Clinical trials: Dependence
HIV Infections, Alcohol Drinking
Boston Alcohol Research Collaboration on HIV/AIDS (ARCH) Cohort: The 4F Study
The purpose of this study is to follow a cohort of HIV-infected adults who have alcohol and/or drug use to: 1) test the associations between alcohol (and illicit drugs and polypharmacy (multiple prescribed medications)) and falls…
- Conditions
- HIV Infections, Alcohol Drinking, Substance-Related Disorders, Bone Diseases
- Trial name
- NCT03414411
- Where
- United States
- Volunteers
- 251 people
- Sponsor
- Boston University
HIV Infection, Alcohol Use
Boston Alcohol Research Collaboration on HIV/AIDS (ARCH) Cohort
The purpose of this study is to expand and continue a cohort of HIV-infected adults to establish the longitudinal Boston ARCH Cohort of 250 HIV-infected men and women with current substance dependence or ever injection drug use…
- Conditions
- HIV Infection, Alcohol Use, Bone Disease, Substance-Related Disorders
- Trial name
- NCT01740115
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Boston Medical Center
Heroin Dependence, Opioid-Related Disorders
Sustained Release d-Amphetamine & Buprenorphine on Drug Seeking Behavior in Opioid & Cocaine Dependent Individuals
The purpose of this study is to determine whether maintenance on different oral doses of sustained release d-amphetamine (SR-AMP) combined with constant-dose sublingual buprenorphine (BUP) is safe and well tolerated and decreases…
- Conditions
- Heroin Dependence, Opioid-Related Disorders, Cocaine Abuse or Dependence
- Trial name
- NCT00429767
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Wayne State University
Alcohol Dependence
Duloxetine Versus Pregabalin for Alcohol Dependence
A 12-week, double-blind, placebo-controlled parallel group study will be conducted with 150 outpatients with alcohol dependence, with random assignment to pregabalin 300 mg/d, duloxetine 40 mg/d, or placebo in conjunction with…
- Trial name
- NCT00929344
- Testing
- Pregabalin, Duloxetine, Standardized behavioral therapy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- The Scripps Research Institute
Cocaine-Related Disorders, Substance-Related Disorders
Quetiapine for Cocaine Use and Cravings
The purpose of this study was to collect pilot data on whether quetiapine may be effective in the reduction of cocaine use and cravings in cocaine dependent individuals.
- Trial name
- NCT00232336
- Testing
- quetiapine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Smoking Cessation, Alcohol-Related Disorders
Effectiveness of Bupropion for Smokers Recovering From Alcohol Dependence
Smoking is often a problem for alcohol dependent individuals. Many people who seek treatment for alcohol dependence are unable to quit smoking.
- Trial name
- NCT00304707
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcoholism
GABA Mechanisms Underlying the Vulnerability to Alcohol Dependence
This Project will explore the hypothesis that individuals with a family history positive for alcohol dependence (without any current Axis I disorder, except nicotine dependence), experience an alteration in the reward "valence"…
- Trial name
- NCT00611767
- Testing
- Thiopental
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Dependence
Brain Derived Neurotrophic Factor Serum Levels Evolution During the Six Months After Alcohol Withdrawal
Alcohol dependence is accompanied by several neurological mechanisms involving neuronal plasticity and neoneurogenesis, requiring Brain Derived Neurotrophic factor (BDNF) synthesis.
- Trial name
- NCT01491347
- Where
- 4 sites in France
- Volunteers
- 389 people
- Sponsor
- Centre Hospitalier Esquirol
Cocaine Dependence
Multisite Controlled Trial of Cocaine Vaccine
The purpose of this study is to test the efficacy of a newly developed active vaccine against cocaine (TA-CD).
- Trial name
- TA-CD (NCT00969878)
- Testing
- TA-CD Vaccination
- Where
- 6 sites in United States
- Volunteers
- 300 people
- Sponsor
- Baylor College of Medicine
Cannabis Abuse, Cannabis Dependence
The Teen Marijuana Check-Up
This behavioral research is an efficacy trial evaluating an intervention called "The Teen Marijuana Check-Up" with non-treatment seeking adolescent marijuana users.
