Clinical trials: Dental Pulp Diseases
Pulp Necrosis
Treatment Outcome With a Revascularization Protocol Using the Triple Versus Double Antibiotic Paste
The purpose of this study is to determine the treatment outcomes in permanent teeth with necrotic pulp and immature root development that undergo a regenerative procedure using a triple antibiotic paste (ciprofloxacin…
- Trial name
- NCT00881491
- Testing
- Double Antibiotic Paste, Triple Antibiotic Paste, Mineral Trioxide Aggregate
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Teeth, Endodontically-Treated, Anterior Teeth
Clinical Evaluation of Laminate Veneers With Coronal Post Versus Post and Core Foundation Restoration With Single Crown for Restoration of Endodontically Treated Anterior Teeth (Randomized Controlled Trial) "In-vivo Study"
Clinical evaluation of Laminate veneers with coronal post versus post and core foundation restoration with single crown for restoration of endodontically treated anterior teeth (Randomized Controlled Trial) "In-vivo Study"
- Trial name
- NCT03314545
- Testing
- laminate veneer with coronal post, post,core and crown
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Cairo University
Endodontic Disease
Evaluation of Antimicrobial Efficacy and Adaptability of Bioceramic Sealer Containing Nanoparticles
Successful endodontic treatment depends primarily on the elimination of infecting microorganisms. This is done by chemo-mechanical preparation of root canals, which is not enough and microorganisms might still survive.
- Trial name
- NCT04481945
- Testing
- bioceramic sealer
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Misr International University
Irreversible Pulpitis (toothache)
Garlic Oil As Root Filling Material in Primary Molars
The goal of this study is to test garlic oil mixed with zinc oxide as a potential root canal filling material of primary molars in children aged from four to eight years.
- Trial name
- NCT06755502
- Testing
- Garlic oil, Calcium Hydroxide, Iodoform, paste
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pulpitis - Irreversible, Apical Periodontitis
Evaluation of Nano Bioactive Glass Combined With i-PRF Scaffold in Vital Pulp Treatments
With consideration of the previous studies regarding the properties of i-PRF, it will be used in combination with another bioactive material: (Nano-BAG) versus using of i-PRF only as a pulpotomy material with using a premixed…
- Trial name
- NCT05902936
- Testing
- Pulpotomy for mature permanent mandibular molars
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Nonvital Tooth
Clinical & Radiographic Evaluation of Neo MTA Versus White MTA in Revascularization of Non-Vital Immature Permanent Teeth
To evaluate and compare the degree of tooth discoloration in tooth crowns induced by Neo MTA versus white MTA over time. Evaluation of the effectiveness of Neo MTA as coronal plug in revascularization of immature teeth with…
- Trial name
- NCT03545139
- Testing
- NeoMTA nusmile, White MTA
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Pulp and Periapical Tissue Disease, Patients With Pulp Necrosis and Apical Periodontitis
Interleukin 8 and10 Levels Changes in Teeth With Necrotic Pulp and Apical Periodontitis
The goal of this observational study is to evaluate changes in interleukin 8 (IL-8) and interleukin 10 (IL-10) levels in gingival crevicular fluid (GCF) and periapical fluid during root canal treatment in patients with necrotic…
- Trial name
- NCT06713174
- Testing
- Assessment of Interleukin 8 and 10 Level Changes Before and During Root Canal Treatment for Necrotic Pulp with Apical Periodontitis
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Pulp Necroses
Assessment of Post-operative Pain After Different Instrumentation Techniques in Pulpectomy Treatment of Primary Molars
The goal of this clinical trial is to compare the post operative pain after using three different instrumentation techniques in pulpectomy treatment of pediatric participant.
- Trial name
- NCT06256250
- Testing
- pulpectomy treatment will be done using the adaptive xp endo shaper., pulpectomy treatment will be done using FANTA AF baby files., pulpectomy treatment will be done using hand k files.
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Pulp Necroses
Laser Activated Irrigation Versus Passive Ultrasonic Irrigation
assessment of bacterial reduction and post-operative pain following Laser activated irrigation using sodium hypochlorite and a 980 nm diode laser device as an adjunct to conventional root canal treatment, and comparing it with…
- Trial name
- NCT04035083
- Testing
- Laser activated irrigation, Passive ultrasonic irrigation
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pulp Necrosis, Root Canal Infection
Frankincense Versus Sodium Hypochlorite for Root Canal Disinfection
This research study is being done to find out if a natural ingredient called frankincense can clean infected root canals as effectively as the standard cleaning solution currently used in dentistry.
