Clinical trials: Dependence
Subarachnoid Hemorrhage, Aneurysmal, Headache
Infusion of Lidocaine and Steroids in Middle Meningeal Artery for Pain in Subarachnoid Hemorrhage
The goal of this clinical trial is to learn if an infusion of lidocaine, with or without steroids, into the middle meningeal artery (MMA) helps relieve severe headaches in patients with spontaneous subarachnoid hemorrhage (SAH).
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Headache, Opiate Dependence, Opioid Use
- Trial name
- NCT07294118
- Testing
- Lidocaine, Lidocaine and Dexamethasone
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Nicotine Dependence
Testing Financial Incentive Interventions in Dyadic-Smoker Couples
The proposed study investigates the feasibility and efficacy of FITs in dual-smoker couples [DSCs]. The core design is a three-group mixed repeated measures design, in which participants are randomized into one of three…
- Trial name
- NCT04832360
- Testing
- Financial Incentives
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Obesity, Alcohol Dependence
Imaging of Cannabinoid 1 Receptors Using [11C]OMAR and PET
The aim of the present study is to conduct a human trial of [C-11]OMAR, a new PET imaging agent for the brain cannabinoid type 1 receptors (CB1), to determine its pharmacokinetics and binding characteristics.
- Conditions
- Obesity, Alcohol Dependence, High Stress
- Trial name
- NCT01719497
- Testing
- [C-11]OMAR
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Yale University
Nicotine Dependence, Tobacco Use
Dissemination of a Tailored Tobacco Quitline for Rural Veteran Smokers
The project is designed to examine the effectiveness of strategies to increase access to treatment for tobacco use and dependence among rural Veteran smokers.
- Trial name
- NCT01892813
- Testing
- Nicotine replacement therapy - Transdermal nicotine patch, Nicotine replacement therapy - Nicotine gum, Nicotine replacement therapy - Nicotine lozenge
- Where
- United States
- Volunteers
- 411 people, healthy volunteers welcome
- Sponsor
- Mark Vander Weg
Alcohol Dependence
Identifying Multiple Mechanisms of Change in Alcoholism Treatment
Cognitive-behavioral therapy (CBT) is an effective treatment for alcohol dependence, but little is known about how CBT works to achieve these effects.
- Trial name
- NCT01168960
- Testing
- Cognitive behavioral therapy for alcohol dependence
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- State University of New York at Buffalo
Substance Related Disorder, Nicotine Dependence
Effects of Nicotine on Elements of Attentions in Smokers and Nonsmokers
Background: Many cigarette smokers claim that smoking helps them stay alert and improves their concentration, and have reported problems in attention and concentration after quitting smoking.
- Trial name
- NCT01034020
- Testing
- Nicotine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcoholism, Alcohol Dependence
Gabapentin Treatment of Alcohol Dependence
Gabapentin treatment for alcohol dependence
- Trial name
- NCT00391716
- Testing
- Gabapentin 900mg, behavioral counseling, gabapentin 1800mg
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- The Scripps Research Institute
COCAINE-RELATED DISORDERS
Improving Learning-based Treatment of Cocaine Dependence With Medication
This study will test the efficacy of d-cycloserine in enhancing response to learning-based treatment for cocaine dependence, specifically contingency management.
- Trial name
- NCT01526538
- Testing
- d-cycloserine, sugar pill
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Substance Abuse Problem, Alcohol Abuse
Designing a Mobile App for Veterans With Substance Use Problems
The purpose of this study is to increase access for rural Veterans to evidence-based, person-centered, individually tailored treatment for alcohol use problems.
- Conditions
- Substance Abuse Problem, Alcohol Abuse, Alcohol Dependence
- Trial name
- NCT01812187
- Testing
- SHIFT Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Michael E. DeBakey VA Medical Center
Cannabis Dependence
Interactions Between Physical Activity and Cannabis Use in Adults
In this study the investigators will explore the relationship between physical activity and cannabis use. The investigators will compare regional brain activation detected by imaging technique(fRMI) before and after exercise in…
- Trial name
- NCT00838448
- Testing
- Exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Alcoholism, Substance Abuse
Recognition and Early Intervention for Alcohol and Substance Abuse in Adolescence in Adolescent
ASSIST mini-intervention is applied in an electric form in adolescent outpatients to see if it
- Conditions
- Alcoholism, Substance Abuse, Alcohol Dependence, Alcohol-Related Disorders
- Trial name
- REAL-SMART (NCT06262958)
- Testing
- ASSIST, Treatment as usual
- Where
- Finland
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Kuopio University Hospital
Opioid-Related Disorders, HIV Infections
Buprenorphine and Integrated HIV Care Evaluation
The purpose of this study is to assess the feasibility, cost and effectiveness of interventions designed to integrate buprenorphine treatment for opioid dependence into HIV primary care in ten HIV care centers in the U.S.
