Clinical trials: Dependence
Amphetamine Abuse, Amphetamine Dependence
A Pilot Study of Citicoline add-on Therapy in Patients With Bipolar Disorder or Major Depressive Disorder and Amphetamine Abuse or Dependence
Bipolar disorder (BD) is a common and severe psychiatric illness. Drug and alcohol abuse are very common in people with BD and other mood disorders and are associated with increased rates of hospitalization, violence towards self…
- Conditions
- Amphetamine Abuse, Amphetamine Dependence, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT00377299
- Testing
- Citicoline
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
HIV, Opioid Dependence
Study of Integrating Antiretroviral Therapy With Methadone Treatment for People Who Inject Drugs
To improve ART initiation among people who inject drugs, the investigators propose to develop and pilot a multi-component Integrated Methadone and Antiretroviral Therapy strategy (IMAT) in Dar es Salaam, Tanzania.
- Trial name
- IMAT (NCT02167425)
- Testing
- IMAT
- Volunteers
- 800 people
- Sponsor
- Pangaea Global AIDS Foundation
Tobacco Dependence, Tobacco Use Disorder
Chatbot for Online Support Groups to Treat Tobacco Addiction
Investigators will conduct a pilot RCT to test the efficacy of an intelligent chatbot to aid small, private, quit-smoking peer support groups.
- Trial name
- NCT06952725
- Testing
- online quit-smoking support group with intelligent chatbot, online quit-smoking support group with unintelligent bot
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Methamphetamine Dependence
Phase 2, Double-Blind, Placebo-Controlled Trial of Bupropion for Methamphetamine Dependence
This study is to assess the efficacy of bupropion in reducing methamphetamine use in subjects with methamphetamine dependence who report using methamphetamine 29 or less days during the 30 days prior to the start of signing…
- Trial name
- NCT00687713
- Testing
- Bupropion
- Where
- 12 sites in United States
- Volunteers
- 200 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cardiovascular Risk Factor, Nicotine Dependence
Short-Term Cardiovascular Effects of E-Cigarettes: Influence of E-Liquid pH
This study will examine the short-term cardiovascular (CV) effects of e-liquid pH in a randomized, crossover clinical and behavioral pharmacology study of experienced adult e-cigarette users (N=21).
- Trial name
- TCORS-2 (NCT04449510)
- Testing
- Electronic Cigarette
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alcoholism
ALK21-010: Long-term Safety of Medisorb® Naltrexone (VIVITROL®) in Alcohol-dependent Adults
This was a Phase 3, multi-center extension of Alkermes' Study ALK21-003EXT (NCT01218971) to further assess the long-term safety of repeat monthly doses of Medisorb® naltrexone (VIVITROL®).
- Trial name
- NCT00156923
- Testing
- Medisorb naltrexone 380 mg, Medisorb naltrexone 190 mg
- Volunteers
- 108 people
- Sponsor
- Alkermes, Inc.
Tobacco Dependence
Evaluation of Tobacco Treatment Strategies for Inpatient Psychiatry
This study aims to evaluate, in a randomized controlled trial, tobacco treatments of varying intensities for smokers hospitalized on acute psychiatric inpatient units.
- Trial name
- NCT00968513
- Testing
- Brief Intervention, Extended Treatment, Usual Care
- Where
- 3 sites in United States
- Volunteers
- 956 people
- Sponsor
- Stanford University
Alcohol Dependence
A New Pharmacotherapy for Alcohol Dependence: Olanzapine
Craving for alcohol has been related to loss of control drinking and is a major target of biological and behavioral interventions for alcohol dependence.
- Trial name
- NCT00746785
- Testing
- 2.5 mg Olanzapine, 5mg Olanzapine
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- The Mind Research Network
Cannabis Use Disorder
CANDIS - Targeted Treatment for Cannabis Disorders
The purpose of this study is to develop a modular treatment program for cannabis use disorders and the evaluation of the effectiveness in a controlled clinical study.
- Trial name
- NCT00252980
- Testing
- Psychotherapy
- Where
- Germany
- Volunteers
- 210 people
- Sponsor
- Technische Universität Dresden
Heroin Dependence
Effect Study of Optimized Intervention to Heroin Addicts
The purpose of this study is to explore barriers and determine whether optimizing protocol is effective in the treatment of heroin dependence in community-based MMT clinics.
