Clinical trials: Dependence
Cannabis, Marijuana Abuse
Dronabinol Interactions With Cognitive Enhancing Drug in Humans
Marijuana use is a major problem among veterans and non-veterans. A patient's use of marijuana while engaged in psychotherapy treatment may affect their memory and, therefore, limit their ability to benefit from treatment.
- Trial name
- NCT00842985
- Testing
- drug condition
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Yale University
Tobacco Dependence, PTSD
Behavioral Activation for Smoking Cessation in PTSD
The purpose of this study is to examine whether behavioral activation as an adjuvant to standard smoking cessation treatment improves smoking cessation outcomes among veterans with PTSD relative to a comparably intense…
- Trial name
- NCT01995123
- Testing
- Behavioral Activation Therapy, Health and Smoking Education, Standard Smoking Cessation Therapy
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Alcohol Dependence
Effectiveness of Naltrexone Versus Placebo to Reduce Craving for Alcohol With Evaluation of Genetic Variability.
The purpose of this study is to determine whether naltrexone (an opiate blocking agent approved for the treatment of alcohol dependence) is more effective in the reduction of alcohol craving and drinking compared to placebo in…
- Trial name
- NCT00366626
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Medical University of South Carolina
Smoking
Varenicline and Bupropion for Smoking Cessation
This study provides an opportunity to combine varenicline and bupropion SR and capitalize on the potential additive benefit. The investigators hypothesize that this will further increase long-term (≥ 6 months) smoking abstinence…
- Trial name
- CHANBAN (NCT00935818)
- Testing
- Varenicline, bupropion SR
- Where
- 3 sites in United States
- Volunteers
- 506 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Opioid Use Disorder
Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Prior to First Dose of VIVITROL® (Naltrexone for Extended-Release Injectable Suspension)
This study will evaluate the safety, effectiveness and tolerance of low doses of oral naltrexone along with buprenorphine to treat opioid use disorder prior to the first injection of VIVITROL.
- Trial name
- NCT02537574
- Testing
- NTX/BUP, NTX/PBO-B, PBO-N/PBO-B
- Where
- 20 sites in United States
- Volunteers
- 380 people
- Sponsor
- Alkermes, Inc.
Nicotine Dependence
Assessment of a Teachable Moment for Smoking Cessation
A teachable moment (TM) refers to life events or transitions, such as physician visits, early detection screening feedback, pregnancy, and hospitalization for, and diagnosis of, disease, that inspire health behavior change.
- Trial name
- TM (NCT00596440)
- Testing
- Transdermal nicotine patch
- Where
- United States
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Smoking Cessation, Medication Adherence
My Mobile Advice Program: A Randomized Pilot Feasibility Study
The purpose of this pilot study is to evaluate the acceptability and feasibility of the proposed smoking cessation intervention (called MyMAP or My Mobile Advice Program).
- Trial name
- MyMAP (NCT02136498)
- Testing
- Varenicline, Cognitive-behavioral self-help, MyMAP (My Mobile Advice Program)
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Kaiser Permanente
Substance Use Disorders
Adaptive Treatment for Alcohol and Cocaine Dependence
1. Primary objective #1: Determine the relative effectiveness of MI-IOP and MI-PC in the full study sample with regard to treatment engagement over weeks 1-12 and cocaine/alcohol use over weeks 1-24.
- Trial name
- NCT01032135
- Testing
- Motivational Interviewing, Telephone counseling, Cognitive Behavioral Therapy (CBT) Counseling
- Where
- 3 sites in United States
- Volunteers
- 500 people
- Sponsor
- University of Pennsylvania
Substance Abuse, Substance Dependence
Cognitive Remediation and Work Therapy in the Initial Phase of Substance Abuse Treatment
The initial phase of substance abuse treatment is a vulnerable period for relapse. Cognitive impairments are common during this phase and may reduce the ability to benefit from other forms of substance abuse and rehabilitation…
- Conditions
- Substance Abuse, Substance Dependence, Cognitive Impairment
- Trial name
- NCT01410110
- Testing
- Cognitive Training + Work Therapy, Work Therapy
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Yale University
Heavy Drinking, Alcohol Dependence
Alcohol Disorder hOsPital Treatment Trial
The specific aims of this pragmatic randomized controlled trial are to compare initiating injectable extended release naltrexone (XR-NTX) or oral naltrexone (PO-NTX) at the time of discharge from a medical hospitalization for…
- Conditions
- Heavy Drinking, Alcohol Dependence, Alcohol Use Disorder
- Trial name
- ADOPT (NCT02478489)
- Testing
- Oral naltrexone (PO-NTX), Extended-release injectable naltrexone (XR-NTX)
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- Boston University
Alcoholism
Varenicline (Chantix™) for the Treatment of Alcohol Dependence
The purpose of this study is to determine the efficacy of varenicline (Chantix™) for the treatment of alcohol dependence.
