Clinical trials: Depressed
Major Depressive Disorder, Post-Traumatic Stress Disorder
Imaging SV2A in Mood Disorders
This study is designed to examine SV2A density in MDD and PTSD as a correlate of synaptic density, and to determine whether ketamine administration will reverse the synaptic loss in vivo in human subjects.
- Trial name
- NCT02734602
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Yale University
Diabetes, Depression
Diabetes and Depression Text Messaging Intervention
The main aim of the "Diabetes and Mental Health Adaptive Notification Tracking and Evaluation" trial (DIAMANTE) is to test a smartphone intervention that generates adaptive messaging, learning from daily patient data to…
- Conditions
- Diabetes, Depression, Physical Activity
- Trial name
- DIAMANTE (NCT03490253)
- Testing
- DIAMANTE Adaptive, DIAMANTE Static
- Where
- United States
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Hypertension, Diabetes
Exercise Impact in Elderly With Multimorbidity: HbA1c and Blood Pressure
The main objective of the study is to compare the effect of two different types of physical exercise modalities on glycated hemoglobin and blood pressure in elderly individuals with multimorbidity.
- Conditions
- Hypertension, Diabetes, Osteoarthritis, Depression Disorders
- Trial name
- NCT06879639
- Testing
- Exercise, Control
- Where
- Portugal
- Volunteers
- 63 people
- Sponsor
- Universidade do Porto
Severe Postpartum Depression
A Study of BRII-296 in Adults With Severe Postpartum Depression (PPD)
The primary purpose of this study is to evaluate the safety and tolerability of BRII-296 administered by 2 intramuscular injections, administered with Depo Medrol as assessed by the incidence of adverse events, changes from…
- Trial name
- NCT06057012
- Testing
- BRII-296, Depo Medrol
- Where
- 11 sites in United States
- Volunteers
- 11 people
- Sponsor
- Brii Biosciences Limited
Bipolar Disorder, Bipolar Depression
Low Field Magnetic Stimulation: Imaging Biomarkers in Geriatric Bipolar Depression
The protocol involves functional Magnetic Resonance Imaging acquisitions immediately before and after Low Field Magnetic Stimulation treatment on two separate days in a sham controlled, randomized trial, in order to assess the…
- Conditions
- Bipolar Disorder, Bipolar Depression, Bipolar I Disorder, Bipolar II Disorder
- Trial name
- LFMSBioMGeri (NCT03484494)
- Testing
- Low Field Magnetic Stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mclean Hospital
Perinatal Depression
Pilot Study of Mothers and Babies Online in Home Visiting
The investigators propose a pilot randomized controlled trial (RCT) that examines how the redesigned version of Mothers and Babies Online (eMB) can be delivered in the context of home visiting (HV) programs that serve pregnant…
- Trial name
- eMB (NCT05714956)
- Testing
- Mothers and Babies Online (eMB)
- Where
- 6 sites in United States
- Volunteers
- 42 people
- Sponsor
- Northwestern University
Panic Disorder, Panic Disorder With Agoraphobia
Construction of a Questionnaire on Panic Disorder and Agoraphobia
For the first time panic disorder and agoraphobia are included as separate disorders in the DSM-5. Thus, agoraphobia no longer represents a subcategory of panic disorder.
- Conditions
- Panic Disorder, Panic Disorder With Agoraphobia, Agoraphobia, Agoraphobia With Panic Attacks
- Trial name
- NCT03885453
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Ulrike Willutzki
Depression
Effectiveness of Story-Centred Care Intervention Program in Older Persons Living in Long-term Care Facilities
The study aim is to evaluate the effectiveness of Story-Centred Care Intervention Program on reducing depressive symptoms, improving cognitive function, HRV, Blood pressure and quality of life in older adults living in a…
- Trial name
- NCT02965937
- Testing
- Story-centred care intervention program, Health consultation control condition
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Tri-Service General Hospital (TSGH)
Mild Cognitive Impairment, Subthreshold Depression
A Trial of Combined Subthreshold Depression in Older Adults With Mild Cognitive Impairment Participating in Art Games
The presence of subthreshold depression accelerates quality of life decline and cognitive impairment in older adults with mild cognitive impairment, increasing the rate of dementia conversion, while the continuous decline in…
- Trial name
- NCT06706739
- Testing
- Online art game intervention group
- Where
- China
- Volunteers
- 87 people
- Sponsor
- Fujian Medical University
Relapse, Cognitive Impairment
MBRP + Vortioxetine VS MBRP on Preventing Relapse in Chronic MA Users
This multicenter, double-blind, Randomized, parallel-group study in subjects with methamphetamine dependence was to assess the efficacy of MBRP combined with vortioxetine and MBRP alone on 24-week abstinence rates, improvement of…
- Conditions
- Relapse, Cognitive Impairment, Depression
- Trial name
- NCT03830827
- Testing
- Vortioxetine
- Volunteers
- 220 people
- Sponsor
- Sir Run Run Shaw Hospital
Intimate Partner Violence
Telephone Intervention to Increase Safety in Abused Women
Although abuse by an intimate partner is very common and has serious negative effects on women's health, few studies have been done to test ways to increase safety for women in abusive relationships.
