Clinical trials: Dependence
Cocaine-Related Disorders, Drug Administration Schedule
Ondansetron for the Treatment of Cocaine Dependence - 1
The purpose of this study is to assess the efficacy and safety of ondansetron to reduce cocaine use in subjects with cocaine dependence.
- Trial name
- NCT00033085
- Testing
- Ondansetron
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance Dependence
Distress Tolerance Treatment for Substance Users
Despite recent advances in substance abuse interventions, a large percentage of clients entering residential treatment for substance use will drop out of treatment prematurely, and of the remaining, many will relapse soon after…
- Trial name
- NCT01741415
- Testing
- SIDI, SC
- Where
- United States
- Volunteers
- 325 people
- Sponsor
- University of South Florida
Opioid Dependence, Opioid Withdrawal
Medical Management of Sleep Disturbance During Opioid Tapering
This study will evaluate whether a dual orexin-receptor antagonist approved by the FDA for sleep disturbance, suvorexant (SUVO; Belsomra), will increase total sleep time in patients with opioid use disorder (OUD) undergoing…
- Conditions
- Opioid Dependence, Opioid Withdrawal, Sleep Disturbance
- Trial name
- NCT03789214
- Testing
- Low Dose Suvorexant, High Dose Suvorexant
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Johns Hopkins University
Benzodiazepine Dependence, Anxiety Disorders
Anxiety Lowering and Deprescribing Through Emotion Regulation
The goal of this clinical trial is to test ALDER (Anxiety Lowering and Deprescribing through Emotion Regulation), an online self-guided positive emotion intervention, in patients over the age of 65 who are candidates for…
- Conditions
- Benzodiazepine Dependence, Anxiety Disorders, Sleep Disturbance
- Trial name
- ALDER (NCT06359314)
- Testing
- ALDER
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Nicotine Dependence
Study on Smoking Cessation and Cost Outcomes in the Duke Smoking Cessation Program
The purpose of this study is to conduct an observational assessment of natural outcomes within the Duke Smoking Cessation Program (DSCP), "Quit at Duke." This assessment will include information regarding abstinence rates…
- Trial name
- NCT02845687
- Where
- United States
- Volunteers
- 209 people
- Sponsor
- Duke University
Substance Related Disorders, Drug Addiction
Contingency Management for Cocaine Dependence: Cash Versus Vouchers
Contingency management (CM) is a demonstrably efficacious intervention for substance abuse and dependence. Although CM protocols have employed a variety of reinforcers, they have almost exclusively relied upon non-cash privileges…
- Conditions
- Substance Related Disorders, Drug Addiction, Substance Abuse
- Trial name
- NCT01366716
- Testing
- Cash CM, Voucher CM
- Where
- United States
- Volunteers
- 352 people
- Sponsor
- Treatment Research Institute
Smoking Cessation, Nicotine Dependence
Study Assessing Efficacy and Safety of NFL-101 as a Tobacco Cessation Therapy
CESTO 2 is a 318 participants, 3-arm, multicentric, randomized, double-blind, placebo-controlled Phase II clinical trial. The main objectives are to select the most efficient dose and to assess long-term efficacy of NFL-101…
- Trial name
- CESTO2 (NCT04571216)
- Testing
- NFL-101 dose 1, NFL-101 dose 2
- Where
- 9 sites in France
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- NFL Biosciences SAS
Cocaine Dependence
A Study of Baclofen ER
This is a Phase II, randomized, double-blind, placebo-controlled study that will examine the efficacy of extended-release baclofen (Baclofen ER) for the treatment of cocaine dependence.
- Trial name
- CURE (NCT02003664)
- Testing
- Baclofen ER
- Where
- United States
- Sponsor
- University of Pennsylvania
Healthy Adults, Mechanical Ventilation Dependence
Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude
This study investigates whether respiratory muscle training (RMT) and dietary nitrate supplementation can improve exercise tolerance under simulated moderate altitude conditions.
- Conditions
- Healthy Adults, Mechanical Ventilation Dependence, Hypoxia, Exercise Training
- Trial name
- NCT07216755
- Testing
- Respiratory Muscle Training (RMT), Dietary Supplement: Beetroot Juice Concentrate
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Embry-Riddle Aeronautical University
Methamphetamine Use Disorder
Bupropion in the Treatment of Methamphetamine Dependence
Methamphetamine dependence is a significant drug use disorder in the Midwest. While a number of psychosocial and pharmacological treatments have been studied, no specific treatments for methamphetamine have been identified.
