Clinical trials: Dependence
Adult Attention Deficit Hyperactivity Disorder, Cocaine Dependence
Study of Adderall-XR for the Treatment of Adult Attention Deficit Hyperactivity Disorder and Cocaine Dependence
The proposed protocol is a 3 group double-blind, placebo-controlled outpatient study of the safety and efficacy of Adderall-XR (ER-MAS) in the treatment of comorbid ADHD and cocaine dependence.
- Trial name
- CAMP (NCT00553319)
- Testing
- Adderall-XR
- Where
- 2 sites in United States
- Volunteers
- 139 people
- Sponsor
- New York State Psychiatric Institute
Tobacco Use Disorder
Project 3, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders
This study will examine extended exposure to cigarettes varying in nicotine content among disadvantaged women. Adults with affective disorders are at increased risk for smoking, nicotine dependence, and using high nicotine yield…
- Trial name
- NCT02232737
- Testing
- Very low nicotine content cigarettes
- Where
- 2 sites in United States
- Volunteers
- 775 people, healthy volunteers welcome
- Sponsor
- Brown University
Nicotine Dependence
The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users
This study will help determine if menthol administered by inhalation via electronic cigarettes (e-cigarette) changes the reinforcing effects of pure nicotine administered intravenously in cigarette smokers who smoke mentholated…
- Trial name
- NCT02102100
- Testing
- nicotine, menthol
- Where
- 2 sites in United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Yale University
Methamphetamine Dependence
Safety and Efficacy Study of Vigabatrin to Treat Methamphetamine Dependence
The objective of this study is to demonstrate that a larger proportion of vigabatrin-treated subjects than placebo-treated subjects will be methamphetamine-free in the last 2 weeks of the study's Treatment Phase (Weeks 11 and 12).
- Trial name
- NCT00730522
- Testing
- CPP-109 vigabatrin
- Where
- 8 sites in United States
- Volunteers
- 55 people
- Sponsor
- Catalyst Pharmaceuticals, Inc.
Cocaine-Related Disorders
Modafinil Treatment for Cocaine-Dependent Individuals
Despite years of active research, there are still no approved medications for the treatment of cocaine dependence. The purpose of this study is to determine the effectiveness of modafinil in treating cocaine-dependent individuals.
- Trial name
- NCT00129285
- Testing
- Low Dose Modafinil, High Dose Modafinil
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- University of Pennsylvania
Stimulant Abuse and Dependence
Exercise as a Treatment for Substance Use Disorders Protocol
The purpose of this study is to investigate if health interventions (intensive exercise or health education) can be used to help improve substance abuse treatment.
- Trial name
- STRIDE (NCT01141608)
- Testing
- Vigorous Intensity High Dose Exercise, Health Education Intervention
- Where
- 9 sites in United States
- Volunteers
- 302 people
- Sponsor
- University of Texas Southwestern Medical Center
Nicotine Dependence
The Interaction of Flavor With Nicotine Form in Adult Smokers
This study seeks to elucidate the impact of e-cigarette flavor on subjective effects and nicotine exposure from e-cigarettes containing different forms of nicotine.
- Trial name
- NCT04262817
- Testing
- Nicotine form, E-cigarette experimental flavor
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yale University
Cocaine Dependence
Disulfiram for Cocaine Abuse
This study examines the influence of dopamine beta-hydroxylase enzyme activity on the clinical efficacy of the novel pharmacotherapy, disulfiram, for treating cocaine dependence in cocaine-dependent patients, some of whom are…
- Trial name
- NCT00395850
- Testing
- Disulfiram
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Heroin Dependence
Buprenorphine Stabilization and Induction Onto Vivitrol for Heroin-dependent Individuals
A short-term treatment with buprenorphine prior to initiating treatment with naltrexone may increase the proportion of heroin-dependent patients successfully inducted onto Vivitrol.
- Trial name
- NCT03711318
- Testing
- Buprenorphine/naloxone
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
Modafinil Treatment for Cocaine Dependence and HIV High-Risk Behavior
The purpose of study is to determine if modafinil promotes cocaine abstinence and reduces high risk behavior in cocaine dependent subjects.
