Clinical trials: Dependence
Tobacco Dependence
Yoga as a Complementary Therapy for Smoking Cessation
This study examines the efficacy of yoga as a complementary therapy for smoking cessation
- Trial name
- NCT01809678
- Testing
- Smoking Cessation, Yoga, Wellness
- Where
- United States
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Cocaine-Related Disorders
Baclofen for the Treatment of Cocaine Dependence - 1
The purpose of this study is to assess the efficacy and safety of baclofen for the treatment of cocaine dependence.
- Trial name
- NCT00082485
- Testing
- Baclofen
- Where
- 8 sites in United States
- Volunteers
- 160 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking, Smoking Cessation
Connect to Quit for Smoking
The purpose of this research study is to examine the effectiveness of an intervention designed to reduce smoking in low income veterans within a regional United States Veterans Administration(VA) health care system.
- Trial name
- CTQ (NCT01299896)
- Testing
- Coordinated Care, Usual Care
- Where
- United States
- Volunteers
- 633 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Opioid-Related Disorders
Blockade Efficacy of Buprenorphine/Naloxone For Opioid Dependence
Buprenorphine, a treatment for opioid dependence, can be mixed with naloxone, to limit abuse potential. The purpose of this study is to examine the effectiveness of buprenorphine/naloxone that is given at less than daily…
- Trial name
- NCT00134888
- Testing
- Buprenorphine/naloxone
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Dependence, Alcohol Abuse
Sweet Preference and Alcohol Craving
Purpose: The proposed 2-year investigation will be the first double-blind, placebo-controlled trial examining the hedonic response to sweet taste (HRST) as a phenotypic predictor of naltrexone (NTX) response in alcohol…
- Trial name
- SweetNal (NCT01296646)
- Testing
- Naltrexone, Brenda Therapy Sessions
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of North Carolina, Chapel Hill
Alcoholism
Naltrexone for Relapse Prevention
This study is to evaluate the safety and effectiveness of an injectable slow releasing preparation of naltrexone to reduce alcohol consumption and risk of relapse in alcohol-dependent subjects.
- Trial name
- NCT00000442
- Testing
- naltrexone (Revia)
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- UConn Health
Caffeine Dependence
A Long-term Safety and Efficacy of EnXtra (E-AG-01) in Healthy Adults
The present study has been proposed to investigate the long-term safety and efficacy of EnXtra in healthy adults habituated to caffeine.
- Trial name
- NCT03731286
- Testing
- Alpinia Galanga, Microcellulose crystalline
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Domestic Violence, Substance Abuse
Treatment of Intimate Partner Violence and Substance Abuse in a Substance Abuse Treatment Facility
Intimate partner violence is a significant societal problem. There is considerable evidence that a strong relationship between the use of alcohol and other drugs and intimate partner violence exists.
- Trial name
- NCT00847873
- Testing
- substance abuse/domestic violence treatment, Cognitive behavioral therapy addressing substance abuse
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- VU University of Amsterdam
Anxiety, Depression
Feasibility Study on the Use of Mindfulness-based Intervention for Family Carers of People With Dementia
The aim of this study is to examine which mindfulness-based intervention protocol, MBCT or MBSR, is more suited for use among local carers of people with dementia (PWD), as measured by better mental health outcomes in PWD such as…
- Conditions
- Anxiety, Depression, Dependency Burden, Stress, Psychological
- Trial name
- NCT02667782
- Testing
- Mindfulness-Based Stress Reduction (MBSR), Mindfulness-Based Cognitive Therapy (MBCT)
- Where
- 2 sites in Hong Kong
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Methamphetamine Dependence
Tolerability and Safety of 30, 45, and 60 mg of Sublingual Lobeline. - 1
The purpose of this study is to assess safety and pharmacokinetics of sublingual lobeline in healthy normal volunteers.
- Trial name
- NCT00519259
- Testing
- Lobeline
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking Cessation, Acceptability of Health Care
Re-Connect Application for Smoking Cessation
This series of studies will explore the acceptability, feasibility, and preliminary efficacy of making access to smartphone applications contingent on objective evidence of smoking abstinence.
