Clinical trials: Dental Treatment
Malocclusion, Periodontal Diseases
Periodontal Health in Adults Treated With Fixed Orthodontic Appliances or Clear Aligners
This prospective observational study will compare the effects of fixed orthodontic appliances and clear aligners on periodontal health during the initial three months of orthodontic treatment.
- Conditions
- Malocclusion, Periodontal Diseases, Periodontal Health
- Trial name
- NCT07802249
- Testing
- Fixed Orthodontic Appliance, Clear Aligner Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ravan Mammadov
Angio Edema Hereditary
Status of Dental Care Practices in Patients With Hereditary Angioedema
Hereditary angioedema (HAE) is a rare genetic disease, it can occur at any age and evolves in flare-ups. These are subcutaneous or submucosal edemas responsible for tightness and pain. All areas can be reached.
- Trial name
- PRADA (NCT05776784)
- Testing
- dental procedure
- Where
- France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Grenoble
Oral Health, Oral Health Related Quality of Life
Inter-organizational Health Planning for Older Adults: Public Dental Care and Municipal Care
Patient participation is key for healthy ageing and essential in health planning and decision-making. Oral health is an important but sometimes neglected part of general health and there is little research on health planning in…
- Conditions
- Oral Health, Oral Health Related Quality of Life, Participation, Participation, Patient
- Trial name
- GAPA (NCT06310798)
- Testing
- Inter-professional team test
- Where
- Sweden
- Volunteers
- 360 people
- Sponsor
- Vastra Gotaland Region
MEDICATION RELATED OSTEONECROSIS OF THE JAW
OZONE_EXO: Comparative Analysis of Protocols for Dental Exactions in Patients at Risk of MRONJ: Case-control Study
Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse reaction of antiresorptive and antiangiogenic agents; it is also a potentially painful and debilitating condition.
- Trial name
- OZONE_EXO (NCT06072404)
- Testing
- OxigenOzone_Insufflation
- Where
- Italy
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Perioperative Anxiety, Preanesthetic Medication
Handheld-multimedia Versus Oral Midazolam in Pediatric on Perioperative Anxiety
The first goal of this study is to compare the efficacy and safety between anxiolysis by multimedia-distraction with an IPAD versus anxiolysis by premedication with midazolam prior to the induction.
- Conditions
- Perioperative Anxiety, Preanesthetic Medication, Inhalation Anesthesia, Ambulatory Surgery
- Trial name
- NCT04273035
- Testing
- Midazolam oral solution, IPAD
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitair Ziekenhuis Brussel
Dental Caries
DPBRN Development of a Patient Based Provider Intervention for Early Caries Management
This study focused on improving the quality of dental care by fostering movement of the latest scientific advances into daily clinical practice.
- Trial name
- NCT01309958
- Where
- 7 sites in United States, Denmark
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Dental Practice-Based Research Network
Immature Permanent Teeth With Open Apex, Pulp Necrosis
Regenerative Root Canal Treatment of Immature Teeth Using Omega-3 Fatty Acids
This clinical study will be conducted to evaluate the effect of using intracanal Omega-3 Fatty acids during revascularization of necrotic immature teeth compared to the traditional induced bleeding technique.
- Trial name
- Regeneration (NCT07371416)
- Testing
- Omega -3 fatty acids, Calcium Hydroxide (Ca(OH)2)
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Caries, Cervical
Evaluation of Low-shrinkage Giomer Versus Resin-Modified Glass Ionomer in Cervical Caries Lesions: A Clinical Trial
Management of cervical lesions presents serious problems with any restorative material. The two most common reasons for restoration failure are secondary caries at the tooth-restoration interface and loss of retention.
- Trial name
- NCT05930548
- Testing
- Low Shrinkage Giomer
- Where
- Egypt
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Implants
Peri-implant Soft Tissue Changes at Small Buccal Dehiscences
This study was designed to assess peri-implant soft tissue health, volume and marginal stability at implants sites which presented small buccal bone dehiscences (<3mm evaluated in a vertical direction) at the time of insertion.
- Trial name
- NCT07501715
- Testing
- Connective tissue graft, horizontal guided bone regeneration
- Where
- Italy
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Dental Caries
In Situ Remineralisation Response of Different Artificial Caries-like Enamel Lesions to Home-care and Professional Fluoride Treatments
This study mainly compared the response of the artificial carious enamel lesions to remineralisation in situ. The tested in vitro demineralising protocols were: MC gel, PA gel, MHDP and Buffer solutions.
- Trial name
- NCT02637830
- Testing
- Application of fluoride varnish (22600 ppm F, Duraphat) at the begining of the study, Application of fluoride toothpaste (1500 ppm F, Crest) twice a day for 3 days of the study
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Edentulous Maxilla, Resorbed Maxilla
Zygomatic Versus Conventional Dental Implants in Augmented Maxillae
Dental implants are used for replacing missing teeth. Placing dental implants is limited by the presence of adequate bone volume permitting their anchorage.
