressive Multiple Sclerosis, Primary Progressive Multiple Sclerosis
Metformin Treatment in Progressive Multiple Sclerosis
The purpose of this study is to assess the safety of metformin for treatment of progressive multiple sclerosis
- Trial name
- NCT05349474
- Testing
- Metformin 500 Mg Oral Tablet, up to 4 tablets a day
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of California, Los Angeles
Multiple Sclerosis Subjects
Task-oriented Circuit Training Combined With Cerebellar tDCS in Multiple Sclerosis Subjects
Aims of the study: This is a double-blind randomized-controlled trial to test the effects of a task oriented training combined with cerebellar transcranial direct current stimulation on locomotor function, mobility and balance in…
- Trial name
- NCT01883310
- Testing
- real tDCS +TOCT
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital of Ferrara
Multiple Sclerosis, Spasticity
Classification of Upper and Lower Limb Spasticity Patterns and Their Impact on Quality of Life in Patients With Multiple Sclerosis
Multiple sclerosis (MS) is a chronic neurological disease frequently associated with spasticity, which may lead to functional limitations and reduced quality of life.
- Conditions
- Multiple Sclerosis, Spasticity, Spasticity With Multiple Sclerosis
- Trial name
- NCT07466823
- Testing
- Observational Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people
- Sponsor
- Marmara University
Multiple Sclerosis
Influence of Emotional Disorders and Executive on the Components Retrograde and Anterograde Episodic Memory in MS
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system responsible for physical disability but can also cause cognitive disturbances annoying social and professional life of patients with the disease.
- Trial name
- ITEMS (NCT02518776)
- Testing
- Neuropsychological tests
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Multiple Sclerosis
Ambulation Study in Multiple Sclerosis
This is a study comparing clinical tests of walking and balance. The goal of this study is to discover which of those tests are best at predicting walking problems due to MS.
- Trial name
- NCT00424359
- Volunteers
- 40 people
- Sponsor
- Brown, Theodore R., M.D., MPH
Multiple Sclerosis
Clinical Factors Associated With Position Sense in Patients With Multiple Sclerosis
Sensory impairment is an important problem for patients with Multiple Sclerosis (MS). Although there is no complete loss of sensation in patients, 80% of patients have a significant sensory impairment.
- Trial name
- NCT04548297
- Testing
- Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Gazi University
Multiple Sclerosis
Neuromuscular Electrical Stimulation and Mobility in Multiple Sclerosis
The purpose of this study is to investigate the capacity of a 6-week treatment with neuromuscular electrical stimulation to improve walking in individuals whose mobility has been compromised by multiple sclerosis.
- Trial name
- NCT02152085
- Testing
- Narrow pulse, Wide pulse
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Colorado, Boulder
Multiple Sclerosis
Expiratory Muscle Conditioning in Multiple Sclerosis Using Magnetic Stimulation
Multiple sclerosis (MS) is a primary disorder of the central nervous system that may affect motor pathways and cause muscle weakness.
- Trial name
- NCT01758224
- Testing
- Functional Magnetic Stimulation, Resistive Expiratory Muscle Training
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- The Cleveland Clinic
Multiple Sclerosis
TWEAK, a New Biomarker for Predicting Inflammatory Relapses in Multiple Sclerosis
A significant variation in the serum concentration of the circulating cytokine TWEAK is associated with the onset of an inflammatory attack of MS.
- Trial name
- TWEAK (NCT03974997)
- Testing
- Determination of the circulating serum concentration of cytoquine TWEAK
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
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