Clinical trials: Depressed
Depression
Functional Neuroanatomy and Regional Metabolism Before and After Treatment With Duloxetine
The findings may guide future investigations on novel therapeutic targets in depressive subjects. Based on the depicted link between personality traits and altered brain metabolism and function, the latter might be used as…
- Trial name
- NCT02658617
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Heinz Boeker
Anxiety, Depression
Probiotics and the Microbiome: Clinical Intervention Trial for Anxiety and Depression
The proposed project will investigate the effects of probiotics on anxiety and associated psychological and physiological factors in humans.
- Trial name
- NCT02035878
- Testing
- Probiotics
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- Acadia University
Resistant Major Depression
Pentoxifylline for Treatment of Resistant Major Depression
A growing body of evidence has highlighted the role of inflammation and phosphodiesterases (PDE)-related pathways in the pathogenesis of neuropsychiatric illnesses such as depression/mood disorders.
- Trial name
- NCT05324735
- Testing
- Pentoxifylline
- Where
- Iraq
- Volunteers
- 60 people
- Sponsor
- Hawler Medical University
Depressive Disorder
Intramuscular Ketamine Versus Aripiprazole and Escitalopram in the Treatment of Resistant Depression
The treatment of resistant depression should be optimized aiming at complete remission of symptoms, a complex condition due to several factors.
- Trial name
- KETProject (NCT04234776)
- Testing
- Ketamine, Cognition, Suicide risk
- Where
- Brazil
- Volunteers
- 88 people
- Sponsor
- University of Sao Paulo
Post Partum, Maternal Depression
Pilot Feasibility Study With Doulas
The purpose of this study is to determine whether an existing evidence-based intervention, You Matter, can be delivered with fidelity by doulas at their community clinic, MAAME, Inc.
- Conditions
- Post Partum, Maternal Depression, Maternal Depression and Parent Practices, Postpartum
- Trial name
- NCT07614789
- Testing
- YouMatter
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Postnatal Depression
Effect of the 'Mother and Baby' Program on Well-Being
The study investigates the effect of the 'Mother and Baby' (M\&B) program on the psychological health and well-being of new mothers 6-10 weeks following the birth of their baby.
- Trial name
- NCT00361478
- Testing
- Exercise and education, Education
- Where
- Australia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Dementia
Cognitive Stimulation Therapy for Dementia
Aim: The aim of this study is to reveal the effectiveness of cognitive stimulation therapy on activities of daily living, depression and life satisfaction in individuals with mild dementia living in nursing homes.
- Trial name
- NCT05514678
- Testing
- Cognitive Stimulation Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ejdane Coskun
Major Depressive Disorder, Major Depressive Disorder, Recurrent, Unspecified
Escitalopram, Placebo and tDCS in Depression: a Non-inferiority Trial
Major depressive disorder (MDD) is a common psychiatric condition, mostly treated with antidepressant drugs, which are limited for issues such as refractoriness and adverse effects.
- Conditions
- Major Depressive Disorder, Major Depressive Disorder, Recurrent, Unspecified, Major Depressive Disorder, Single Episode, Unspecified
- Trial name
- ELECT-TDCS (NCT01894815)
- Testing
- Escitalopram oxalate, transcranial direct current stimulation
- Where
- 2 sites in Brazil
- Volunteers
- 245 people
- Sponsor
- University of Sao Paulo
Unipolar Depression, Anxiety Disorder
Improve: Integrating Emotion Focused Components Into Psychological Therapy
The primary purpose of this study is to compare the efficacy of two treatment-as-usual (TAU) conditions: TAU with integration of emotion focused components (EFT) and TAU with focus on self-regulation (SR).
- Conditions
- Unipolar Depression, Anxiety Disorder, Adjustment Disorder
- Trial name
- Improve (NCT02822443)
- Testing
- Psychological therapy (PT) as TAU with integrated emotion focused components (TAU - EFT), Psychological therapy (PT) as TAU with focus on self-regulation (TAU - SR)
- Where
- Switzerland
- Volunteers
- 104 people
- Sponsor
- University of Bern
Burnout
The Predictors of Depression and Burnout Among Surgical Residents: A Cross-sectional Study From Kuwait
To assess the prevalence and risk factors for depression and burnout among residents across surgical specialties in Kuwait.
- Trial name
- NCT04808635
- Testing
- no intervention, this is a cross sectional questionnaire based study.
- Where
- Kuwait
- Volunteers
- 80 people
- Sponsor
- Ministry of Health, Kuwait
HIV, Insomnia
Effect of Dolutegravir Compared With Darunavir/Cobicistat on the Severity of Neuropsychiatric Effects al 12 Weeks in Antirretroviral Treatment-Naive Adults.
