Clinical trials: Demyelinating Disorder
Progressive Multiple Sclerosis
Neural Stem Cell Transplantation in Multiple Sclerosis Patients
This is a phase I study evaluating the feasibility, safety and tolerability of intrathecally administered human Neural Stem Cells (hNSCs), at an escalating dose ranging from 0.7x10^6±10% cells to 5.7x10^6±10% cells/kg of body…
- Trial name
- STEMS (NCT03269071)
- Testing
- human fetal-derived Neural Stem Cells (hNSCs)
- Where
- Italy
- Volunteers
- 4 people
- Sponsor
- IRCCS San Raffaele
Multiple Sclerosis
Oral Ponesimod Versus Teriflunomide In Relapsing MUltiple Sclerosis
International clinical trial to compare ponesimod and teriflunomide in relapsing multiple sclerosis
- Trial name
- OPTIMUM (NCT02425644)
- Testing
- ponesimod, teriflunomide
- Where
- 162 sites in United States, Belarus and 26 more
- Volunteers
- 1,133 people
- Sponsor
- Actelion
Multiple Sclerosis, Relapsing Forms
Safety and Tolerability Study of MEDI-551, a B-cell Depleting Agent, to Treat Relapsing Forms of Multiple Sclerosis
The purpose of this study is to evaluate the safety and tolerability of ascending intravenous (IV) and subcutaneous (SC) doses of MEDI-551 in adult subjects with relapsing forms of multiple sclerosis (MS).
- Trial name
- NCT01585766
- Testing
- MEDI-551 30 MG-IV, MEDI-551 60 MG-SC, MEDI-551 100 MG-IV
- Where
- 16 sites in United States, Poland and 2 more
- Volunteers
- 56 people
- Sponsor
- MedImmune LLC
Pain, Pain Syndrome
Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Central Neuropathy of Any Genesis
Over the last years a rising medical need for treatment of chronic pain was identified. Based on previous findings indicating the pain modulating effects of cannabinoids in chronic pain disorders, this clinical trial investigates…
- Conditions
- Pain, Pain Syndrome, Pain, Chronic, Chronic Pain
- Trial name
- NCT06072001
- Testing
- Adezunap (AP707)
- Where
- Germany
- Volunteers
- 558 people
- Sponsor
- Apurano Pharmaceuticals GmbH
Multiple Sclerosis, Cognitive Dysfunction
HOBSCOTCH-MS-Efficacy Trial
The purpose of this study is to assess the ability of the home-based intervention, HOBSCOTCH-MS to improve the quality of life and cognitive function in Service Members, Veterans and civilians who have multiple sclerosis with…
- Conditions
- Multiple Sclerosis, Cognitive Dysfunction, Memory Disorders, Memory Impairment
- Trial name
- NCT06951919
- Testing
- Home Based Self- management and Cognitive Training Changes lives in Multiple Sclerosis (HOBSCOTCH-MS)
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Multiple Sclerosis
Factorial Optimization Trial to Test Cognitive Behavioral Therapy Components for Multiple Sclerosis Fatigue
This randomized controlled factorial trial will examine whether and how relaxation training, behavioral activation, and cognitive therapy improve fatigue and functioning in fatigued adults living with multiple sclerosis.
- Trial name
- NCT06809192
- Testing
- 4-session Relaxation Training, 4-session Behavioral Activation, 4-session Cognitive Therapy
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- University of Washington
Multiple Sclerosis
Efficacy of Square- Stepping Exercises in Individuals With Multiple Sclerosis
Square stepping exercises can promote correct foot placement, fast and coordinated step patterns, and sensory-motor interaction.
- Trial name
- NCT05682963
- Testing
- Square Step Exercises Program, Home Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Pamukkale University
Type 1 Diabetes Mellitus, Multiple Sclerosis
T and B Cell Responses in Autoimmune Diseases
The study aims to establish whether defects in immune cell function are shared across multiple autoimmune diseases and whether those problems match to similar genes in the cells.
- Conditions
- Type 1 Diabetes Mellitus, Multiple Sclerosis, Arthritis, Rheumatoid, Crohn's Disease
- Trial name
- SRA01 (NCT01947036)
- Where
- 6 sites in United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Multiple Sclerosis
Designing Virtual Reality-based Software for People With Multiple Sclerosis
The study aims to designing virtual reality-based testing and rehabilitation software for people with multiple sclerosis and assess the feasibility of software.
- Trial name
- NCT05420532
- Testing
- Exergaming
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Yuzuncu Yil University
Multiple Sclerosis
Evaluation of the Response to Acthar Gel Therapy in Patients Who Failed Intravenous Methylprednisolone (IVMP) for MS Relapses
Although ACTHAR gel is approved for the treatment of acute relapses, it is currently not widely used. Thus, we propose to conduct a small open-label proof-of-concept trial to evaluate the response to ACTHAR gel therapy in…
- Trial name
- NCT01900093
- Testing
- Acthar Gel
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Aaron Miller
Multiple Sclerosis
Effects of Mat and Reformer Pilates in Multiple Sclerosis
Our study aims to investigate the effects of core stability-based Mat Pilates and Equipment-Based Pilates training on anticipatory postural adjustments (APA), balance, and gait in individuals with Multiple Sclerosis (MS).
