Clinical trials: Dependence
Nicotine Dependence
Effects of Smoking Cues on Tobacco Craving Responses and the Reinforcing Efficacy of Cigarettes in Adolescent Smokers
Background: Multiple social, psychological, and environmental factors contribute to adolescents' use of cigarettes. Environmental smoking cues have been shown to play an important role in the maintenance of nicotine addiction and…
- Trial name
- NCT01148355
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Tobacco Use Disorder, Tobacco Use Cessation
Efficacy of Varenicline in Ambivalent Smokers
The purpose of this study is to test whether Varenicline can help ambivalent smokers (those who are interested in quitting at some point in the future but have no current plans to quit) to reduce their smoking and eventually quit.
- Conditions
- Tobacco Use Disorder, Tobacco Use Cessation, Nicotine Dependence
- Trial name
- NCT00595868
- Testing
- Varenicline
- Where
- 2 sites in United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of Vermont Medical Center
Cocaine-Related Disorders
Assessment of Potential Interactions Between Cocaine and RPR 102681 - 1
The purpose of this study is to assess Potential Interactions Between iv Cocaine and RPR 102681
- Trial name
- NCT00067535
- Testing
- Cocaine-Related Disorders
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid-Related Disorders
Suboxone: (Buprenorphine/Naloxone) Comparison of Two Taper Schedules - 1
The purpose of this protocol is to to compare the clinical utility of two dosage tapering regimens in Buprenorphine/Naloxone stabilized subjects for opiate detoxification.
- Trial name
- NCT00078117
- Testing
- Buprenorphine
- Where
- 11 sites in United States
- Volunteers
- 516 people
- Sponsor
- University of California, Los Angeles
Nicotine Dependence
Incentives to Promote Smoking Cessation in Low SES Women
The purpose of this study is to investigate the feasibility of a mobile-phone based contingency management (CM) intervention for smoking in low-SES women.
- Trial name
- ProjectMIST (NCT03173274)
- Testing
- Brief Motivational Intervention, Contingency Management, Non-Contingent Reinforcement
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Brown University
Tobacco Use Disorder, Psychiatric Disorder
Transcranial Magnetic Stimulation for Nicotine Dependence: An Effectiveness-Implementation Trial
Tobacco smoking is the leading preventable cause of morbidity and mortality worldwide. However, currently available treatments, including standard pharmacotherapy and behavioural support, are limited in their efficacy…
- Conditions
- Tobacco Use Disorder, Psychiatric Disorder, Nicotine Dependence
- Trial name
- NCT06534047
- Testing
- Brainsway H4 deep Repetitive Transcranial Magnetic Stimulation (rTMS) coil, Nicotine replacement
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre for Addiction and Mental Health
Alcohol Use Disorder (AUD)
The Efficacy and Neurobehavioural Mechanism of Cannabidiol (CBD) for Alcohol Dependence
The study will explore the psychophysiological and neurobiological and mechanisms of CBD in participants with alcohol use disorder
- Trial name
- NCT05387148
- Testing
- Cannabidiol (CBD)
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- South West Sydney Local Health District
Tobacco Dependence
Nicotine Pharmacodynamics With a New Oral Nicotine Replacement Therapy and Nicotine Gum
A comparison of two products for oral nicotine replacement with respect to relief of urges to smoke after single doses of nicotine.
- Trial name
- NCT01368016
- Testing
- Nicotine
- Where
- 2 sites in Sweden
- Volunteers
- 346 people
- Sponsor
- McNeil AB
Hemoadsorption, Vasopressor Therapy
Hemodynamic, Laboratory, and Clinical Outcomes of Hemoadsorption Therapy
This single-center retrospective observational cohort study aims to evaluate the clinical, hemodynamic, and laboratory effects of adjunctive hemoadsorption therapy in critically ill adult patients treated in the Intensive Care…
- Trial name
- HOPE-FUL (NCT07679555)
- Testing
- Hemoadsorption
- Where
- Hungary
- Volunteers
- 60 people
- Sponsor
- Pest County Flór Ferenc Hospital
Tobacco Use Cessation, Tobacco Use Disorder
Treating Tobacco Dependence in Adolescents With Co-occurring Psychiatric Disorders
This research aims to identify efficacious strategies for treating tobacco dependence among adolescent smokers with co-occurring psychiatric disorders.
