Clinical trials: Dependence
Pain, Chronic Pain
Developing rTMS Treatment Strategies for Pain in Opiate Dependence
The purpose of this study is to parametically evaluate two different types of repetitive Transcranial Magnetic Stimulation (rTMS) treatment strategies as a potential treatment for pain in individuals currently taking prescription…
- Conditions
- Pain, Chronic Pain, Opioid Dependence, Opioid Use
- Trial name
- NCT03576781
- Testing
- Real iTBS, Real cTBS
- Where
- 2 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Opioid Induced Bowel Dysfunction
Study to Evaluate the Safety and Efficacy of Naldemedine (S-297995) for the Treatment of Opioid-Induced Bowel Dysfunction in Subjects With Chronic Pain
The primary objective of the study is to evaluate the safety of single doses of oral naldemedine in adults physically dependent on opioids.
- Trial name
- NCT01122030
- Testing
- Naldemedine
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Shionogi
Substance Withdrawal Syndrome
Process Evaluation Standardised Nurse-led Approach for Risk Screening and Decrease of Alcohol Withdrawal in ENT
In ear, nose, throat (ENT) and jaw surgery departments, up to 60% of patients suffer from alcohol dependence (Allen et al., 2009), and may develop an alcohol withdrawal syndrome (AWS) when undergoing sur-gery.
- Trial name
- NCT02782156
- Testing
- Process evaluation
- Where
- Switzerland
- Volunteers
- 89 people
- Sponsor
- University Hospital, Basel, Switzerland
an Acute Pathology
Preventing Iatrogenic Dependence Linked to Hospitalisation in Elderly Patients Hospitalised in Acute Geriatrics
Iatrogenic dependence linked to hospitalisation DILH is very frequent, severe but avoidable in 80% of cases. Extensive research has identified 6 main causes of DILH in the elderly, which interact and have common risk factors…
- Trial name
- TAKE CARE (NCT06449053)
- Testing
- ORGANIZATIONAL
- Where
- France
- Volunteers
- 918 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Alcohol Dependence
The Efficacy of A Smartphone-based Support System to Reinforce Alcohol Abstinence in Treatment-seeking Patients
Background: Interactive and mobile technology to manage alcohol use problem potentially provide continuing care by offering emotional and instrumental support anywhere and in time, but the effectiveness for maintaining abstinence…
- Trial name
- NCT02385643
- Testing
- SmartPhone Support System
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Ming-Chyi Huang
Methamphetamine Dependence
Modafinil vs Placebo for the Treatment of Methamphetamine Dependence
Modafinil is a non-amphetamine type stimulant that acts as a wakefulness-promoting drug, and is approved for managing symptoms of narcolepsy (i.e., daytime somnolence).
- Trial name
- Modafinil (NCT00469508)
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Cocaine-Related Disorders
Carbamazepine Treatment for Cocaine Dependence - 5
The purpose of this study is to assess carbamazepine as a pharmacotherapy for cocaine dependence.
- Trial name
- NCT00000191
- Testing
- Carbamazepine
- Where
- United States
- Sponsor
- University of Pennsylvania
Opioid Abuse
Combined Therapy of Methadone and Dextromethrophan
The purpose of this study is to determine the pharmacological effects and outcomes of DM therapy with this add-on study. And to determine the immunological changes between the baseline and the end point of the study.
- Trial name
- DM (NCT01189097)
- Testing
- Dextromethorphan
- Where
- Taiwan
- Volunteers
- 1,500 people
- Sponsor
- National Cheng-Kung University Hospital
Cocaine Dependence
Imaging the Neurobiology of a Behavioral Treatment for Cocaine Dependence
The purpose of this study is to determine whether patients with the greatest loss of dopamine transmission due to cocaine dependence at pre-treatment PET and MRI scans will be those who fail to respond to substance abuse…
- Trial name
- PET-CRA (NCT00376558)
- Testing
- Community Reinforcement Approach
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Post-traumatic Stress Disorder, Alcohol Abuse
Adolescent Trauma Recovery and Stress Disorders Collaborative Care (ATRSCC) Model Program Trial
Recent needs assessments suggest that difficulties exist in care coordination between emergency medical services (EMS) systems and primary care for injured adolescents with alcohol problems and post-traumatic stress disorder…
- Conditions
- Post-traumatic Stress Disorder, Alcohol Abuse, Alcohol Dependence
- Trial name
- ATRSCC (NCT00619255)
- Testing
- Adolescent Trauma Support Program
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Washington
Nicotine Dependence
The Gender-Sex Hormone Interface With Craving & Stress-Related Changes in Smoking
The purpose of the overall parent study is to determine the impact of gender and hormones (estradiol, progesterone, testosterone and cortisol) on responses to stress and smoking cues presented in daily, "real-world" cue…
- Trial name
- SCOR-III (NCT01576874)
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Kevin Gray, MD
Nicotine Dependence
Extinction Based Treatment for Nicotine Dependence
The purpose of this study is to test two quit smoking therapies and to study brain function while each therapy is being used. You will be randomly assigned (like flipping a coin) to one of the two groups.