- Conditions
- Opioid-Related Disorders, HIV Infections, AIDS
- Trial name
- NCT00124358
- Testing
- Buprenorphine, Integrated HIV care and office-based opioid dependence treatment
- Where
- 10 sites in United States
- Volunteers
- 1,350 people
- Sponsor
- The New York Academy of Medicine
Opioid-use Disorder, Opioid Dependence
Comparing Home, Office, and Telehealth Induction for Medication Assisted Treatment for Opioid Use Disorder
HOMER is a national study comparing three methods of induction for Medication Assisted Treatment (MAT) for Opioid Use Disorder (OUD); home versus office versus telehealth-based inductions.
- Trial name
- HOMER (NCT04664062)
- Testing
- Medication Assisted Treatment
- Where
- 2 sites in United States
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Substance-Related Disorders
Job-Seekers Training for Patients With Drug Dependence - 1
The purpose of this study is to examine the effectiveness of a 12-hour basic job-training program designed to give drug abuse treatment patients the skills they need to find and secure a job and set vocational goals and methods…
- Trial name
- NCT00102362
- Testing
- Behavior Therapy
- Where
- 13 sites in United States
- Volunteers
- 627 people
- Sponsor
- Johns Hopkins University
Potential Treatment for Alcohol Dependence-Alcohol Interaction
Effects of Ethanol on the Pharmacokinetics of PT-150 (Formerly ORG34517) (PT150 PK Study)
The purpose of this clinical study is to assess pharmacokinetic interactions between ethanol (EtOH) and PT150 (900 mg qd) in non-treatment-seeking alcohol-experienced volunteers-(to include military service members, veterans…
- Trial name
- NCT04331288
- Testing
- PT150, Beverage
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pop Test Oncology LLC
Nicotine Dependence, Alcohol Use
Pilot Study on Mindfulness for Tobacco and Alcohol in University Students
A. The study follows a randomized controlled design with approximately 60 smokers with a history of alcohol abuse age 18-29. The study will compare a 7-week mindfulness intervention to a matched 7-week education intervention to…
- Trial name
- NCT01679236
- Testing
- Mindfulness Training for Smokers, Interactive Learning for Smokers
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Wisconsin, Madison
Opiate Dependence
Study of Buprenorphine-Naloxone Sublingual Spray and Suboxone® Sublingual Film in Healthy Volunteers
The primary objective of this study is to compare the bioavailability of a test formulation of Buprenorphine Naloxone Sublingual (SL) spray to that of a single dose of Suboxone® (buprenorphine and naloxone) sublingual film, under…
- Trial name
- NCT02477267
- Testing
- SL spray, SL film
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- INSYS Therapeutics Inc
Cocaine Related Disorders
Efficacy of Caffeine, With and Without Biperiden, in the Detoxification of Cocaine Dependent Patients
The aim of this study is to assess the efficacy of caffeine compared to placebo in detoxifying cocaine dependent patients. Caffeine potentiation with biperiden will be also studied.
- Trial name
- NCT00495092
- Testing
- Caffeine, Biperiden
- Where
- Spain
- Volunteers
- 85 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Cigarette Smoking, Nicotine Dependence
Effects of Very Low Nicotine Content Cigarettes Among Adults Who Smoke Daily in South Korea
The goal of this clinical trial is to learn how switching to very low nicotine content (VLNC) cigarettes affects smoking behavior and nicotine exposure among adults in South Korea who smoke conventional cigarettes daily.
- Trial name
- NCT07755891
- Testing
- SPECTRUM cigarettes
- Where
- South Korea
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Sung-il Cho
Cannabis Dependence
An Open-Label Trial of N-Acetylcysteine in Cannabis Dependent Adolescents
The purpose of this pilot study is to determine the feasibility of conducting a trial of N-Acetylcysteine in cannabis dependent adolescents.
- Trial name
- NAC MJ Pilot (NCT00542750)
- Testing
- N-Acetylcysteine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Medical University of South Carolina
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