Clinical trials: Dental Surgery
Dental Pain
Dental Pain Study of Analgesics in Patients Undergoing Molar Removal
Accessing the efficacy and safety of pregabalin when used alone and in combo with acetaminophen in a dental pain model. To test whether pre-operative dose of pregabalin increases the time to significant post-operative pain (NRS ≥…
- Trial name
- NVK009-0001 (NCT03652818)
- Testing
- Pre-Op pregabalin, Post-Op pregabalin
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Nevakar, Inc.
Dental Surgery
Evaluation of a Non-cross-linked Porcine Acellular Dermal Matrix Used in Dental Surgery
The general objective of the study is to confirm the medium/long-term safety and clinical performance of the CELLIS Dental membrane used in dental surgery and to identify emerging risks in comparison to clinical data related to…
- Trial name
- NCT05435976
- Testing
- CELLIS Dental (Porcine Acellular Dermal Matrix, PADM)
- Where
- 5 sites in France
- Volunteers
- 50 people
- Sponsor
- Meccellis Biotech
Moderate Pain, Severe Pain
Efficacy and Safety of DIT112 in the Treatment of Moderate to Severe Pain After Dental Surgery for the Extraction of Impacted Third Molars
The purpose of this study is to evaluate the efficacy and safety of DIT112 in adolescents and adults with acute pain after dental surgery for the extraction of impacted third molars.
- Trial name
- ALIV (NCT06237231)
- Testing
- DIT112, DIPYRONE, TRAMADOL
- Volunteers
- 252 people
- Sponsor
- EMS
Tooth, Impacted, Teeth Impact
Performance of Safety of SILKAM® Suture Material in Oral Surgery
Assessment of SILKAM® suture material in mucosal closure in oral surgery (mucosal sutures). A prospective, monocentric, single arm observational study.
- Conditions
- Tooth, Impacted, Teeth Impact, Tooth Impaction, Mucosal Wound
- Trial name
- SILKOS (NCT05296902)
- Testing
- Mucosal Closure
- Where
- Spain
- Volunteers
- 105 people
- Sponsor
- Aesculap AG
Post-surgical Dental Pain
Post-operative Dental Pain Study Comparing Analgesic Efficacy
GlaxoSmithKline will be conducting this trial to compare analgesics efficacy of paracetamol 1000mg vs 500mg . The post-surgical dental pain model will be used to evaluate the analgesic efficacy of paracetamol.
- Trial name
- NCT01082081
- Testing
- Paracetamol 1000 mg, Paracetamol 500 mg
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- GlaxoSmithKline
Pain
A Dental Pain Study to Test the Effectiveness of a New Pain Reliever Medicine
To assess the safety and effectiveness one dose of a new pain reliever medicine (JNJ-10450232 at either the 250 or 1000 mg strength) compared with placebo (sugar pill) or acetaminophen 1000 mg after surgical removal of third…
- Trial name
- NCT02209181
- Testing
- JNJ-10450232 / Not yet marketed, acetaminophen / Tylenol
- Where
- United States
- Volunteers
- 269 people
- Sponsor
- McNeil Consumer Healthcare Division of McNEIL-PPC, Inc.
Pain
Study Evaluating A Novel Ibuprofen Formulation In The Treatment Of Dental Pain
This study will compare the pain relieving effect of a single-dose of a novel ibuprofen formulation to placebo and two formulations of standard ibuprofen in the treatment of post-surgical dental pain following "wisdom" tooth…
- Trial name
- NCT01098747
- Testing
- Novel Ibuprofen, Standard Ibuprofen
- Volunteers
- 335 people
- Sponsor
- Pfizer
Partial Edentulism
Evaluation of Immediate Versus Delayed Loading of Dental Implants With a Modified Surface
The purpose of this study is to evaluate the performance of a new dental implant with a modified surface in different loading protocols.
- Trial name
- NCT00782171
- Testing
- SLActive dental implant
- Where
- 19 sites in United States, Austria and 7 more
- Volunteers
- 266 people
- Sponsor
- Institut Straumann AG
Pain
Evaluation of the Efficacy of Novel Ibuprofen Acetaminophen Combination Formulations in the Treatment of Post-surgical Dental Pain
This study will determine the overall analgesic efficacy of three different fixed dose ibuprofen plus acetaminophen formulations compared to ibuprofen alone and to placebo.
- Trial name
- NCT01559259
- Testing
- Ibuprofen/acetaminophen, Ibuprofen
- Where
- United States
- Volunteers
- 394 people
- Sponsor
- Pfizer
Pain
Injectable Diclofenac for the Prevention of Post-operative Dental Pain
This is a prospective, randomised, double-blind, placebo-controlled, parallel group study in approximately 75 patients undergoing surgical removal of an impacted lower third molar.