- Trial name
- MOD6 (NCT00368290)
- Testing
- Modafinil, Cognitive Behavioral Therapy (CBT)
- Volunteers
- 94 people
- Sponsor
- Kyle Kampman
Smoking
Testing Methylphenidate for Smoking Abstinence
Cigarette smoking continues to be a major public health problem. Tobacco dependence interventions, as recommended by the USPHS Clinical Practice Guideline are not effective for all smokers.
- Trial name
- NCT00549640
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Opioid-Related Disorders, Opiate Dependence
Acceptability and Safety of Switching From Subutex or Other Opioid Drug Dependence Therapy to Suboxone (NIS P05444)
The purpose of this study is to evaluate the acceptability and safety of switching to Suboxone® (buprenorphine plus naloxone) and the effect of the switch on medication dispensing.
- Conditions
- Opioid-Related Disorders, Opiate Dependence, Drug Abuse
- Trial name
- NCT00725608
- Testing
- buprenorphine/naloxone
- Where
- Austria
- Volunteers
- 339 people
- Sponsor
- Indivior Inc.
Cocaine Dependence
Modafinil for Smoked Cocaine Self-Administration
Modafinil has been reported to reduce cocaine use in a clinical sample of infrequent users (2 days/week), but the effects of modafinil on cocaine self-administration in the laboratory have not been studied.
- Trial name
- NCT01778010
- Testing
- Modafinil 0 mg, Modafinil 200 mg, Modafinil 400 mg
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- New York State Psychiatric Institute
Nicotine Dependence
Testing Financial Incentive Interventions in Dyadic-Smoker Couples
The proposed study investigates the feasibility and efficacy of FITs in dual-smoker couples [DSCs]. The core design is a three-group mixed repeated measures design, in which participants are randomized into one of three…
- Trial name
- NCT04832360
- Testing
- Financial Incentives
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Opiate Dependence
Counseling for Primary Care Office-based Buprenorphine
The major goal is to determine whether adding cognitive behavioral therapy to physician management will increase the efficacy of buprenorphine/naloxone treatment in an office-based primary care setting.
- Trial name
- NCT00595764
- Testing
- Manual-guided Physician Management (PM), Physician Management (PM) combined with on-site manual-guided Cognitive Behavioral Therapy (CBT)
- Where
- 2 sites in United States
- Volunteers
- 141 people
- Sponsor
- Yale University
Nicotine Dependence
Testing an Organizational Change Model to Address Smoking in Mental Healthcare
Despite an overall reduction in US smoking rates from >50% in the 1960s to about 20% by 2000, the rate of smoking among persons with a serious mental illness (SMI) remains 2-3 times greater than in the general population.
- Trial name
- NCT02849652
- Testing
- ATTOC Intervention, UC Intervention
- Where
- United States
- Volunteers
- 832 people
- Sponsor
- University of Pennsylvania
Alcohol, Drinking, Alcohol Use Disorder
Sustaining Patient-centered Alcohol-related Care
Alcohol use is the third greatest cause of disability and death for US adults. Care for unhealthy alcohol use is lacking in most primary care settings.
- Trial name
- SPARC (NCT02675777)
- Testing
- Quality Improvement Intervention
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Nicotine Dependence, Smoking Cessation
D-cycloserine (DCS) Pretreatment + CBT + Nicotine Replacement Therapy for Smoking Cessation (DCS)
1. Compare the relative efficacy of ten weeks of once weekly 250 mg D-cycloserine (DCS) vs. placebo (both in conjunction with cognitive behavioral therapy (CBT) and nicotine replacement therapy (NRT) on reducing cigarette smoking…
- Trial name
- DCS (NCT01842334)
- Testing
- Cognitive Behavioral Therapy, Nicotine Replacement Therapy
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Methamphetamine Dependence
Transcranial Magnetic Stimulation Used to Both Measure Cortical Excitability and Explore Methamphetamine Cue Craving
Specific Primary Aims include: Aim # 1. The investigators explore the feasibility of using the TMS to investigate the cortical excitability and to inhibit meth cue craving in meth dependent population.
- Trial name
- NCT01685463
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cocaine Dependence
Therapeutic Cocaine Vaccine: Human Laboratory Study
Clinical data demonstrate that a cocaine vaccine (TA-CD: Celtic Pharmaceutical) produces selective anti-cocaine antibodies, yet the impact of these antibodies on cocaine's direct effects is unknown.
- Trial name
- NCT00965263
- Testing
- Cocaine vaccine (TA-CD)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute