Clinical trials: Dependence
Web Based Intervention, Mastectomy
Web-Assisted Interactive Nurse Program in Mastectomy Patients: A Mixed Method Study
This study is planned to examine the levels of bodily value, care dependence and psychosocial cohesion-self-notification of patients in the Web Assisted Interactive Nursing Program (WDIHP) designed according to the Self…
- Conditions
- Web Based Intervention, Mastectomy, Illness Perception, Nursing Caries
- Trial name
- Mastectomy (NCT05222763)
- Testing
- Web-assisted patient education intervention designed according to the self-regulation model, The website where the mastectomy patients handbook
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University
Anxiety Disorders, Anxiety
Personalized Feedback for Smokers With Elevated Anxiety Sensitivity
This project will develop and refine a computer-delivered integrated Personalized Feedback Intervention (PFI) that directly addresses smoking and anxiety sensitivity (AS).
- Conditions
- Anxiety Disorders, Anxiety, Tobacco Dependence, Smoking, Cigarette
- Trial name
- NCT03382093
- Testing
- Personalized Feedback Intervention, Smoking Information Control
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Houston
Substance Use Disorders, Substance Dependence
Correlation of Genetic Variations With Clinical Response in Substance Use Disorder
This research outcomes can be summarized as follows: 1. Pharmacogenomic analysis of Substance Use Disorder (SUD) and medications used for the treatment of SUD. 2.
- Trial name
- NCT05833399
- Testing
- Quetiapine, olanzapine, mirtazapine, carbamazepine, sertraline, amitriptyline, chlorpromazine and risperidone
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Drug Abuse, Intravenous, Substance Dependence
A Cross-Sectional Observational Study on Retained Drug Needle Fragments in People Who Use Intravenous Drugs
In addition to the well-known toxicological harms of intravenous drug (IVD) use, there can also be local tissue complications, including infections, venous sclerosis, tissue necrosis, and drug needle fragment retentions.
- Conditions
- Drug Abuse, Intravenous, Substance Dependence, Needle Injury, Soft Tissue Injuries
- Trial name
- NCT05679284
- Testing
- Low-dose X-ray of subcutaneous tissues
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Tampere University Hospital
Alcohol Abuse, Alcohol Dependence
Remote Brief Intervention and Referrals to Treatment Service for Alcohol
The traditional paradigm that relies upon training physicians and nurses or uses on-site interventionists to perform screening, brief intervention, and referral to treatment (SBIRT) for alcohol has proven unsustainable in most…
- Trial name
- RBIRT (NCT02622984)
- Testing
- RBIRT, SBIRT
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Polaris Health Directions
Alcoholism
Prazosin Alcohol Dependence IVR Study
This double-blind placebo controlled pilot trial will test the hypothesis that prazosin, an alpha-1 adrenergic receptor antagonist, reduced alcohol consumption and alcohol craving in alcohol dependent individuals without Post…
- Trial name
- NCT00167687
- Testing
- prazosin
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Washington
Loss of Consciousness
Alteration of Temporal Organization of EEG Microstate Sequences During Propofol-induced Loss of Consciousness
Temporal dynamics of the EEG microstates show scale-free monofractal properties. This means that information is encoded in the same way at different scales.
- Trial name
- Fractal (NCT02125214)
- Testing
- Target Controlled Infusion system (Orchestra Base Primea, Fresenius, France)
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Julien Maillard
Coronary Artery Disease, Coronary Artery Bypass
Preload Dependency Evaluation With Stroke Volume Variation During Alveolar Recruitment Manoeuvres
The principal aim is to assess impact of alveolar recruitment manoeuvres (ARM) on stroke volume variation, evaluated by trans-oesophageal echocardiography (TEE).
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass, Hypovolemia, Anesthesia, General
- Trial name
- PreDeARM (NCT02678559)
- Testing
- tee measurement, flotrac measurement, clearsight measurement
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Clermont-Ferrand
Addiction
Establishment of Cessation Therapy by Clinical Trials for Subjects With Betel-quid Dependence and Oral Pre-cancer
No medication existed for BQ dependence. No clinical trials existed for the drug therapy. Previous study showed that BQ possessed the antidepressant effect via pathway of monoamine oxidase A (MAO-A).
