Clinical trials: Dependence
Methamphetamine-dependence, Methamphetamine Abuse
Trial of Naltrexone/Bupropion for the Treatment of Methamphetamine Use Disorder
The primary objective of this study is to evaluate the efficacy of extended release naltrexone plus bupropion XL (XR-NTX/BUP-XL) compared to matched injectable and oral placebo (iPLB/oPLB) in reducing methamphetamine (MA) use in…
- Trial name
- NCT06233799
- Testing
- extended-release naltrexone (XR-NTX), extended release bupropion (BUP-XL) tablets (BUP-XL), iPLB
- Where
- 11 sites in United States
- Volunteers
- 360 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Pain, Chronic, Opioid Dependence
The Effects of Daily Anti-inflammatory Supplementation on Foundation Pain Index Scores in Chronic Opiate Patients
This is a research study to evaluate the effectiveness of daily supplementation with Root.Health, a plant-based dietary supplement, on reducing levels of 11 abnormal urine biomarkers associated with chronic pain.
- Conditions
- Pain, Chronic, Opioid Dependence, Opioid Use, Inflammation Chronic
- Trial name
- NCT05896878
- Testing
- Root.Health Dietary Supplement
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Hudson Medical
Alcohol Use Disorders
Effect of Cognitive Training on Alcohol Use Outcomes
To purpose of the present study is to investigate the feasibility and efficacy of a computerized working memory training in improving cognitive functioning and alcohol use outcomes, in individuals with alcohol use disorders.
- Trial name
- COGALC (NCT02113618)
- Testing
- Cogmed training, Standard Training
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Karolinska University Hospital
Nicotine Dependence
Assessment of a Teachable Moment for Smoking Cessation
A teachable moment (TM) refers to life events or transitions, such as physician visits, early detection screening feedback, pregnancy, and hospitalization for, and diagnosis of, disease, that inspire health behavior change.
- Trial name
- TM (NCT00596440)
- Testing
- Transdermal nicotine patch
- Where
- United States
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Aging, Emergency Room
Robustness Predictive Factors in People Aged Over 75 Years After Going to the Emergency Room (ROB-U)
After emergency room visits, the elderly patients can increase their dependence and functional decline. In this context the goal of this study is to demonstrate that there are robustness predictive factors after visit to the…
- Conditions
- Aging, Emergency Room, Risk Factors
- Trial name
- ROB-U (NCT04683380)
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Lille Catholic University
Alcoholism
The Role of Neural Systems for Emotion Regulation in Coping With Alcohol Craving
Cognitive Behavioral Coping Skills Therapy (CBCST) is a commonly utilized, evidence-based psychosocial therapy (talk therapy) for alcohol dependence.
- Trial name
- FRAME (NCT02316574)
- Testing
- Cognitive Behavioral Coping Skills Therapy
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
Effectiveness of N-Acetylcysteine (NAC) in Treating Cocaine Dependent Individuals - 1
Currently, no effective drug treatment exists for cocaine dependence. Glutamate levels are disrupted with long-term cocaine use.
- Trial name
- NAC (NCT00218491)
- Testing
- N-Acetylcysteine
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Medical University of South Carolina
Ventriculoperitoneal Shunt (VPS), Hydrocephalus
Intraoperative Ultrasound Guided Compared to Stereotactic Navigated Ventriculoperitoneal Shunt Placement
This study is to prospectively compare Ultrasound guided (US-G) Ventriculoperitoneal Shunt (VPS) placement to stereotactic navigation in a randomized controlled fashion with the surgical intervention time as primary outcome.
- Trial name
- NaVPS (NCT04450797)
- Testing
- US -G VPS placement, done by BK Medical 5000 US with burr hole probe (type 9063 N11C5S, 11-5 MHz)., Stereotactic navigation for VPS placement (Brainlab Dual Curve System with cranial navigation software version 3.1).
- Where
- Switzerland
- Volunteers
- 136 people
- Sponsor
- University Hospital, Basel, Switzerland
Opiate Dependence
ALK21-013: Efficacy and Safety of Medisorb® Naltrexone (VIVITROL®) in Adults With Opioid Dependence
This is a Phase 3 multi-center trial designed to evaluate the clinical efficacy and safety of VIVITROL® (Medisorb® naltrexone 380 mg) versus placebo when administered to adults upon discharge from inpatient treatment for opioid…
- Trial name
- NCT00678418
- Testing
- VIVITROL® 380 mg
- Where
- Russia
- Volunteers
- 250 people
- Sponsor
- Alkermes, Inc.