- Trial name
- DP4 (NCT01706588)
- Testing
- Diclofenac sodium
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- IBSA Institut Biochimique SA
Dental Pain
Single Dose Study of N1539 in the Treatment of Pain Secondary to Dental Impaction Surgery
To evaluate the safety and efficacy of single IV doses of N1539 after dental impaction surgery.
- Trial name
- NCT00945763
- Testing
- N1539, Motrin
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Alkermes, Inc.
Postoperative Pain, Acute Pain
Pharmacokinetic, Efficacy and Safety Study of Tapentadol Oral Solution in Children With Postoperative Pain
To find out if a drug called tapentadol administered by mouth safely relieves pain in children. Look at the amount of tapentadol in the blood after a single oral dose.
- Trial name
- NCT01729728
- Testing
- Tapentadol
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Grünenthal GmbH
Oral Surgical Procedures
Retrospective Observational Study of Implant-supported Restorations With Dental Implants.
This retrospective study aims to value the bone loss and the success and survival of the dental implants produced by additive manufacturing installed in an area grafted with Plenum® Osshp (synthetic bone graft).
- Trial name
- NCT06154057
- Testing
- Dental Implants installed in an grafted area (sinus lifting), Dental Implants installed in an grafted area (ridge augmentation), Dental Implants installed in an grafted area (extraction sites)
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- M3 Health
Pain, Dental Impaction
A Single-dose Study of Intranasal Ketorolac in the Treatment of Pain Secondary to Dental Impaction Surgery
The purpose of this study is to evaluate the analgesic efficacy of a single intranasal (IN) administration of ketorolac after dental impaction surgery.
- Trial name
- NCT01356225
- Testing
- Ketorolac tromethamine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Egalet Ltd
Jaw, Edentulous, Partially
Study to Evaluate Implant Survival Rate of Astra Tech Fixture ST in the Posterior Maxilla With One-stage Surgery and Early Loading
The purpose of this study is primarily to evaluate implant survival rate of Astra Tech Fixture ST placed in the posterior maxilla.
- Trial name
- NCT00748241
- Testing
- Astra Tech Fixture ST
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- Dentsply Sirona Implants and Consumables
Pain
A Dental Pain Study Comparing The Analgesic Efficacy Of Ibuprofen/Caffeine
An efficacy study assessing analgesic effect of ibuprofen/caffeine in post-surgical dental pain.
- Trial name
- NCT02863575
- Testing
- Ibuprofen/Caffeine, Ibuprofen
- Where
- United States
- Volunteers
- 374 people
- Sponsor
- Pfizer
Dental Pain
Study of Naproxen Capsules to Treat Dental Pain
The purpose of the study is to determine whether Naproxen Test Formulation Capsules are safe and effective for the treatment of dental pain.
- Trial name
- NCT01229228
- Testing
- Naproxen Test, Naprosyn
- Where
- United States
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Iroko Pharmaceuticals, LLC
Degeneration; Bone
Comparison of a PEG Membrane and a Collagen Membrane for the Treatment of Bone Dehiscence Defects at Bone Level Implants
The aim of the study is to test in a randomized comparative study the performance of Straumann® MembraGel (PEG Membrane) to act as a barrier for guided bone regeneration compared to that of a standard collagen membrane (BioGide®)…
- Trial name
- NCT01012921
- Testing
- barrier membrane, MembraGel, Bio-Gide® membrane
- Where
- 9 sites in Belgium, Germany and 5 more
- Volunteers
- 117 people
- Sponsor
- Institut Straumann AG
Partial Edentulism
Study to Confirm Accuracy and Safety of the Inliant Surgical Navigation System
A confirmatory dual-clinic, non-randomized study of the Inliant device to aid in dental implant placement in humans. The hypothesis is that using the Inliant Surgical Navigation System ("Inliant") will provide a high degree of…
- Trial name
- NCT03934853
- Testing
- Dynamic Dental Navigation
- Where
- Canada
- Volunteers
- 53 people
- Sponsor
- Navigate Surgical Technologies Inc.
Analgesia
A Comparison of Analgesic Efficacy Between a Single Dose of ORG 28611, Morphine, and Placebo After Dental Impaction Surgery (Study P05800)
Patients will receive a single intravenous (IV) infusion administered over 3 minutes of either ORG 28611 (SCH 900111), 0.12 mg/kg morphine sulphate, or placebo, within 6 hours after dental surgery, when they experience moderate…
- Trial name
- NCT00782951
- Testing
- Org 28611, morphine sulfate
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC