Clinical trials: Dental Caries (Disorder)
Dental Caries
Clinical Evaluation of Kerr SonicFill™ 2 vs 3M ESPE Filtek™ Supreme Ultra Universal Restorative
The purpose of this study is to compare esthetic, functional and biological properties of two restoration materials used to fill cavities.
- Trial name
- NCT03032705
- Testing
- SonicFill™ 2, Filtek™ Supreme
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Tufts University
Dental Caries
Efficacy of Three Toothpastes Using an in Situ Caries Model
This will be a single-centre, randomized, blinded, placebo-controlled, 6-treatment, 4-period crossover, incomplete block design, in situ caries study in healthy adults who wear a removable bilateral mandibular partial denture.
- Trial name
- NCT02751320
- Testing
- 0.425 % w/w phytate,1150ppm F, 0.85 % w/w phytate,1150ppm F, 0.85 % w/w phytate,0.3%ZnCl2 0.5% sodium citrate, 1150ppm F
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Caries, Unsatisfactory or Defective Restoration of Tooth
Clinical Investigation of the F-Composite 2 System in Direct Filling Therapy
The objective of this study is to evaluate the clinical performance of F-Composite 2 system in Class I and Class II cavities in permanent teeth.
- Trial name
- NCT03221660
- Testing
- F-Composite 2 system
- Where
- Liechtenstein
- Volunteers
- 50 people
- Sponsor
- Ivoclar Vivadent AG
Dental Caries
A Study to Evaluate the Safety and Microbiology of C16G2 Varnish Administered in Multiple Doses to Dental Subjects
The purpose of this single-blind study is to evaluate whether C16G2 Varnish administered in multiple doses can effectively kill the bacteria in the oral cavity that cause dental caries.
- Trial name
- NCT03004365
- Testing
- C16G2 Varnish
- Where
- 3 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Armata Pharmaceuticals, Inc.
Dental Caries
Pharmacokinetics of Advantage Arrest in Children
The purpose of this study is to characterize basic PK parameters (Cmax, t1/2, AUC) in healthy children to contribute to evidence for the safety of Advantage Arrest, consistent with Guidance for Industry--Exposure--Response…
- Trial name
- NCT04186663
- Testing
- Silver Diamine Fluoride
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Advantage Silver Dental Arrest, LLC
Dental Caries, Secondary Dental Caries
A Comparative Study of Papacarie® and the Conventional Method for Dental Caries Treatment
The purpose study are to evaluate the efficacy of Papacarie® for caries removal in comparison to the conventional drilling method.
- Conditions
- Dental Caries, Secondary Dental Caries, Personal Satisfaction
- Trial name
- NCT01641861
- Testing
- Papacarie®, Conventional method
- Where
- Thailand
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Dental Caries
Enamel Remineralization Potential of Dentifrices in Situ
This study will use an oral in-situ caries model to study remineralization of enamel due to the action of different combinations of fluoride salts delivered from dentifrices.
- Trial name
- NCT01128946
- Testing
- NaF, SnF, NaMFP
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Caries
In Vivo Comparison of Salivary Fluoride Levels Following the Application of Different 5% NaF Varnishes
This study will be a cross-over single blinded clinical study to evaluate the in vitro fluoride release of three different brands of 5% NaF varnish.
- Trial name
- NCT01629290
- Testing
- Enamel Pro, Duraphat, Vanish
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Dental Plaque, Dental Caries
Evaluation of Oral Plaque Removal Utilizing an Adjunct Enzyme Pre-rinse
This study aims to investigate the impact of a bromelain pre-rinse adjunct on oral plaque removal in orthodontic subjects. The study's null hypothesis states that there is no statistically significant difference in visual plaque…
- Trial name
- NCT04512482
- Testing
- Bromelain, Powdered sugar
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Indiana University
Preventive Oral Health
Oral Health Training Program for Pediatric Residents
The purpose of this study was to compare the effect of the addition of hands on training by a pediatric dentist on the pediatric residents skills, confidence, opinions and practice related to preventive oral health.
