Clinical trials: Dependence
Gambling, Tobacco Use Disorder
N-Acetyl Cysteine Plus Behavioral Therapy for Nicotine Dependent Pathological Gamblers
The objective of this application is to examine whether, given its mechanism of action, the dietary supplement, N-acetyl cysteine (NAC) will reduce both tobacco use and pathological gamblers (PG) symptoms in nicotine dependent…
- Trial name
- NCT00967005
- Testing
- N Acetyl Cysteine, Sugar Pill
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- University of Chicago
Cocaine Dependence
Oxytocin in Cocaine Dependence
Stress is likely involved in relapse to cocaine use. This project will investigate the role oxytocin may play in the stress response in cocaine-dependent men and women and examine how oxytocin may impact brain activity in…
- Trial name
- NCT01573273
- Testing
- Oxytocin, Saline
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Medical University of South Carolina
Alcohol Dependence
Study of Campral (Acamprosate) for Alcohol Dependence in a Family Medicine Clinic
This is a study of a medication, acamprosate, which is an FDA approved medication for alcohol problems. We will be examining whether acamprosate compared to a sugar pill (placebo) is more effective for helping with drinking in a…
- Trial name
- NCT00381043
- Testing
- Acamprosate (Campral)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of North Carolina, Chapel Hill
Stress Disorders, Post-Traumatic, Alcohol Abuse
Combined Treatment for Alcohol-Dependent Individuals With PTSD
This treatment intervention trial is designed for men and women with either alcohol misuse (e.g. hazardous or binge drinking) or alcohol use disorders (alcohol abuse or dependence) and comorbid PTSD.
- Conditions
- Stress Disorders, Post-Traumatic, Alcohol Abuse, Substance-Related Disorders
- Trial name
- NCT00262223
- Testing
- Seeking Safety, Sertraline
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- New York State Psychiatric Institute
Smoking
Reducing Tobacco-associated Lung Cancer Risk: A Randomized Clinical Trial of AB-free Kava
Tobacco use is the leading cause of many preventable diseases, particularly lung cancer. Based on the national cancer data in 2020, Florida has the highest lung cancer incidence (18,150 cases) with the most deaths (10,580 deaths)…
- Trial name
- NCT05081882
- Testing
- Kava
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Florida
Methamphetamine-dependence, Methamphetamine Abuse
Multiple-Dose Study to Evaluate the Safety and Efficacy of IXT-m200
This Phase 2 study will evaluate the safety and efficacy of monthly intravenous doses of IXT-m200 in treatment-seeking individuals with methamphetamine (METH) use disorder.
- Trial name
- OUTLAST (NCT05034874)
- Testing
- IXT-m200
- Where
- 9 sites in United States
- Volunteers
- 61 people
- Sponsor
- InterveXion Therapeutics, LLC
Nicotine Dependence
Targeted Interventions for Weight-Concerned Smokers
Weight gain after quitting smoking is an important barrier to treatment for many smokers. This study will test a drug called naltrexone with weight-concerned smokers to investigate whether or not this drug both improves smoking…
- Trial name
- NCT00105482
- Testing
- Naltrexone, Transdermal nicotine replacement, Behavioral counseling
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- Yale University
Tobacco Dependence
Tobacco Dependence Treatment for Asian Americans
Nicotine dependence is very common among Asian Americans; yet, research on understanding and treating nicotine dependence in this group is almost nonexistent.
- Trial name
- NCT01091363
- Testing
- Standard, Deep Cultural
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Boston
Opioid Dependence
Completion of OST - a Prospective Study
Only limited information on the process of completing long-term opiate substitution treatment (OST) with substances like methadone exist.
- Trial name
- NCT01722435
- Testing
- Opiate Substitution Treatment
- Volunteers
- 78 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Nicotine Dependence
A Smoking Cessation Treatment for Adult Women
The purpose of this study is to develop and pilot test a smoking cessation counseling that focuses on the perceived risks of quitting smoking (e.g., weight gain, managing cravings and negative affect, loss of enjoyment).
