Clinical trials: Dental Disease
Molar Incisor Hypomineralization
Zirconia Reinforced Glass Ionomer in MIH
Molar-incisor hypomineralization (MIH) is a qualitative enamel defect, in which molars and incisors involved are prone to post-eruptive enamel breakdown leading to sensitivity, and caries.
- Trial name
- NCT05494749
- Testing
- zirconomer, HVGI-Equia Forte
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Hams Hamed Abdelrahman
Enamel Hypoplasia, Molar-Incisor Hypomineralization (MIH)
Clinical Comparison of CAD/CAM Nanohybrid Composite and Hybrid Ceramic Overlays in Children With Molar-Incisor Hypomineralisation
This clinical study was conducted to compare two different dental materials used in the treatment of children who have a condition called molar-incisor hypomineralization (MIH).
- Conditions
- Enamel Hypoplasia, Molar-Incisor Hypomineralization (MIH), Restoration of Permanent Molars Affected by MIH With CAD/CAM Blocks
- Trial name
- NCT06987448
- Testing
- Semi-direct onlay restoration using CAD/CAM hybrid composite block, Semi-direct onlay restoration using CAD/CAM hybrid ceramic block
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Alp Akça
Reversible Pulpitis, Ibuprofen
Pain Management in Teeth With Reversible Pulpitis
Effective intraoperative pain management is vital in paediatric dentistry, especially during vital pulp therapy (VPT) for reversible pulpitis.
- Trial name
- NCT07114198
- Testing
- Ibuprofen 10 mg/kg
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Inonu University
Jaw, Edentulous, Dental Implant
An Implant With an Acid-etched Fixture Surface and Internal-hex Collar May Achieve Greater Osseointegration.
Brånemark System® dental implant osseointegration was introduced clinically in 1965 as a novel approach to the replacement of missing teeth.
- Trial name
- NCT01641198
- Testing
- Configuration 1, Configuration 2, Configuration 3
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Université de Montréal
Jaw, Edentulous, Partially
Straumann Roxolid Multi-Center Study
The primary objective of this study is to demonstrate non-inferiority of the Straumann Bone Level Ø 3.3 mm NC SLActive Roxolid Implants compared to Straumann Bone Level Ø 4.1 mm RC SLActive Roxolid Implants based on mean crestal…
- Trial name
- NCT01842958
- Testing
- Straumann Bone Level Implants, 4.1 mm implant diameter, Straumann Bone Level Implants, 3.3 mm implant diameter
- Where
- 5 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institut Straumann AG
Bacteremia, Endocarditis
An Oral Doxycycline Regimen to Prevent Bacteremia Following Dental Procedures
Although controversy exists regarding the efficacy of antibiotic prophylaxis for patients at risk of infective endocarditis, expert committees continue to publish recommendations for antibiotic prophylactic regimens.
- Trial name
- NCT06422221
- Testing
- Clindamycin, Doxycycline
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- University of Santiago de Compostela
Tooth Hypersensitivity
A Clinical Study for the Effect of 4th Generation Poly AmidoAmine Dendrimer on Post-Bleaching Hypersensitivity and Shade Stability
This study assessed the impact of four desensitizing agents on both color stability and dental sensitivity following a bleaching procedure, spanning from the 24-hour to the 1-year follow-up assessment periods.
- Trial name
- NCT06358911
- Testing
- Poly amido amine dendrimer (PAMAM), Manufacturer's desensitizing agent, Ultra EZ, MI paste plus, desensitizing agent
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Dental Diseases
Dental Dyschromia and Quality of Life in Early Prolonged Hyperbilirubinemia
The main objective of this study is to assess the prevalence of dental discoloration (dental dyschromia) in children who experienced high levels of bilirubin in their blood (hyperbilirubinemia) during their early years.
- Trial name
- SMILE (NCT06506734)
- Testing
- Questionnaires
- Where
- 9 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Toulouse
Peri-Implantitis
Effect of Hyaluronic Acid on Perimplantitis
The effect of the hyaluronic acid treatment on peri-implantitis has not been tested. The aim was to analyze the effect of a hyaluronic acid-containing gel on the clinical variables and the expression of biochemical inflammatory…
- Trial name
- NCT03157193
- Testing
- Hyaluronic Acid, Hydroxypropyl Guar
- Volunteers
- 61 people
- Sponsor
- Universidad de Granada
Pulp Exposure, Dental, Pulp Disease, Dental
The Effect of Genetic Polymorphisms on the Success of Vital Pulp Therapy
This study employs saliva-based DNA analysis to investigate the effect of genetic polymorphisms, particularly SNPs in MMP, TIMP, TNF-α, and BMP genes, on the success of vital pulp therapy in permanent teeth with pulpitis…
- Conditions
- Pulp Exposure, Dental, Pulp Disease, Dental, Pulp Caping, Pulpitis
- Trial name
- NCT07130214
- Testing
- Biodentine
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Ataturk University
Dental Caries
Effect of Shortening the Etching Time on the Clinical Performance of Resin Composite Restorations in Primary Teeth
The aim of this study is to evaluate the effect of shortening the etching time on the 18-month clinical performance of resin composite restorations in primary molars after partial carious removal.
