Clinical trials: Dentin Hypersensitivity
Dentin Sensitivity
Study Investigating Efficacy of an Occluding Dentifrice for Dentine Hypersensitivity
This study will investigate the efficacy of an experimental dentifrice containing 0.454% weight/weight (w/w) stannous fluoride in relieving dentine hypersensitivity (DH) after twice daily brushing, over a 2 week treatment period…
- Trial name
- NCT02705716
- Testing
- 0.454% w/w stannous fluoride (1100ppm fluoride), 0.76% sodium monofluorophosphate (1000ppm fluoride)
- Where
- 3 sites in United Kingdom
- Volunteers
- 409 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dentin Sensitivity
Effectiveness of Two Water-Based Potassium Oxalate Desensitizers
This study will compare the safety and effectiveness of two water-based potassium oxalate desensitizers on existing dentinal hypersensitivity.
- Trial name
- NCT02192307
- Testing
- Potassium oxalate
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Dentin Sensitivity
A Clinical Study to Evaluate the Efficacy of a Stannous Fluoride Toothpaste for the Relief of Dentine Hypersensitivity in a Chinese Population
The purpose of this study is to evaluate the efficacy of the 0.454 percentage (%) weight/weight (w/w) stannous fluoride (SnF2) toothpastes for the relief of dentine hypersensitivity (DH) in China.
- Trial name
- NCT05750745
- Testing
- Sensodyne Sensitivity & Gum, Crest Cavity Protection Fresh Lime, Sensodyne Repair and Protect
- Where
- China
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- HALEON
Dentin Sensitivity
Exploratory Clinical Study to Investigate the Ability of an Experimental Combination Dentifrice to Protect Sensitive Teeth
This proof of principle (PoP) study will evaluate the ability of an experimental combination toothpaste formulation to protect sensitive teeth from dentine hypersensitivity.
- Trial name
- NCT05243745
- Testing
- 3% PVM/MA + 5% KNO3 Combination, 3% PVM/MA only, 5% KNO3 Only
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- HALEON
Tooth Sensitivity
An Evaluation of the Efficacy of Oral-B New Product Sensi-Stop on Dentinal Hypersensitivity
The purpose of the study is to evaluate the efficacy of Sensi-StopTM strips (Procter \& Gamble™) on the relief of dentinal hypersensitivity.
- Trial name
- SSDH (NCT02476032)
- Testing
- Prof applied oxalate, Self applied oxalate
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Dentin Sensitivity
A Real-World Evidence Study Evaluating Oral Health Related Quality Of Life With Use Of A Stannous Fluoride Anti-Sensitivity Toothpaste For Dentin Hypersensitivity Management
This study will evaluate the impact of long-term use of a desensitizing toothpaste containing 0.454 percent (%) stannous fluoride (SnF2) on oral health related quality of life (OHrQoL) in a population of self-reported dentin…
- Trial name
- NCT06045026
- Testing
- Stannous fluoride
- Where
- United States
- Volunteers
- 536 people
- Sponsor
- HALEON
Dentin Sensitivity
A Clinical Study Assessing the Effects of a Marketed Dentifrice on Tooth Sensitivity While Undergoing Tooth Bleaching
The aim of this study is to investigate the efficacy of a marketed dentifrice containing 5 percent (%) NovaMin (Calcium Sodium Phosphosilicate) to reduce tooth sensitivity during and post tooth bleaching compared to a marketed…
- Trial name
- NCT06608368
- Testing
- Test Dentifrice (Sensodyne Repair and Protect Original Mint), Positive Control Dentifrice (Sensodyne Fresh Mint), Reference Dentifrice (Crest Cavity Protection Regular)
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- HALEON
Dentin Hypersensitivity, Dentin Sensitivity
Study to Characterize the Efficacy of a Dual Active Dentifrice for the Relief of Dentin Hypersensitivity
This exploratory study will characterize the efficacy profile of an experimental dual active 5 percent (%) potassium nitrate/0.454% stannous fluoride dentifrice, compared to a single active 0.454% stannous fluoride desensitizing…
- Trial name
- NCT03943095
- Testing
- Potassium Nitrate, Stannous Fluoride
- Where
- Canada
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dentin Sensitivity
A Clinical Study to Evaluate a Stannous Fluoride Toothpaste for the Relief of Dentinal Hypersensitivity
The purpose of this study is to provide evidence of clinical efficacy of an experimental dentifrice containing stannous fluoride (SnF2) compared to regular fluoride dentifrice in the reduction of dentinal hypersensitivity (DH).
