Clinical trials: Dependence
Malignant Abdominal Neoplasm, Malignant Head and Neck Neoplasm
Digital and Behavioral Tele-Health Tapering Program for Lowering Dependence on Opioids in Patients Undergoing Surgery
This clinical trial studies the effect of behavioral health support including tele-health in helping surgical patients taper off of prescription opioid pain medications.
- Conditions
- Malignant Abdominal Neoplasm, Malignant Head and Neck Neoplasm, Malignant Solid Neoplasm, Malignant Thoracic Neoplasm
- Trial name
- NCT04963972
- Testing
- Behavioral Intervention, Best Practice, Questionnaire Administration
- Where
- United States
- Volunteers
- 272 people
- Sponsor
- Lucid Lane, Inc
Alcohol Dependence
A Study of Brain Receptor Occupancy in Healthy Subjects
To measure the occupancy of brain kappa opioid receptors after single oral doses of LY2456302.
- Trial name
- NCT01232439
- Testing
- opioid receptor kappa antagonist
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Alcohol Dependence
The Approach and Avoidance Task (AAT) in Alcoholic Inpatients
The approach and avoidance task (AAT) has evolved as a promising treatment add-on in the realm of psychology. Certain psychiatric diseases, such as behavioural addictions, social anxiety disorder, and arachnophobia, are…
- Trial name
- NCT04054336
- Testing
- Inhibit AAT, classical AAT, Control Group
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Tobacco Use Disorder, Nicotine Dependence
Novel Determinants and Measures of Smokeless Tobacco Use: Study 2
The research project will determine the level of nicotine in ST products that will lead to the greatest reduction in toxicant exposure
- Trial name
- NCT01067599
- Testing
- Low nicotine, Medium nicotine, High nicotine
- Where
- 2 sites in United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cocaine Dependence
Effectiveness of Extended Treatment for Drug Dependence (ETDD) in the City Study
This protocol (a supplement to 805466) is to test whether our telephone continuing care model can be implemented successfully by "real world" publicly funded programs.
- Trial name
- NCT01153464
- Testing
- Recovery Support Counseling
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Pennsylvania
Cigarette Smoking, Nicotine Dependence
Incentives for Oklahoma Tobacco Helpline Engagement in Persistent Poverty Counties
The proposed pilot project is designed to evaluate the feasibility and potential efficacy of offering small financial incentives for the completion of smoking cessation counseling and self-reported abstinence at follow-up among…
- Trial name
- CLIMB (NCT05095779)
- Testing
- Coaching calls, Nicotine replacement therapy, Financial Incentives
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Substance Use Disorders, Alcohol Abuse
Reinforcement of Abstinence and Continuing Care in Substance Abuse Treatment
The Contracts, Prompts, and Social Reinforcement (CPR) intervention was designed to address the continuing care adherence needs of veterans presenting for substance use disorder (SUD) treatment.
- Conditions
- Substance Use Disorders, Alcohol Abuse, Alcoholism, Substance Dependence
- Trial name
- NCT00288886
- Testing
- Contracting, Prompting and Reinforcement arm, Control arm
- Where
- 2 sites in United States
- Volunteers
- 183 people
- Sponsor
- US Department of Veterans Affairs
Atrial Fibrillation, Atrial Flutter
Triggers and Risk Factors for Recurrence of Atrial Arrhythmias With the Use of Long-term Monitoring
A prospective cohort study to evaluate the association between various triggers encountered in daily life and induction of atrial arrhythmias (atrial fibrillation, atrial flutter, atrial tachycardia and premature atrial…
- Conditions
- Atrial Fibrillation, Atrial Flutter, Atrial Arrhythmia, Atrial Tachycardia
- Trial name
- TriggersAF (NCT05526170)
- Testing
- Devices for long-term monitoring of objective and subjective parameters of the body
- Where
- Lithuania
- Volunteers
- 182 people
- Sponsor
- Vilnius University
Pressure Injury Prevention
The Effect of Web-Based Training and Counseling Given to Caregivers on the Pressure Injury Risk, Level of Dependence-Independence, and Caregivers' Burden of Care in Bedridden Patients
Education and counseling of patients and caregivers, either face-to-face or using various communication technologies, are reported to have significant effects.
- Trial name
- NCT06832345
- Testing
- Experimental group
- Volunteers
- 31 people
- Sponsor
- Istanbul University - Cerrahpasa
Cocaine Abuse
ALK33BUP-101: Safety and Pharmacodynamic Effects of ALKS 33-BUP Administered Alone and When Co-administered With Cocaine
The purpose of this study is to assess the safety and tolerability of ALKS33-BUP when administered to opioid-experienced cocaine abusers.
- Trial name
- NCT01366001
- Testing
- ALKS 33-BUP, ALKS 33
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Alkermes, Inc.
Tobacco Use
Early Tobacco Abstinence - 5
This proposal will conduct a prospective examination of the clinical course (intensity, content and duration) of tobacco (nicotine) abstinence effects in male and female smokers who are either heavy/light alcohol drinkers…
- Trial name
- NCT00224965
- Testing
- Behavior Therapy
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Progesterone Treatment for Cocaine-dependent Women: A Pilot Study
The purpose of this pilot treatment trial is to evaluate the efficacy of oral micronized PROG in cocaine-dependent women. Since we have shown (Evans \& Foltin, 2006) that oral micronized PROG attenuates the positive subjective…
- Trial name
- PROG (NCT00632099)
- Testing
- Oral micronized progesterone
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- New York State Psychiatric Institute
Nicotine Dependence
Family Consultation for Health-Compromised Smokers
Although spousal support predicts the success of a smoker's cessation efforts, "social support" interventions based on teaching partners better support skills have had consistently disappointing results.
- Trial name
- NCT00400751
- Testing
- FAMCON (Family Consultation)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Arizona
Alcohol Dependence, Cocaine Dependence
Combined Treatment for Cocaine-Alcohol Dependence - 1
The purpose of this study is to examine whether Naltrexone and cognitive behavioral therapy can be helpful in patients who want to stop using cocaine and alcohol.
- Trial name
- NCT00218569
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Alcohol Dependence
Effectiveness of Naltrexone and/or Ondansetron to Reduce Craving for Alcohol and Drinking
The purpose of this study is to determine whether naltrexone (an opiate blocking agent approved for the treatment of alcohol dependence), ondansetron a serotonin 3 antagonist medication approved to treat nausea) or their…
- Trial name
- NCT00183222
- Testing
- naltrexone (up to 50 mg/day) for 8 days; ondansetron (0.25 mg twice a day) for 8 days
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Opioid Dependence, on Agonist Therapy
Multi-Center, Open-Label, 24-Week Study of OX219 Safety and Efficacy for Maintenance Treatment of Opioid Dependence
The purpose of this study was to assess safety, efficacy, and treatment retention following extended treatment with OX219, a higher-bioavailability buprenorphine/naloxone (BNX) sublingual tablet formulation in opioid-dependent…
- Trial name
- NCT01903005
- Testing
- Higher bioavailability BNX sublingual tablets
- Where
- 28 sites in United States
- Volunteers
- 668 people
- Sponsor
- Orexo AB
Opiate Addiction
Comparison of Buprenorphine/Naloxone With Naltrexone in Opioid Dependent Adolescents
This study is designed to determine the relative effectiveness of buprenorphine/naloxone (Suboxone) pharmacotherapy versus naltrexone pharmacotherapy for treatment retention, relapse prevention and opioid craving reduction among…
- Trial name
- NCT01015066
- Testing
- Buprenorphine/naloxone, Naltrexone
- Where
- United States
- Sponsor
- State University of New York at Buffalo
HIV Infections, Opioid-Related Disorders
Drug Treatment Combined With Drug and Risk Reduction Counseling to Prevent of HIV Infection and Death Among Injection Drug Users
Drug abuse and HIV/AIDS are serious global health problems. Injection drug use is currently the major mode of transmission of HIV in many countries.
- Trial name
- NCT00270257
- Testing
- Buprenorphine/Naloxone
- Where
- 4 sites in China, Thailand
- Volunteers
- 1,251 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cannabis Use Disorder
Psilocybin-assisted Treatment for Cannabis Use Disorder
This pilot study will evaluate the therapeutic potential of psilocybin in people with Cannabis Use Disorder (CUD). This study will examine the impact of psilocybin treatment on cannabis use and related variables in 12 people with…
- Trial name
- NCT06660381
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins University
Caffeine, Caffeine Withdrawal
Consumption Status of Caffeine and Adverse Effects Experience Among Anesthetists
High-caffeine consumption has been increasing in physicians, frequently causing the most common symptoms such as tremor, insomnia, anxiety, and nervousness and rarely leading to serious adverse effects like seizure, acute mania…
- Conditions
- Caffeine, Caffeine Withdrawal, Caffeine Dependence
- Trial name
- NCT05323578
- Testing
- Survey
- Where
- Egypt
- Volunteers
- 168 people
- Sponsor
- Ain Shams University
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