- Trial name
- NCT00572234
- Testing
- bupropion SR
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Nebraska
Analgesic Drug Dependence, Sensory Deficit
Quantitative Sensory Testing in Chronic Pain Patients Undergoing Opioid Treatment and Opioid Tapering
Few studies have used quantitative sensory tests to study the effect of chronic opioid treatment on sensation. The investigators will test chronic pain patients who are on different MEDDs, normal volunteers, and patients…
- Trial name
- NCT03375216
- Testing
- sensory testing (Heat, cold, and pressure), Promis Survey
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Diabetes Mellitus
Genetic Variants Replication Study Associated With Dependence on Sulfonylurea in Participants With Type 2 Diabetes
This study was designed to reproduce candidate single nucleotide variants found by whole exome sequencing in some type 2 diabetic patients dependent on sulfonylurea in a separate patient group.
- Trial name
- NCT04123587
- Testing
- discontinuation of Sulfonylureas
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Methamphetamine Addiction
A Pilot Trial of Modafinil for Treatment of Methamphetamine Dependence
Patients treated for methamphetamine dependence have high rates of relapse, and no pharmacotherapy has yet been demonstrated to be efficacious.
- Trial name
- NCT00538655
- Testing
- modafinil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- California Pacific Medical Center Research Institute
Smoking, Nicotine Dependence
E-Cigarettes: Dynamic Patterns of Use and Health Effects
The proposed research will provide in-depth, longitudinal data, based on real-time reports, which will address key priorities for the FDA including, increased understanding of the relations between electronic cigarette (e-cig)…
- Trial name
- NCT02527980
- Testing
- No intervention: observation only
- Where
- 2 sites in United States
- Volunteers
- 422 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cannabis Use Disorder
CANDIS - Targeted Treatment for Cannabis Disorders
The purpose of this study is to develop a modular treatment program for cannabis use disorders and the evaluation of the effectiveness in a controlled clinical study.
- Trial name
- NCT00252980
- Testing
- Psychotherapy
- Where
- Germany
- Volunteers
- 210 people
- Sponsor
- Technische Universität Dresden
Social Isolation or Loneliness, Anxiety
Health Surveillance at Constructor University Bremen (CUB)
The aim of Health Surveillance is to analyze and describe the state of health of students at Constructor University, key influencing factors and individual resources by using mixed-method design.
- Conditions
- Social Isolation or Loneliness, Anxiety, Anxiety Depression (Mild or Not Persistent), Health Behavior
- Trial name
- CUB-HS2025 (NCT06899308)
- Testing
- questionnaire
- Where
- 2 sites in Germany
- Volunteers
- 373 people, healthy volunteers welcome
- Sponsor
- Jacobs University Bremen gGmbH
Alcohol Dependence
Extended-release Naltrexone for Alcohol Dependence in Primary Care
Naltrexone is an opioid antagonist with a high affinity for the mu opioid receptor. The efficacy of extended-release naltrexone (Vivitrol) as a treatment for alcohol dependence has been demonstrated in clinical trials, raising…
- Trial name
- NCT00620750
- Testing
- Extended release injectable naltrexone (Vivitrol)
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- NYU Langone Health
Chronic Pain, Pain
A Study of Cebranopadol for Opioid Withdrawal Symptoms in Adults With Chronic Pain
This Phase 2 study will evaluate whether multiple doses of cebranopadol suppress opioid withdrawal signs and symptoms compared with placebo in adults with chronic pain who are physically dependent on prescribed opioids.
- Conditions
- Chronic Pain, Pain, Opioid Withdrawal (Disorder), Opioid Use Disorder
- Trial name
- NCT07874620
- Testing
- Cebranopadol
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- Adneuris Therapeutics, Inc.
Opioid-use Disorder
A Strategy to Improve Success of Treatment Discontinuation in Buprenorphine Responders
This study is an open--label randomized outpatient trial to evaluate feasibility and efficacy of rapid buprenorphine (BUP) discontinuation followed by brief course of treatment with long--acting naltrexone (XR--NTX) and to…
- Trial name
- NCT03232346
- Testing
- Vivitrol, Buprenorphine
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Substance-Related Disorders
Behavioral Treatment for Substance Abuse
This pilot project will evaluate a new mind-body intervention called Mind-Body Bridging (MBB) for reducing substance abuse problems in women who are undergoing a substance abuse treatment program.
- Trial name
- NCT01438346
- Testing
- Substance Abuse Education, Mind-body Bridging
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- University of Utah
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