Clinical trials: Depressed
Treatment Resistant Depression
Deep Brain Stimulation in Treatment Resistant Depression
Recurrent major depressive disorder affects about 3-5% of the population. It is anticipated that by 2020, depression will be the most common cause of disability worldwide in the 18-55 age group.
- Trial name
- NCT01435148
- Testing
- Deep Brain Stimulation, implanted
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- North Bristol NHS Trust
Refractory Major Depressive Disorder
A Long Term Study of ALKS 5461 in the Treatment of Refractory Major Depressive Disorder (MDD)
This study will assess the long-term safety and tolerability of ALKS 5461 as an adjunctive treatment for refractory MDD.
- Trial name
- NCT03610048
- Testing
- ALKS 5461
- Where
- 34 sites in United States, Australia and 1 more
- Volunteers
- 175 people
- Sponsor
- Alkermes, Inc.
Mental Health, Parenting / Maternal Behavior
Healing Hearts: A Mindfulness App for Parents Navigating Divorce or Separation
This study examines online programs for parents navigating divorce or separation. Researchers will study whether a self-guided mindfulness app called Healing Hearts, followed by a self-guided online parenting program called the…
- Conditions
- Mental Health, Parenting / Maternal Behavior, Parenting Anxiety, Parenting Behavior
- Trial name
- NCT07871916
- Testing
- Healing Hearts, electronic New Beginnings Program, Curated internet resources
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Cerebral Palsy
Study of the Effect of Compassion-Based Education Program Applied to Mothers of Children Diagnosed With Cerebral Palsy
Purpose of the study; The aim of this study is to examine the effect of a compassion-based education program applied to mothers of children with cerebral palsy on compassion fatigue, depression, and psychological resilience.
- Trial name
- NCT06245733
- Testing
- Compassion-Based Education Program Adapted for Adults
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Hasan Kalyoncu University
Musculoskeletal Pain, Insomnia
The Association of Sleep and Psychological Symptoms With Prognosis of MSK Pain in Danish General Practice
Musculoskeletal (MSK) pain is a major public health concern. Approximately one in four consult their general practitioner (GP) with a musculoskeletal problem during the course of a year, making it the largest diagnostic group.
- Conditions
- Musculoskeletal Pain, Insomnia, Anxiety, Depressive Symptoms
- Trial name
- NCT03726138
- Where
- Denmark
- Volunteers
- 299 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Dementia
Mindfulness Research Program: Designed to Enhance Wellbeing in People Living With Dementia and Their Spouses
People with dementia forget things and have trouble concentrating. In addition, they and their caregivers can become depressed. This project will show whether Mindfulness-Based Cognitive Therapy (MBCT) can lessen depression…
- Trial name
- MBCT_AD (NCT01774448)
- Testing
- Mindfulness-Based Cognitive Therapy
- Volunteers
- 36 people
- Sponsor
- Lakehead University
Depression, Chronic Pain
Neuromodulation to Facilitate the Effect of Ketamine
application of external neuromodulation along with ketamine infusion.
- Conditions
- Depression, Chronic Pain, Substance Abuse
- Trial name
- TMS/ketamine (NCT01816958)
- Testing
- co-administration of TMS and infused ketamine
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- The Neuroscience Center, LLC
Bipolar Disorder
Study of Aripiprazole in Patients With Bipolar I Disorder With a Major Depression Episode
The purpose of this study is to evaluate flexible doses (5-30mg) of aripiprazole versus placebo in patients with bipolar depression.
- Trial name
- NCT00080314
- Testing
- Aripiprazole
- Where
- 28 sites in United States
- Volunteers
- 400 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Mental Wellbeing, Depression, Anxiety
Effects of Vitamin D on the Behaviours, Mental, and Physical Health of Prisoners
This study aims to understand how vitamin D (VD) affects human health. Typically, prisoners are low on vitamin D, as it is difficult to receive through diet, and is mostly obtained via exposure to the sun.
- Conditions
- Mental Wellbeing, Depression, Anxiety, Bone Density, Low, Vitamin D Deficiency
- Trial name
- NCT05724316
- Testing
- Vitamin D supplement
- Where
- United Kingdom
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Oxford Brookes University
Mothers, Postpartum Depression
Early Half Swaddling and Kangaroo Care Practices on Maternal Sleep Quality and Postpartum Depression in Term Babies
Aim: In this prospective, randomized controlled study, it was aimed to examine the effects of early half-swaddle and kangaroo care practices in term babies on maternal sleep quality and postpartum depression.
