Clinical trials: Dependence
Cocaine Dependence
5HT2CR Balance in Brain Connectivity in Cocaine Dependence
This project will evaluate the role of the 5-HT2CR:5-HT2AR balance in impulsive action and cue reactivity in cocaine-dependent subjects as compared to non-drug using controls.
- Trial name
- NCT03921151
- Testing
- Mirtazapine 15 MG Oral Tablet
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Nicotine Dependence, Symptoms of Anxiety
Integrated Treatment for Smoking Cessation & Anxiety in People With HIV
During the 1-year formative phase of a study to develop an integrated treatment for quitting smoking for anxiety-vulnerable HIV+ smokers.
- Conditions
- Nicotine Dependence, Symptoms of Anxiety, HIV
- Trial name
- Project Quit (NCT01393301)
- Testing
- Integrated cognitive-behavioral therapy for smoking cessation and anxiety, Control
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Massachusetts General Hospital
Smoking Cessation, Alcohol-Related Disorders
Effectiveness of Bupropion for Smokers Recovering From Alcohol Dependence
Smoking is often a problem for alcohol dependent individuals. Many people who seek treatment for alcohol dependence are unable to quit smoking.
- Trial name
- NCT00304707
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Dependence
A Double-Blind Trial of Psilocybin-Assisted Treatment of Alcohol Dependence
Several lines of evidence suggest that classic hallucinogens such as psilocybin can facilitate behavior change in addictions such as alcohol dependence.
- Trial name
- NCT02061293
- Testing
- Psilocybin, Diphenhydramine, Motivational Enhancement and Taking Action (META)
- Where
- 2 sites in United States
- Volunteers
- 95 people
- Sponsor
- NYU Langone Health
Cocaine Dependence
Cognitive Remediation for Cocaine Dependence
The purpose of this study is to evaluate treatments designed to improve cocaine treatment success by combining medications that target cocaine-related cognitive impairments.
- Trial name
- NCT01393457
- Testing
- levodopa/carbidopa, Ropinirole 2 mg/d, Ropinirole 4 mg/d
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- The University of Texas Health Science Center, Houston
Tobacco Dependence
European Regulatory Science on Tobacco: Policy Implementation to Reduce Lung Diseases (EUREST-PLUS)
The main objective of EUREST-PLUS is to monitor and evaluate the impact of the Tobacco Products Directive (TPD) within the context of FCTC ratification at an EU level.
- Trial name
- EUREST-PLUS (NCT02773836)
- Testing
- Questionnaire
- Where
- Belgium
- Volunteers
- 6,036 people, healthy volunteers welcome
- Sponsor
- European Network For Smoking and Tobacco Prevention
Tobacco Dependence
Nicotine Lozenge or Tobacco-Free Snuff for Smokeless Tobacco Reduction
Smokeless tobacco (ST) is a known human carcinogen. Long-term ST use is known to increase the risk for oropharyngeal cancer. Extant literature on cigarette smokers suggests that smoking reduction increases smoking abstinence…
- Trial name
- NCT01018394
- Testing
- nicotine lozenges, tobacco-free snuff
- Where
- 2 sites in United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Nicotine Dependence
Maintaining Nonsmoking
The research is based on a chronic disorder model of cigarette smoking which suggests that long-term treatment targeted to prevent relapse may be useful.
- Trial name
- NCT01162239
- Testing
- Varenicline, Initial Individual counseling, Check-ins with medical staff
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cannabis Dependence, Marijuana Dependence
Combined Pharmacotherapy for Cannabis Dependency
The purpose of this study is to see if Lofexidine in combination with Marinol is superior to placebo in achieving abstinence, reducing cannabis use and reducing withdrawal in cannabis-dependent patients seeking treatment for…
- Trial name
- D-LUCS (NCT01020019)
- Testing
- Dronabinol, Lofexidine
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- New York State Psychiatric Institute
Depression, Alcoholism
Fluoxetine and Bupropion to Treat Patients With Depression and Alcoholism
We will study patients with a current major depressive episode, comorbid alcoholism and a history of a past suicide attempt. All subjects with alcohol dependence will be evaluated for risk of alcohol withdrawal prior to…
- Conditions
- Depression, Alcoholism, Suicidal Behavior
- Trial name
- NCT00449007
- Testing
- fluoxetine, bupropion
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
Pharmacotherapy & CM for Opioid and Cocaine Dependence
The purpose of this study is to compare the efficacy of the combined treatment modafinil + Contingency Management (CM) to either treatment condition alone or to yoked-controls on cocaine abstinence.
- Trial name
- NCT00838981
- Testing
- Modafinil, Sugar Pill, Contingency Management
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Yale University
Alcohol Consumption
Network Support for Alcohol Treatment 2
The Network Support project is part of an ongoing effort to improve treatment for alcohol dependent patients. The Network Support Project is designed to help patients change their social network from one that reinforces drinking…
- Trial name
- NCT01129804
- Testing
- Coping Skills Training
- Where
- United States
- Volunteers
- 193 people
- Sponsor
- UConn Health
Alcohol Dependence
Gabapentin for Abstinence Initiation in Alcohol Dependence
Primary Hypotheses: 1. Gabapentin will significantly reduce alcohol consumption and promote abstinence as compared to placebo. The primary outcome measure will be the number of the heavy drinking days (defined as any day where…
- Trial name
- GAINS (NCT01141049)
- Testing
- Gabapentin
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- New York State Psychiatric Institute
Opioid Dependence, Chronic Pain
Feasibility and Preliminary Efficacy of an Opioid Stewardship Program in Hospitalized Patients With Chronic Pain
This study aims to investigate the feasibility and preliminary efficacy of an enhanced opioid stewardship program, tailored to the needs of hospitalized patients with chronic pain with opioid dependence, incorporating real-time…
- Trial name
- NCT05370326
- Testing
- Enhanced Opioid Stewardship Program
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- Yale University
Smoking Dependence, Smoking
Provoked Craving Assessment
Evaluation of the ability of a nicotine mini lozenge to provide early relief of craving for a cigarette in smokers
- Trial name
- NCT01506908
- Testing
- oral nicotine
- Where
- United States
- Volunteers
- 323 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Major Depressive Disorder, Alcohol Abuse
Acamprosate Added to Escitalopram and Behavioral Treatment for Comorbid Depression and Alcoholism
This is a study about treatment for people who suffer from both major depression and alcohol abuse or dependence. The study will examine whether the addition of acamprosate to escitalopram and behavioral interventions will…
- Conditions
- Major Depressive Disorder, Alcohol Abuse, Alcohol Dependence
- Trial name
- NCT00452543
- Testing
- acamprosate, escitalopram, Medical management
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Massachusetts General Hospital
Acute Kidney Injury, Fluid Overload
Restrictive Versus Liberal Rate of Extracorporeal Volume Removal Evaluation in Acute Kidney Injury
Critically ill patients with acute kidney injury and fluid overload who are frequently treated by fluid removal during dialysis are at an increased risk of complications and death.
- Conditions
- Acute Kidney Injury, Fluid Overload, Hypotension, Dialysis; Complications
- Trial name
- RELIEVE-AKI (NCT05306964)
- Testing
- Restrictive UFnet Rate Strategy, Liberal UFnet Rate Strategy
- Where
- 2 sites in United States
- Volunteers
- 99 people
- Sponsor
- University of Pittsburgh
Alcoholism, Opiate Dependence
ALK21-006EXT: Long-term Safety of Medisorb® Naltrexone (VIVITROL®) in Alcohol- or Opioid-dependent Adults (Extension of Study ALK21-006 [NCT01218997])
This was a multicenter extension of Alkermes' Study ALK21-006 (NCT01218997) designed to assess the long-term safety of repeat monthly doses of naltrexone long-acting injection.
- Trial name
- NCT00156936
- Testing
- Medisorb naltrexone 380 mg, Oral naltrexone to Medisorb naltrexone 380 mg
- Volunteers
- 108 people
- Sponsor
- Alkermes, Inc.
Hepatitis C, Opiate Dependence
Effective Treatment of Hepatitis C in Substance Users
We hypothesize that integrating Hepatitis C into methadone and buprenorphine treatment will improve Hepatitis C outcomes as well as drug treatment outcomes in patients who are addicted to opiates.
- Trial name
- NCT00633243
- Testing
- Modified Directly Observed Therapy (mDOT), Self-Administered Therapy (SAT)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Yale University
Cannabis Dependence
Treatment for Cannabis Withdrawal and Dependence
Cannabis is the most widely used illicit drug in the United States, and worldwide, with 1 in 10 users estimated to meet diagnostic criteria for cannabis dependence.
- Trial name
- NCT01611948
- Testing
- Aprepitant, Manual-guided behavioral counseling
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- The Scripps Research Institute