Clinical trials: Depressed
Depression, Major Depressive Disorder
Study of Naltrexone-Induced Blockade of Antidepressant Effects
The goal of this study is to determine whether antidepressant placebo effects and contextual cues broadly, can be blocked by one single dose of the µ-opioid antagonist naltrexone.
- Trial name
- SONRISA2 (NCT04322526)
- Testing
- Naltrexone 50 Mg Oral Tablet
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Marta Peciña, MD PhD
Heart Failure, Congestive, Chronic Heart Failure
Antidepressant Medication Treatment for Depression in Individuals With Chronic Heart Failure
This study will examine the effect of antidepressant medication on rates of death and disease in depressed people with chronic heart failure.
- Conditions
- Heart Failure, Congestive, Chronic Heart Failure, Depression
- Trial name
- SADHART-CHF (NCT00078286)
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 469 people
- Sponsor
- Duke University
Diabetes Mellitus, Bipolar Disorder
Improving Outcomes for Individuals With Serious Mental Illness and Diabetes
This project tests a model for improving illness self-management among persons who have both serious mental illness and diabetes and will be performed within a primary care setting at a safety net hospital system.
- Conditions
- Diabetes Mellitus, Bipolar Disorder, Depression, Psychotic Disorders
- Trial name
- TTIM (NCT01410357)
- Testing
- Targeted Training in Illness Management (TTIM)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Case Western Reserve University
Depression
PEERS Using Peer Mentors to Deliver Depression Care
Fifteen to twenty percent of older Americans (6 to 8 million people) suffer from depression but more than one-half do not receive any services, a burden disproportionately shared by low-income and minority older adults who…
- Trial name
- NCT04319094
- Testing
- PEERS, Social interaction
- Where
- 2 sites in United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Burnout, Stress
Inner Engineering Online (IEO) Intervention for a Specific Company Employee Program
In this randomized controlled trial; differences in overall stress, burnout and wellbeing will be assessed for employees of a company participating in Inner Engineering Online, an online mind-body course that incorporates both…
- Conditions
- Burnout, Stress, Depression, Anxiety
- Trial name
- NCT04126564
- Testing
- Inner Engineering Online, Reading a book/ journal
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Major Depressive Disorder
Transcranial Laser Therapy for Major Depressive Disorder
The purpose of this study is to see if using Transcranial LED Therapy (TLT) using the PhotoMedex's Omnilux NEw-U LED helps improve symptoms of major depressive disorder (MDD).
- Trial name
- ELATED (NCT01538199)
- Testing
- Near-infrared radiation via Transcranial LED Therapy
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Paolo Cassano
HIV Infections, Fatigue
Effectiveness of Modafinil for Treating Fatigue in Adults With HIV/AIDS
This study will determine whether modafinil (Provigil®), a medication approved for the treatment of narcolepsy, is effective in reducing fatigue in adults with HIV/AIDS.
- Trial name
- NCT00118378
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- New York State Psychiatric Institute
Orthopedic Surgery, Older Adults
Perioperative Mental Health in Orthopedic Surgery
This Hybrid 1 Study will test the effectiveness of a bundled intervention comprised of behavioral activation and medication optimization in reducing symptoms of depression and anxiety in older adults undergoing Orthopedic surgery…
- Conditions
- Orthopedic Surgery, Older Adults, Depression, Anxiety
- Trial name
- CPMH (NCT05697835)
- Testing
- Behavioral activation, Medication optimzation, Care as usual
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Washington University School of Medicine
Hearing Loss, Depression
Treating Hearing Loss to Improve Mood and Cognition in Older Adults
Age-related hearing loss (ARHL) is the third most common health condition affecting older adults after heart disease and arthritis and is the fifth leading cause of years lived with disability worldwide.
- Trial name
- NCT03321006
- Testing
- Phonak Audeo B-R 90 hearing aid device (Active), Duloxetine or escitalopram
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- New York State Psychiatric Institute
Treatment-resistant Depression
A Study to Evaluate the Efficacy, Safety, and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression
The purpose of this study is to compare the efficacy and safety of switching treatment-resistant depression (TRD) subjects from a prior antidepressant treatment (to which they have not responded) to either intranasal esketamine…
- Trial name
- TRANSFORM-2 (NCT02418585)
- Testing
- Esketamine, Duloxetine (Oral Antidepressant), Escitalopram (Oral antidepressant)
- Where
- 48 sites in United States, Czechia and 3 more
- Volunteers
- 236 people
- Sponsor
- Janssen Research & Development, LLC
Refractory Major Depressive Disorder
A Long Term Study of ALKS 5461 in the Treatment of Refractory Major Depressive Disorder (MDD)
This study will assess the long-term safety and tolerability of ALKS 5461 as an adjunctive treatment for refractory MDD.
