Clinical trials: Dependence
Nicotine Dependence
Behavioral Exercise Intervention for Smoking Cessation
The purpose of this study is to test the effect of a moderate-intensity aerobic exercise intervention for smokers interested in quitting smoking.
- Trial name
- NCT00713063
- Testing
- aerobic exercise, Health Education Control
- Volunteers
- 61 people
- Sponsor
- Butler Hospital
Alcoholism
Characterization of [11C]Flumazenil to Image GABA Transmission in Healthy Adult Subjects and Subjects With Alcohol Dependence
Background: This study is being done to examine the role of a chemical GABA in the brain of alcohol dependent patients. GABA is the chief inhibitory neurotransmitter in the central nervous system.
- Trial name
- NCT01904487
- Testing
- [11C]flumazenil, Tiagabine
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Rajesh Narendran
Ventilator Dependency
The Impact of Inspiratory Muscle Strength Training
The study is a pre-post test with quasi experimental design. Forty-two intubated-adults who had been mechanically ventilated for more than 21 days were selected on the basis of inclusion criteria in respiratory care ward.
- Trial name
- IMT (NCT03997214)
- Testing
- inspiratory muscle strength training
- Where
- Taiwan
- Volunteers
- 43 people
- Sponsor
- Fooyin University
Tobacco Dependence
UW Quitting Using Intensive Treatment Study (QUITS)
This research will determine whether two highly promising modifications to varenicline treatment (i.e. use of a nicotine patch adjuvant and extended 24-week duration) produce superior smoking outcomes when they are either used…
- Trial name
- QUITS (NCT03176784)
- Testing
- Varenicline, Nicotine patch
- Where
- 2 sites in United States
- Volunteers
- 1,251 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cannabis, Dependence
Effects of Sativex(Registered Trademark) and Oral THC on Attention, Affect, Working Memory, Reversal Learning, Physiology and Brain Activation
Background: The therapeutic modalities of cannabis have received more research attention recently with the discovery of its ability to stimulate appetite and to provide pain and nausea relief in patients with AIDS, cancer, and…
- Conditions
- Cannabis, Dependence, Cannabis Abuse, Pharmacokinetics
- Trial name
- NCT01037608
- Testing
- Sativex(Registered Trademark), THC
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
GLP-1 Agonism for Blocking Cocaine Euphoria and Self-Administration
The investigators plan to explore the effects of acute pre-treatment with the glucagon like peptide-1 (GLP-1) agonist, exenatide versus placebo, on the subjective (e.g., euphoric) and behavioral effects (e.g.…
- Trial name
- NCT02302976
- Testing
- cocaine hydrochloride, exenatide
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Yale University
Vascular Complications, Vascular Stiffness
Cardiovascular Effects of Chronic Snus Use
The current study proposes to investigate the effects of chronic snus use on the blood vessels. Several cardiovascular endpoints are measured using various methods in healthy daily snus users as well as in healthy matched…
- Conditions
- Vascular Complications, Vascular Stiffness, Tobacco Dependence
- Trial name
- CHROS (NCT02564289)
- Where
- Sweden
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Umeå University
Methamphetamine Dependence, Methamphetamine Abuse
Varenicline as a Treatment for Methamphetamine Dependence
The primary purpose of the study is to determine the effects of treatment with varenicline (1 and 2 mg daily), compared to treatment with placebo, on methamphetamine-induced craving and subjective effects in…
- Conditions
- Methamphetamine Dependence, Methamphetamine Abuse, Substance Abuse
- Trial name
- Varenicline (NCT01571167)
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Baylor College of Medicine
Heroin Addiction
Buprenorphine for Prisoners
This five-year study examines the effectiveness of buprenorphine treatment provided to previously-addicted inmates(N=320; 160 males, 160 females) initiated in prison and continued in the community.
- Trial name
- NCT00574067
- Testing
- Buprenorphine +OTP, Buprenorphine +CHC, Counseling +OTP
- Where
- 2 sites in United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Friends Research Institute, Inc.
