Clinical trials: Dependence
Cannabis Dependence
A Trial of N-Acetylcysteine (an Over-the-Counter Medicine) in Adolescents Who Smoke Marijuana
This study is investigating how N-Acetylcysteine (NAC), an over-the-counter medication, will reduce marijuana use when combined with Contingency Management, a behavioral treatment.
- Trial name
- NCT01005810
- Testing
- N-Acetylcysteine, Contingency Management
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Medical University of South Carolina
Cocaine Dependence
First in Humans Study of JDTic
This is the first study to be conducted in humans for JDTic, a new chemical entity, with evaluations focusing on the safety, tolerability, and pharmacokinetics (PK) of JDTic following administration of single oral doses.
- Trial name
- NCT01431586
- Testing
- JDtic
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- RTI International
Alcohol Dependence
Ambivalence Model of Craving: Re-examining the Drinking-craving Relationship
The current study combines both clinical trial and daily process methodology to examine the dynamic longitudinal relationships between daily approach and avoidance inclinations (i.e., craving) and drinking behaviors in those…
- Trial name
- NCT01883089
- Testing
- Motivational Enhancement Therapy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of South Florida
Alcohol Abuse, Alcohol Use Disorder
Skills-training for Reducing Risky Alcohol Use in App Form
This study evaluates the efficacy of a skills training web-based mobile phone application, Telecoach among individuals in the general population seeking help for their risky alcohol consumption on the Internet.
- Conditions
- Alcohol Abuse, Alcohol Use Disorder, Alcohol Drinking, Alcohol Dependence
- Trial name
- NCT03696888
- Testing
- Telecoach, TeleCoach control
- Where
- Sweden
- Volunteers
- 678 people
- Sponsor
- Karolinska Institutet
Alcohol Dependence
Neuromodulation and Mindfulness Patients With AUD
Our primary objective is to integrate tVNS and mindfulness meditation within a structured mindfulness-based relapse prevention (MBRP) program for detoxified alcohol-dependent patients (AD).
- Trial name
- NCT06308484
- Testing
- Transcutaneous vagus nerve stimulation, Closed-loop AM-tACS
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Charite University, Berlin, Germany
Cataract (Post-operative Cataract Surgery Follow-up), Refraction Error
Can Tailored Surgical Incisions Reduce Refractive Error and Dependence on Glasses After Cataract Surgery?
Astigmatism is a common cause of continued dependence on glasses after cataract surgery and may lead to patient dissatisfaction with surgical outcomes.
- Trial name
- AST-2 (NCT07623317)
- Testing
- Adapted clear corneal incisions
- Volunteers
- 100 people
- Sponsor
- Linkoeping University
Asperger's Disorder, Asperger Disorder
QAIAx - SGI/SI Smart Health Cities: Microcity Enclave Program (Quantum SI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos. 64/074,526, 64/063,557, 64/105,164, 63/903,181, 63/729,428, 64/125,360; USPTO EO 9424 Assignment ID: 2101042 / ARN: REEL/FRAME: 76481/0026 - OUSD-R&E, Department of War)
BRIEF SUMMARY A. "What is the purpose of this study?" BACKGROUND. The QAIAx clinical trial (Quantum SI/SGI Public Health Agency), known operationally as the "AI City Hall Project," represents a landmark intergovernmental research…
- Conditions
- Asperger's Disorder, Asperger Disorder, Autism Disorder, Autism
- Trial name
- QAIAx (NCT07661823)
- Testing
- AI City Hall Project (AIhealth4u - Public Health Central), AI City Hall Project (QAIAx Microcity A - AI Public Health Central)
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Veterans Recovery Network Inc.
HIV/AIDS, Substance Abuse
Directly Observed Therapy for Community-Released HIV+ Prisoners
The aim of this study is to develop effective interventions for HIV-infected prisoners who are released to the community. The intervention that we will study will be directly observed therapy (DAART/DOT) and we will compare this…
- Trial name
- Connect (NCT00786396)
- Testing
- Directly administered antiretroviral therapy
- Where
- 2 sites in United States
- Volunteers
- 151 people
- Sponsor
- Yale University
Methamphetamine Dependence
A Trial of Long-Acting Injectable Risperidone in the Treatment of Methamphetamine Dependence
Objective of the Project. -Methamphetamine (MA) use is growing to epidemic proportions and existing treatments for MA dependence demonstrate sub-optimal efficacy.
