Clinical trials: Dependence
Alcohol Dependence
Network Support for Treatment of Alcohol Dependence
Relapse is the most serious problem in alcoholism treatment. The overall aim of the present study was to determine if a treatment directed at changing the patient's social network, from one that reinforces drinking behavior to…
- Trial name
- NCT00845208
- Testing
- Network Support
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- UConn Health
Heroin Dependence
Naltrexone and Adrenergic Agents to Reduce Heroin Use in Heroin Addicts
Naltrexone is a medication that is currently used to treat drug and alcohol addiction. Guanfacine is a medication that is currently used to manage the withdrawal symptoms in individuals undergoing opioid detoxification.
- Trial name
- NCT00142948
- Testing
- Naltrexone
- Where
- Russia
- Volunteers
- 301 people
- Sponsor
- Baylor College of Medicine
Opioid-Related Disorders
Assessment of Tramadol as a Treatment for Opioid Addiction
Opioids are one of the most commonly abused drugs among individuals who seek treatment for drug abuse. Thus, it is necessary to develop new treatments for opioid addiction.
- Trial name
- NCT00301210
- Testing
- Tramadol
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Johns Hopkins University
Nicotine Dependence
Selegiline for Smoking Cessation - 1
The purpose of this study is designed to examine the effects of Selegiline Transdermal System and behavioral intervention in smoking cessation as compared to behavioral intervention alone.
- Trial name
- NCT00439413
- Testing
- Selegiline Transdermal Patch, Smoking Cessation Counseling
- Where
- 4 sites in United States
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Dependence
IV Pulsed-Nicotine as a Model of Smoking: The Effects of Dose and Delivery Rate
This project will examine the impact of the nicotine dose and delivery rate on nicotine's abuse potential, versus its potentially beneficial effects on smoking urges and withdrawal.
- Trial name
- NCT05176418
- Testing
- low dose Nicotine, high dose Nicotine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Hepatitis C, Opiate Dependence
Effective Treatment of Hepatitis C in Substance Users
We hypothesize that integrating Hepatitis C into methadone and buprenorphine treatment will improve Hepatitis C outcomes as well as drug treatment outcomes in patients who are addicted to opiates.
- Trial name
- NCT00633243
- Testing
- Modified Directly Observed Therapy (mDOT), Self-Administered Therapy (SAT)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Yale University
Drug Abuse
Youth Drug Abuse Family and Cognitive-Behavioral Therapy
This Stage II study is in response to NIDA's Behavioral Therapies Development Program (PA-99-107). A randomized clinical trial is proposed to evaluate the direct, mediated, and moderated effects of Integrated Family and…
- Trial name
- NCT00198874
- Testing
- Integrated Family and Cognitive-Behavioral Therapy, Education
- Where
- United States
- Volunteers
- 296 people
- Sponsor
- University of Florida
Smoking Cessation; Tobacco Dependence
Smoking Cessation Program With CBT and Mindfulness Audio Support: A Randomized Controlled Trial
This protocol describes a randomized controlled trial evaluating the effectiveness of a smoking cessation program with two intervention methods.
- Trial name
- NCT06901713
- Testing
- cognitive behaviour thearpy, mindfulness
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Sir Run Run Shaw Hospital
Nicotine Dependence, Smoking Cessation
Smoking Cessation and Reduction With an Electronic Nicotine Delivery Device (ENDD)
The study's major aim is to investigate the ability of a commercial Electronic Nicotine Delivery Device (ENDD) to induce long-term smoking reduction/abstinence in smokers unwilling to quit.