- Trial name
- NCT01422239
- Testing
- Tailored treatment, Standard Treatment
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Yale University
Cocaine Dependence
Imaging the Neurobiology of Behavioral and Medication Treatment for Cocaine Dependence
The proposed study will look at cocaine dependent individuals and will consist of three consecutive phases: 1) the 2-week outpatient lead-in phase during which behavioral therapy will be administered; 2) the 15-21 day inpatient…
- Trial name
- COST (NCT01468012)
- Testing
- levodopa carbidopa and entacapone (LCE)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Nicotine Dependence
Trial on the Effectiveness of Mindfulness Training for Smokers
The Mindfulness Training for Smokers study follows a randomized controlled design with 240 total participants. Both the study group and the control group will be enrolled in the Wisconsin Tobacco Quit Line and will receive four…
- Trial name
- MTS (NCT01093599)
- Testing
- Quit Line plus MTS, Quit Line Only
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- University of Wisconsin, Madison
Heavy Drinking, HIV
Topiramate to Reduce Heavy Drinking in HIV-Positive Heavy Drinkers
Heavy drinking (HD) is a risk factor for HIV transmission and is more common in HIV+ individuals than in the general population.
- Conditions
- Heavy Drinking, HIV, Alcohol Dependence
- Trial name
- NCT01764685
- Testing
- Topiramate, Medical Management
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Pennsylvania
Cigarette Smoking, Nicotine Dependence
Treatment of Smoking Among Individuals With PTSD
This study will examine the effect of combining prolonged exposure, a cognitive-behavioral treatment program for post-traumatic stress disorder (PTSD) with medication (varenicline) and counseling treatments for smoking cessation.
- Conditions
- Cigarette Smoking, Nicotine Dependence, Post-traumatic Stress Disorder, Tobacco Use Disorder
- Trial name
- NCT00937235
- Testing
- Varenicline, Medication Management Counseling, Prolonged Exposure
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- University of Pennsylvania
Nicotine Dependence
Selegiline for Smoking Cessation - 1
The purpose of this study is designed to examine the effects of Selegiline Transdermal System and behavioral intervention in smoking cessation as compared to behavioral intervention alone.
- Trial name
- NCT00439413
- Testing
- Selegiline Transdermal Patch, Smoking Cessation Counseling
- Where
- 4 sites in United States
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Hepatitis C, Opiate Dependence
Effective Treatment of Hepatitis C in Substance Users
We hypothesize that integrating Hepatitis C into methadone and buprenorphine treatment will improve Hepatitis C outcomes as well as drug treatment outcomes in patients who are addicted to opiates.
- Trial name
- NCT00633243
- Testing
- Modified Directly Observed Therapy (mDOT), Self-Administered Therapy (SAT)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Yale University
Nicotine Dependence, Smoking Cessation
Smoking Cessation and Reduction With an Electronic Nicotine Delivery Device (ENDD)
The study's major aim is to investigate the ability of a commercial Electronic Nicotine Delivery Device (ENDD) to induce long-term smoking reduction/abstinence in smokers unwilling to quit.
- Trial name
- NCT01195597
- Testing
- E-Cigarette 7.2 mg nicotine
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Catania
Cocaine Abuse, Cocaine Dependence
n-Acetylcysteine and Cocaine
This study will determine the initial efficacy, safety and tolerability of n-acetylcysteine as a pharmacotherapy for cocaine dependence.
- Trial name
- NCT02141620
- Testing
- Cocaine, n-Acetylcysteine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Substance Abuse, Substance Dependence
Cognitive Remediation and Work Therapy in the Initial Phase of Substance Abuse Treatment
The initial phase of substance abuse treatment is a vulnerable period for relapse. Cognitive impairments are common during this phase and may reduce the ability to benefit from other forms of substance abuse and rehabilitation…
- Conditions
- Substance Abuse, Substance Dependence, Cognitive Impairment
- Trial name
- NCT01410110
- Testing
- Cognitive Training + Work Therapy, Work Therapy
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Yale University
Alcohol Dependence
Effectiveness of Gabapentin When Used With Naltrexone to Treat Alcohol Dependence Compared to Placebo and Naltrexone Alone
The purpose of this study is to determine whether, after a period of abstinence, adding 6 weeks of gabapentin (a medication approved to treat seizures) to a standard 16-week naltrexone (an opiate blocking agent approved for the…
- Trial name
- NCT00183196
- Testing
- Naltrexone, Naltrexone plus Gabapentin
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Medical University of South Carolina