- Trial name
- TMCU3 (NCT00350285)
- Testing
- Motivational enhancement therapy, Marijuana education
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- University of Washington
Alcohol Drinking, Alcohol Use Disorder
Improving Care for Unhealthy Alcohol Use in Primary Care
In order to improve the quality of alcohol-related care for those with unhealthy alcohol use, the current research will use an evidence-based implementation strategy, practice facilitation, at one VA primary care site to pilot…
- Trial name
- NCT04565899
- Testing
- Practice facilitation implementation intervention
- Where
- 2 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Attention Deficit Hyperactivity Disorder, Nicotine Dependence
Bupropion for ADHD in Adolescents With Substance Use Disorder
Attention deficit hyperactivity disorder (ADHD) is one of the most common co-occurring psychiatric disorders (30-50%) in adolescents with substance use disorders (SUD).
- Conditions
- Attention Deficit Hyperactivity Disorder, Nicotine Dependence, Cannabis Use Disorder
- Trial name
- NCT00936299
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Colorado, Denver
Alcohol Dependence
Lifestyle Physical Activity Intervention for Depressed Alcohol Dependent Women
Building on the large body of evidence for the effect of exercise in decreasing depressive symptoms and the few preliminary findings of its effect on craving and drinking outcomes, the purpose of this study is to develop a…
- Trial name
- NCT02705898
- Testing
- LPA+Fitbit, HEC
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Butler Hospital
Smoking
Novel Psychosocial Influences on Smoking Cessation
Our overall research goal is to determine how these novel psychosocial factors impact cessation. This pilot study will answer how dual use of other tobacco products, direct to consumer marketing, and the new phenomenon of…
- Trial name
- NCT02173938
- Testing
- Tobacco Dependence Treatment
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Nicotine Dependence, Tobacco Use
Puff Topography and Sensory Effects Across IQOS Device Generations
The goal of this clinical trial is to learn how people use two generations of IQOS heated tobacco devices and how each device affects their smoking behavior and sensory experience.
- Trial name
- NCT07712887
- Testing
- IQOS Iluma i with TEREA Tobacco Sticks, IQOS 2.4 with HEETS Tobacco Sticks
- Where
- 2 sites in Lebanon
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Nicotine Dependence
Pilot Study of Transcranial Magnetic Stimulation (TMS) in Nicotine Addiction
Background: Treatment for nicotine addiction is characterized by high rates of relapse. New treatment therapies for nicotine addiction are exploring the use of brain scanning equipment to control and decrease nicotine and…
- Trial name
- NCT01031693
- Testing
- Transcranial Magnetic Stimulation
- Where
- 2 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcoholism
Naltrexone Treatment of Alcohol Dependence
The long-range goal of this ongoing research program is to find more effective treatments for alcohol dependence by combining medication with the appropriate psychosocial support.
- Trial name
- NCT00000452
- Testing
- naltrexone (Revia), Compliance Enhancement Tech., Cognitive Behavior Therapy
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Tobacco Dependence
Study to Determine if a New Nicotine Replacement Therapy Can Safely Help Smokers to Quit Smoking
This study is to see if a new nicotine replacement therapy safely helps people to quit smoking if it is used the way it would be if it were sold at the pharmacy and used at home.
- Trial name
- NCT01296698
- Testing
- Nicotine
- Where
- 19 sites in United States
- Volunteers
- 257 people
- Sponsor
- McNeil Consumer Healthcare Division of McNEIL-PPC, Inc.
Smoking, Smoking Cessation
Identifying Treatments to Motivate Smokers to Quit
At any given point in time, most smokers are not interested in making a serious quit attempt. Data suggest that 30% of smokers have no plans to quit, 30% plan to quit at some future date, 30% plan to quit in the next 6 months…
- Conditions
- Smoking, Smoking Cessation, Motivation, Nicotine Dependence
- Trial name
- Motivation (NCT01122238)
- Testing
- Nicotine Patch, Nicotine Gum, Motivational Interviewing
- Where
- United States
- Volunteers
- 517 people
- Sponsor
- University of Wisconsin, Madison
Alcoholism, Alcohol Dependence
Drug Treatment for Depressed Alcoholics (Naltrexone/Fluoxetine)
This study will examine the effects of combing naltrexone and fluoxetine (Prozac) versus fluoxetine and placebo in alcoholics with co-occurring major depression.
- Conditions
- Alcoholism, Alcohol Dependence, Depression
- Trial name
- NCT00006204
- Testing
- naltrexone (Revia), fluoxetine (Prozac)
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
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