- Conditions
- Pulp Necrosis, Root Canal Infection, Apical Periodontitis
- Trial name
- FSHRCD: RCT (NCT07823868)
- Testing
- Sodium hypochlorite 3%, Frankincense-based irrigant
- Where
- Oman
- Volunteers
- 30 people
- Sponsor
- Oman Dental College
Teeth, Endodontically-Treated
Safety and Efficacy of Using the Endodontic Self Adjusting File - SAF for Root Canal Treatment
The study's primary goal is to assess the safety of the SAF (Self Adjusting File) device for root canal treatments. The study's secondary goal is to evaluate the effectiveness of the SAF device for root canal treatments
- Trial name
- NCT00497042
- Testing
- Self Adjusting File
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- ReDent Nova
Immature Permanent Teeth With Open Apex, Pulp Necrosis
Efficiency of Asiaticoside as Intracanal Medication in Revascularization Process
This study assess the ability of Asiaticoside based Intracanal medication compared to the commonly used Intracanal medicament ( calcium hydroxide Ca(OH) 2) on the outcome of the revascularization process in immature permanent…
- Trial name
- NCT07802340
- Testing
- Intracanal medication
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Mansoura University
Endodontic Disease, Pulp Disease, Dental
Anti-bacterial Potential of Nano Calcium Hydroxide as an Intracanal Medication
The aim of the study is to evaluate the anti-bacterial potential of Nano Calcium Hydroxide as an intracanal medication in primary endodontic treatment of permanent molars.
- Trial name
- NCT06196515
- Testing
- Calcium hydroxide, nano calcium hydroxide
- Where
- Egypt
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Necrotic Pulp, Acute Apical Periodontitis of Pulpal Origin
Clinical Efficacy of Novel Jasminum-based Calcium Hydroxide Medicament
A triple-blind, parallel group, randomized trial with an allocation ratio of 1:1. Participants randomly allocated into two groups A and B.
- Trial name
- NCT06653608
- Testing
- Nano-reinforced calcium hydroxide medicament, Calcium hydroxide without nanoparicles
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Medical Sciences
Pulpotomy
Assessment of Pulpotomy Procedure Using NeoMTA Plus in Permanent Teeth With Carious Exposure
Many deep carious teeth are treated unnecessarily by root canal therapy, while with using current techniques and advances in compatible dental materials in addition to better understanding of biological response of the dental…
- Trial name
- PULPOTOMY (NCT03522051)
- Testing
- calcium silicate based material,
- Where
- Jordan
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Tooth, Nonvital
Pain Following One-visit Versus Two-visit Root Canal of Necrotic Teeth Using Protaper Next
To evaluate the incidence and severity of postoperative pain after root canal therapy of necrotic teeth in one appointment versus two appointments using Protaper next instrument.
- Trial name
- NCT02984488
- Testing
- single visits, two visits
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Necrotic Pulp With Symptomatic Apical Periodontitis
Assessment of Postoperative Pain After Using Two Formulations of Calcium Hydroxide Intracanal Medication .
Calcium hydroxide is advocated as an intracanal medication for various purposes, including prevention of post-treatment symptoms.
- Trial name
- NCT05021809
- Testing
- Calcium hydroxide intracanal medication application
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Suez Canal University
Molar-Incisor Hypomineralization (MIH), Pulp Disease, Dental
Assessment of Inflammatory Biomarkers in Molar-Incisor Hypomineralization-Affected First Permanent Molars
Molar-Incisor Hypomineralization (MIH) is a qualitative developmental defect of enamel primarily affecting the permanent first molars and often incisors. The global prevalence of MIH ranges from 2.9% to 44%.
- Conditions
- Molar-Incisor Hypomineralization (MIH), Pulp Disease, Dental, Inflamation
- Trial name
- NCT07008599
- Testing
- Pulpal Blood Sample
- Where
- Turkey (Türkiye)
- Volunteers
- 83 people
- Sponsor
- Marmara University
Necrotic Pulp
Effect of Etidronate in Sodium Hypochlorite Versus Sodium Hypochlorite on the Intensity of Postoperative Pain
To compare the effect of using Etidronate in sodium hypochlorite versus sodium hypochlorite irrigating solution on: Postoperative pain in patients with necrotic pulp.
- Trial name
- NCT04035330
- Testing
- etidronate in sodium hypochlorite, sodium hypochlorite
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cleft Lip and Palate
Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients
The aim of this study is to perform the bone tissue engineering to reconstruct the alveolar bone defect in cleft lip and palate patients using mesenchymal stem cells from deciduous dental pulp associated with a collagen and…
- Trial name
- NCT01932164
- Testing
- maxillary alveolar graft by tissue engineering, Bone tissue engineering using mesenchymal stem cells
- Where
- Brazil
- Volunteers
- 5 people
- Sponsor
- Hospital Sirio-Libanes