Cocaine-Related Disorders
Aripiprazole to Reduce Cocaine Relapse
Despite the many behavioral and cognitive treatment therapies that exist for cocaine addiction, individuals who complete cocaine abuse treatment are still at high risk for relapsing.
- Trial name
- NCT00276874
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Craig Rush
Tobacco Dependence
Varenicline for Long-term Nicotine Replacement Therapy (NRT) Users
Primary aim: Will varenicline be better than placebo to get long-term users of NRT to stop? Secondary aim: To assess in details some side effects of varenicline i.e. nausea and abnormal dreams.
- Trial name
- NCT00977249
- Testing
- support and visits, varenicline
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Alcohol Dependence
Mindfulness Meditation for Health
The purpose of this 52-week clinical trial is to see if the meditation-based intervention, adjunctive to standard of care therapy, can reduce relapse and improve psychological health among adults recovering from alcohol…
- Trial name
- NCT01056484
- Testing
- Mindfulness Based Relapse Prevention for Alcohol Dependence, "Wait-list" control
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- University of Wisconsin, Madison
Substance Withdrawal Syndrome, Nicotine Dependence
Electronic Cigarettes in Daily Dependent Smokers
The aim of this study is to measure nicotine cue- and withdrawal-induced craving in current smokers under four distinct conditions: after smoking a conventional cigarette, an electronic cigarette (e-Cigarette) containing…
- Trial name
- NCT02108626
- Testing
- Nicotine
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- Centre for Addiction and Mental Health
Alcohol Use Disorder, Alcohol Dependence
Psilocybin-assisted Therapy for Alcohol Use Disorder
To explore the effectiveness of psilocybin-assisted therapy on reducing alcohol consumption in a double-blind, randomised, phase II clinical trial.
- Conditions
- Alcohol Use Disorder, Alcohol Dependence, Depression, Anxiety
- Trial name
- NCT06444243
- Testing
- Psilocybin, Niacin
- Volunteers
- 90 people
- Sponsor
- University of Sydney
Alcohol Dependence
Citicoline for Alcohol Dependence
The purpose of this study is to determine if citicoline, as an add-on therapy, will help reduce alcohol use in outpatients with alcohol dependence.
- Trial name
- NCT02074735
- Testing
- Citicoline
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Texas Southwestern Medical Center
Nicotine Dependence, Cigarettes
Impact of Nicotine Messaging on Nicotine Beliefs and Tobacco Use Behavior
This is a 2-arm, randomized controlled, population based trial to test the impact of multiple exposures to brief nicotine corrective messages among adult tobacco cigarette smokers and non-smokers followed in waves over 12 weeks.
- Trial name
- NCT04805515
- Testing
- Nicotine Corrective Messages
- Where
- United States
- Volunteers
- 794 people
- Sponsor
- University of Vermont
Nicotine Dependence, Cigarettes
Negotiating a Quit Date or Not in Online Interventions
The primary purpose of the current study is to test the effect of providing users of automated web-based smoking cessation interventions with the option of negotiating and re-negotiating the quit date.
- Trial name
- NCT03194919
- Testing
- Endre: a digital smoking cessation counsellor
- Where
- 2 sites in Czechia, Norway
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Tobacco Use Disorder, Nicotine Dependence
Examining a Text Message Intervention for Smoking Cessation
The primary goal of this study is to use qualitative interviews and focus groups to aid us in adapting a face-to-face smoking cessation intervention for delivery through text messaging.
- Trial name
- NCT01166464
- Testing
- text messaging for smoking cessation, Generic text messages
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Cannabis Abuse, Cannabis Dependence
Biobehavioral Effects of Topiramate on Cannabis-Related Outcomes in Adolescents
Cannabis use is a significant public health concern that disproportionately affect youth. Although promising psychosocial interventions are being developed, most youth do not benefit from these interventions alone.
- Trial name
- NCT01110434
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Brown University
Nicotine Dependence, Smoking Cessation
D-cycloserine (DCS) Pretreatment + CBT + Nicotine Replacement Therapy for Smoking Cessation (DCS)
1. Compare the relative efficacy of ten weeks of once weekly 250 mg D-cycloserine (DCS) vs. placebo (both in conjunction with cognitive behavioral therapy (CBT) and nicotine replacement therapy (NRT) on reducing cigarette smoking…
- Trial name
- DCS (NCT01842334)
- Testing
- Cognitive Behavioral Therapy, Nicotine Replacement Therapy
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.