Clinical trials: Dependence
Smoking Cessation
Computer MI for Tobacco Quitline Engagement in Smokers Living With HIV
The long-term goal of this program of research is to disseminate an effective, brief computer-based intervention that can be readily integrated into HIV treatment settings to motivate tobacco quitline use among smokers living…
- Trial name
- MI-HIV (NCT01886924)
- Testing
- Brief Computer MI for Smoking Cessation, Nutrition Control
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Butler Hospital
Amphetamine Dependence
Dose Response of Mirtazapine to Methamphetamine Induced Interest, Mood Elevation and Reward
The primary purpose of this study is to determine if Mirtazapine will produce a decrease in interest in the drug, a decrease in mood elevation, and/or a decrease in reward when given before methamphetamine compared to placebo.
- Trial name
- NCT00600145
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Virginia
Nicotine Addiction, Drug Addiction
Clinical Trial of Smoking Cessation Mobile Phone Program
The Sponsor is doing a research study to assess the effects of a smartphone program designed to help users smoke less and eventually quit. When participants join, their involvement in the core study will last 8 weeks.
- Conditions
- Nicotine Addiction, Drug Addiction, Drug Dependence, Substance Use Disorder
- Trial name
- NCT02656745
- Testing
- Mobile Smoking Cessation Solution
- Where
- United States
- Volunteers
- 416 people
- Sponsor
- Click Therapeutics, Inc.
Schizophrenia, Nicotine Dependence
Effects of Smoking Cues on Tobacco Craving Responses and the Reinforcing Efficacy of Cigarettes in Smokers With and Without Schizophrenia
In this study, we will compare cue-reactivity in smokers with and without schizophrenia and the influence of smoking cues on responding for cigarette puffs under a PR schedule of reinforcement.
- Trial name
- NCT00770237
- Testing
- Smoking Cues, Neutral Cues
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
HIV Infections, Drug Abuse
Disulfiram Interactions With HIV Medications: Clinical Implications
The purpose of this study is to determine whether disulfiram might be a safe and effective treatment for cocaine and/or alcohol dependence in patients with HIV disease.
- Trial name
- NCT00878306
- Testing
- Disulfiram, Disulfiram + Efavirenz, Disulfiram + Atazanavir
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Tobacco Use Cessation, Sleep Disorders
Impact of Smoking Cessation on Sleep - 5
Smoking is a major health problem with a direct link to elevated heart- and lung-related problems. Nicotine is highly addictive, which makes quitting difficult and relapse after quitting highly probable.
- Trial name
- NCT00132821
- Testing
- Bupropion, Transdermal Nicotine Patch
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Dependence
Comparative Trial Of Disulfiram, Naltrexone And Acamprosate In The Treatment Of Alcohol Dependence
The aim of this study was to compare the effect of manual based cognitive therapy in adjunct of three different pharmacotherapy.
- Trial name
- DNA (NCT00435435)
- Testing
- Disulfiram, Acamprosate, Naltexone
- Where
- Finland
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
Tobacco Dependence
Bioequivalence Between Two New Oral Nicotine Replacement Therapy Products and Nicorette® Microtab
The purpose of this study is to assess the bioequivalence between two new oral nicotine replacement therapy products and Nicorette® microtab.
- Trial name
- NCT01238640
- Testing
- Code STD, Code STE, Nicorette Microtab
- Where
- Sweden
- Volunteers
- 84 people
- Sponsor
- McNeil AB
Anxiety, Depression
Feasibility Study on the Use of Mindfulness-based Intervention for Family Carers of People With Dementia
The aim of this study is to examine which mindfulness-based intervention protocol, MBCT or MBSR, is more suited for use among local carers of people with dementia (PWD), as measured by better mental health outcomes in PWD such as…
- Conditions
- Anxiety, Depression, Dependency Burden, Stress, Psychological
- Trial name
- NCT02667782
- Testing
- Mindfulness-Based Stress Reduction (MBSR), Mindfulness-Based Cognitive Therapy (MBCT)
- Where
- 2 sites in Hong Kong
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Alcohol Abuse, Alcohol Drinking
TREAT Child Alcohol Use Disorder (C-AUD) in Eastern Uganda
The investigators will investigate the existence of alcohol drinking among children living under adult supervision and care, living within the communities.
- Conditions
- Alcohol Abuse, Alcohol Drinking, Alcoholism, Alcohol Use Disorder
- Trial name
- TREAT C-AUD (NCT04743024)
- Where
- Uganda
- Volunteers
- 7,188 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Tobacco Use Disorder
Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders
While the prevalence of smoking in the United States general population has declined over the past 50 years, there has been little to no decline among people with mental health conditions.
- Trial name
- NCT04090879
- Testing
- Either normal nicotine content cigarettes (15.8mg/g) or reduced nicotine content cigarettes (0.4mg/g), E-Cigarettes
- Where
- 2 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Brown University
Tobacco Dependence
Early Withdrawal Exposure and Negative Affect Withdrawal (NAW) Regulation Training for Smoking Cessation
Smoking remains the single most preventable cause of morbidity and mortality in the United States, accounting for approximately half a million deaths every year.
- Trial name
- NCT03912194
- Testing
- cognitive-behavioral withdrawal regulation strategies, relaxation strategies, early withdrawal exposure
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Cocaine Dependence
Randomized, Double-blind, Placebo-controlled Cannabis Extract x Placebo for Cocaine Addicts
2.1. General To evaluate the efficacy and safety of a Cannabis sativa extract (CBD (Cannabidiol) + up to 0.3% THC (Delta-9-tetrahydrocannabinol)), compared to placebo, in the treatment of cocaine/crack use disorder. 2.2.
- Trial name
- NCT06159387
- Testing
- Cannabis Extract Oil SR Capsule
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Alcohol Withdrawal, Alcohol Dependence
Oxytocin Treatment of Alcohol Dependence
This study will test in individuals who have alcohol dependence (alcohol addiction) the hypotheses 1) that intranasal oxytocin treatment will decrease withdrawal symptoms during medical detoxification and 2) that intranasal…
- Trial name
- OT-ETOH2 (NCT02275611)
- Testing
- intranasal oxytocin spray
- Volunteers
- 13 people
- Sponsor
- University of North Carolina, Chapel Hill
Obesity, Smoking Cessation
Gut Hormones in Obesity, Nicotine and Alcohol Dependence
The "Gut Hormones in Addiction" study is a proof-of-concept experimental medicine human study to answer the following questions: 1.
- Conditions
- Obesity, Smoking Cessation, Alcoholism
- Trial name
- GHADD (NCT02690987)
- Testing
- Exenatide, Desacyl ghrelin, Saline
- Where
- United Kingdom
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Cocaine Dependence
Effect of HF rTMS on Serum BDNF in Cocaine Use Disorder
This study aims to explore the effect of 5-Hz rTMS over the left dorsolateral prefrontal cortex on the BDNF, craving and cognitive function.
- Trial name
- NCT06189690
- Testing
- rTMS
- Where
- Mexico
- Volunteers
- 102 people
- Sponsor
- Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente
Neonatal Abstinence Syndrome
How to Treat Opiate Withdrawal in Neonates
Three different drugs are used in a randomised, double blind, clinical multi-centre trial with three arms. Major objective is to investigate the duration of drug treatment based on the Finnegan score.
- Trial name
- NCT02810782
- Testing
- Phenobarbital, Chlorpromazine, Morphine
- Volunteers
- 120 people
- Sponsor
- University of Zurich
Heroin Dependence, Amphetamine Dependence
An Open-label Study of Oral Paliparidone for the Treatment of Patients With Co-occurring Opioid and ATS Dependence
The proposed study will evaluate the tolerability, acceptability and potential efficacy of paliparidone for the treatment of co-occurring opioid and amphetamine-type stimulant (ATS) dependence.
- Trial name
- NCT02541513
- Testing
- paliparidone
- Where
- Malaysia
- Volunteers
- 40 people
- Sponsor
- Universiti Sains Malaysia
Heroin Dependence
University of Houston Drug Abuse Research Development Program II
The study is examining the impact of a Virtual Reality Cue Exposure Therapy intervention on heroin cravings compared to Relapse Prevention Drug Education.
- Trial name
- UHDARDP-II (NCT03557632)
- Testing
- Virtual Reality Cue Exposure Therapy, Relapse Prevention Drug Education
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Houston
Cancer, Tobacco Dependence
Tobacco Cessation Care for Cancer Patients by Automated Interactive Outreach
This is a multi-arm, randomized controlled, pilot study which will recruit cancer patients who have been seen by a UCSF Cancer Center-affiliated clinical department to evaluate the efficacy of "CareConnect".
- Conditions
- Cancer, Tobacco Dependence, Tobacco Use Cessation
- Trial name
- NCT05829824
- Testing
- CareConnect, AutoReach, Biospecimen samples
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of California, San Francisco
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