- Trial name
- NCT01144390
- Testing
- cognitive behavioral therapy, methadone maintenance treatment
- Where
- 4 sites in China
- Volunteers
- 240 people
- Sponsor
- Shanghai Mental Health Center
Opioid Addiction
Neuroimaging Predictors of Relapse During Treatment for Opiate Dependence
This study proposes to use functional magnetic resonance imaging (FMRI) to observe brain activity and behavior associated with decision-making about rewards (DD task), working memory and working memory cognitive persistence (WM…
- Trial name
- NCT02696096
- Testing
- FMRI, Suboxone
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Butler Hospital
Tobacco Dependence
System Based Tracking and Treatment for Emergency Patients Who Smoke: STTEPS
Emergency Departments (EDs) are a critical component of the U.S. healthcare system, treating over 119 million patients each year.
- Trial name
- STTEPS (NCT01839903)
- Testing
- EDIS, Care as usual
- Where
- 2 sites in United States
- Volunteers
- 444 people
- Sponsor
- The Miriam Hospital
Dependence, Opioid
A Brief Values Intervention to Support Veterans in Early Buprenorphine Treatment
The US Veteran community continues to feel the impact of the overdose crisis, and opioid use disorder (OUD) diagnoses among Veterans continue to rise.
- Trial name
- NCT05189223
- Testing
- Brief, values based intervention for early buprenorphine treatment
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
Alcohol Dependence
ALK33-005: A Study of ALKS33 (RDC-0313) in Adults With Alcohol Dependence
This study will evaluate the safety and efficacy of ALKS33 (RDC-0313) compared with placebo in adults with alcohol dependence. There will be 11 study visits conducted over a period of about 4 months.
- Trial name
- NCT00981617
- Testing
- ALKS33 (RDC-0313) (1 mg), ALKS33 (RDC-0313) (2.5 mg), ALKS33 (RDC-0313) (10 mg)
- Where
- 27 sites in United States
- Volunteers
- 406 people
- Sponsor
- Alkermes, Inc.
Opiate Dependence
ALK21-013: Efficacy and Safety of Medisorb® Naltrexone (VIVITROL®) in Adults With Opioid Dependence
This is a Phase 3 multi-center trial designed to evaluate the clinical efficacy and safety of VIVITROL® (Medisorb® naltrexone 380 mg) versus placebo when administered to adults upon discharge from inpatient treatment for opioid…
- Trial name
- NCT00678418
- Testing
- VIVITROL® 380 mg
- Where
- Russia
- Volunteers
- 250 people
- Sponsor
- Alkermes, Inc.
Cataract (Post-operative Cataract Surgery Follow-up), Refraction Error
Can Tailored Surgical Incisions Reduce Refractive Error and Dependence on Glasses After Cataract Surgery?
Astigmatism is a common cause of continued dependence on glasses after cataract surgery and may lead to patient dissatisfaction with surgical outcomes.
- Trial name
- AST-2 (NCT07623317)
- Testing
- Adapted clear corneal incisions
- Volunteers
- 100 people
- Sponsor
- Linkoeping University
COCAINE-RELATED DISORDERS
Improving Learning-based Treatment of Cocaine Dependence With Medication
This study will test the efficacy of d-cycloserine in enhancing response to learning-based treatment for cocaine dependence, specifically contingency management.
- Trial name
- NCT01526538
- Testing
- d-cycloserine, sugar pill
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Nicotine Dependence
IV Pulsed-Nicotine as a Model of Smoking: The Effects of Dose and Delivery Rate
This project will examine the impact of the nicotine dose and delivery rate on nicotine's abuse potential, versus its potentially beneficial effects on smoking urges and withdrawal.
- Trial name
- NCT05176418
- Testing
- low dose Nicotine, high dose Nicotine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Alcohol Dependence, Alcohol Abuse
Community Reinforcement and Family Training (CRAFT) for Treatment-resistant Individuals With Alcohol Use Disorders
The present study examines the efficacy of the Community Reinforcement and Family Training (CRAFT) for Concerned Significant Others (CSOs) of individuals with alcohol use disorders (AUDs) using a randomized waiting list (WL)…
- Trial name
- CRAFT (NCT02112396)
- Testing
- Community Reinforcement and Family Training
- Where
- Germany
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of Luebeck
Healthy Infants
Age-dependency of Thrombin Generation Using a New Standardized Assay
The aim of this study is to establish normal values of thrombin generation assay parameters in pediatrics, according to different age groups. The standardized thrombin generation assay "Genesia™" will be used.
- Trial name
- TGT (NCT03007108)
- Testing
- blood withdrawal
- Where
- France
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
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