- Trial name
- NCT06348316
- Testing
- Half swaddle, Kangaroo care
- Where
- Turkey (Türkiye)
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Trakya University
Depression
Study Evaluating the Effects of DVS SR and Paroxetine on the Pharmacokinetics of Desipramine in Healthy Subjects
The purpose of this study is to evaluate the effects of multiple doses of DVS SR and paroxetine on the pharmacokinetics of a single dose of desipramine in healthy subjects.
- Trial name
- NCT00329147
- Testing
- desvenlafaxine SR, desipramine, paroxetine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Bipolar Disorder
Tai Chi/Qigong for Subsyndromal Depression and Cognition in Older Age Bipolar Disorder
It is expected that by 2030, the percentage of patients with bipolar disorder (BD) in Canada over 60 years of age will exceed 50%.
- Trial name
- NCT04450147
- Testing
- Tai Chi/Qigong vs. Walking/Stretching
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Lady Davis Institute
COVID 19, Depression
COVID-19 : Stress Within Hospital Workers
As of December 2019, the global pandemic of COVID-19 has spread rapidly throughout the world, putting healthcare staff at the frontline.
- Conditions
- COVID 19, Depression, Stress, Psychological, Burnout
- Trial name
- NCT05037214
- Where
- France
- Volunteers
- 779 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Depression
Motivational Interviewing to Improve Medication Adherence Among Hispanic Adults With Depression
This study will determine the effectiveness of motivational interviewing in improving antidepressant medication adherence among Hispanics.
- Trial name
- NCT00356304
- Testing
- Motivational interviewing, Treatment as usual
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Insomnia, Post Traumatic Stress Disorder
Effectiveness of Digital Cognitive Behavioral Therapy for Insomnia in Frontline Health Care Workers (The HCW-CBTi Study)
The COVID-19 pandemic has resulted in increased workload and concerns about personal and family safety for frontline healthcare workers (HCWs), which can lead to decreased well-being and worsening mental health.
- Conditions
- Insomnia, Post Traumatic Stress Disorder, Anxiety Disorders, Depression
- Trial name
- HCW-CBTi (NCT05816304)
- Testing
- Digital Cognitive Behavioral Therapy for Insomnia (dCBTi)
- Where
- 2 sites in Canada
- Volunteers
- 366 people
- Sponsor
- University Health Network, Toronto
Depression
Optimizing Clinical Screening and Management of Maternal Mental Health: Predicting Women at Risk for Perinatal Depression
The purpose of this study is to determine if medical, biological, psychological, and social risk factors can be used to develop algorithms that will predict perinatal depression (PND).
- Trial name
- NCT03144752
- Where
- United States
- Volunteers
- 298 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Depression
Quality of Life and Its Related Factors of Patients With Major Depressive Disorder
The purpose of this study was to explore the quality of life and its related factors of patients with major depressive disorder. This study adopted cross-sectional research design.
- Trial name
- NCT00172549
- Sponsor
- National Taiwan University Hospital
Depression, Post-Partum, Massage
Investigation of the Effect of Massage Application on Functional Status and Depression in Postpartum Mothers
Postpartum depression is a condition with high morbidity in mothers and negatively affects all family relationships. It has been observed that depression in the mother at only 2 months of age negatively affects the relationship…
- Conditions
- Depression, Post-Partum, Massage, Functional Status
- Trial name
- NCT06539858
- Testing
- massage
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Yalova
Burnout, Professional, Stress, Psychological
Foundational Programs to Combat Clinician Stress
This is a prospective, randomized, controlled clinical trial in which clinicians from University of Pennsylvania Health Systems (UPHS) including Penn Medicine- Lancaster General Health (LGH) and Massachusetts General Hospital…
- Conditions
- Burnout, Professional, Stress, Psychological, Stress, Physiological, Psychological Well-Being
- Trial name
- FACCTS (NCT07220421)
- Testing
- Sudarshan Kriya Yoga (SKY) Breathing and Sahaj Meditation, Health Education Program (HEP)
- Where
- 6 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Lancaster General Hospital
Type 1 Diabetes Mellitus, Depression
Telematic Program for the Treatment of Depression in Type 1 Diabetes
In diabetes, web programs have been designed that have integrated cognitive-behavioral therapy (CBT) with diabetes education, obtaining positive results in the mood of the patient.
- Trial name
- NCT03473704
- Testing
- Treatment group (TG), Control group (CG)
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
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