- Trial name
- Extinction01 (NCT00831155)
- Testing
- Nicotine Patches, Denicotinized Cigarettes
- Where
- United States
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- Duke University
Depression, Anxiety
Creatine for Depressed Male and Female Methamphetamine Users
Assess the antidepressant/anxiolytic effect of creatine in male and female methamphetamine users Assess creatine's effect on methamphetamine use Assess the safety of creatine in male methamphetamine users with depression
- Conditions
- Depression, Anxiety, Methamphetamine Dependence
- Trial name
- NCT02568878
- Testing
- Creatine monohydrate
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Montana State University
Chronic Pain, Opioid Use
Cognitive Function and Addiction Under Opioid Tapering
This study evaluates the effects of opioid dose reduction in the treatment of chronic pain in adults. Participants were divided in two groups: 1) patients that reduced opioid dose and 2) patients that kept the same opioid dose…
- Trial name
- NCT03365817
- Testing
- Opioids taper off, Opioid stable treatment
- Volunteers
- 75 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cocaine-Related Disorders, Substance-Related Disorders
Pharmacotherapy and Intensive Treatment - 2
The purpose of this study is to evaluate desipramine and carbamazepine in reducing cocaine craving; increase outpatient treatment capacity and evaluate their incidence of psychiatric disorders.
- Trial name
- NCT00000218
- Testing
- Carbamazepine
- Where
- United States
- Volunteers
- 353 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Tobacco Use Disorder
Effect of Progesterone on Smoking Behavior in Male and Female Smokers
Past research on nicotine addiction has shown that changes in estradiol and progesterone hormone levels during menstruation may cause women to respond differently than men to nicotine.
- Trial name
- NCT00271206
- Testing
- Progesterone, sugar pill
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Yale University
Opioid Dependence
Community Studies of Long Acting Buprenorphine (CoLAB)
Despite research demonstrating the efficacy of buprenorphine (BPN), effectiveness in real-world settings has been limited by shorter retention than for methadone, and the need for daily or near-daily dosing (frequently supervised…
- Trial name
- CoLAB (NCT03809143)
- Testing
- RBP-6000
- Where
- 6 sites in Australia
- Volunteers
- 100 people
- Sponsor
- The University of New South Wales
Alcoholism
Combined Pharmacotherapies for Alcoholism
This study would like to test whether the combination of ondansetron and naltrexone will be superior to either medication alone or placebo in the treatment of alcohol dependence.
- Trial name
- NCT00768508
- Testing
- Ondansetron 4 ug/kg b.i.d. + Cognitive Behavioral Therapy, Naltrexone 50 mg/day + Cognitive Behavioral Therapy, Ondansetron 4 ug/kg b.i.d.+ Naltrexone 50 mg/day + Cognitive Behavioral Therapy
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Bankole Johnson
Patients Hospitalized in a FRC Department
Validation of a SOFMER Activity Scale
A person's dependency is defined as the total or partial inability to perform without helps the necessary activities of daily life due to activity limitations in the usual environment.
- Trial name
- SAS (NCT03116204)
- Testing
- Assessment of score SAS
- Where
- 9 sites in France
- Volunteers
- 152 people
- Sponsor
- Hospices Civils de Lyon
Chronic Ventilator Dependency
HFCWO in Prolonged Mechanical Ventilation Patients
The effectiveness, safety and tolerance/comfort of high-frequency chest wall oscillation (HFCWO) in prolonged mechanical ventilation patients remain unknown.
- Trial name
- NCT02077738
- Testing
- HFCWO (Hill-Rom Vest™ Airway Clearance System)
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Taichung Veterans General Hospital
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