Clinical trials: Dependence
Alcoholism
The Effects of Topiramate on Alcohol Use in Alcohol Dependent Subjects
This investigation will assess the effectiveness of topiramate in reducing ethanol consumption by alcohol dependent subjects. It also will seek to establish whether topiramate can be safely used in this population including…
- Trial name
- NCT00329407
- Testing
- Topiramate (Topamax)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Boston University
Opioid Dependence, Opioid Withdrawal
Effects of Gabapentin Versus Placebo on Buprenorphine Detoxification of Opioid-dependent Individuals
This study involves inducting treatment seeking opioid dependent participants onto buprenorphine. Once the participant reaches a stable dose they will receive either placebo or gabapentin to determine if gabapentin helps ease…
- Conditions
- Opioid Dependence, Opioid Withdrawal, Opioid Detoxification
- Trial name
- Detox (NCT01262092)
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Arkansas
Methamphetamine Abuse, Methamphetamine Dependence
Safety Assessment of Atomoxetine With MA IV Administration
This is a study of 4 nontreatment seeking individuals who were MA-dependent and the safety and tolerability of atomoxetine. This double-blind, placebo-controlled, within-subjects study is to determine the safety and tolerability…
- Trial name
- NCT01019707
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of California, Los Angeles
Cannabis Dependence
Study of Long-Acting Injectable Naltrexone to Treat Cannabis Dependence
This is an 8 week, outpatient research study testing the use of long-acting naltrexone (Vivitrol) as a treatment for marijuana dependence.
- Trial name
- NCT02088177
- Testing
- Long-acting injectable naltrexone
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- New York State Psychiatric Institute
HIV Infections, Behavioral Symptoms
Friendship Bench Adaptation to Improve Mental Health & HIV Care Engagement Outcomes Among PLWH and PWID in Vietnam
This project will adapt and pilot a feasible and effective problem-solving therapy designed for low-resource settings to address common mental disorders like depression and anxiety - the Friendship Bench- in a Vietnamese…
- Conditions
- HIV Infections, Behavioral Symptoms, Depression, Anxiety
- Trial name
- VITAL (NCT04790201)
- Testing
- Friendship Bench Delivered by Professional Counselor, Friendship Bench Delivered by Lay Counselor, Enhanced Usual Care
- Where
- Vietnam
- Volunteers
- 77 people
- Sponsor
- University of North Carolina, Chapel Hill
Tobacco Dependence
CO Monitoring for Tobacco Cessation in Quitlines
The present study is a 3-arm randomized controlled pilot study. Participants who call the Maryland Tobacco Quitline and are eligible for study participation are randomized to receive quitline tobacco cessation treatment as usual…
- Trial name
- NCT05327660
- Testing
- Quitline Treatment as Usual (TAU), Remote Carbon Monoxide (CO) Monitoring, Incentivized Remote CO Monitoring
- Where
- United States
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Consumer Wellness Solutions
Smoking, Nicotine Dependence
Placebo-controlled Trial of Bupropion for Smoking Cessation in Pregnant Women
Smoking during pregnancy adversely affects the health of the mother and her developing baby. Maternal smoking approximately doubles the risk of miscarriage, placental complications, preterm delivery, low birth weight and fetal…
- Trial name
- BIBS (NCT02188459)
- Testing
- Bupropion
- Where
- 3 sites in United States
- Volunteers
- 129 people
- Sponsor
- Henry Kranzler
Heroin Addiction
Buprenorphine for Prisoners
This five-year study examines the effectiveness of buprenorphine treatment provided to previously-addicted inmates(N=320; 160 males, 160 females) initiated in prison and continued in the community.
- Trial name
- NCT00574067
- Testing
- Buprenorphine +OTP, Buprenorphine +CHC, Counseling +OTP
- Where
- 2 sites in United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Friends Research Institute, Inc.
Tobacco Dependence
Predictors of Treatment Outcome for Smokers With and Without Schizophrenia
The primary purpose of this investigation is to determine the predictive value of task persistence as measured by a mirror tracing task.