- Trial name
- NCT00284206
- Testing
- long-acting injectable risperidone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Bipolar Disorder, Alcohol Use Disorder
Ondansetron for Bipolar Disorder and Alcohol Use Disorders
The purpose of the study is to determine if ondansetron, as an add-on therapy, is associated with reduced depressive symptoms and alcohol use in outpatients with bipolar disorder (BPD), cyclothymic disorder, schizoaffective…
- Conditions
- Bipolar Disorder, Alcohol Use Disorder, Dual Diagnosis
- Trial name
- NCT02082678
- Testing
- Ondansetron
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Texas Southwestern Medical Center
Lung Cancer
Risk Communication in African American Smokers
The study aims to understand the effects of learning about one's genetic risk for lung cancer that is specific to their ancestry.
- Trial name
- NCT04084561
- Testing
- HRHA, LRLA, HRLA
- Where
- 2 sites in United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Temple University
Smoking, Smoking Cessation
Wisconsin Tobacco Quit Line Medicaid Incentive Evaluation
The study is designed to test the hypotheses that financial incentives can increase both participation in smoking cessation treatment and resulting cessation rates, when they are offered to BadgerCare Plus (Medicaid) smokers as…
- Conditions
- Smoking, Smoking Cessation, Nicotine Dependence
- Trial name
- NCT02713594
- Testing
- Counseling from WTQL, Financial incentive to participate
- Volunteers
- 1,900 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Opioid Dependence
A Study of Thienorphine Hydrochloride Tablets in Relapse Prevention Treatment of Opioid Dependence
Opioid addiction is common worldwide. Thienorphine hydrochloride is a newly partial opioid receptor agonist drugs. It's affinity with opioid receptors was much higher than opioids, which could effectively prevents opioid…
- Trial name
- NCT03656120
- Testing
- 0.2mg group, 0.5mg group
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Wei Hao
Cocaine-Related Disorders, Opioid-Related Disorders
Fluoxetine to Reduce Cocaine Use in Cocaine and Opioid Addicts
Cocaine addiction is a serious health problem with no available medical treatment for preventing relapse. Fluoxetine, a medication that is currently used to treat depression and anxiety disorders, may also be effective at…
- Trial name
- NCT00142779
- Testing
- Fluoxetine
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Colchicine, ICH - Intracerebral Hemorrhage
Colchicine for the Reduction of Dependency and Vascular Events After an Acute Intracerebral Hemorrhage
Data indicate that patients with intracerebral hemorrhage (ICH) are at high risk for thromboembolic events and disability that is not being sufficiently mitigated by current treatment strategies.
- Conditions
- Colchicine, ICH - Intracerebral Hemorrhage, Stroke, Dependence
- Trial name
- CoVasc-ICH2 (NCT06587737)
- Testing
- Colchicine 0.5 MG
- Volunteers
- 1,125 people
- Sponsor
- Population Health Research Institute
Heroin Addiction, Substance Use Disorders
Malmö Treatment Referral and Intervention Study
This study aims to study and implement active referral of heroin users from a syringe exchange programme to evidence-based treatment for heroin addiction.
- Trial name
- MATRIS (NCT01457872)
- Testing
- Strength-based case management, Control condition - referral only
- Where
- Sweden
- Volunteers
- 79 people
- Sponsor
- Region Skane
Cocaine Abuse, Cocaine-Related Disorders
Medications for Stopping Cocaine Dependence and Preventing Relapse
Cocaine dependence is a major public health problem; an effective primary treatment for cocaine dependent individuals has yet to be found.
- Trial name
- NCT00218023
- Testing
- Modafinil, Levodopa/Carbidopa, Naltrexone HCl
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Cigarette Smoking, Nicotine Dependence
Comparison of Internet Stop Smoking Intervention to Usual Care on Smoking Cessation at 6 Months
The primary goal of this project is to carry out a randomized controlled trial (RCT) comparing quit rates of a Spanish/English stop smoking Web site to those of a no-intervention or "quit on your own" control.
- Trial name
- TC5Redes (NCT01639079)
- Testing
- Internet Smoking Cessation Web Site
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Opioid-Related Disorders
Blockade Efficacy of Buprenorphine/Naloxone For Opioid Dependence
Buprenorphine, a treatment for opioid dependence, can be mixed with naloxone, to limit abuse potential. The purpose of this study is to examine the effectiveness of buprenorphine/naloxone that is given at less than daily…
- Trial name
- NCT00134888
- Testing
- Buprenorphine/naloxone
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Tobacco Dependence
S-Adenosyl-L-Methionine (SAMe) for Smoking Abstinence
Cigarette smoking is of great public health importance and is the single most important preventable cause of morbidity, mortality and excess health care costs in the United States.
- Trial name
- NCT00722124
- Testing
- S-Adenosyl-L-Methionine
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
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