Clinical trials: Dependence
HIV
HIV Risk Reduction in Subutex Injectors in Tbilisi
This study will obtain pilot data on the acceptability of a 12-week course of daily observed suboxone and methadone, followed by a dose taper or referral to a local treatment program for 80 opioid dependent patients (40 group)…
- Trial name
- NCT01131273
- Testing
- methadone, buprenorphine-naloxone (Suboxone) for 12 weeks
- Where
- Georgia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Tobacco Smoking, Nicotine Dependence
Smoking Interventions in General Medical Practices
Primary care physicians can play an important role in reducing tobacco smoking in the population. The general practice is a suitable setting for implementing proactive smoking interventions, because a large proportion of the…
- Trial name
- PRO GP (NCT00679861)
- Testing
- Counselling Intervention, Expert-system intervention
- Volunteers
- 3,215 people
- Sponsor
- University Medicine Greifswald
Opioid-Related Disorders, Heroin Dependence
Buprenorphine Maintenance Treatment of Opioid Dependence in Primary Care: A Randomized Clinical Trial
The study will assess the effectiveness of at-home vs. in-office induction for patients entering buprenorphine maintenance at Associates in Internal Medicine (AIM) primary care clinic.
- Trial name
- NCT00684554
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- New York State Psychiatric Institute
Cocaine-Related Disorders
Risperidone for the Treatment of Cocaine Dependence - 7
The purpose of this study is to evaluate clinical safety and pharmacological efficacy in the treatment of cocaine dependence, to evaluate impact of treatment on craving, and to correlate evidence of baseline neurotoxic damage of…
- Trial name
- NCT00000342
- Testing
- Risperidone
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Patients Above 18 Years, Patient Discharge
One Year Pacing Dependency After TAVR
Pace maker implantation after the procedure of TAVR can be estimated at 15% of patients. However, some studies have shown that the conduction disturbances after TAVR could resolve over time, and that roughly between one- and…
- Conditions
- Patients Above 18 Years, Patient Discharge, Pacing Therapy, Aortic Stenosis (Treated With TAVI)
- Trial name
- PACETAVI (NCT06756282)
- Testing
- Pacemaker and defibrillator
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Montpellier
Dysfunctional Breathing, Physical Activity
Prevalence and Association of Dysfunctional Breathing With Nicotine Dependence and Physical Activity Among Young Smokers
We will structure the study's summary to provide a clear and accessible overview for patients, families, and healthcare providers.
- Conditions
- Dysfunctional Breathing, Physical Activity, Nicotine Dependence
- Trial name
- NCT07843524
- Testing
- Observational evaluation.
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Istinye University
Nicotine Dependence
Human Laboratory Study Of Varenicline in Smokers
The purpose of this study is to test the ways that a drug called varenicline helps smokers to quit smoking. Varenicline is also called Chantix® and is approved by the United States Food and Drug Administration (FDA) to help…
- Trial name
- NCT00709696
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Tobacco Dependence
Use of Nicotine Pouches Among Daily Smokers
The purpose of this clinical trial is to understand the health effects of a new oral nicotine pouch, and also to understand if this product can help reduce traditional cigarette smoking. The main aims are: 1.