- Trial name
- NCT03310268
- Testing
- 0.454% Stannous fluoride (SnF2) and 0.072% sodium fluoride (NaF): 1450 ppm fluoride in total, 1400 ppm fluoride as sodium monofluorophosphate (SMFP), Stannous Chloride (SnCl2) and 0.15% NaF: 1450 ppm fluoride in total
- Where
- China
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dentine Sensitivity
Clinical Study to Evaluate the Efficacy of Two Dentifrices for Dentine Hypersensitivity
An 8 week clinical study to evaluate the ability of an experimental dentifrice containing calcium sodium phosphosilicate and sodium fluoride to provide relief from dentine hypersensitivity compared to a marketed dentifrice…
- Trial name
- NCT02371616
- Testing
- Calcium sodium phosphosilicate, Sodium fluoride, Sodium monofluorophosphate
- Where
- 3 sites in United Kingdom
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dentin Sensitivity
Clinical Efficacy in Relieving Dentin Hypersensitivity of Nanohydroxyapatite-Containing Toothpastes and Cream
This study will investigate the effectiveness of nanohydroxyapatite (nano-HAP)-containing toothpastes and cream to relieve dentin hypersensitivity, comparing it with those of a commercial desensitizing dentifrice containing…
- Trial name
- NCT02918617
- Testing
- Control toothpaste containing Novamin® technology, Control toothpaste containing 1500 ppm fluoride as MFP, Test toothpaste with nano-HAP (high concentration)
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Dentin Sensitivity
A Study to Measure the Efficacy of a Toothpaste on Dentinal Hypersensitivity
Double blind parallel study to measure the efficacy of a toothpaste containing calcium-silicate/phosphate on dentinal hypersensitivity compared to a control toothpaste containing fluoride
- Trial name
- NCT03244618
- Testing
- CSSP Toothpaste, Fluoride Toothpaste
- Where
- United Kingdom
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Dentin Sensitivity
To Evaluate the Efficacy of an Experimental Dissolvable Strip in Rapidly Relieving Dentinal Hypersensitivity (DH)
A proof of principle single-centre, randomized-controlled, examiner-blind, two treatment group study to investigate the efficacy of an experimental 15% w/w dissolvable strip in relieving dentine hypersensitivity (DH) after a…
- Trial name
- NCT02937623
- Testing
- Dissolvable polymer strip containing Novamin (calcium sodium phosphosilicate)
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dentin Hypersensitivity
The Efficacy of a Toothpaste to Reduce Sensitivity
Hypersensitivity
- Trial name
- NCT00763269
- Testing
- Triclosan, Silicon dioxide, fluoride, Triclosan, fluoride
- Where
- United States
- Volunteers
- 626 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dentin Sensitivity
A Clinical Study of Two Dentinal Hypersensitivity Treatments Used With Normal Oral Hygiene
This study will compare the safety and effectiveness of normal oral hygiene with two different marketed dentifrices, on longer term dentinal hypersensitivity response following use of potassium oxalate desensitizers.
- Trial name
- NCT02221349
- Testing
- Potassium oxalate, Sodium fluoride paste, Stannous fluoride paste
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Sensitivity, Tooth
Evaluation of Gluma Desensitizer in Post-treatment Sensitivity in Posterior Composite
To evaluate the effect of Gluma desensitizer in controlling immediate post-treatment sensitivity in posterior occlusal composite restorations.
- Trial name
- NCT04248803
- Testing
- GLUMA (Kulzer GmbH, Germany) desensitizing agent
- Where
- India
- Volunteers
- 570 people, healthy volunteers welcome
- Sponsor
- Tamil Nadu Dr.M.G.R.Medical University
Dentin Sensitivity
Tooth Sensitivity Relief by Two Mouthrinses
This study is for people with sensitive teeth and involves going to the dentist for 6 visits over 8 weeks. During the first 2 weeks, everyone will just brush their teeth two times a day with the fluoride toothpaste provided.
- Trial name
- NCT01133379
- Testing
- 12027-019, 12027-020, 12027-021
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Dentine Hypersensitivity
Efficacy of Potassium Nitrate Solution in Reducing Dentinal Hypersensitivity
An exploratory study investigating the direct application of potassium nitrate (KNO3) solutions of different concentrations in reducing dentine hypersensitivity.
- Trial name
- NCT01115452
- Testing
- 5% Potassium nitrate, 2.5% Potassium nitrate, Sterile water
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- GlaxoSmithKline
Inflammation
Anti-inflammatory Steroids in the Prevention of Tooth Sensitivity
Clinical randomized, triple-blind, used to measure the level of tooth sensitivity on volunteers using a modified virtual analog scale (VAS).
- Trial name
- NCT02956070
- Testing
- Dexamethasone acetate, Potassium Nitrate
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Gingival Recession
Study of Root Coverage With Acellular Dermal Matrix: Puros® Dermis Versus Alloderm®
The purpose of the study is to evaluate whether clinical parameters for Puros Dermis are, at minimum, equivalent when compared to AlloDerm, the current industry standard, for the treatment of single, non-adjacent Miller's Class I…
- Trial name
- NCT00881959
- Testing
- Puros® Dermis versus Alloderm®
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- Zimmer Biomet