Clinical trials: Dependence
Nicotine Dependence
Effects of Menthol in E-cigarettes on Smoking Behaviors
The overall goal of this proposal is to understand the relationship between nicotine metabolism and menthol flavor in e-cigarettes on smoking behavior in smokers.
- Trial name
- NCT04521647
- Testing
- Nicotine
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Yale University
Methamphetamine-dependence, Postpartum Abstinence
PRevention Of Methamphetamine Use Among Postpartum Women Trial (PROMPT)
The PRevention Of Methamphetamine Use among Postpartum Women Trial (PROMPT) is randomized controlled trial of postpartum individuals with methamphetamine use disorder to 12 weeks of 200 mg oral micronized progesterone twice daily…
- Trial name
- NCT05128071
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Utah
Nicotine Dependence
Trial on the Effectiveness of Mindfulness Training for Smokers
The Mindfulness Training for Smokers study follows a randomized controlled design with 240 total participants. Both the study group and the control group will be enrolled in the Wisconsin Tobacco Quit Line and will receive four…
- Trial name
- MTS (NCT01093599)
- Testing
- Quit Line plus MTS, Quit Line Only
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- University of Wisconsin, Madison
Second Hand Tobacco Smoke, Nicotine Dependence
Kids Safe and Smokefree (KiSS)
The study's primary aim is to test the hypothesis that an intervention integrating pediatric clinic-level quality improvement with home-level behavioral counseling (CQI+BC) will result in greater reductions in child cotinine (a…
- Trial name
- KiSS (NCT01745393)
- Testing
- Clinic Quality Improvement + Behavioral Counseling, Clinic Quality Improvement + Attention Control
- Where
- 4 sites in United States
- Volunteers
- 327 people
- Sponsor
- Temple University
Opioid Dependence
Dronabinol Naltrexone Treatment for Opioid Dependence
The goal of this two-year study is to test the efficacy of dronabinol as an adjunct to maintenance treatment with naltrexone in opioid-dependent individuals.
- Trial name
- Domino (NCT01024335)
- Testing
- injectable naltrexone and dronabinol
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- New York State Psychiatric Institute
Alcoholism
N-acetylcysteine in Alcohol Dependence
The present study is designed to find out if N-acetylcysteine works in reducing alcohol drinking and craving.
- Trial name
- NCT00568087
- Testing
- N-acetylcysteine
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Cannabis Dependence
Study of Quetiapine Treatment for Cannabis Dependence
Marijuana is the most commonly used illicit drug in the United States. However, the treatment options for cannabis dependence are limited; notably, no effective pharmacotherapy has been developed.
- Trial name
- STUC (NCT00954681)
- Testing
- quetiapine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- New York State Psychiatric Institute
Nicotine Dependence
Smoking Cessation Medications: Efficacy, Mechanisms and Algorithms
The proposed work will advance the understanding and effectiveness of tobacco dependence treatment and result in more smokers quitting successfully.
- Trial name
- NCT00332644
- Testing
- nicotine patch, nicotine lozenge, nicotine patch + nicotine lozenge
- Where
- 2 sites in United States
- Volunteers
- 1,504 people
- Sponsor
- University of Wisconsin, Madison
Methamphetamine Dependence
Citicoline Treatment of Methamphetamine Dependence
The purpose of the study is to determine if citicoline (a nutritional supplement) is effective in helping people reduce their dependence on methamphetamine.
- Trial name
- NCT00950352
- Testing
- Citicoline
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Perry Renshaw
Substance Abuse, Cocaine Dependence
Bupropion-Enhanced Contingency Management (CM) for Cocaine Dependence
This project will examine effects of bupropion extended release (XL) at a dose of 300mg/day for cocaine abstinence among persons receiving methadone for the treatment of opioid use disorder.