- Conditions
- Smoking Cessation, Acceptability of Health Care, Nicotine Dependence, Cigarettes
- Trial name
- NCT05224154
- Testing
- Abstinent Contingent (AC) Re-Connect
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Rowan University
Contraceptive Usage, Opioid Dependence
Improving Effective Contraceptive Use Among Opioid-maintained Women
Nearly 9 of every 10 pregnant opioid-dependent women report that the current pregnancy was unintended and the majority of non-pregnant opioid-maintained women do not use contraception or use less effective methods like condoms.
- Trial name
- NCT01425060
- Testing
- Contraceptive management program, Usual care
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Vermont
Nicotine Dependence
A Controlled Laboratory Study of the Effects on Cue-Induced Craving in Dependent Smokers
The purpose of this study is to investigate the use of repetitive transcranial magnetic stimulation (rTMS) to block craving for cigarettes in smokers.
- Trial name
- rTMS (NCT00901459)
- Testing
- Active rTMS Condition, rTMS Location Control Condition, rTMS Frequency Control Condition
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Duke University
Substance Dependence
GSK618334 Repeat Dose Study
The proposed study will evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics of repeated oral doses of GSK618334 in healthy male and female volunteers.
- Trial name
- NCT01036061
- Testing
- GSK618334 Low Dose, GSK618334 PET subjects, GSK618334 Medium Dose
- Where
- United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Nicotine Dependence
Nicotine Dependence, Withdrawal and Replacement Therapy Assessed by PET Imaging
The proposed research will provide significant new gender-specific information of scientific and clinical relevance on the function of the mu-opioid system in nicotine dependence and therapeutic effectiveness of nicotine…
- Trial name
- NCT01664741
- Testing
- Nicotine patch - transdermal
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Tobacco Dependence
Tobacco Treatment for Employable Californians, Total IMPACT Study
Previous findings indicate elevated risk for tobacco use among adults in California who are unemployed and seeking work. In a pilot study, tobacco use was associated with a longer duration of time out of work.
- Trial name
- TTEC (NCT02478697)
- Testing
- ProChange ExpertSystem
- Where
- 3 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Stanford University
Tobacco Use Disorder, Tobacco Dependence
Study to Evaluate the Safety and Efficacy of Dietary Supplement Anatabloc in Reducing Daily Smokers' Urge to Smoke
This study will consist of 2 phases. Phase 1 will be a one day crossover study to see the effects of study product on a smoker's desire to smoke, measured by changes in scores on questionnaires given over time.
- Conditions
- Tobacco Use Disorder, Tobacco Dependence, Smoking
- Trial name
- NCT01428310
- Testing
- Anatabloc(TM), CigRx(R)
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Rock Creek Pharmaceuticals, Inc.
Alcohol Use Disorder
Pioglitazone for the Treatment of Alcohol Use Disorder
Alcohol Use Disorder (AUD) is common among Veterans but medication treatment is used infrequently and the impact of these treatments are small to moderate at best.
- Trial name
- PAUSE (NCT03864146)
- Testing
- Brief Behavioral Compliance Enhancement Treatment
- Where
- 2 sites in United States
- Volunteers
- 201 people
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder, Alcohol Abuse
Neurocognitive and Neurobehavioral Mechanisms of Change Following Psychological Treatment for Alcohol Use Disorder
Alcohol Use Disorder (AUD) is a significant public health problem, with prevalence rates of 13.9% for current and 29.1% for lifetime diagnosis (Grant et al., 2015).
- Conditions
- Alcohol Use Disorder, Alcohol Abuse, Alcohol Drinking, Alcohol Dependence
- Trial name
- ABQTREAT (NCT03842670)
- Testing
- Cognitive Behavior Therapy, Mindfulness Based Relapse Prevention
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of New Mexico
Cocaine Dependence
Randomised Placebo-Controlled Trial of Modafinil for Cocaine Dependence
The study aims to evaluate the safety and efficacy of modafinil (200 mg/day) over 10 weeks plus a tailored cognitive behavioural therapy program in the treatment of cocaine dependence.
- Trial name
- NCT00123383
- Testing
- Modafinil
- Where
- 2 sites in Australia
- Volunteers
- 10 people
- Sponsor
- The University of New South Wales
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