- Trial name
- NCT01195597
- Testing
- E-Cigarette 7.2 mg nicotine
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Catania
Tobacco Use Disorder, Tobacco Smoking
Cannabidiol for Reducing Cigarette Use
The goal of this research is to evaluate the efficacy of cannabidiol (CBD) in reducing cigarette smoking. Although there are safe and effective treatments for smoking cessation, not everyone who attempts smoking cessation is…
- Conditions
- Tobacco Use Disorder, Tobacco Smoking, Tobacco Dependence
- Trial name
- NCT06218056
- Testing
- Cannabidiol (CBD) 800 mg
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Los Angeles
Addiction, Behavioral Addiction
Mobile Health for Problematic Behaviors and Substance Use
The aim of the study is to evaluate the effectiveness of long-term and short-term app-based self-guided psychological interventions to reduce craving and lapse risk in problematic behaviors (compulsive sex, pornography…
- Conditions
- Addiction, Behavioral Addiction, Nicotine Addiction, Nicotine Dependence
- Trial name
- NCT05434429
- Testing
- mobile application
- Where
- Poland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- PredictWatch
Usage of Prescription Opioids
Determining Genetic Biomarkers Predictive of the Development of Prescription Opioid Addiction
This is a clinical study on patients who have been prescribed opioids (narcotic pain relievers) for the treatment of pain, to determine what genetic factors influence outcome of treatment.
- Trial name
- NCT01562353
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Analgesic Solutions
Cocaine-Related Disorders
Cocaine Abuse and ADHD - 10
The purpose of this study is to evaluate the safety and efficacy of buproprion in treating individuals with adult attention-deficit hyperactivity disorder (ADHD) and cocaine dependence.
- Trial name
- NCT00000275
- Testing
- Flupenthixol
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Abuse, Cocaine Dependence
n-Acetylcysteine and Cocaine
This study will determine the initial efficacy, safety and tolerability of n-acetylcysteine as a pharmacotherapy for cocaine dependence.
- Trial name
- NCT02141620
- Testing
- Cocaine, n-Acetylcysteine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Cocaine-Related Disorders
Gepirone vs Placebo in Treatment of Cocaine Dependence - 3
The purpose of this study is to test antidepressant medication, gepirone, as a pharmacotherapy for cocaine dependent subjects.
- Trial name
- NCT00000189
- Testing
- Gepirone
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Pennsylvania
Substance Abuse, Substance Dependence
Cognitive Remediation and Work Therapy in the Initial Phase of Substance Abuse Treatment
The initial phase of substance abuse treatment is a vulnerable period for relapse. Cognitive impairments are common during this phase and may reduce the ability to benefit from other forms of substance abuse and rehabilitation…
- Conditions
- Substance Abuse, Substance Dependence, Cognitive Impairment
- Trial name
- NCT01410110
- Testing
- Cognitive Training + Work Therapy, Work Therapy
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Yale University
Kidney Injury, Renal Failure, Acute
Prevalence of Hypotension Associated With Preload Dependence During Continuous Renal Replacement Therapy
Per-dialytic hypotension is common in Intensive Care Unit patients under continuous renal replacement therapy, and occurs in nearly 50% of the patients.
- Trial name
- PRELOAD-CRRT (NCT03139123)
- Testing
- Hemodynamic monitoring during passive leg raising
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Hospices Civils de Lyon
Type 1 Diabetes Mellitus
B-Lymphocyte Immunotherapy in Islet Transplantation
Type 1 diabetes is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed, resulting in poor blood sugar control.
- Trial name
- NCT00468442
- Testing
- Allogeneic Pancreatic Islet Cells, Antithymocyte globulin, Daclizumab
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Anxiety, Prescription Drug Abuse and Dependency
Prescription of Benzodiazepines by General Practitioners: Characteristics of Prescribing Trend and Implementation of an Online Educational Program
Portugal has the highest benzodiazepine utilization compared to other European countries. The high utilization of benzodiazepines has been a concern due to reported side effects of long-term use and dependence.
- Trial name
- NCT04925596
- Testing
- ePrimaPrescribe online educational program, ComunicaSaudeMental online educational program
- Where
- Portugal
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
Opioid-use Disorder
Improving Office Based Treatment of Opioid Use Disorder With Technology
The goal of this study is to evaluate whether using a novel drug-device combination to deliver buprenorphine/naloxone (B/N) to patients in office-based treatment for Opioid Use Disorder (OUD) is an effective way to improve…
- Trial name
- NCT03586466
- Testing
- BupreCare, Buprenorphine/naloxone, MEMS
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- MedicaSafe, Inc.
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.