- Trial name
- NCT06043362
- Testing
- 0 mg nicotine pouch, 3 mg nicotine pouch, 6 mg nicotine pouch
- Where
- 2 sites in United States
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Chronic Pain, Opiate Dependence
Cognitive-Behavioral Therapy for Pain and Opioid Dependence in Methadone Maintenance Treatment
This study involves the comparison of two treatment approaches for patients with chronic pain who are entering methadone maintenance treatment (MMT) for opioid addiction: (a) an integrated counseling that addresses both chronic…
- Trial name
- NCT01334580
- Testing
- Cognitive-Behavioral Therapy for Pain and Opioid Dependence, Methadone Drug Counseling
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Yale University
Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome
Intervention of HIV, Drug Use and the Criminal Justice System in Malaysia
The purpose of this study is to evaluate the relative impact a medical drug (methadone) or behavioral counseling program (Holistic Health Recovery Program) or both (methadone and Holistic Health Recovery Program) has on reducing…
- Conditions
- Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome, Opiate Addiction, Drug Dependence
- Trial name
- Harapan (NCT02396979)
- Testing
- Methadone, Holistic Health Recovery Program
- Volunteers
- 300 people
- Sponsor
- Yale University
Geriatrics, Home Care Services
Live Better at Home in Catalonia
The intensity of the home care interventions for dependent older people offered in Spain, and specifically in Catalonia, may not be sufficient to help keep older people at home and delay institutionalisation in a nursing home…
- Trial name
- VMCat (NCT05567965)
- Testing
- Home care intervention
- Volunteers
- 160 people
- Sponsor
- University of Vic - Central University of Catalonia
Tobacco Dependence
Prolonged Smoking Cessation Using Prescription Step Care
Smoking is the number one preventable cause of morbidity and mortality in this nation. Unfortunately, more than 50% of those who quit following a smoking cessation intervention typically relapse within two weeks, with…
- Trial name
- NCT00170079
- Testing
- Smoking Cessation Intervention
- Where
- 2 sites in United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Alcohol Dependence
The Approach and Avoidance Task (AAT) in Alcoholic Inpatients
The approach and avoidance task (AAT) has evolved as a promising treatment add-on in the realm of psychology. Certain psychiatric diseases, such as behavioural addictions, social anxiety disorder, and arachnophobia, are…
- Trial name
- NCT04054336
- Testing
- Inhibit AAT, classical AAT, Control Group
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Heroin Dependence, Morphine Dependence
Buprenorphine/Naloxone Versus Clonidine for Outpatient Opiate Detoxification - 1
The purpose of this study is to assess buprenorphine/naloxone versus clonidine for outpatient opiate detoxification.
- Conditions
- Heroin Dependence, Morphine Dependence, Substance Withdrawal Syndrome
- Trial name
- NCT00032968
- Testing
- Buprenorphine/naloxone
- Where
- 7 sites in United States
- Volunteers
- 341 people
- Sponsor
- University of California, Los Angeles
Cocaine Dependence
Modafinil Treatment for Cocaine Dependence and HIV High-Risk Behavior
The purpose of study is to determine if modafinil promotes cocaine abstinence and reduces high risk behavior in cocaine dependent subjects.
- Trial name
- MOD6 (NCT00368290)
- Testing
- Modafinil, Cognitive Behavioral Therapy (CBT)
- Volunteers
- 94 people
- Sponsor
- Kyle Kampman
Smoking Cessation, Harm Reduction
Assisting Smokers to Switch to a JUUL E-Cigarette by Devaluing Combustible Cigarettes
This study will evaluate a reward devaluation strategy in which smokers use the JUUL e-cigarette immediately before any combustible cigarettes (CCs) are smoked.
- Conditions
- Smoking Cessation, Harm Reduction, E-Cig Use, Cigarette Smoking
- Trial name
- RECON (NCT04188197)
- Testing
- JUUL
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Older People, Care Dependency
Implementing the Transcultural Social-Ethical-Care Model -TEC-MED for Older People in the Mediterranean Basin
Implementation of the TEC-MED model of social and health care in the elderly population of the Mediterranean basin through a quasi-experimental trial.
- Conditions
- Older People, Care Dependency, Social Exclusion
- Trial name
- TEC-MED (NCT06184178)
- Testing
- Socio-health care
- Where
- Spain
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- REGINA ALLANDE CUSSO
Cocaine-Related Disorders
Topiramate to Reduce Cocaine Dependence
Cocaine addiction is a serious health problem with no available medical treatment for preventing relapse. Topiramate, a medication which lowers dopamine levels, may have the ability to diminish cocaine cravings in addicts.
- Trial name
- NCT00223626
- Testing
- Topiramate
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Bankole Johnson
Nicotine Dependence
Evaluation of Moclobemide, a Reversible MAO-A Inhibitor, as an Adjunct to Nicotine Replacement Therapy in Female Smokers
The proposed study will assess the efficacy of moclobemide, a selective, reversible MAO-A inhibitor, in facilitating smoking cessation in treatment-seeking female smokers.
- Trial name
- RIMA (NCT01926626)
- Testing
- Nicotine Patch, Moclobemide
- Where
- 3 sites in United States
- Volunteers
- 76 people
- Sponsor
- Jed E. Rose
Nicotine Dependence, Electronic Cigarette Use
Methadone-Maintained Smokers Switching to E-Cigarettes
Participants in this randomized clinical trial will be methadone-maintained smokers interested in switching to electronic cigarettes (ECs).
- Trial name
- SHINE (NCT05206435)
- Testing
- Electronic Cigarette, Nicotine Lozenge
- Where
- United States
- Volunteers
- 183 people
- Sponsor
- Butler Hospital
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