- Trial name
- NCT03010761
- Testing
- escitalopram, Moclobemide
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Marijuana Dependence
Vaping THC From Electronic Cigarettes
This study aims to understand THC pharmacology and the safety of cannabis vaping, including the pharmacology and safety of co-administration of nicotine and THC.
- Trial name
- V-PAX (NCT02955329)
- Testing
- Nicotine, Cannabis, PAX Loose Leaf Vaporizer
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alcoholism, Anxiety Disorders
Trial of Seroquel SR for Alcohol Dependence and Comorbid Anxiety
Alcohol use disorders (AUDs) are a major problem facing our society. Their treatment is complex, and involves multiple behavioral and pharmacotherapy interventions.
- Conditions
- Alcoholism, Anxiety Disorders, Generalized Anxiety Disorder, Post-Traumatic Stress Disorder
- Trial name
- NCT00352469
- Testing
- Seroquel XR
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Creighton University
Heart Failure
Dependence of LV Hemodynamics on Pacing Site
The purpose of this study is to evaluate the effects of epicardial and endocardial pacing at each side of the left ventricular (LV) segments on cardiac hemodynamics in patients with impaired LV function undergoing epicardial…
- Trial name
- NCT01564173
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Abbott Medical Devices
Nicotine Dependence
Evaluation of Short-term Safety and Use Patterns of an Electronic Nicotine Delivery System
Electronic Nicotine Delivery Systems (ENDS), commonly referred to as electronic cigarettes have gained in popularity over the last several years.
- Trial name
- NCT01898169
- Testing
- NJOY King 26 mg nicotine Electronic Nicotine Delivery System
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- LA Clinical Trials
Alcohol Dependence, Sleep Disorder
Validation of a Short Questionnaire (SSI) for Sleep Disorders in Patients With Alcohol
Sleep disorders are very common in alcohol patients (40-90% according to studies) These sleep disorders may persist after withdrawal and represent a major factor in relapse.
- Trial name
- NCT04007042
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Alcohol Dependence
Prometa Protocol for Alcohol Dependence
This is a placebo controlled trial (some people receive active and some people receive inactive medication) to evaluate the effectiveness of a new protocol to treat alcohol dependence.
- Trial name
- NCT00262639
- Testing
- Flumazenil and Gabapentin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Medical University of South Carolina
Opioid-Related Disorders, Substance-Related Disorders
Buprenorphine Maintenance for Opiate Dependence - 6
The purpose of this study is to determine the efficacy of buprenorphine as a substitution pharmacotherapy for opiate dependence.
- Trial name
- NCT00000357
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Dependence
EEG & Behavioral Predictors of Changes in Smoking Trajectories in Young Light Smokers
The purpose of the proposal is to identify new predictors of smoking progression in young light smokers (YLS: 18-25 years \& cpd < 5) using an 18-month longitudinal design and to relate these predictors of progression to the…
- Trial name
- NCT02129387
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Southern Illinois University Carbondale
Opioid Dependence
Usability of Zubsolv Sublingual Tablets 5.7/1.4 to Suboxone Sublingual Film 8/2 In Buprenorphine/Naloxone Treated Opioid Dependent Population
The primary objective of this study is to compare overall patient preference for either Suboxone® sublingual film 8/2 or Zubsolv® sublingual tablets 5.7/1.4.
- Trial name
- NCT02038790
- Testing
- Suboxone Sublingual Film, Zubsolv sublingual tablets
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Indivior Inc.
Alcoholism
Effect of JNJ 31001074 on Urge to Drink in Alcohol-Dependent Adults
The purpose of this study is to assess whether JNJ-31001074 taken for 7 days reduces the urge to drink alcohol in alcohol-dependent study participants who are not seeking treatment.
- Trial name
- NCT01362699
- Testing
- JNJ-31001074
- Where
- United States
- Sponsor
- Janssen Research & Development, LLC
Alcohol Dependence, Alcohol Abuse
Project Motion, A Study of Motivational Interviewing to Reduce Heavy or Problematic Drinking
The purpose of this pilot study is to investigate the critical components of motivational interviewing (MI), a psychotherapeutic intervention, in reducing heavy or problematic drinking.
- Trial name
- NCT00665249
- Testing
- Motivational Interviewing, Spirit-Only Motivational Interviewing, Self-Change
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Northwell Health
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