- Trial name
- NCT06931522
- Testing
- Mat Pilates, Reformer Pilates
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gazi University
Multiple Sclerosis, Neurorehabilitation
Comprehensive Therapeutic Program For People With Multiple Sclerosis
This study investigates the effectiveness of an intensive multidisciplinary rehabilitation program for people with multiple sclerosis (PwMS).
- Conditions
- Multiple Sclerosis, Neurorehabilitation, Rehabilitation, Rehabilitation Exercise
- Trial name
- BIB_MS (NCT07248657)
- Testing
- Outpatient physiotherapy, group psychotherapy
- Where
- Czechia
- Volunteers
- 26 people
- Sponsor
- Charles University, Czech Republic
Autoimmune Disease, Neurologic Autoimmune Disease
Autologous Stem Cell Transplant for Neurologic Autoimmune Diseases
This phase II trial studies the side effects and how well carmustine, etoposide, cytarabine and melphalan together with antithymocyte globulin before a stem cell transplant works in treating patients with autoimmune neurologic…
- Conditions
- Autoimmune Disease, Neurologic Autoimmune Disease, Autologous Transplant Autoimmune, Multiple Sclerosis Transplant
- Trial name
- NCT00716066
- Testing
- Anti-Thymocyte Globulin, Autologous Hematopoietic Stem Cell Transplantation, Carmustine
- Where
- 3 sites in United States
- Volunteers
- 53 people
- Sponsor
- Fred Hutchinson Cancer Center
Canavan Disease
Oral Glyceryl Triacetate (GTA) in Newborns With Canavan
Canavan disease is caused by Aspartoacylase deficiency. There is no treatment for the disease, but there is a food additive that includes acetate .
- Trial name
- NCT00724802
- Testing
- GTA (Glyceryl triacetate), GTA glyceryl triacetate
- Where
- Israel
- Volunteers
- 1 people
- Sponsor
- Shaare Zedek Medical Center
NMO Spectrum Disorder
Monoclonal Antibody-Based Therapies for AQP4-Positive NMOSD
The primary objective of this registry study is to evaluate the therapeutic efficacy and safety profiles of distinct monoclonal antibody-based therapies for aquaporin-4 immunoglobulin G-seropositive neuromyelitis optica spectrum…
- Trial name
- NCT06885957
- Testing
- Mab Therapy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Tongji Hospital
Multiple Sclerosis
An Observational Study on the Progression of Clinically Isolated Syndrome to Multiple Sclerosis Over a 2-year Period
This is a prospective, multicentric, observational study with a 2 years recruitment period. The purpose of the study is to observe the multiple sclerosis (MS) progression of subjects since their first episode of neurological…
- Trial name
- NEO (NCT01112657)
- Where
- 6 sites in Taiwan
- Volunteers
- 154 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Multiple Sclerosis
Silent Progression Activity Monitoring - SPAM Study
Real-World Data (RWD) exploring the natural history of MS suggested that relapses do not significantly influence the progression of irreversible disability.
- Trial name
- SPAM (NCT05650281)
- Testing
- NO INTERVENTION
- Where
- France
- Volunteers
- 2,230 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Multiple Sclerosis
Effects of Exercises in MS on Postural Control With Dual Task
Multiple sclerosis is a progressive neurological disease that associated with demyelinization and axonal damage. Decreased postural control is one of the initial symptom of disease.
- Trial name
- MScombined (NCT03718819)
- Testing
- exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 13 people
- Sponsor
- Dokuz Eylul University
Multiple Sclerosis
Endurance and Walking Training by Nordic Walking in Multiple Sclerosis
Walking capacity is one of the most valuable body functions among persons with multiple sclerosis (MS) and it is one of the most frequently affected, even in early stages of the disease.
- Trial name
- NCT03976128
- Testing
- Nordic Walking Training, Conventional endurance training
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Multiple Sclerosis Center of Catalonia
Neurogenic Overactive Bladder, Multiple Sclerosis
Enhancing Pelvic Floor Function With Transcranial Magnetic and Tibial Nerve Stimulation for Neurogenic Bladder in MS
Multiple Sclerosis (MS) is a chronic, autoimmune, inflammatory, and degenerative neurological disorder that affects the central nervous system.
- Trial name
- NCT06581341
- Testing
- Repetitive Transcranial Magnetic Stimulation and Percutaneous Tibial Nerve Stimulation, Repetitive Transcranial Magnetic Stimulation, Percutaneous Tibial Nerve Stimulation
- Volunteers
- 60 people
- Sponsor
- Sierra Varona SL