- Trial name
- NCT02969538
- Testing
- Total etching time, Half-reduced etching time
- Where
- Brazil
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Santa Maria
Dental Implant, Edentulous Mouth
Occlusion and Dis-Occlusion Time in Mandibular Overdentures Supported by Conventional Versus Mini- Dental Implants
The aim of the study will be comparing between the occlusion and disocclusion time in mandibular single overdenture supported with immediately loaded two conventional implants versus immediately loaded four mini-implants.
- Trial name
- NCT07256106
- Testing
- mini dental implant, conventional dental implant
- Where
- 2 sites in Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Dental Plaque
Comparative Accuracy of AI Models and Clinical Assessment for Dental Plaque Detection in Children
This diagnostic accuracy study aims to evaluate the effectiveness of various artificial intelligence models in detecting dental plaque from intraoral images compared to clinical assessments performed by dentists among children.
- Trial name
- NCT06760104
- Testing
- Dental Plaque Detection Using AI Models
- Where
- Egypt
- Volunteers
- 323 people
- Sponsor
- Naema Ahmed
Dental Plaque
U Shaped Toothbrush in Removing Plaque in Children
The aim of this study is to evaluate the effectiveness of a U-shaped toothbrush in removing plaque in preschool children which can be a simple, acceptable, and effective way to remove plaque in children in order to improve their…
- Trial name
- NCT06288581
- Testing
- Traditional toothbrush group, U shaped toothbrush group
- Where
- Syria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Damascus University
Dental Caries
Checking Occlusion During Stainless Steel Crown Placement
Stainless steel crowns are arguably the most successful posterior restorations in primary teeth and have been so for more than 50 years.
- Trial name
- NCT02437565
- Testing
- Stainless steel crown, Occlusal Template
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Riyadh Colleges of Dentistry and Pharmacy
Gingival Recession
Root Coverage in Smokers With Acellular Dermal Matrix Graft and Enamel Matrix Derivative
Smoking has a negative effect on the predictability and stability of root coverage procedures because of decreased blood supply and fibroblast activity.
- Trial name
- NCT02135471
- Testing
- acellular dermal matrix graft, enamel matrix derivative
- Where
- Brazil
- Volunteers
- 19 people
- Sponsor
- University of Sao Paulo
Body Mass Index, Dental Caries
The Relationship Between Body Mass Index, Dental Eruption and Dental Caries Prevalence in School Children
The aim of the current study will be to explore the relationship between body mass index, dental eruption and dental caries prevalence in school Children.
- Conditions
- Body Mass Index, Dental Caries, Eruption
- Trial name
- NCT05902611
- Testing
- BMI determination, Eruption Time Assessment, Caries Assessment
- Where
- Egypt
- Volunteers
- 1,224 people
- Sponsor
- Al-Azhar University
Edentulous
Implant Placement With Simultaneous Gum Grafting
This study is a comparison of implant placed and simultaneously grafted with either autogenous connective tissue or a connective tissue allograft.
- Trial name
- NCT01431144
- Testing
- connective tissue autograft, connective tissue allograft
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Periapical Periodontitis
Encapsulated Acellular System From Mesenchymal Stem Cells for Dental Pulp Regeneration
To evaluate the security and efficacy in the administration of encapsulated acellular system derived from Mesenchymal Stem Cells as a novel regenerative endodontic procedure which to promote the pulpar regenration.
- Trial name
- NCT05599087
- Testing
- Acellular system
- Where
- Chile
- Volunteers
- 10 people
- Sponsor
- Universidad de los Andes, Chile
Endodontic Disease
Evaluation of Antimicrobial Efficacy and Adaptability of Bioceramic Sealer Containing Nanoparticles
Successful endodontic treatment depends primarily on the elimination of infecting microorganisms. This is done by chemo-mechanical preparation of root canals, which is not enough and microorganisms might still survive.
- Trial name
- NCT04481945
- Testing
- bioceramic sealer
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Misr International University
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