- Conditions
- Edentulous Maxilla, Resorbed Maxilla, Implant Therapy
- Trial name
- NCT01961284
- Testing
- Zygomatic implant placement, conventional implants and augmentation of maxilla
- Where
- 2 sites in United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- NHS Lothian
Pulp Necrosis
This Study Compares Two Different Ways of Cleaning and Shaping Root Canals During Root-canal Treatment: the Step-down Technique and the Step-back Technique. Iu Want to Find Out Which Method Causes Less Pain After the Procedure. Patients Will be Randomly Placed Into One of the Two Groups, Treated Wit
This randomized clinical trial aims to compare the step-back and step-down root canal preparation techniques in patients with pulp necrosis. The study will evaluate which technique results in less postoperative pain.
- Trial name
- NCT07290192
- Testing
- Step down technique
- Where
- Pakistan
- Volunteers
- 110 people
- Sponsor
- Armed Forces Post Graduate Medical Institute (AFPGMI), Rawalpindi
Dental Care for Institutionalized Elderly Persons
Evaluation of the Agreement Between a Consultation With a Nurse Acquiring Three-dimensional Intraoral Images Made With a 3D Intraoral Camera and the Standard Consultation With a Dental Surgeon, in Institutionalized Elderly Subjects
The primary objective of this study will be to assess the agreement between a dental consultation with a nurse acquiring intraoral images, using a 3D intraoral camera, and a standard consultation with a dental surgeon, in…
- Trial name
- GEROdonto3D (NCT06387992)
- Testing
- Three-dimensional dental acquisition
- Where
- France
- Volunteers
- 50 people
- Sponsor
- CHU de Reims
Root Caries, Cognitive Impairment
High Fluoride and Root Caries in Older Adults (NIT-RCL-UTALCA)
This project aims to provide an effective solution for root caries lesions (RCLs), specifically in older persons with cognitive impairment through a non-invasive therapy with Silver Diamine Fluoride (SDF).
- Conditions
- Root Caries, Cognitive Impairment, Fluor
- Trial name
- SDF-RCL (NCT06749275)
- Testing
- 5,000 ppm fluoride toothpaste, 22,600 ppm fluoride varnish, 38% SDF
- Where
- Chile
- Volunteers
- 179 people
- Sponsor
- University of Talca
Pain, Postoperative Pain
Dose-Response Study of MR-107A-01 in The Treatment of Post-Surgical Dental Pain
MR-107A-01 is being studied to investigate its efficacy, safety, and dose-response after dental surgery.
- Conditions
- Pain, Postoperative Pain, Pain, Acute
- Trial name
- NCT04571515
- Testing
- MR-107A-01
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Mylan Inc.
Periodontal Diseases
Treatment of Periodontal Disease With Two Different Bioactive Gels for Home Oral Care
This study is an open-label split-mouth study in which periodontal patients will be treated in order to obtain periodontal health.
- Trial name
- NCT04781478
- Testing
- Application of Biorepair Gel, Irrigation of Chlorhexidine 1.00% gel
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Pavia
Postoperative Pain
A Study of Two Approved Drugs in the Treatment of Postoperative Dental Pain (0966-182)
The purpose of this study is to compare the safety and effectiveness of two approved drugs in the treatment of pain following dental surgery.
- Trial name
- NCT00092313
- Testing
- MK0966, rofecoxib, Comparator: oxycodone and acetaminophen
- Volunteers
- 271 people
- Sponsor
- Merck Sharp & Dohme LLC
Dental Biofilm pH
In Vivo Study of Sucrose and Liquid Oral Pediatric Medicines of Long-term Effect on Dental Biofilm pH
The aims of this study were to determine the sucrose and liquid oral pediatric medicines of long-term effect on dental biofilm pH to evaluate the cariogenic potential in vivo.
- Trial name
- SPMedicines (NCT01819350)
- Testing
- G1, G2 and G3, G4 and G5
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Federal University of Paraíba
Dental Caries
Properties of Glass Ionomer Cements Associated With Chlorhexidine or Doxycycline
This study assessed the clinical performance of a resin-modified glass ionomer cement containing different concentrations of chlorhexidine digluconate and doxycycline hyclate.
- Trial name
- NCT02168374
- Testing
- Indirect pulp treatment
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Aline R F de Castilho
Dental Care for Disabled
Optimization of Procedural Sedation Protocol Used for Dental Care Delivery in People With Mental Disability
The study aims to compare procedural sedation protocols, specifically applied for the delivery of regular dental care in persons with a mental disability.
- Trial name
- OptiSeDent (NCT02078336)
- Testing
- Midazolam Mylan, Lorazepam Mylan, Valium + Akineton + Dehydrobenzperidol + Atropine sulfate
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
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