Clinical trials: Dental Pulp Regeneration
Pulp Necroses, Apical Periodontitis
Transplantation of Allogeneic MSC in Patients With Pulp Necrosis and Chronic Apical Periodontitis
The purpose of the study is to evaluate the effect of Mesenchymal Stromal Cell (MSC) implantation on pulp and periapical regeneration of immature teeth with pulp necrosis and chronic apical periodontitis.
- Trial name
- MSC (NCT04545307)
- Testing
- Allogenic transplant of BM-MSC in a root canal from patients with immature apexes and pulpar necrosis and apical periodontitis
- Where
- Venezuela
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Universidad Central de Venezuela
Dental Pulp Necrosis, Periapical Abscess
Efficiency of Triple Antibiotic Paste, Ciprofloxacin/Propolis, Ciprofloxacin/Metronidazole, Propolis/Metronidazole Combinations on Revascularization Process of Immature Necrotic Maxillary Incisors of Patients 8-18 Years Old.
This Study Was Made to Evaluate the Antibacterial Effect of Different Antibacterial Combinations on Revascularization Process in Permanent Anterior Immature Teeth.
- Conditions
- Dental Pulp Necrosis, Periapical Abscess, Root Canal Infection
- Trial name
- NCT03533231
- Testing
- Canal Disinfection Triple Antibiotic Paste (TAP), Ciprofloxacin + Propolis Paste, Ciprofloxacin + Metronidazole Paste
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tariq Yehia
Apexification, Apexogenesis
Comparison of Two Dental Techniques Used to Treat Teeth Which Have Become Infected or Painful Following Trauma
Children often damage their front teeth. In approximately 6% of cases, the nerve inside the affected tooth dies (becomes 'non-vital') and natural root development stops.
- Conditions
- Apexification, Apexogenesis, Pulp Necrosis, MTA
- Trial name
- NCT01817413
- Testing
- Mineral trioxide aggregate, Revascularisation
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Liverpool
Pulp Necroses
Efficacy of Combined Blood Clot and Platelet Rich Fibrin Scaffolds in Regeneration of Necrotic Immature Permanent Teeth
The aim of the present study is to assess clinically and radio-graphically the regenerative potential of immature permanent teeth with necrotic pulp using blood clot and Platelet rich fibrin scaffolds.
- Trial name
- NCT04390854
- Testing
- Blood clot scaffold, Blood clot scaffold combined with PRF
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Nourhan M.Aly
Pulpitis - Irreversible
Effectiveness of Mineral Trioxide Aggregate and Platelet Rich Fibrin Along With Biodentine. .
The aim of this study was to clinically and radiographically evaluate the effectiveness of MTA, Biodentine, Platelet Rich Fibrin along with Mineral Trioxide Aggregate and Platelet Rich Fibrin along with Biodentine as pulpotomy…
- Trial name
- NCT04773886
- Testing
- Mineral trioxide aggregate, Biodentine, Platelet rich fibrin
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Maharishi Markendeswar University (Deemed to be University)
Endodontic Disease
Effect of Platelet-Rich Plasma Biomembrane on Enhancing Bone Regeneration Following Endodontic Surgery
This study was conducted to evaluate clinical and radiographical outcome of using a standardized platelet-rich plasma (PRP) biomembrane following endodontic surgery and its correlation with the growth factors content in this…
- Trial name
- NCT04109417
- Testing
- osteotomy filled with PRP-gel and covered with PRP-biomembrane, osteotomy site following the surgical intervention was left empty
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Alexandria University
Immature Permanent Teeth With Open Apex, Pulp Necrosis
Regenerative Root Canal Treatment of Immature Teeth Using Omega-3 Fatty Acids
This clinical study will be conducted to evaluate the effect of using intracanal Omega-3 Fatty acids during revascularization of necrotic immature teeth compared to the traditional induced bleeding technique.
- Trial name
- Regeneration (NCT07371416)
- Testing
- Omega -3 fatty acids, Calcium Hydroxide (Ca(OH)2)
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Necrotic Pulp
Pulp Revascularization Versus MTA Apexification
This study compared the efficiency of pulp revascularization and MTA apexification in the treatment of patients with necrotic immature anterior teeth.
- Trial name
- RCT (NCT03083015)
- Testing
- revascularization, Apexification
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Enas Ebrahim Sayed
Pulpal Necrosis
The Use of Platelet Rich Fibrin in Pulpal and Periodontal Regeneration in Mature Teeth
In cases of permanent tooth avulsion, it is widely accepted that some necrosis always occurs after avulsion injury. If the pulp tissue does not revascularize or if endodontic therapy is not performed, the pulp space can become…
- Trial name
- NCT02477358
- Testing
- Left Tooth Platelet Rich Fibrin; Right Tooth Implant Alone, Right Tooth Platelet Rich Fibrin; Left Tooth Implant Alone
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Necrotic Pulp
Comparative Evaluation of the Regenerative Capacity of Two Platelet Concentrates
Injectable platelet-rich fibrin (I-PRF) is a flowable blood concentrate that is entirely natural and allows ease of access and flow within the root canal. It was first developed in 2014 by modifying the centrifugation parameters.
