Clinical trials: Dental Disease
Dental Caries
Study to Evaluate the Safety and Microbiology of C16G2 in Adolescent and Adult Dental Subjects
The purpose of the clinical study is to evaluate the safety and bacterial impact of study drug (C16G2) administered in multiple oral gel doses to adolescent and adult dental subjects.
- Trial name
- NCT02509845
- Testing
- C16G2
- Where
- 5 sites in United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Armata Pharmaceuticals, Inc.
Osteolysis, Dental Implants
Regular Home-use Dual Light Photodynamic Therapy in the Prevention of Osteolysis After Dental Implant Surgery
The aim of the study is to determine whether regular use of the antibacterial, photodynamic, CE-marked Lumoral device reduces the risk of osteolysis after dental implant surgery.
- Trial name
- NCT06041828
- Testing
- Lumoral Treatment, Standard oral hygiene
- Where
- Finland
- Sponsor
- Koite Health Oy
Dental Caries Pit and Fissure, Oral Disease
Effectiveness and Retention of Pit and Fissure Sealants in Rural Setup: A School-based Clinical Trial in Nepal
The program titled "Campus to Community: breaking the barrier in oral health education and dental care" is uniquely designed program to link University (Kathmandu University School of Medical Sciences) to community (Sanghutar…
- Trial name
- NCT05894200
- Testing
- Glass Ionomer cement pit and fissure sealant, Silver Diamine Fluoride
- Where
- Nepal
- Volunteers
- 377 people
- Sponsor
- Kathmandu University School of Medical Sciences
Dental Plaque, Gingivitis
The Clinical Investigation of a New Toothpaste Containing Stannous Fluoride as Compared to a Commercially Available Fluoride Toothpaste in Reducing Plaque and Gingivitis
The objective of this study is to evaluate the clinical efficacy of a new toothpaste containing stannous fluoride (SnF) as compared to Colgate Fluoride Toothpaste in reducing gingivitis and dental plaque.
- Trial name
- NCT03852056
- Testing
- MFP Fluoride toothpaste, Stannous fluoride toothpaste
- Where
- China
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Health, Subjective, Gastrointestinal Dysfunction
Personalized Lifestyle Intervention for Improving Functional Health Outcomes Using N-of-1 Tent-Umbrella-Bucket Design
The LIFE-HOUSE research project is designed to evaluate the impact of a personalized lifestyle intervention program on functional capacity as an approach to quantitating health, and its relationship to well understood disease…
- Conditions
- Health, Subjective, Gastrointestinal Dysfunction, Cardiovascular Risk Factor, Autoimmune Diseases
- Trial name
- LIFE-HOUSE (NCT04005456)
- Testing
- Supplements and/or medical foods, Behavioral change support program, Food plan
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Metagenics, Inc.
Pain
The Effectiveness of Sweet Solution Versus Cryotherapy in Reducing Pain During Administration of Local Anesthesia Among Children
the porpose of study to assess The Effectiveness of Sweet Solution Versus Cryotherapy in Reducing Pain During Administration of Local Anesthesia Among Children
- Trial name
- NCT07002528
- Testing
- sucrose solution, Cryotherapy, topical anesthesia
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Dental Anxiety, Dental Diseases
Behavioral Support Techniques on Anxiety and Physical Reaction From Dental Treatment
Application of deep touch pressure (DTP) has been suggested to provide positive effects on anxiety modulation. However, empirical and theoretical evidence linked to the clinical effects of DTP is relatively rare in the behavioral…
- Conditions
- Dental Anxiety, Dental Diseases, Dental Trauma
- Trial name
- NCT03819166
- Testing
- with deep touch pressure application, without deep touch pressure application
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Dental Plaque
Vertical vs Horizontal Brushing: a Randomized Split-mouth Clinical Trial
The aim of this randomized, single-blind, split-mouth design, clinical trial was to evaluate the effectiveness in plaque removal of the vertical and the horizontal brushing methods. Trauma on soft tissues were also registered.
- Trial name
- NCT01900353
- Testing
- brushing methods
- Where
- Italy
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Milan
Survival, Prosthesis, Peri-Implantitis
Maxillary Sinus Floor Augmentation With Different Grafting Materials
Implant placement in the posterior maxilla is compromised due to atrophy of the alveolar process and maxillary sinus pneumatisation. Bone augmentation is frequently necessary before or in conjunction with implant placement.
- Conditions
- Survival, Prosthesis, Peri-Implantitis, Patient Satisfaction
- Trial name
- NCT04749953
- Testing
- Maxillary sinus floor augmentation
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Dental Erosion, Gastroesophageal Reflux
Gastro-oesophageal Reflux in Oligosymptomatic Patients With Dental Erosion
Dental erosions, the chemical dissolution of enamel without bacterial involvement, are considered to be an established complication of gastroesophageal reflux disease (GERD) by the Montreal global consensus statement.
