Clinical trials: Dependence
Cocaine Use Disorder, Cocaine Dependence
Transcranial Direct Current Stimulation (tDCS) for Treatment of Substance Use Disorder
The researchers will test whether cognitively enhanced transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex can reduce craving in inpatients with cocaine use disorder or opioid use disorder.
- Conditions
- Cocaine Use Disorder, Cocaine Dependence, Substance Use Disorder (SUD), Opioid Use Disorder
- Trial name
- NCT07318480
- Testing
- Transcranial Direct Current Stimulator (tDCS), Cognitive Reappraisal Training
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Opioid Abuse
Combined Therapy of Methadone and Dextromethrophan
The purpose of this study is to determine the pharmacological effects and outcomes of DM therapy with this add-on study. And to determine the immunological changes between the baseline and the end point of the study.
- Trial name
- DM (NCT01189097)
- Testing
- Dextromethorphan
- Where
- Taiwan
- Volunteers
- 1,500 people
- Sponsor
- National Cheng-Kung University Hospital
Cocaine-Related Disorders, HIV
Diversion to Treatment for Injection Drug Users Arrested for Possession of Heroin
More Americans are arrested for drug offenses than for any other crime. In 2009, over 294,000 arrests were made for possession of cocaine or heroin.
- Conditions
- Cocaine-Related Disorders, HIV, Heroin Dependence
- Trial name
- NCT01723527
- Testing
- Methadone, Buprenorphine, Employment-based drug abstinence reinforcement
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Johns Hopkins University
Schizophrenia, Cannabis Abuse
Clozapine for Cannabis Use in Schizophrenia
Many individuals with schizophrenia also suffer from marijuana addiction that worsens their problems related to schizophrenia. Most of the medications prescribed for schizophrenia have no effect on reducing marijuana use.
- Conditions
- Schizophrenia, Cannabis Abuse, Cannabis Dependence, Dual Diagnosis
- Trial name
- CLOCS (NCT01639872)
- Testing
- Clozapine, Risperidone
- Where
- 9 sites in United States
- Volunteers
- 49 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Alcohol Dependence
Multimodal Neuroimaging of Stress and Reward Cues to Assess Alcoholism Risk and Relapse
Extending previous findings, and applying a novel multi-method translational approach, this project hypothesizes that there are alcohol-related neuroendocrine and neural changes observable in acute and protracted abstinence, and…
- Trial name
- NCT02616094
- Testing
- Multi-method Neuroendocrine and Neuroimaging Procedure Scan 1, Multi-method Neuroendocrine and Neuroimaging Procedure Scan 2
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Yale University
Opioid Use
Rectal Acetaminophen Use During Oocyte Retrievals to Reduce Post-Operative Opioid Utilization
The primary aim of this study is to evaluate the administration of rectal acetaminophen to current and standard anesthesia and analgesia protocol in oocyte retrievals would reduce postoperative utilization of opioids (Tylenol…
- Trial name
- NCT03732469
- Testing
- Acetaminophen, Fentanyl, Propofol
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Tobacco Dependence
Testing the Effect of ENDS Flavors on Neurotransmission
The overarching goal of this translational proposal is to determine if neuroactive flavor chemicals can enhance the addiction potential of electronic nicotine delivery systems (ENDS) by altering brain function and behavior.
- Trial name
- TEN (NCT05836051)
- Testing
- Flavor
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Milton S. Hershey Medical Center
Nicotine Dependence
Pexacerfont to Reduce Stress-induced Tobacco Craving
Background: Stressful situations often cause tobacco cravings. These cravings can make it very difficult for smokers who are trying to quit. Research has shown that craving may involve hormone pathways in the brain.
- Trial name
- NCT01557556
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Use Disorder
Severe Alcohol-use Disorder: a tDCS and Response Inhibition Training Intervention
Most severe forms of alcohol-use disorder are thought to reflect an abnormal interplay between two neural systems: an overly active impulsive one driven by immediate rewards prospects and a weak reflective one, tuned on long-term…
- Trial name
- ALCOSTIM (NCT03447054)
- Testing
- Combined TDCS active and ICT active, Combined TDCS active and ICT inactive
- Where
- Belgium
- Volunteers
- 136 people
- Sponsor
- Brugmann University Hospital
Nicotine Dependence, Smoking, Cigarette
Isradipine Enhancement of Virtual Reality Cue Exposure for Smoking Cessation
The proposed study represents a crucial and important stage in translating basic research to strategies for treating nicotine dependence.