- Trial name
- NCT00846066
- Testing
- Hands on training, Web based training
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Dental Caries
Decision Aids for the Management of Suspicious Occlusal Caries Lesions
The study will determine whether clinicians who use a diagnostic device treat suspicious occlusal carious lesions (SOCL) surgically more often, with the same frequency, or less frequently, than dentists not relying on a…
- Trial name
- SOCL (NCT02340767)
- Testing
- Spectra Device, DIAGNOdent
- Where
- 6 sites in United States
- Volunteers
- 3,085 people, healthy volunteers welcome
- Sponsor
- The National Dental Practice-Based Research Network
Dental Caries
Conventional Bite Wing Radiography Versus Stationary Intraoral Tomosynthesis, a Comparison Study
A comparison of caries detection rates between conventional intraoral bitewing radiography and a stationary intraoral digital tomosynthesis (s-IOT) using a carbon nanotube X-ray source array.
- Trial name
- NCT02873585
- Testing
- Stationary intraoral tomosynthesis, Standard conventional bitewing radiography
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Dental Caries
European Study on Three Different Approaches to Managing Class 2 Cavities in Primary Teeth
The purpose of this randomized clinical trial is to compare the clinical effectiveness of three treatments involving different caries management strategies (conventional restorations, Hall technique, and Non-Restorative Caries…
- Trial name
- NCT01797458
- Testing
- Hall Technique, Non-Restorative Caries Treatment, Conventional Restoration
- Where
- 3 sites in Germany, Lithuania and 1 more
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Dental Caries
Clinical Study on a New Flowable Composite as a Restorative in Adult Teeth
Study hypothesis: a new, low polymerization stress flowable composite performs no differently to a conventional, highly filled composite filling material when used as a restorative in small cavities in back teeth.
- Trial name
- NCT01369108
- Testing
- Flowable composite, Conventional composite restorative
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Solventum US LLC
Dental Caries in Children
Silver Diamine Fluoride Gel: Single Group Observational Study
A single group observational study to determine the clinical response of dental caries lesions in primary teeth where 38% silver diamine fluoride gel is applied and cover with 2.5% sodium fluoride varnish.
- Trial name
- KiruPoderoso (NCT05395065)
- Testing
- Silver Diamine Fluoride/Sodium Fluoride Varnish
- Where
- 5 sites in Peru
- Volunteers
- 237 people
- Sponsor
- Advantage Silver Dental Arrest, LLC
Dental Caries, Unsatisfactory or Defective Restoration of Tooth
Clinical Evaluation of a Bulk Fill Resin Composite
The purpose of this clinical trial is to measure the clinical outcomes of Tetric PowerFill Class I and II restorations cured in 3 seconds with the Bluephase PowerCure curing unit.
- Trial name
- NCT04686422
- Testing
- Tetric PowerFill
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Ivoclar Vivadent AG
Dental Caries, Quality of Life
Comparative Effectiveness of School-based Caries Prevention
Dental caries (tooth decay) is the most prevalent childhood disease in the world. Multiple interventions are available to treat and prevent caries.
- Trial name
- NCT03442309
- Testing
- Silver Diamine Fluoride, Fluoride Varnishes, Glass Ionomer
- Where
- United States
- Volunteers
- 7,418 people, healthy volunteers welcome
- Sponsor
- NYU College of Dentistry
Dental Caries
Older Adult Effectiveness of 2 Treatments
The study is a cluster randomized clinical trial (RCT) to be conducted in 40 (22 originally planned +16 additional) publicly subsidized housing facilities/sites (HUD Section 202) and other low-income housing voucher programs in…
- Trial name
- NCT03916926
- Testing
- A "simple medical strategy" consisting of silver diamine fluoride (SDF), B "typical dental strategy" consisting of atraumatic restorative treatment (ART) with glass ionomer cement + Fluoride varnish (FV)
- Where
- United States
- Volunteers
- 568 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Dental Caries in Children, Dental Caries Class II
Treatment of Interproximal Cavities on Primary Molar Teeth With Silver Diamine Fluoride
This study investigates whether 1) Silver diamine fluoride (SDF) application using Super Floss can arrest and/or reverse initial interproximal caries on primary molars and 2) whether SDF applied with Super Floss is more effective…
- Conditions
- Dental Caries in Children, Dental Caries Class II, Dental Caries
- Trial name
- NCT03770286
- Testing
- 5% Fluoride Varnish, 38% Silver diamine fluoride, Super Floss
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Dental Caries, Denture, Partial, Removable
Nobio Clinical Study - Demineralization Prevention With a New Antibacterial Restorative Composite
Nobio has developed dental restorative materials with long term antibacterial properties in order to fight recurrent decay/caries around restorations.
- Trial name
- Nobio (NCT04059250)
- Testing
- Nobio composite, traditional composite
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco