Clinical trials: Dependence
Smoking, Tobacco Dependence
Varenicline Treatment for Active Alcoholic Smokers
Alcohol dependence is a significant and prevalent public health problem affecting approximately 4% of the U.S. adult population.
- Conditions
- Smoking, Tobacco Dependence, Alcohol Dependence
- Trial name
- NCT01347112
- Testing
- Varenicline
- Where
- 2 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Heroin Dependence, Morphine Dependence
Buprenorphine/Naloxone Versus Clonidine for Inpatient Opiate Detoxification - 1
The purpose of this study is to assess buprenorphine/naloxone versus clonidine for inpatient opiate detoxification.
- Conditions
- Heroin Dependence, Morphine Dependence, Substance Withdrawal Syndrome
- Trial name
- NCT00032955
- Testing
- Buprenorphine/naloxone
- Where
- 6 sites in United States
- Volunteers
- 163 people
- Sponsor
- University of California, Los Angeles
Heroin Addiction
Efficacy Evaluation of Traditional Chinese Medicine JITAI Combined Comprehensive Model Among Heroin Addicts After Detoxification
The purpose of this research is to observe the efficacy of comprehensive treatment model to improve treatment compliance and relapse prevention.
- Trial name
- NCT01580163
- Testing
- JITAI Combined with psychological intervention, Methadone, Traditional Chinese Medicine JITAI
- Where
- 2 sites in China
- Volunteers
- 554 people
- Sponsor
- Shanghai Mental Health Center
Depression, Opioid Dependence
Desvenlafaxine in Opioid-Dependent Patients
Background: Although substitution therapy has been shown to be highly effective to retain opioid-dependent patients in treatment and reduce drug use, this population is afflicted by numerous conditions including depression.
- Conditions
- Depression, Opioid Dependence, Methadone Treatment
- Trial name
- NCT02200406
- Testing
- Desvenlafaxine
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Severe Mental Illness, Nicotine Dependence
Electronic Decision Support Systems for Smokers With Severe Mental Illness
This randomized clinical trial among SMI smokers assessed whether the EDSS with carbon monoxide monitor and health-checklist feedback lead to higher rates of initiation of smoking cessation treatment, days of smoking abstinence…
- Conditions
- Severe Mental Illness, Nicotine Dependence, Schizophrenia, Tobacco Use Disorder
- Trial name
- NCT01412866
- Testing
- EDSS with CO feedback and health checklist, EDSS with health checklist feedback alon
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Dual Diagnosis, Cocaine Abuse
Abstinence-Linked Money Management Multisite
Randomized clinical trial comparing a money management-based intervention involving storage and management of client funds, substance abuse counseling, and risk reduction counseling to individualized drug counseling.
- Conditions
- Dual Diagnosis, Cocaine Abuse, Cocaine Dependence, Polysubstance Abuse
- Trial name
- NCT01327586
- Testing
- ATM, Individual Drug Counseling
- Where
- 2 sites in United States
- Volunteers
- 108 people
- Sponsor
- Yale University
Smoking, Nicotine Dependence
Low-Dose Naltrexone Combined With Bupropion to Stop Smoking With Less Weight Gain
This study will test a combination of the drugs naltrexone and bupropion with weight-concerned smokers to investigate whether or not this combination of drugs improves smoking cessation quit rates and minimizes post quit weight…
- Trial name
- NCT00129246
- Testing
- Naltrexone, Bupropion
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Yale University
Nicotine Dependence
Effects of Varenicline on Smoking Reminders
Varenicline is the best smoking cessation agent to date; however it is only effective in a subgroup of smokers and is associated with undesirable side effects in other subgroups.
- Trial name
- VSMK (NCT01524627)
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- University of Pennsylvania
Drug Addiction, Nicotine Dependence
Assessing Top Down and Bottom Up Attention Mechanisms in Smokers Using Nicotine Nasal Spray
Background: Smoking is the leading cause of preventable death in the United States, and researchers are interested in gaining a better understanding of the perceived beneficial effects of nicotine to help improve treatment…
- Trial name
- NCT01136642
- Testing
- Nicotrol
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Photoaging
Investigating Age Dependence of Fibroblast and Extracellular Matrix Responses to Cross-linked Hyaluronic Acid Filler in Human Skin
The purpose of the study is to investigate the impact of the injection of dermal filler on the quality of the skin dermal extracellular matrix in persons between the ages of 30-50 years.
- Trial name
- NCT06195605
- Testing
- Restylane-L, Vehicle
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Michigan
Smoking, Smoking Cessation
Identifying Optimal Smoking Cessation Intervention Components (Cessation)
The goal of this research is to identify the best smoking cessation intervention components to be combined into a state-on-the-art, comprehensive smoking cessation intervention.
- Conditions
- Smoking, Smoking Cessation, Nicotine Dependence
- Trial name
- Cessation (NCT01116986)
- Testing
- Counseling before quit attempt, Minimal In-person counseling during quit attempt, Intensive in-person counseling during the quit attempt
- Where
- United States
- Volunteers
- 637 people
- Sponsor
- University of Wisconsin, Madison
Opioid Abuse, Opioid Dependence
A Within Subject Comparison of Opioid Withdrawal in Opioid Dependent Individuals
Buprenorphine is an approved medication for the treatment of opioid dependence. It is typically administered once daily as a sublingual tablet combined with naloxone (i.e., Suboxone).
- Trial name
- NCT01136356
- Testing
- buprenorphine, morphine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins University
Nicotine Dependence, Tobacco Toxicity
Cigarette Harm Reduction With Electronic Cigarette Use
This is an observational, crossover study that will be examine use behaviors, chemical exposures, and biological effects of SREC compared to TC use in subjects confined to a research ward setting.
- Conditions
- Nicotine Dependence, Tobacco Toxicity, Nicotine Dependence, Cigarettes, Cardiovascular Risk Factor
- Trial name
- NIDA-SREC (NCT03473483)
- Testing
- SREC
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cocaine Dependence
The Effect of Glutamatergic Modulation on Cocaine Self-administration
Repeated drug consumption may progress to problematic use by triggering neuroplastic adaptations that attenuate sensitivity to natural rewards while increasing reactivity to craving and drug cues.
- Trial name
- NCT02596022
- Testing
- CI-581a, CI-581b
- Volunteers
- 18 people
- Sponsor
- New York State Psychiatric Institute
Alcohol Dependence
Efficacy and Safety of Baclofen for Maintenance of Abstinence in Alcohol Dependent Patients
The purpose of the study is to assess the efficacy of Xylka® (baclofen) compared to placebo on continuous abstinence rate during 20 weeks of treatment, after withdrawal, in alcohol dependent patients receiving Brenda therapy…
- Trial name
- ALPADIR (NCT01738282)
- Testing
- Baclofen
- Where
- 38 sites in France
- Volunteers
- 316 people
- Sponsor
- Ethypharm
Smokeless Tobacco Use, Tobacco Dependence
Novel Determinants and Measures of Smokeless Tobacco Use: Study 1
The extent of toxicity varies considerably across different brands of smokeless tobacco (ST) products and data suggest that greater toxicity may result in greater health risks.
- Trial name
- NCT01067586
- Where
- 3 sites in United States
- Volunteers
- 359 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Rib Fractures
Pain Relief for Ventilated Patients With Multiple Rib Fractures Using the ON-Q Pain Relief System
The purpose of this study is to find out if patients having the ON-Q post-op Pain Relief System for pain management of multiple rib fractures will require fewer ventilator days, and will need less IV pain medicine to control…
- Trial name
- ON-Q (NCT00880529)
- Testing
- ON-Q bupivicaine administration, IV opioid administration
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- The Cooper Health System
Amphetamine-Related Disorders
Extended-Release Naltrexone to Treat Methamphetamine Dependence in Men Who Have Sex With Men (MSM)
Extended-release naltrexone (XR-NTX, VIVITROL) is an FDA-approved medication with efficacy in treating alcohol dependence and prevention of relapse to opioid dependence.
- Trial name
- TREX (NCT01449565)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- San Francisco Department of Public Health
Tobacco Use Disorder
Effect of Progesterone on Smoking Behavior in Male and Female Smokers
Past research on nicotine addiction has shown that changes in estradiol and progesterone hormone levels during menstruation may cause women to respond differently than men to nicotine.
- Trial name
- NCT00271206
- Testing
- Progesterone, sugar pill
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Yale University
Cocaine-Related Disorders, Substance-Related Disorders
Prepulse Inhibition of Startle in Cocaine Dependence - 7
The purpose of this study is to assess the effects of chronic cocaine use on the acoustic startle response and on gating of this response in humans.
- Trial name
- NCT00015249
- Testing
- Amantadine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
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