- Trial name
- NCT00618943
- Testing
- Tobacco Use Cessation
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Francisco
Alcohol Dependence
Fish Oil vs. Placebo on Subjective Effects of Alcohol
This project represents a first step in examining the potential use of fish oil for the treatment of alcohol use disorder (AUD).
- Trial name
- NCT03010917
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Yale University
Tobacco Use
The Effect of AAT Training in Smokers
The purpose of this research study is to investigate the effect of a brief computer task (Approach Avoidance Task) on smoking cessation.
- Trial name
- NCT02481752
- Testing
- Approach Avoidance Training
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Jasper A. Smits
Alcohol Abuse, Alcohol Addiction
Does Semaglutide Reduce Alcohol Intake in Patients With Alcohol Use Disorder and Comorbid Obesity?
This 26-week long, double-blinded randomized clinical trial aims to investigate the effects of the GLP-1 receptor agonist semaglutide s.c.
- Conditions
- Alcohol Abuse, Alcohol Addiction, Alcohol Dependence, Alcohol Use Disorder
- Trial name
- SEMALCO (NCT05895643)
- Testing
- Semaglutide Injectable Product
- Where
- Denmark
- Volunteers
- 108 people
- Sponsor
- Psychiatric Centre Rigshospitalet
Tobacco Dependence
Bioequivalence Between an Oral Nicotine Replacement Product and Nicorette® Gum
This study examines the bioequivalence between an oral nicotine replacement product and Nicorette® gum.
- Trial name
- NCT01152749
- Testing
- Nicotine, Nicotine Gum
- Where
- Sweden
- Volunteers
- 76 people
- Sponsor
- McNeil AB
Nicotine Dependence
Effects of Menthol in E-cigarettes on Smoking Behaviors
The overall goal of this proposal is to understand the relationship between nicotine metabolism and menthol flavor in e-cigarettes on smoking behavior in smokers.
- Trial name
- NCT04521647
- Testing
- Nicotine
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Yale University
Opioid-Related Disorders, Substance-Related Disorders
Effects of Buprenorphine and Naloxone in Opiate Addicts - 4
The purpose of this study is to evaluate the behavioral and physiological effects of buprenorphine and naloxone, both alone and in combination.
- Trial name
- NCT00000355
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid-Related Disorders
Evaluation of Pharmacy Students' Perception of Opioid / Opiate Dependence
The pharmacist in his professional activity may have to manage opioid dependent patients. This professional activity will result in the provision of opioid substitution treatment (OST), single-use syringes, harm reduction kits…
- Trial name
- STUD_TOX (NCT03859778)
- Testing
- survey
- Where
- France
- Volunteers
- 2,034 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Iron Overload
MRI T2* Mapping of Myocardium, Liver, Pancreas and Pituitary Gland
All patients were investigated using a 3T MRI and 1,5 T MRI scanners. For myocardium, pancreas and pituitary gland iron overload quantification in children we have used special sequences for T2*-mapping.
- Trial name
- NCT04835285
- Testing
- Npf.
- Where
- Russia
- Volunteers
- 152 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
PPPD
Identification of Visual Dependence in PPPD Patients With the Aid of Virtual Reality.
The aim of this study is to evaluate whether increased visual dependence can be identified with the help of Virtual Reality (VR).
- Trial name
- OKAN (NCT06017908)
- Testing
- Optokinetic stimulation through Virtual Reality
- Where
- Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Methamphetamine-dependence, Postpartum Abstinence
PRevention Of Methamphetamine Use Among Postpartum Women Trial (PROMPT)
The PRevention Of Methamphetamine Use among Postpartum Women Trial (PROMPT) is randomized controlled trial of postpartum individuals with methamphetamine use disorder to 12 weeks of 200 mg oral micronized progesterone twice daily…
- Trial name
- NCT05128071
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Utah
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