- Trial name
- NCT02111798
- Testing
- Bupropion XL, Abstinence Initiation, Relapse Prevention
- Where
- 2 sites in United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cocaine Dependence
Cocaine/Crack and Reduction of Compulsion With Biperiden
Considering the effects of the cholinergic system on the drug reward and self-administration mechanisms, acetylcholine (Ach) may play an important role on cocaine dependence process.
- Trial name
- NCT01251393
- Testing
- Biperiden
- Where
- Brazil
- Volunteers
- 111 people
- Sponsor
- Federal University of São Paulo
Cigarette Smoking-Related Carcinoma
Gender Differences in Switching From Smoking Regular Cigarettes to E-Cigarettes
This early phase I trial studies potential differences between men and women when switching from the use of combustible cigarettes to the National Institute on Drug Abuse's Standard Research E-Cigarette (SREC).
- Trial name
- NCT03856515
- Testing
- Nicotine Replacement, Questionnaire Administration, Electronic Cigarette
- Where
- United States
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Nicotine Dependence, Alcohol Use Disorder
Combining Varenicline and Naltrexone for Smoking Cessation
This study is a double-blind, randomized clinical trial using a two group medication design consisting of the combination of VAR (1 mg twice daily) + NTX (50 mg once daily) and VAR (1 mg twice daily) + PLA (matched to NTX), for…
- Trial name
- NCT02698215
- Testing
- Varenicline, Varenicline plus Naltrexone
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- University of California, Los Angeles
Smoking Cessation, Nicotine Dependence
Varenicline and Motivational Advice for Smokers With Substance Use Disorders
The purpose of this study is to evaluate the effects of 12 weeks of varenicline as compared to nicotine replacement therapy for smoking cessation among outpatients in treatment for substance use disorders.
- Trial name
- VARSUD (NCT00756275)
- Testing
- Nicotine Replacement Treatment (NRT), varenicline, Behavioral counseling for smoking cessation
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Brown University
Tobacco Dependence
Multiple-dose Nicotine Pharmacokinetics With a New Oral Nicotine Replacement Product.
A comparison of three products for oral nicotine replacement with respect to pharmacokinetics after multiple-doses of nicotine.
- Trial name
- NCT01084707
- Testing
- Oral Nicotine, Nicotine Lozenge, Nicotine gum
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- McNeil AB
Tobacco Dependence
Tobacco Dependence Treatment for Asian Americans
Nicotine dependence is very common among Asian Americans; yet, research on understanding and treating nicotine dependence in this group is almost nonexistent.
- Trial name
- NCT01091363
- Testing
- Standard, Deep Cultural
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Boston
Nicotine Dependence, Cigarettes
Penn State TXT2STAYQUIT Study- a Texting Study to Help Hospitalized Smokers Stay Quit
This study aims to pilot a method of collecting the post-discharge follow-up data required by the Joint Commission Tobacco Measure Set, using text messages sent to and received from patients' cellular-telephones.
- Trial name
- NCT02986711
- Testing
- Motivational Text Messages, Control
- Where
- United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Marijuana Dependence
Effect of Oxytocin on Craving and Therapy Response
The purpose of this study is to examine the impact of a medication called oxytocin on marijuana use and therapy response in people who frequently use marijuana.
- Trial name
- NCT01827332
- Testing
- Oxytocin, Saline
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Medical University of South Carolina
Opioid Abuse, Opioid Dependence
Effects of Ibudilast on Oxycodone Self-administration in Opioid Abusers
Opioid drugs increase glial cell activation which may be related to the abuse liability of opioid drugs. Data supporting this hypothesis have demonstrated that glial cell attenuators decrease the positive rewarding aspect of…
- Trial name
- NCT01740414
- Testing
- MN-166 (50 mg) First
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Use Disorder, Cocaine Dependence
Theta-Burst Stimulation as a Treatment for Reducing Cocaine Use
Objective: The goal of this clinical trial is to assess the tolerability of an accelerated intermittent theta burst stimulation (iTBS), a form of transcranial magnetic stimulation, intervention in participants with cocaine use…
- Trial name
- NCT02927236
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)