- Trial name
- ChA (NCT00705523)
- Testing
- varenicline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
Opioid-use Disorder, Opioid Dependence
Remote Observed Dosing of Suboxone to Improve Clinical Practice
This is a 15-week, outpatient study of remote observed dosing to improve suboxone compliance in opiate dependent subjects.The main purpose of this study is to see if watching patients take their medication will improve treatment…
- Conditions
- Opioid-use Disorder, Opioid Dependence, Opiate Dependence
- Trial name
- NCT03769025
- Testing
- Suboxone Remote Observed Dosing, Suboxone Attention Control
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Pennsylvania
Cancer of Head and Neck, Breast Cancer
Brain Stimulation For Cancer Smokers
Smoking cessation and relapse prevention represent and important opportunity to improve cancer survival rates, reduce the risk of cancer treatment complication, and improve the quality of life of patients with and survivors of…
- Conditions
- Cancer of Head and Neck, Breast Cancer, Prostate Cancer, Nicotine Dependence
- Trial name
- NCT03419741
- Testing
- Transcranial Magnetic Stimulation Clinical Research System
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Medical University of South Carolina
Marijuana Abuse and Dependence
Development and Efficacy Test of Computerized Treatment for Marijuana Dependence
More US residents are dependent on marijuana than on any other illicit drug, and the number enrolled in treatment for marijuana continues to increase such that it is now comparable to that for cocaine and heroin.
- Trial name
- NCT00594659
- Testing
- Psychotherapy, Computerized Psychotherapy, Motivational enhancement therapy
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Opioid-use Disorder, Opioid Dependence
SMART Effectiveness Trial
The current study piloted two psychosocial interventions developed to increase buprenorphine-naloxone adherence in individuals with opioid use disorder (OUD).
- Conditions
- Opioid-use Disorder, Opioid Dependence, Treatment Adherence
- Trial name
- NCT04464421
- Testing
- Contingency Management (CM), Brief Motivational Intervention + Substance Free Activities Session + Mindfulness-Based Adherence Promotion (BSM)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Karen Derefinko, PhD
Marijuana Dependence
Baclofen Effects on Marijuana Dependence
Studies show that certain reminders of drug use such as the sight of someone using marijuana, pictures of blunts, particular moments throughout the day, prompt marijuana users to smoke marijuana.
- Trial name
- NCT02011516
- Testing
- Baclofen, Psychosocial
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Tobacco Use Disorder
Project 2, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Opioid Abusers
This study will examine extended exposure to cigarettes varying in nicotine content among adults with opioid use disorder. Those with opioid use disorder are at increased risk for smoking, nicotine dependence, and using high…
- Trial name
- P2S2 (NCT02250664)
- Testing
- Very low nicotine content cigarettes
- Where
- 2 sites in United States
- Volunteers
- 775 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Nicotine Dependence, Alcohol Use
Pilot Study on Mindfulness for Tobacco and Alcohol in University Students
A. The study follows a randomized controlled design with approximately 60 smokers with a history of alcohol abuse age 18-29. The study will compare a 7-week mindfulness intervention to a matched 7-week education intervention to…
- Trial name
- NCT01679236
- Testing
- Mindfulness Training for Smokers, Interactive Learning for Smokers
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Wisconsin, Madison
Tobacco, Posttraumatic Stress Disorder
Improving Functional Outcomes of Veterans With PTSD and Tobacco Dependence
Veterans with PTSD have high rates of smoking (34%-86% vs. 18% in the general population) and have substantial difficulties with quitting tobacco.
- Trial name
- ACT-PT (NCT02576899)
- Testing
- Acceptance and Commitment Therapy for PTSD and Tobacco Use, Freedom From Smoking
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Cannabis Dependence
Open-Label Pilot Study of Guanfacine-Extended Release for the Treatment of Cannabis Dependence
The purpose of this study is to determine whether guanfacine represents a tolerable, potentially effective pharmacotherapy option for cannabis dependence.
- Trial name
- GUAN (NCT01467999)
- Testing
- Guanfacine
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- New York State Psychiatric Institute