Clinical trials: Dependence
Nicotine Dependence
Trial on the Effectiveness of Mindfulness Training for Smokers
The Mindfulness Training for Smokers study follows a randomized controlled design with 240 total participants. Both the study group and the control group will be enrolled in the Wisconsin Tobacco Quit Line and will receive four…
- Trial name
- MTS (NCT01093599)
- Testing
- Quit Line plus MTS, Quit Line Only
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- University of Wisconsin, Madison
Cocaine-Related Disorders, Substance-Related Disorders
Reserpine for the Treatment of Cocaine Dependence - 1
The purpose of this study is to assess the efficacy and safety of reserpine for the treatment of cocaine dependence.
- Trial name
- NCT00033033
- Testing
- Reserpine
- Where
- 3 sites in United States
- Volunteers
- 140 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Dependence
Brain Activity and Smoking Cessation
In the current study, the investigators propose to test: (1) whether brain activation and connectivity in a resting state, assessed by ASL perfusion MRI, BOLD fMRI, and diffusion tensor imaging (DTI) predicts smoking relapse, and…
- Trial name
- NCT01186055
- Testing
- Smoking Cessation Counseling
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Second Hand Tobacco Smoke, Nicotine Dependence
Kids Safe and Smokefree (KiSS)
The study's primary aim is to test the hypothesis that an intervention integrating pediatric clinic-level quality improvement with home-level behavioral counseling (CQI+BC) will result in greater reductions in child cotinine (a…
- Trial name
- KiSS (NCT01745393)
- Testing
- Clinic Quality Improvement + Behavioral Counseling, Clinic Quality Improvement + Attention Control
- Where
- 4 sites in United States
- Volunteers
- 327 people
- Sponsor
- Temple University
Substance Abuse
Psychopharmacotherapy in Multiple Substances Abuse
Add-on of memantine or placebo treatment will proceed in a double-blinded fashion for 12 weeks after adjusted methadone dose. During the study, the investigators will evaluate treatment response and adverse effect from multiple…
- Trial name
- MM opioid (NCT01189214)
- Testing
- Memantine
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Cheng-Kung University Hospital
Opioid Dependence
Dronabinol Naltrexone Treatment for Opioid Dependence
The goal of this two-year study is to test the efficacy of dronabinol as an adjunct to maintenance treatment with naltrexone in opioid-dependent individuals.
- Trial name
- Domino (NCT01024335)
- Testing
- injectable naltrexone and dronabinol
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- New York State Psychiatric Institute
Alcohol Abuse or Dependence
Web-based CBT4CBT for Alcohol
The investigators are conducting a randomized clinical trial of our new web-based version of the CBT4CBT (Computer Based Training for Cognitive Behavioral Therapy) program specifically designed for alcohol to evaluate its…
- Trial name
- CBT4CBT Etoh (NCT01615497)
- Testing
- Standard Treatment as Usual (TAU), Web-based CBT4CBT for alcohol plus TAU, Web-based CBT with minimal clinical contact
- Where
- 2 sites in United States
- Volunteers
- 68 people
- Sponsor
- Yale University
Tobacco Dependence
Tobacco Treatment for Employable Californians, Total IMPACT Study
Previous findings indicate elevated risk for tobacco use among adults in California who are unemployed and seeking work. In a pilot study, tobacco use was associated with a longer duration of time out of work.
- Trial name
- TTEC (NCT02478697)
- Testing
- ProChange ExpertSystem
- Where
- 3 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Stanford University
Opioid-Related Disorders, Cocaine-Related Disorders
The Effects of Pharmacotherapy on Brain Mechanisms Underlying Cocaine Dependence.
The overall aim of this project is to use an advanced brain imaging technique, PET, in order to monitor the progress of pharmacotherapy with modafinil or topiramate for cocaine dependence in methadone-maintained patients who use…
- Trial name
- NCT00396734
- Testing
- Provigil (Modafinil), Topamax (Topiramate)
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Hadassah Medical Organization
Alcoholism
N-acetylcysteine in Alcohol Dependence
The present study is designed to find out if N-acetylcysteine works in reducing alcohol drinking and craving.