- Trial name
- NCT02087345
- Where
- Switzerland
- Volunteers
- 500 people
- Sponsor
- Brain-Gut Research Group
Dental Erosion
The Effect of Chlorhexidine on the Oral Microbiome and Saliva in Dental Erosion
Dental erosion happens when the teeth lose some of their parts because of acid from the things people eat and/or drink or even from stomach. It can make teeth hurt and become sensitive.
- Trial name
- NCT06171594
- Testing
- Chlorhexidine mouthwash
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
Dental Caries
Efficacy of Dentifrices Containing Arginine Versus Fluoride on Microbial Acid
This study will be conducted to evaluate the effect of arginine versus fluoride containing toothpaste on neutralization of microbial acid produced by Cariogenic bacteria in adult population using chair side assessment method.
- Trial name
- NCT03143023
- Testing
- arginine toothpaste, fluoride toothpaste
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gingivitis
Flossing With Chlorhexidine
To determine if flossing with a dental floss presoaked in chlorhexidine, an anti-microbial mouth wash, would improve the clinical signs of gingivitis, an inflammation of the gums characterized by red, swollen, bleeding gums.
- Trial name
- NCT00471783
- Testing
- Chlorhexidine is the generic name of the mouthwash, Peridex is the brand name.
- Where
- Canada
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Edentulous Jaw
A Clinical Study of the TSV Dental Implant System
This will be a prospective, randomized, observational study. All implants will be placed in either the maxilla or mandible and loaded within 2 months with a provisional or definitive prosthesis.
- Trial name
- Blue Sky (NCT04236336)
- Testing
- TSV dental implant
- Where
- 5 sites in United States, Spain
- Volunteers
- 104 people
- Sponsor
- ZimVie
Dental Caries Class I (Disorder), Dental Caries Class II
Clinical Evaluation of Bulk-fill vs Layered Composite Resin in Class I and II Posterior Restorations
The aim of this study is to evaluate the clinical performance of Filtek Bulk Fill Posterior Restorative in Class I and Class II restorations compared to the conventional incremental technique using Filtek Z350XT over the period…
- Trial name
- NCT03306602
- Testing
- Filtek Bulk Fill Posterior Restorative, Filtek Z350 XT
- Where
- Malaysia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Melaka Manipal Medical College
TMJ Disorder
MJ Arthrocentesis Using the Dental Implant Motor Irrigation Pump and the Conventional Technique in Treatment of Internal Derangement
Background: Millions of individuals worldwide suffer from temporomandibular joint (TMJ) disorders and are characterized by pain and joint dysfunction.
- Trial name
- NCT07239037
- Testing
- Motor irrigation with 80% power, Motor irrigation with 40% power, conventional TMJ arthrocentesis
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Alexandria University
Dental Caries (Diagnosis), Dental Plaque
Clinical Assessment of Caries and Dental Plaque Based on Auto-fluorescence Imaging System
The purpose of this study was to evaluate the applicability of auto-fluorescence imaging system to detect and quantify caries and dental plaque.
- Conditions
- Dental Caries (Diagnosis), Dental Plaque, Optical Imaging
- Trial name
- NCT03038412
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hui Chen
Pulp Exposure, Dental
Octenidine and Sodium Hypochlorite for Pulp Irrigation in Direct Pulp Capping
In the included patients, after complete removal of caries from the entire cavity, the exposed pulp will be treated with either a 2.5% NaOCl or 0.1% Octenidine solution.
- Trial name
- NCT06946719
- Testing
- pulp lavage Octenidine, pulp lavage NaOCl
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Dental Caries
Microbiome Changes After Laser and Chlorhexidine Disinfection in Caries Removal
The aim of this study was to investigate the effects of cavity disinfection with laser and chlorhexidine on the microbiome in cavities prepared using different caries removal methods.
- Trial name
- NCT06765330
- Testing
- CHX disinfection, Laser Disinfection, Tungsten carbide bur
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Mersin University
Edentulous Mouth, Complete Edentulism
Mandibular Overdentures Retained by Mini Implants: a Clinical Trial Comparing Different Surgical and Loading Protocols
This study aims to test the combined effects of different loading protocols and surgical approaches on clinical and patient-reported outcome measures (PROMs) following the use of four mini implants for mandibular overdenture…
- Trial name
- SMIS (NCT04760457)
- Testing
- Implant placement with flapped surgery, Implant placement with flapless surgery, Implant immediate loading
- Where
- Brazil
- Volunteers
- 74 people
- Sponsor
- Universidade Federal de Goias
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