This clinical trial aimed at evaluating changes in neuropsychiatric scales for depression, anxiety, insomnia, and sleep quality in people living with HIV (PLHIV) who initiate antiretroviral therapy (ART) with a regimen of…
- Conditions
- HIV, Insomnia, Anxiety
- Trial name
- MORFEO (NCT06787976)
- Testing
- Dolutegravir (DTG), Darunavir/Cobicistat (FDC)
- Volunteers
- 140 people
- Sponsor
- Instituto Mexicano del Seguro Social
Depression
Co-Designing and Evaluating Additional Mothers and Babies Program Content for Expectant and New Parents of Children With Down Syndrome
Goal: This R34 study will pilot an adaptation for the Mothers and Babies (MB) program for expectant and new parents of infants with Down syndrome (MBDS).
- Trial name
- MBDS (NCT07469176)
- Testing
- Mothers and Babies, Mothers and Babies Down Syndrome
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Depression
Long-term Safety and Tolerability of BMS-820836 in the Treatment of Patients With Treatment Resistant Major Depression
The purpose of this study it to evaluate the long-term safety and tolerability of BMS-820836 in patients with depression.
- Trial name
- NCT01361555
- Testing
- BMS-820836
- Where
- 144 sites in United States, Argentina and 10 more
- Volunteers
- 789 people
- Sponsor
- Bristol-Myers Squibb
PTSD
Prevention of Combat-related PTSD Using Attention Bias Modification (ABM): A Randomized Controlled Trial
Military deployment to combat zones involves exposure to trauma at a higher than average rate and therefore presents a unique opportunity to study predisposing factors to posttraumatic stress reactions and test strategies…
- Trial name
- NCT01723215
- Testing
- Active ABMT8, Active ABMT4
- Where
- Israel
- Volunteers
- 862 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Anxiety Depression, Aneurysm Cerebral
Psychiatric Outcomes of Unruptured Intracranial Aneurysms (POUIA)
The impact of cerebrovascular procedures on patients experiencing anxiety and depression is not well studied despite the high prevalence of these mental health disorders.
- Conditions
- Anxiety Depression, Aneurysm Cerebral, Mental Health Wellness 1
- Trial name
- POUIA (NCT06123325)
- Testing
- Clipping, Endovascular embolization, Surveillance imaging
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Montefiore Medical Center
Pain, Depressive Symptoms
Depression and Pain Perseverance Through Empowered Recovery Intervention
African American women who are 50 years of age and older with depressive symptoms, pain and difficulty with mobility will participate in the DAPPER intervention study that includes 8 nurse visits in participants' homes to help…
- Conditions
- Pain, Depressive Symptoms, Frailty, Aging
- Trial name
- DAPPER (NCT04091347)
- Testing
- DAPPER
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Johns Hopkins University
Depression / Major Depressive Disorder, Bipolar Disorder (BD)
Identifying Biomarkers of Response to Digital Interventions for Mood Disorders
The proposed study will be a single-arm pragmatic clinical trial examining the feasibility of online CBT within the CAN-BIND sites and the biomarkers of treatment response to online CBT for mood disorders.
- Trial name
- CAN-BIND-iCBT (NCT07783633)
- Testing
- Online Cognitive Behavioural Therapy
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Centre for Addiction and Mental Health
Parkinson's Disease
Psychiatric and Cognitive Manifestations of Parkinson's Disease
Parkinson's Disease (PD) is often thought of as affecting movement only. In fact, most patients also experience psychiatric and cognitive symptoms, sometimes from the disease itself, and sometimes as a side-effect of PD…
- Trial name
- NCT00360633
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Depression
Accelerated iTBS for Depression: Monitoring Brain Hemodynamics With Simultaneous iTBS/fNIRS
This study will investigate the cortical hemodynamic response variability of an accelerated form of TBS stimulation over left dorsolateral prefrontal cortex (DLPFC) using a concurrent TBS/fNIRS setup.
- Trial name
- NCT06971549
- Testing
- Accelerated iTBS
- Where
- Hong Kong
- Volunteers
- 1 people
- Sponsor
- The Hong Kong Polytechnic University
Depression Mild, Depression Moderate
Integrated Depression Care
The Integrated DEpression CAre (IDECA) Programme is a multi-faceted intervention strategy aiming to improve guideline adherence and shared care practices for depression management in both providers and patients, as measured…
- Conditions
- Depression Mild, Depression Moderate, Depression Severe
- Trial name
- IDECA (NCT05788198)
- Testing
- Integrated care
- Where
- 2 sites in Belgium
- Volunteers
- 150 people
- Sponsor
- University Ghent
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