Clinical trials: Dependence
Alcohol Dependence
Outpatient Psychotherapeutic Treatment for Alcohol Dependent Individuals With Comorbid Psychiatric Disorders
Research has shown that alcohol dependence often co-occurs with comorbid anxiety disorders and/or depression. Anxiety and depression influence the course and treatment of alcohol dependence and are a major risk factor for alcohol…
- Trial name
- NCT02141789
- Testing
- Outpatient Cognitive Behavioral Psychotherapy
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University of Konstanz
Cocaine Dependence
Citalopram for Cocaine Dependence
This is a phase 2 clinical trial of citalopram pharmacotherapy for treatment of cocaine dependence. Using a double-blind, randomized controlled design, eligible cocaine dependent patients will be assigned equally to one of three…
- Trial name
- NCT01535573
- Testing
- Citalopram
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Joy Schmitz
Cardiovascular Insufficiency
Passive Leg Raising - an Important Diagnostic Manoeuvre
The aim is to describe the physiological background for PLR and the interpretation of a PLR manoeuvre. The protocol entails the measurement of stroke volume (SV) at baseline (semirecumbent patient position), during PLR and after…
- Trial name
- PLR-ANS (NCT03454802)
- Testing
- Passive Leg Raising
- Where
- Denmark
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Region MidtJylland Denmark
Benzodiazepine Dependence
Baclofen for Improving Benzodiazepine Titration in Benzodiazepine Dependence
Benzodiazepines and related molecules are among the most prescribed psychotropic treatments in France and Europe. 13.4% of the French population had at least one reimbursement of benzodiazepines in 2015, which places France…
- Trial name
- BABET (NCT05935553)
- Testing
- Baclofen 30 mg, Baclofen 60 mg
- Where
- 2 sites in France
- Volunteers
- 93 people
- Sponsor
- Hospices Civils de Lyon
Colchicine, ICH - Intracerebral Hemorrhage
Colchicine for the Reduction of Dependency and Vascular Events After an Acute Intracerebral Hemorrhage
Data indicate that patients with intracerebral hemorrhage (ICH) are at high risk for thromboembolic events and disability that is not being sufficiently mitigated by current treatment strategies.
- Conditions
- Colchicine, ICH - Intracerebral Hemorrhage, Stroke, Dependence
- Trial name
- CoVasc-ICH2 (NCT06587737)
- Testing
- Colchicine 0.5 MG
- Volunteers
- 1,125 people
- Sponsor
- Population Health Research Institute
Alcohol Dependence, Borderline Personality Disorder
Topiramate for Treatment of Patients With Borderline Personality Disorder and Alcohol Dependence
The objective of the present study is to evaluate the efficacy of topiramate (250mg/day) versus placebo in decreasing aggression and reducing alcohol consumption in patients with borderline personality disorder (BPD) and alcohol…
- Trial name
- NCT00463775
- Testing
- Topiramate
- Sponsor
- Elizabeth Ralevski
Asthma, Elevated Blood Eosinophils
An Efficacy and Safety Study of Reslizumab Subcutaneous in Patients With Oral Corticosteroid Dependent Asthma and Elevated Blood Eosinophils
The primary objective of the study is to determine the ability of reslizumab administered by subcutaneous injection to produce a corticosteroid-sparing effect in patients with oral corticosteroid (OCS)-dependent asthma and…
- Conditions
- Asthma, Elevated Blood Eosinophils, Oral Corticosteroid Dependence
- Trial name
- NCT02501629
- Testing
- Reslizumab, Non-Oral Corticosteroid (non-OCS) Asthma Medication, Oral Corticosteroid (OCS)
- Where
- 127 sites in United States, Argentina and 15 more
- Volunteers
- 177 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Nicotine Dependence
Study of Varenicline (Champix) for Smoking Cessation/Reduction in Patients With Bipolar Disorder
Bipolar Disorder is a chronic relapsing mental disorder characterized by periods of elevated, expansive and irritable mood, often alternating with periods of significant clinical depression.
- Trial name
- NCT01093937
- Testing
- varenicline
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Centre for Addiction and Mental Health
Nicotine Dependence
GABA (Gamma Amino Butyric Acid) Medication for Tobacco
The goal of this study is to examine the effects of a GABA (gamma amino butyric acid)-enhancing medication, pregabalin (300 mg/day), on smoking behavior, tobacco withdrawal and cigarette craving in smokers.
- Trial name
- NCT00644137
- Testing
- pregabalin, cigarettes
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Yale University
PTSD, Alcohol Use Disorder
MDMA-assisted Prolonged Exposure Therapy for Comorbid Alcohol Use Disorder and Post-traumatic Stress Disorder
To explore the effectiveness of of MDMA-assisted prolonged exposure therapy in improving treatment outcomes for individuals with comorbid PTSD and alcohol use disorder in a double-blind randomised placebo-controlled trial.
