Clinical trials: Deprescriptions
Deprescription, Antidepressants
Deprescription of Antidepressants in Primary Care (DAPriCare)
Introduction The consumption of antidepressants has increased considerably worldwide, including in Spain. Despite their effectiveness in cases of moderate to severe depression, their long-term use in mild cases is questioned.
- Trial name
- DAPriCare (NCT06796946)
- Testing
- Deprescription of Antidepressants (fluoxetine, citalopram, sertraline, paroxetine, and escitalopram)
- Where
- Spain
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- University of Huelva
Coronary Artery Disease, Acute Myocardial Infarction
Beta Blocker De-prescription Following Coronary Artery Bypass Graft Surgery (BEEFBURGER Trial).
Beta-blockers have the greatest cardiovascular impact in patients with reduced heart function/heart failure and in reducing the peri-operative risk of atrial fibrillation.
- Conditions
- Coronary Artery Disease, Acute Myocardial Infarction, Coronary Artery Stenosis, ST Elevation Myocardial Infarction
- Trial name
- BEEFBURGER (NCT04788186)
- Testing
- De-prescribe beta blocker therapy
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Saskatchewan
Benzodiazepine Withdrawal
Brief Motivational Intervention (BMI) on the Deprescription of Benzodiazepines and Related Substances in Adult Chronic Drug Users
We hypothesise that a short-term intervention by dispensing pharmacists is feasible and relatively easy to implement, and that it could have an impact on the deprescribing of BZD/Z in adult patients.
- Trial name
- BENZ_HALTE (NCT06446349)
- Testing
- Brief motivational intervention
- Where
- 20 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Grenoble
Frailty, Deprescription
Understanding Benzodiazepine and Non-benzodiazepine Sedative Use
Inappropriate medication use among the elderly ranges from 11% to 62% and is a major concern for patient safety. Benzodiazepines account for approximately 20 to 25% of inappropriate medications prescribed to the elderly, thus…
- Conditions
- Frailty, Deprescription, Aged
- Trial name
- NCT02833272
- Testing
- EMPOWER Educational Brochure
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Fall, Fall Injury
A Clinical Decision Support System and Patient Portal for Preventing Medication-related Falls in Older Patients
Falls in older adults represents a growing public health challenge. The use of certain medication is recognized as an important modifiable risk factor for falls.
- Conditions
- Fall, Fall Injury, Fall Patients, Accidental Fall
- Trial name
- ADFICE_IT (NCT05449470)
- Testing
- CDSS, Patient Portal
- Where
- 10 sites in Netherlands
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Dementia
Optimal Medication Management in Alzheimer's Disease and Dementia
The study objective is to conduct a pragmatic deprescribing intervention for people with Alzheimer's Disease or Related Dementia with Multiple Chronic Conditions (ADRD-MCC) so that these patients are on 'just right' medication…
- Trial name
- Optimize (NCT03984396)
- Testing
- Educational Materials - Patient & Clinician
- Where
- United States
- Volunteers
- 7,398 people
- Sponsor
- Kaiser Permanente
End-Of-Life, Inappropriate Prescribing
Effectiveness of a Person-centred Prescription Model at the End of Life
This study's main objective is to investigate whether the application of an adapted person-centred prescription model during a hospital stay would reduce the use of inappropriate or futile regular medications in older people at…
- Conditions
- End-Of-Life, Inappropriate Prescribing, Deprescriptions, Palliative Medicine
- Trial name
- NCT05454644
- Testing
- Person-Centred Prescription Model
- Where
- Spain
- Volunteers
- 114 people
- Sponsor
- Matia Foundation
Fall, Congestive Heart Failure
Reducing High-Risk Geriatric Polypharmacy Via EHR Nudges: Pilot Phase
Polypharmacy is common among older adults in the United States and is associated with harms such as adverse drug reactions and higher costs of care.
- Conditions
- Fall, Congestive Heart Failure, Chronic Kidney Failure, Adverse Drug Event
- Trial name
- NCT03791580
- Testing
- Commitment nudge, Justification nudge
- Where
- United States
- Sponsor
- RAND
Deprescription, Benzodiazepine (BZD) and Related Drugs
Multimodal Educative Data Feedback for Deprescribing BZD and Related Drugs in Outpatients: a Cluster RCT
Benzodiazepine (BZD) and related drugs are sedative anxiolytics and hypnotics that should be avoided especially in people aged 65 years and older, given the high risk of falling, fracture, dependence, respiratory depression and…
- Trial name
- NCT05859555
- Testing
- Thematic quality circles - Deprescription
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- Réseau de soins Delta
Hypothyroidism
REduction of LEvothyroxine in Adults; a SElf Controlled Study
Many older persons use the thyroid hormone levothyroxine which is often continued for life. Scientifically, there is much uncertainty whether simple continuation is the optimal approach.
- Trial name
- RELEASE (NCT05821881)
- Testing
- Discontinuation of levothyroxine treatment
- Where
- Netherlands
- Volunteers
- 513 people
- Sponsor
- Leiden University Medical Center
Hypertension, Frailty
Antihypertensive Deprescribing in Long-term Care
Frail older adults are commonly prescribed blood pressure medication, yet it is unclear if blood pressure medication is actually beneficial for them.
- Trial name
- OptimizeBP (NCT05047731)
- Testing
- Antihypertensive medication
- Where
- Canada
- Volunteers
- 522 people
- Sponsor
- University of Alberta
Drug-Related Side Effects and Adverse Reaction, Digoxin Overdose
Introducing Electronic Alerts to Reduce Inappropriate Digoxin Prescribing in Older Adults
The intervention consists of introducing computerized alerts into the electronic medical record of the CSAPG (MIRA software), which are triggered when a physician prescribes digoxin at a dose higher than the recommended amount…
- Trial name
- Aldigo (NCT07008144)
- Testing
- Digoxin alarm
- Where
- 2 sites in Spain
- Volunteers
- 5,954 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Medication Overuse, Deprescriptions
Prescribing Outcomes of a GP-Targeted Deprescribing Educational Intervention: A Cluster Randomized Trial
Polypharmacy is a common and growing public health concern across healthcare settings worldwide and is associated with an increased risk of inappropriate prescribing and adverse drug events.
- Conditions
- Medication Overuse, Deprescriptions, Polypharmacy, Frailty Syndrome
- Trial name
- NCT06470308
- Testing
- Medication Reviews and Deprescribing
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- University of Crete
Dementia, Deprescriptions
Optimization of Deprescribing Antidepressants in Nursing Home Residents With Dementia
The effectiveness of psychotropic medication on behavioral and psychological symptoms in dementia (BPDS) is limited, while they are associated with a higher risk of morbidity and mortality.
- Conditions
- Dementia, Deprescriptions, Antidepressive Agents, BPSD
- Trial name
- NCT04985305
- Testing
- Teaching material, Pre-visit reflection tool, Dialogue tool
- Where
- Denmark
- Volunteers
- 180 people
- Sponsor
- University of Copenhagen