Clinical trials: Dental Caries
Vital Pulp Therapy
Diagnostic Biomarkers to Correlate Molecular Changes and Inflammatory Cascade in the Dental Pulp.
This study aimed to evaluate the molecular changes that occur within the pulp tissue during inflammation and its correlation with vital pulp therapy with its different treatment modalities (Direct pulp capping, Partial Pulpotomy…
- Trial name
- NCT05464797
- Testing
- Pulp therapy, Cytokines level in pulpal blood.
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Dental Caries
Evaluation of Preventive Regimens With Different Toothpastes vs Fluoride Varnish & Toothpaste in High Caries Patients
This study will be conducted in order to determine the prevention effect of caries preventive regimen using herbal toothpaste and regimen using fluoride toothpaste versus fluoride toothpaste and fluoride varnish on the caries…
- Trial name
- NCT04436913
- Testing
- Himalaya complete care toothpaste, Signal toothpaste, Signal toothpaste and fluoride varnish
- Where
- Egypt
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Cairo University
Tooth Decay
Clinical Assessement of Glazed Versus Polished Lithium Disilicate Crowns in Surface Roughness and Enamel Antagonists Wear
It is believed that final glazing yields the most acceptable ceramic surfaces in terms of smoothness. However, since reglazing must be performed in a dental laboratory with the use of a thermal furnace, it requires multiple…
- Trial name
- NCT03696849
- Testing
- polished emax Press
- Volunteers
- 28 people
- Sponsor
- Cairo University
Congenital Heart Defect, Dental Caries in Children
Oral Health Intervention Program for Children With Congenital Heart Defects
Background: Children with congenital heart defects (CHD) are reported to have poorer oral health compared with healthy children.
- Conditions
- Congenital Heart Defect, Dental Caries in Children, Dental Erosion, Dental Plaque
- Trial name
- NCT03311438
- Testing
- Oral health intervention program
- Volunteers
- 75 people
- Sponsor
- University of Bergen
HIV Infection, HIV Infections
Raltegravir Activity In Lymphoid Tissues
The reduction with antiretroviral therapy (ART) of HIV RNA in blood, and HIV RNA in infected cells and in viruses associated with the follicular dendritic cell (FDC) network in lymphatic tissues, typically follows a two-phase…
- Trial name
- NCT00863668
- Testing
- Efavirenz + Tenofovir DF/Emtricitabine, Raltegravir + Tenofovir DF/Emtricitabine, Colonoscopy with biopsies
- Where
- United States
- Sponsor
- University of Minnesota
Tricho Hepato Enteric Syndrome
Clinical and Biological Characterization of Patients and Collection of Samples
Objectives: Collect clinical and biological data about patients with SD/THE, collect samples of patients; create a secure on line database to collect worldwide data about SD/THE Partners : APHM, HCL, APHP Currently10 patients (8…
- Trial name
- THE-RNA (NCT04499040)
- Testing
- Blood sample, Fecal samples, Neuropsychological
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Dental Pulp Disease
Manual and Rotatory Instrumentation Pulpectomy in Primary Mandibular Molars
In this study, the aim is to compare manual and rotatory pulpectomy techniques on 100 primary mandibular molars on children between the ages of 4 and 8 years.
- Trial name
- RotaPulp (NCT04636450)
- Testing
- Rotatory technique pulpectomy, Manual pulpectomy
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Universidad de Guanajuato
Dentin, Carious, Indirect Pulp Capping
Clinical Success of Indirect Pulp Capping: 1-Year Follow-Up
The goal of this clinical trial is to compare the clinical success of theracal pt, therabase, and biodentine indirect pulp capping on primary molars with deep dentin caries.
- Trial name
- NCT06325540
- Testing
- indirect pulp capping with theracal pt, indirect pulp capping with therabase, indirect pulp capping with biodentine
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Dental Caries
Stopping Cavities Study: Diammine Silver Fluoride
This study is being conducted to test whether the use of diammine silver fluoride (also called silver diamine fluoride) hardens the cavity sufficiently so that it arrests.
- Trial name
- NCT02536040
- Testing
- 38% diammine silver fluoride, Water
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Advantage Dental Services, LLC
Dental Caries
Clinical Study 3MESPE Crowns CR15/02
This clinical study seeks to address four independent questions that are all part of the delivery of care associated with the provision of a single item of treatment; an indirect restoration (known as a 'crown') to restore and…
- Trial name
- NCT02735304
- Testing
- Impression intervention
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Root Caries
36-Month Clinical Performance of Different Restorative Materials in the Treatment of Root Caries Lesions
This is a split-mouth, randomized clinical study that evaluating the 36-month performance of different restorative materials in the treatment of root caries lesions.