- Conditions
- PTSD, Alcohol Use Disorder, Alcohol Dependence, Post-traumatic Stress Disorder
- Trial name
- MPATHY (NCT05709353)
- Testing
- Prolonged exposure therapy, MDMA, Niacin
- Where
- 2 sites in Australia
- Volunteers
- 120 people
- Sponsor
- University of Sydney
Nicotine Dependence
E-cigarettes and Blood Vessel Function
Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, and sham control, on endothelial function and markers of oxidative stress.
- Trial name
- NCT02740595
- Testing
- one time exposure to e-cig with nicotine, one time exposure to e-cig without nicotine, one time exposure to empty e-cig
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Nicotine Dependence, Nicotine Withdrawal
Human Laboratory Study of Varenicline and Bupropion for Nicotine Dependence
The objective of this proposal is to elucidate effects of bupropion SR + varenicline on smoking-cessation related processes in early abstinence using a human laboratory model.
- Trial name
- ChanBan (NCT00749658)
- Testing
- Bupropion, Varenicline
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cocaine Dependence
Psychopharmacology for Cocaine Dependence - Buspirone
Chronic cocaine use may produce disruption of neurotransmitter functions (including dopamine). This may in turn contribute to measurable dysfunction in important cognitive and behavioral processes.
- Trial name
- NCT01267292
- Testing
- Buspirone, Methylphenidate
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The University of Texas Health Science Center, Houston
Alcohol Dependence
Brain Derived Neurotrophic Factor Serum Levels Evolution During the Six Months After Alcohol Withdrawal
Alcohol dependence is accompanied by several neurological mechanisms involving neuronal plasticity and neoneurogenesis, requiring Brain Derived Neurotrophic factor (BDNF) synthesis.
- Trial name
- NCT01491347
- Where
- 4 sites in France
- Volunteers
- 389 people
- Sponsor
- Centre Hospitalier Esquirol
Nicotine Dependence, Electronic Cigarette Use
E-cigarette Nicotine Study
This is a pilot randomized controlled trial (RCT) with the overarching aim of testing the influence of reducing electronic nicotine delivery system (ENDS) use or nicotine on addiction and combustible cigarette (CC) smoking among…
- Conditions
- Nicotine Dependence, Electronic Cigarette Use, Cigarette Smoking
- Trial name
- NCT04709471
- Testing
- Nicotine, Juul e-cigarette, Reduction
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Myelodysplastic Syndromes, Anemia
Efficacy of Luspatercept in ESA-naive LR-MDS Patients With or Without Ring Sideroblasts Who do Not Require Transfusions
Anemia in patients with very low, low or intermediate risk myelodysplastic syndromes (MDS), that are non-transfusion dependent
- Trial name
- LENNON (NCT05384691)
- Testing
- Luspatercept Injection
- Where
- 22 sites in Germany
- Volunteers
- 213 people
- Sponsor
- University of Leipzig
Nicotine Dependence
Stress Neuroadaptation in Tobacco Dependence
The objective of the current study is to evaluate the validity of the No Shock, Predictable Shock, Unpredictable Shock (NPU) stressor task for use as a surrogate endpoint to predict short-term clinical outcomes among smokers…
- Trial name
- NCT03262233
- Testing
- nicotine
- Where
- United States
- Volunteers
- 226 people
- Sponsor
- University of Wisconsin, Madison
Substance Dependence
Relapse Prevention Study in Newly Abstinent Smokers
The purpose of this study is to determine the effect of GSK598809 as compared to placebo in preventing recently-quit smokers from going back to smoking.
- Trial name
- NCT00793468
- Testing
- GSK598809, Nicotine Replacement Transdermal Patch
- Where
- 10 sites in United States
- Sponsor
- GlaxoSmithKline
Drug Use Disorders, Drug Abuse
Evaluation of a Health Plan Initiative to Mitigate Chronic Opioid Therapy Risks
Background: Sixty million American adults suffer from moderate to severe chronic pain. Of these, 5 to 8 million currently use opioids long-term.
- Conditions
- Drug Use Disorders, Drug Abuse, Drug Addiction, Drug Dependence
- Trial name
- CARE (NCT02224508)
- Volunteers
- 1,588 people
- Sponsor
- Kaiser Permanente
Alcohol Dependence, Anxiety Disorder
Disulfiram Combined With Lorazepam for Alcohol Dependence and Anxiety Disorder
The proposed design is a single-group open-label trial. Qualified consenting participants with active alcohol dependence and primary or secondary anxiety disorder will receive monitored disulfiram and lorazepam, in the context of…
- Trial name
- NCT00721526
- Testing
- disulfiram plus lorazepam
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of New Mexico
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.