- Trial name
- NCT00501007
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Nicotine Dependence
Evaluation of Moclobemide, a Reversible MAO-A Inhibitor, as an Adjunct to Nicotine Replacement Therapy in Female Smokers
The proposed study will assess the efficacy of moclobemide, a selective, reversible MAO-A inhibitor, in facilitating smoking cessation in treatment-seeking female smokers.
- Trial name
- RIMA (NCT01926626)
- Testing
- Nicotine Patch, Moclobemide
- Where
- 3 sites in United States
- Volunteers
- 76 people
- Sponsor
- Jed E. Rose
Nicotine Dependence
A Study to Help People Quit Smoking.
You are invited to participate in a research study at the VA Connecticut Healthcare System (West Haven campus) that examines whether a medication called galantamine can improve your learning and memory, and also help you to quit…
- Trial name
- NCT01880099
- Testing
- Galantamine 8mg, Galantamine 16mg
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Tobacco Dependence
Web Assisted Tobacco Intervention With Community Colleges
This trial will test the effectiveness of an enhanced web-based smoking cessation intervention for student smokers at 2-year Community Colleges.
- Trial name
- WATI (NCT01692730)
- Testing
- Enhanced Web Assisted Tobacco Intervention, Basic Web Assisted Tobacco Intervention
- Where
- United States
- Volunteers
- 1,452 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Cocaine Abuse, Cocaine Dependence
n-Acetylcysteine and Cocaine
This study will determine the initial efficacy, safety and tolerability of n-acetylcysteine as a pharmacotherapy for cocaine dependence.
- Trial name
- NCT02141620
- Testing
- Cocaine, n-Acetylcysteine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Alcohol Dependence
Study of Acamprosate to Prevent Alcohol Relapse in Criminal Justice Supervisees
The purpose of this study is to test how tolerable and effective acamprosate is when used to prevent alcohol relapse in criminal justice supervisees (those on probation, parole, or in drug court).
- Trial name
- NCT00249379
- Testing
- Acamprosate
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Virginia Commonwealth University
Cocaine Dependence
Modafinil, Sleep Architecture and Cocaine Relapse
The medication modafinil has been shown to reduce cocaine use in some cocaine users. The investigators have shown that modafinil taken in the morning improves sleep in chronic cocaine users.
- Trial name
- NCT01137396
- Testing
- Modafinil, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Yale University
Cocaine Use Disorder
Trial Of NS2359 For The Treatment of Cocaine Dependence
NS2359 attenuates the euphoria associated with cocaine use. In a manner parallel to cocaine, NS2359 blocks the reuptake of dopamine (DA), norepinephrine (NE), and serotonin (5HT) with nanomolar affinities at the 3 transporters.
- Trial name
- NCT02798627
- Testing
- NS2359
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Pennsylvania
Cocaine Dependence, Nicotine Dependence
Efficacy of Varenicline in Methadone-Stabilized Cocaine Users
Cocaine addiction continues to be an important public health problem in the US with a significant cost to the individual and society.
- Trial name
- NCT00567320
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Yale University
Cocaine-Related Disorders
Effectiveness of Modafinil and D-amphetamine in Treating Cocaine Dependent Individuals
Cocaine dependence is a major public health problem; an effective primary treatment for cocaine dependent individuals has yet to be found.
- Trial name
- NCT00218062
- Testing
- D-Amphetamine 30mg, D-Amphetamine 60mg, Modafinil 200mg
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Tobacco Use Disorder, Dual Tobacco Use
Addictive Potential of LCCs in Dual Users
This study is about whether or not little cigars and cigarillos cause or maintain addiction, and if flavors, such as fruit, make them more addictive.
- Conditions
- Tobacco Use Disorder, Dual Tobacco Use, Tobacco Dependence, Smoking
- Trial name
- NCT03496077
- Testing
- Flavored and unflavored little cigars/cigarillos (LCCs)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- UConn Health
Nicotine Dependence
A Smoking Cessation Treatment for Adult Women
The purpose of this study is to develop and pilot test a smoking cessation counseling that focuses on the perceived risks of quitting smoking (e.g., weight gain, managing cravings and negative affect, loss of enjoyment).
- Trial name
- NCT01422239
- Testing
- Tailored treatment, Standard Treatment
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Yale University