- Conditions
- Nicotine Dependence, Smoking, Cigarette, Smoking Cessation, Smoking Behaviors
- Trial name
- NCT03083353
- Testing
- Isradipine, Cue Exposure
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Jasper A. Smits
Opiate Dependence, Stimulant Dependence
Atomoxetine for ATS and Opioid Dependence During Buprenorphine Maintenance Treatment in Malaysia
To evaluate the tolerability, acceptability and potential effect size of the efficacy of 4 months of atomoxetine treatment for patients with co-occurring ATS and heroin dependence (COATS) receiving buprenorphine maintenance…
- Trial name
- NCT01863251
- Testing
- Atomoxetine
- Where
- Malaysia
- Volunteers
- 90 people
- Sponsor
- Yale University
HIV
HIV Risk Reduction in Subutex Injectors in Tbilisi
This study will obtain pilot data on the acceptability of a 12-week course of daily observed suboxone and methadone, followed by a dose taper or referral to a local treatment program for 80 opioid dependent patients (40 group)…
- Trial name
- NCT01131273
- Testing
- methadone, buprenorphine-naloxone (Suboxone) for 12 weeks
- Where
- Georgia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Nicotine Dependence
Study of Varencline Effects on Cigarette Smoking Reward and Craving During a Model of Brief Quit Attempt
Study of varenicline 2.0 mg/day treatment for 2 weeks with smoking test done in laboratory on Day 8 and a 1 week quit attempt from Day 8-14.
- Trial name
- VarenSmoke (NCT00571805)
- Testing
- varencline
- Where
- United States
- Sponsor
- NYU Langone Health
Alcohol Abuse, Alcohol Problem
Efficacy of a Brief Alcohol Intervention for Non Dependant Alcohol-misusing Patients Undergoing a Scheduled Surgery
Excessive alcohol consumption is a worldwide major public health problem. Brief interventions have shown to be an efficient treatment modality for problem drinkers, but have never been tested in scheduled surgery.
- Conditions
- Alcohol Abuse, Alcohol Problem, AOD Misuse
- Trial name
- ITBCHIR (NCT01348113)
- Testing
- Brief Alcohol intervention
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Rennes University Hospital
Tobacco Use Cessation, Alcohol-related Disorders
Concurrent Alcohol and Smoking Treatment: Effects on Alcohol Relapse Risk
The majority of individuals with alcohol problems remain current smokers, and the negative health consequences of smoking among these individuals are substantial.
- Trial name
- NCT00861146
- Testing
- behavioral counseling plus contingency management
- Where
- 2 sites in United States
- Volunteers
- 151 people
- Sponsor
- Yale University
Benzodiazepine Dependence, Benzodiazepine Dependent
Blended Care for the Discontinuation of Benzodiazepine Use
This study aims to compare two strategies performed by GPs to help patients taking benzodiazepines on a daily basis for at least six months to discontinue their use.
- Conditions
- Benzodiazepine Dependence, Benzodiazepine Dependent, Benzodiazepine Withdrawal
- Trial name
- Big Bird (NCT03937180)
- Testing
- Blended care, Usual care
- Where
- 110 sites in Belgium
- Volunteers
- 924 people
- Sponsor
- Kristien Coteur
Opioid-use Disorder
A Strategy to Improve Success of Treatment Discontinuation in Buprenorphine Responders
This study is an open--label randomized outpatient trial to evaluate feasibility and efficacy of rapid buprenorphine (BUP) discontinuation followed by brief course of treatment with long--acting naltrexone (XR--NTX) and to…
- Trial name
- NCT03232346
- Testing
- Vivitrol, Buprenorphine
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Alcohol Abuse
Optimisation of Functional MRI-based Neurofeedback for Alcohol Use Disorders
Participants will undergo a single session of functional magnetic resonance imaging (fMRI)-based neurofeedback (approximately 1 hour).
- Trial name
- NCT02406456
- Testing
- Neurofeedback
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Cardiff University
Laparoscopic Surgery
Dynamic Preload Dependence Indices in Laparoscopic Surgery
A goal-directed fluid management is definitely beneficial in high risk surgery. The fluid administration can be directed by cardiac output monitoring which evaluate the response to repeated fluid challenge or by preload…
- Trial name
- VPP Coelio (NCT02541656)
- Testing
- Study of preload dependence indices after volume expansion in laparoscopy with Saldinger technique.
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
ARDS PATIENTS WITH HEMODYNAMIC INSTABILITY
Preload Dependence During Prone Position In ARDS Patients
Preload dependence assessment is difficult during prone position, and to date, no hemodynamic parameters have been validated to rationalize fluid loading in that position.
- Trial name
- PRD-ARDS-PP (NCT01965574)
- Testing
- Trendelenburg position
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Hospices Civils de Lyon
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