- Trial name
- NCT00568087
- Testing
- N-acetylcysteine
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Cannabis Dependence
Study of Quetiapine Treatment for Cannabis Dependence
Marijuana is the most commonly used illicit drug in the United States. However, the treatment options for cannabis dependence are limited; notably, no effective pharmacotherapy has been developed.
- Trial name
- STUC (NCT00954681)
- Testing
- quetiapine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- New York State Psychiatric Institute
Nicotine Dependence, Substance Use Disorders
Healthy People Initiative (HPI)
Addictions do not occur in isolation. Tackling addictions requires addressing social determinants such as isolation, homelessness, marginalization, and unemployment.
- Trial name
- HPI (NCT03506867)
- Testing
- Life skills, training, education and work/volunteer opportunities, Usual Care
- Where
- Canada
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Nicotine Dependence
Smoking Cessation Medications: Efficacy, Mechanisms and Algorithms
The proposed work will advance the understanding and effectiveness of tobacco dependence treatment and result in more smokers quitting successfully.
- Trial name
- NCT00332644
- Testing
- nicotine patch, nicotine lozenge, nicotine patch + nicotine lozenge
- Where
- 2 sites in United States
- Volunteers
- 1,504 people
- Sponsor
- University of Wisconsin, Madison
Cocaine Dependence
Vouchers vs. Prizes for Cocaine-Dependent Methadone Patients - 2
The purpose of this study is to compare voucher-based contingency management (CM) procedures to a lower-cost CM system that provides opportunities to win prizes.
- Trial name
- NCT00249535
- Testing
- Contingency management
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- UConn Health
Methamphetamine Dependence
Citicoline Treatment of Methamphetamine Dependence
The purpose of the study is to determine if citicoline (a nutritional supplement) is effective in helping people reduce their dependence on methamphetamine.
- Trial name
- NCT00950352
- Testing
- Citicoline
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Perry Renshaw
Opioid Dependency
Study of Probuphine in Patients With Opioid Dependence
Buprenorphine (BPN) is an approved treatment for opioid dependence; however, in taking oral tablets, patients experience withdrawal and cravings when the variable BPN levels in the blood are low.
- Trial name
- PRO-809 (NCT00772785)
- Testing
- Probuphine (buprenorphine implant)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Titan Pharmaceuticals
Chronic Ventilator Dependency
HFCWO in Prolonged Mechanical Ventilation Patients
The effectiveness, safety and tolerance/comfort of high-frequency chest wall oscillation (HFCWO) in prolonged mechanical ventilation patients remain unknown.
- Trial name
- NCT02077738
- Testing
- HFCWO (Hill-Rom Vest™ Airway Clearance System)
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Taichung Veterans General Hospital
Substance Abuse, Cocaine Dependence
Bupropion-Enhanced Contingency Management (CM) for Cocaine Dependence
This project will examine effects of bupropion extended release (XL) at a dose of 300mg/day for cocaine abstinence among persons receiving methadone for the treatment of opioid use disorder.
- Trial name
- NCT02111798
- Testing
- Bupropion XL, Abstinence Initiation, Relapse Prevention
- Where
- 2 sites in United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cocaine Dependence
Cocaine/Crack and Reduction of Compulsion With Biperiden
Considering the effects of the cholinergic system on the drug reward and self-administration mechanisms, acetylcholine (Ach) may play an important role on cocaine dependence process.
- Trial name
- NCT01251393
- Testing
- Biperiden
- Where
- Brazil
- Volunteers
- 111 people
- Sponsor
- Federal University of São Paulo
Cigarette Smoking-Related Carcinoma
Gender Differences in Switching From Smoking Regular Cigarettes to E-Cigarettes
This early phase I trial studies potential differences between men and women when switching from the use of combustible cigarettes to the National Institute on Drug Abuse's Standard Research E-Cigarette (SREC).
- Trial name
- NCT03856515
- Testing
- Nicotine Replacement, Questionnaire Administration, Electronic Cigarette
- Where
- United States
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
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