- Trial name
- NCT00457522
- Testing
- Nurse/community health worker telephone intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
Thyroid Cancer, Distress
The Effects of T4 Versus T4/T3 on Psychological Distress After Total Thyroidectomy in Thyroid Cancer Patients
The goal of this research is to compare the effects on psychological distress between T4 mono replacement group and T4/T3 combination replacement group after total thyroidectomy in thyroid cancer patients. 1.
- Conditions
- Thyroid Cancer, Distress, Depression, Anxiety
- Trial name
- NCT03024151
- Testing
- Comthyroid, Synthroid
- Where
- 2 sites in South Korea
- Volunteers
- 150 people
- Sponsor
- Inje University
Chronic Non-Malignant Pain (Chronic Musculoskeletal Pain, Chronic Widespread Pain)
Effectiveness of Acceptance and Commitment Therapy for Chronic Non-Malignant Pain: A Randomized Controlled Trial
This study is evaluating whether Acceptance and Commitment Therapy (ACT) helps adults with chronic non-malignant pain (pain lasting 3 months or longer that is not caused by cancer).
- Trial name
- NCT07709572
- Testing
- Acceptance and Commitment Therapy (ACT), Cognitive Behavioral Therapy (CBT)
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- GIFT University
Somatic Symptom
Efficacy and Safety of Toluedesvenlafaxine Hydrochloride Extended-release Tablets in Somatic Symptoms of Depression
The purpose of this study is to evaluate efficacy and safety of toludesvenlafaxine hydrochloride sustained-release tablets in the treatment of somatic symptoms in depression, to provide evidence-based basis for clinical rational…
- Trial name
- NCT05849272
- Testing
- toludesvenlafaxine hydrochloride sustained-release tablets
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Mental Health Center
Depressive Symptoms
Exploring the Effects of Strength Training on Depressive Symptoms and Cardiovascular Risk in Black Men
This study will address a gap in the literature and advance the field of minority men's health. Specifically, it will be the first randomized controlled trial of resistance exercise as a dual intervention for depression symptoms…
- Trial name
- NCT03107039
- Testing
- Exercise, Health Education
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Teachers College, Columbia University
Cardiovascular Diseases, Depression
Omega-3 Fatty Acids to Improve Depression and Reduce Cardiovascular Risk Factors
This study will determine the effects of omega-3 fatty acid (FA) augmentation of sertraline on depression and cardiac endpoints after myocardial infarction (MI).
- Conditions
- Cardiovascular Diseases, Depression, Heart Diseases, Myocardial Infarction
- Trial name
- NCT00116857
- Testing
- Sertraline/omega-3, Sertraline/Corn Oil
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- Washington University School of Medicine
Depression, Schizophrenia
Olanzapine Versus Active Comparator in the Treatment of Depression in Patients With Schizophrenia
This is a research study comparing the safety and efficacy of two active study medications
- Conditions
- Depression, Schizophrenia, Schizoaffective Disorder
- Trial name
- NCT00034801
- Testing
- olanzapine, ziprasidone
- Where
- 30 sites in United States
- Volunteers
- 378 people
- Sponsor
- Eli Lilly and Company
Screening Tool for Depresion in Cancer Pain Patients
The Edmonton Symptom Assessment System (ESAS) as a Screening Tool for Depression in Cancer Pain Patients
Compare Thai versions of the Edmonton Symptom Assessment System (ESAS) and the Hospiral Anxiety and Depression Scale (HADS) with Diagnostic and Statistical Manual (DSM-5), as a screening tool for depression in cancer pain patients
- Trial name
- NCT03686605
- Testing
- Thai version of the Edmontom Symptom Assessment System (ESAS)
- Where
- Thailand
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Major Depressive Disorder
Electroencephalography (EEG) Biomarkers of Response in Depression
There are two specific aims of this project: 1. To identify physiologic indicators of venlafaxine treatment response using quantitative EEG (QEEG) cordance, and to determine if cordance changes are specifically associated with…
- Trial name
- NCT00759122
- Testing
- venlafaxine (Effexor)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of California, Los Angeles
Depressive Disorder, Depressive Disorder, Major Depressive Disorder
Detection Algorithm for Recurrence or Relapse of Depression Thanks to a Smartwach
Globally, 3.8% of the population, or approximately 280 million people, suffer from depression. In France, 12.5% of adults experienced a major depressive episode (MDE) in 2021, with women being twice as affected as men.
- Conditions
- Depressive Disorder, Depressive Disorder, Major Depressive Disorder, Depressive Disorder Not Otherwise Specified (NOS)
- Trial name
- DALIA (NCT06789822)
- Testing
- Invitation to wear the smartwatch
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Dalia Care
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