- Trial name
- NCT03610048
- Testing
- ALKS 5461
- Where
- 34 sites in United States, Australia and 1 more
- Volunteers
- 175 people
- Sponsor
- Alkermes, Inc.
Post Traumatic Stress Disorder, Major Depressive Disorder
Accelerated TMS to a Novel Brain Target in MDD and PTSD
This is a Clinical Trial designed to evaluate novel transcranial magnetic stimulation (TMS) methods for treating depression/PTSD. TMS is an FDA-approved procedure for treatment-resistant depression.
- Trial name
- NCT03114891
- Testing
- Transcranial Magnetic Stimulation (TMS), Task, fMRI-guided TMS target
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
Chronic Pain, Depression, Anxiety
Cognitive Behavioral Therapy and Real-Time Pain Management Intervention for Sickle Cell Via Mobile Applications
The investigators are conducting a comparative effectiveness trial among adult patients with sickle cell disease (SCD) who report chronic pain (N = 350), randomized to receive either mobile phone-delivered computerized cognitive…
- Conditions
- Chronic Pain, Depression, Anxiety, Opioid Use
- Trial name
- CaRISMA (NCT04419168)
- Testing
- cCBT, m-Education
- Where
- 7 sites in United States
- Volunteers
- 359 people
- Sponsor
- University of Pittsburgh
Depression, Child Development
Healthcare Providers as Trusted Messengers to Increase Receipt of Tax Credits Among Low-income Families
The purpose of this study is to pilot test the feasibility and preliminary efficacy of healthcare provider referrals to a tax filing app within parent-child health programs to test whether such referrals can increase receipt of…
- Conditions
- Depression, Child Development, Stress, Physical Illness
- Trial name
- NCT05612685
- Testing
- Healthcare provider referral to a tax filing app
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Depression, Suicidal Ideation
Text2Connect, Component 2 of iCHART (Integrated Care to Help At-Risk Teens)
This study proposes to develop and examine a personalized, text-based intervention designed to improve engagement with mental health (MH) treatment.
- Trial name
- T2C (NCT03982043)
- Testing
- Text2Connect
- Where
- 4 sites in United States
- Volunteers
- 47 people
- Sponsor
- University of Pittsburgh
Depression, Unipolar
Ketamine + Mindfulness for Depression
In this project, the investigators will administer a single infusion of IV ketamine to depressed patients and randomize the patients to receive either a) usual/typical infusion conditions or b) mindfulness training and exercises…
- Trial name
- NCT05168735
- Testing
- Intravenous Ketamine, Brief Mindfulness Exercises, Academic Exercises
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Rebecca Price
Major Depressive Disorder, MDD
Virtual Reality Behavioral Activation: An Intervention for Major Depressive Disorder
The primary purpose of this study is to test the safety and feasibility of virtual reality (VR) technology in the use of behavioral activation (BA) as a treatment for major depressive disorder (MDD).
- Conditions
- Major Depressive Disorder, MDD, Depression
- Trial name
- NCT04268316
- Testing
- Virtual Reality Behavioral Activation, Behavioral Activation in real-life
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Unipolar Depression, Bipolar Depression
Ketamine as an Augmentation Strategy for Electroconvulsive Therapy (ECT) in Depression
The study aims to compare outcomes of Electroconvulsive Therapy (ECT) using ketamine versus methohexital anesthesia in depressed patients.
- Trial name
- NCT01881763
- Testing
- Ketamine, Methohexital
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Northwell Health
Insomnia, Depression
Reducing Suicidal Ideation Through Insomnia Treatment
Epidemiologic reports have linked insomnia to suicidal ideation and suicide death. However, no studies have determined whether treating insomnia decreases the risk of suicidality.
- Conditions
- Insomnia, Depression, Suicidal Ideation
- Trial name
- REST-IT (NCT01689909)
- Testing
- Zolpidem-CR
- Where
- 4 sites in United States
- Volunteers
- 103 people
- Sponsor
- Augusta University
Major Depressive Disorder
Transcranial Direct Current Stimulation Therapy for Major Depression
Depression is a prevalent and debilitating disorder. The most common treatments are antidepressant medications and talking therapies. However, for many individuals, these are not their treatment of choice.
- Trial name
- NCT03632434
- Testing
- transcranial direct current stimulation
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University of East London
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