- Trial name
- NCT03722758
- Testing
- Spectrum TPH3, Riva LC
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Dental Caries
Effectiveness of ART and Conventional Treatment - Practice-based Clinical Trial
Background: Dental caries is still a public health problem among Brazilian children and doubts still exist regarding the most effective restorative technique.
- Trial name
- NCT02568917
- Testing
- Atraumatic Restorative Treatment - Ketac Molar Easy Mix, Conventional Restoration - Composite Resin (Bulk Fill)
- Where
- Brazil
- Volunteers
- 800 people
- Sponsor
- University of Sao Paulo
Dental Caries, Artificial Intellegence
Accuracy of an Artificial Intelligence-assisted Diagnostic System for Caries Diagnosis: a Prospective Multicenter Clinical Study
This clinical trial was designed as a prospective, multicenter, multi-reader multi-case (MRMC), superiority, parallel-controlled study. Participants who met the trial criteria and signed the informed consent form were enrolled.
- Conditions
- Dental Caries, Artificial Intellegence, Diagnosis, Machine Learning
- Trial name
- NCT06428344
- Volunteers
- 220 people
- Sponsor
- Zhejiang Provincial People's Hospital
Dental Caries, Pulpotomies Primary Teeth
Ferric Sulfate and Sodium Hypochlorite Pulpotomies in Vital Primary Teeth
This study aims to compare the clinical and radiographic success of two commonly used pulpotomy agents, ferric sulfate (FS) and sodium hypochlorite (NaOCl), in vital primary molars.
- Trial name
- NCT07548008
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Marmara University
Dental Caries
Caries Prevention Effect of S-PRG Filler Incorporated in Denture Base Resins on Edentulous Elderly People
The purpose of this study is to determine whether a novel material of S-PRG fillers containing in a daily-used resin denture base and their capability of fluoride release and recharge to elevate the salivary fluoride level and…
- Trial name
- NCT02460562
- Testing
- S-PRG filler, PMMA resin
- Where
- 3 sites in Thailand
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Kritirat Kiatsirirote
Preterm Birth, Periodontal Disease
Saving Lives at Birth: Primary Prevention of Periodontal Disease in Relation to Preterm Birth in Malawi
The hypothesis of the investigators' project is that comprehensive primary preterm birth prevention, inclusive of maternal oral health with xylitol chewing gum (the intervention), will reduce the rate of periodontal disease and…
- Conditions
- Preterm Birth, Periodontal Disease, Caries, Dental
- Trial name
- PPaX (NCT02333227)
- Testing
- Xylitol gum
- Where
- United States
- Volunteers
- 10,069 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Dental Plaque, Saliva Altered
Effects of Two Sugar Substituted Chewing Gums on Caries and Gingivitis Variables
The purpose of this study is to determine the effect of three times a day mastication, during a follow-up period of 4 weeks, of two sugar-substituted chewing gums on various factors associated with dental caries and gingivitis.
- Conditions
- Dental Plaque, Saliva Altered, Gingivitis
- Trial name
- NCT01578603
- Testing
- xylitol, casein phosphopeptide amorphous calcium phosphate complex
- Where
- Colombia
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
Pediatric Obesity, Pediatric Dentistry
Oral Health in Children and Adolescents With Obesity and Normal Weight
We aimed to compare the oral health status (dmft/DMFT index, IDCAS-II, BEWE, plaque index, gingival index, probing depth) between normal-weight (NW) and obese (OW) children/adolescents.
- Trial name
- NCT06283602
- Testing
- oral health status
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Dental Pulp Cavity, Root Canal Treatment
Endoscopic Treatment During Endodontic Procedures
The objectives of this Phase I study is to evaluate the safety and effectiveness of the endoscopic endodontic equipment device for root canal assistance treatment as well as to evaluate the ease of use of this device, by a…
- Conditions
- Dental Pulp Cavity, Root Canal Treatment, Endoscopy
- Trial name
- NCT01192607
- Testing
- Endoscopic treatment during root canal treatment
- Where
- Israel
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Barzilai Medical Center
Root Caries, Vertical Root Fracture
Evaluation of Corrective Surgery Versus Dental Implants in Compromised Mandibular Molars
This study seeks to assess the clinical, radiographic, and patient-reported outcomes of hemisection versus implant over a 12 months period, generating robust evidence to guide clinical decision-making and enhance patient care.
- Trial name
- NCT07633834
- Testing
- hemi sectioning
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
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