- Trial name
- NCT03698188
- Testing
- Injectable platelet-rich fibrin, Platelet-rich plasma
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontal Diseases
Periodontal Regeneration of Chronic Periodontal Disease Patients Receiving Stem Cells Injection Therapy
The purpose of this study is to evaluate the safety of clinical injection of allogeneic human dental pulp stem cell(DPSC) in local infected periodontal tissue and determine whether injection of allogeneic DPSC is a effective way…
- Trial name
- NCT02523651
- Testing
- DPSC injection
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Songlin Wang
Pulpal Regeneration, Pulp Revascularization
Pulp Transplantation in Necrotic Mature Teeth With Periapical Radiolucency
This randomized clinical trial aims to compare autologous dental pulp transplantation alone or combined with concentrated growth factor (CGF) with conventional root canal treatment in necrotic mature teeth with periapical…
- Trial name
- TRANSP (NCT07258888)
- Testing
- Conventional root canal therapy, Autologous dental pulp transplantation, Pulp transplantation with CGF
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Necrotic Pulp, Apical Periodontitis
Regenerative Endodontic Treatment of Mature Necrotic Teeth With Apical Periodontitis
The aim of this prospective, randomized, controlled double-blind study is to evaluate the effectiveness of biodentine compared with MTA used as pulp space barrier on discoloration of teeth after regenerative based non-obturation…
- Trial name
- NCT04018456
- Testing
- Biodentine, White MTA
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Cairo University
Endodontic Disease
Outcome of Regenerative Endodontic Procedures
Clinical management of immature non-vital (necrotic) permanent teeth is challenging, due to inherent structural weakness. Earlier management of such teeth relied on the traditional calcium hydroxide (Ca(OH)2) apexification…
- Trial name
- NCT05612451
- Testing
- Regenerative Endodontic Procedures, non-setting calcium hydroxide, modified triple antibiotic paste
- Where
- Jordan
- Volunteers
- 45 people
- Sponsor
- King Abdullah University Hospital
Pulp Necrosis, Periapical Lesion
Success Rate of Single Versus Two Visit Regenerative Treatment Protocol in Non Vital Mature Anterior Teeth
This study evaluates success rate of non vital mature anterior teeth with periapical lesion treated by regenerative endodontic protocol in single visit versus two visit technique.
- Conditions
- Pulp Necrosis, Periapical Lesion, Anterior Teeth
- Trial name
- NCT03717337
- Testing
- Single visit pulp regeneration, Two visit pulp regeneration
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Pulp Regeneration
Comparison of Tissue in Regenerative Endodontic Procedures and Apexification
The purpose of our study is to characterize the composition of the hard and soft tissues present after regenerative endodontic procedures in root canals of teeth previously diagnosed with the need for extraction for orthodontic…
- Trial name
- NCT01805388
- Testing
- Experimental: Regeneration Treatment Group, Control Non-Study Drug Group
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Kenneth Hargreaves
Necrotic Pulp
Healing Potentiality Of Blood Clot S-PRF and A-PRF in the Treatment Of Necrotic Mature Single-Rooted Teeth With Chronic Peri-Apical Periodontitis
Earlier, it was believed that successful regeneration cannot be achieved once tooth has become infected. However, recent studies suggest that regenerative endodontics may in fact be possible in teeth with pulpal necrosis and…
- Trial name
- NCT04606719
- Testing
- Advanced Platelet Rich fibrin
- Where
- Egypt
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontal Diseases
Periodontal Regeneration Using Dental Pulp Stem Cells (DPSCs)
The goal of this study is to evaluate if dental pulp stem cells (DPSCs) delivered into intrabony defects in a collagen scaffold would enhance the clinical and radiographic parameters of periodontal regeneration.
- Trial name
- NCT03386877
- Testing
- periodontal regeneration
- Where
- 2 sites in Italy
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Nonvital Tooth
Clinical & Radiographic Evaluation of Neo MTA Versus White MTA in Revascularization of Non-Vital Immature Permanent Teeth
To evaluate and compare the degree of tooth discoloration in tooth crowns induced by Neo MTA versus white MTA over time. Evaluation of the effectiveness of Neo MTA as coronal plug in revascularization of immature teeth with…
- Trial name
- NCT03545139
- Testing
- NeoMTA nusmile, White MTA
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University