Cocaine Dependence
Behavioral Treatment for Cocaine Dependent Women
To compare the efficacy of Community Reinforcement Approach (CRA) and 12-Step Facilitation (TSF) counseling and of voucher based reward therapy (VBRT) and a yoked, non-contingent voucher control (VC) for the treatment of cocaine…
- Trial name
- NCT00914381
- Testing
- Behavioral therapy
- Where
- 2 sites in United States
- Volunteers
- 145 people
- Sponsor
- Yale University
Opioid-Related Disorders
Neurobiology of Opioid Dependence: 4 - 4
The purpose of this study is to determine the effect of chronic naltrexone pre-treatment on the response to yohimbine in healthy volunteers.
- Trial name
- NCT00000195
- Testing
- Naltrexone
- Where
- United States
- Sponsor
- Yale University
Tobacco Use Cessation, Tobacco Use Disorder
Smoking Treatment of Prisoners
The purpose of this study is to determine the efficacy of a 10-week smoking cessation therapy combined with NicoDerm CQ for smoking cessation among female prisoners.
- Trial name
- STOP (NCT00110630)
- Testing
- 10-week smoking cessation group therapy combined with NicoDerm CQ
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Pharmacogenetic Trial of Doxazosin for Treatment of Cocaine Abuse
Cocaine use disorders affect approximately 1.5 million Americans annually. Currently, there are no US Food and Drug Administration approved medications for treatment of cocaine dependence; however, both animal and human studies…
- Trial name
- NCT01953432
- Testing
- Doxazosin
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Nicotine Dependence
Stage Ib Trial of mSMART for Smoking Cessation Medication Adherence
The primary aim of this study is to conduct a 60-patient feasibility, acceptability, and preliminary efficacy study of mSMART (Mobile App based Personalized Solutions and Tools for Medication Adherence of Rx Pill), a smartphone…
- Trial name
- mSMART-Ib (NCT02635919)
- Testing
- mSMART
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Alcohol Dependence
Safety of Acamprosate for Alcohol Dependence in the Elderly: An Open-Label Study (SAFADIE)
Alcohol abuse and dependence are very prevalent and result in significant morbidity, mortality and cost to society (Harwood 2000).
- Trial name
- SAFADIE (NCT00655967)
- Testing
- Acamprosate (Campral), Acamprosate
- Where
- United States
- Sponsor
- University of New Mexico
Breast Cancer, Tobacco Dependence
Tobacco Dependence in Breast Cancer Patients Trial of Varenicline (Chantix)
Breast cancer patients who smoke, are at greater risk for treatment complications. The purpose of this study is to see if the researchers can find ways to help patients who have breast cancer quit smoking.
- Trial name
- NCT01532232
- Testing
- varenicline
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Nicotine Dependence
E-cigarettes, Nicotine Inhaler, and Blood Vessel Function
Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, nicotine inhaler, and sham-control on endothelial function, oxidative stress and sympathetic nerve activity
- Trial name
- NCT03072628
- Testing
- e-cig with nicotine, e-cig without nicotine, nicotine inhaler
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Opioid-Related Disorders
Evaluation of Liquid vs. Tablet Buprenorphine - 6
The purpose of this study is to evaluate the steady-state pharmacokinetics and bioavailability of buprenorphine sublingual tablets vs. sublingual solution.
- Trial name
- NCT00000341
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cirrhosis, Alcohol Dependence
Nalmefene in Patients With Alcoholic Compensated Cirrhosis for the Treatment of Alcohol Dependence.
Nalmefene is the first drug to obtain Marketing Authorisation in France for reduction of alcohol consumption.
- Conditions
- Cirrhosis, Alcohol Dependence, Nalmefene
- Trial name
- NalmeCir (NCT02824354)
- Testing
- Nalmefene (Selincro®) 18 mg tablet
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Caffeine Dependence
A Long-term Safety and Efficacy of EnXtra (E-AG-01) in Healthy Adults
The present study has been proposed to investigate the long-term safety and efficacy of EnXtra in healthy adults habituated to caffeine.
- Trial name
- NCT03731286
- Testing
- Alpinia Galanga, Microcellulose crystalline
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
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