Clinical trials: Depressed
Schizophrenia, Schizoaffective Disorder
Naltrexone for Antipsychotic-Induced Weight Gain
This study is designed to look at the effects of naltrexone on weight loss in individuals treated with antipsychotic medications.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder, Bipolar Disorder
- Trial name
- NTX (NCT01866098)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Yale University
Depressive Disorder, Treatment-Resistant
A Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Adult Participants With Treatment-resistant Depression
The purpose of this study is to assess the efficacy of intranasal esketamine plus an oral antidepressant compared with an oral antidepressant (active comparator) plus intranasal placebo in delaying relapse of depressive symptoms…
- Trial name
- SUSTAIN-1 (NCT02493868)
- Testing
- Esketamine, Duloxetine (Oral Antidepressant), Escitalopram (Oral antidepressant)
- Where
- 155 sites in United States, Belgium and 13 more
- Volunteers
- 719 people
- Sponsor
- Janssen Research & Development, LLC
Arthritis, Diabetes
Can Mental Health Chatbots Help Chronic Disease Populations?
Past research has shown that patients suffering from chronic health conditions tend to experience high levels of negative mental health symptoms (e.g., depression).
- Conditions
- Arthritis, Diabetes, Depression, Anxiety
- Trial name
- NCT04620668
- Testing
- Wysa
- Where
- Canada
- Volunteers
- 79 people
- Sponsor
- Luke MacNeill
Pain, Chronic, Depressive Symptoms
Pain Reduction Through Empowered Recovery (PRIME) Study
Chronic pain and depression or low mood are often experience by women who age with or into disabilities. Due to various factors women with disabilities often experience this cycle of pain and depression.
- Conditions
- Pain, Chronic, Depressive Symptoms, Depression, Disability Physical
- Trial name
- PRIME (NCT05619510)
- Testing
- PRIME Intervention
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Johns Hopkins University
Depression, Dysthymia
Cognitive Behavioral Therapy (REBT/CBT) Evaluation for Dysthymia in the Practice of Clinical Social Work at Primary Care
Introduction: Minor psychiatric disorders are important in primary care, because of its high prevalence and consumption of healthcare resources generated.
- Conditions
- Depression, Dysthymia, Ambulatory Health Services
- Trial name
- NCT02112708
- Testing
- Rational-Emotive-Behavioral Therapy, Control Group usual care
- Where
- Spain
- Volunteers
- 129 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Alzheimer's Disease, Depression
Venlafaxine for Depression in Alzheimer's Disease (DIADs-3)
This study will test the use of venlafaxine to treat the depression in Alzheimer's Disease. Venlafaxine works by increasing natural substances in the brain (serotonin and norepinephrine) that help maintain mental balance.
- Trial name
- DIADs-3 (NCT01609348)
- Testing
- Venlafaxine
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Johns Hopkins University
Bipolar Disorder, Depression
Study of the Efficacy of a Fixed-dose Regimen of Cariprazine Compared to Placebo for Treatment of the Depressive Episode in Participants With Bipolar I Disorder
This study is designed to prospectively confirm the efficacy of a fixed-dose regimen of cariprazine 1.5 milligrams (mg)/day or 3 mg/day compared to placebo for treatment of the depressive episode in participants with bipolar I…
- Trial name
- NCT02670538
- Testing
- Cariprazine
- Where
- 89 sites in United States, Bulgaria and 6 more
- Volunteers
- 493 people
- Sponsor
- Forest Laboratories
Depression
Investigation on the Value of Bilateral Index (BIS) Monitoring for Magnetic Seizure Versus Electroconvulsive Therapy
Electroconvulsive therapy (ECT) has been shown to be an effective treatment for patients suffering from depression, who do not respond to medical treatment.
- Trial name
- NCT01318018
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital, Bonn
Major Depressive Disorder, Partner Relational Disorder (V61.10)
Treatment of Mood and Marriage Study (TOMMS)
The primary goal of this study is to develop and test a depression-specific marital therapy tailored for use with older adult populations.
- Trial name
- NCT00612807
- Testing
- Weekly marital therapy, As indicated: Sertraline, bupropion, venlafaxine, mirtazepine, nortriptyline, tranylcypromine, lithium augmentation, etc.
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Duke University
Major Depressive Disorder (MDD)
To Assess the Safety and Tolerability of an Oral Aripiprazole/Escitalopram Combination Therapy in Participants With Major Depressive Disorder (MDD)
This is a multicenter, 52-week, open-label study designed to assess the safety and tolerability of an oral aripiprazole/escitalopram combination therapy in outpatients with major depressive disorder (MDD).
- Trial name
- NCT01123707
- Testing
- Aripiprazole, Escitalopram
- Volunteers
- 173 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Bipolar Disorder, Major Depressive Episode
Light Therapy for Bipolar Disorder. Efficacy of Light Therapy for Bipolar Depression: A Randomized Controlled Trial
The purpose of this study is to understand the efficacy of light therapy for bipolar depression.
- Trial name
- NCT00852592
- Testing
- 7000lux broad-spectrum light, 50lux dim red light
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Northwestern University
Diabetes, Depression
INtegrating DEPrEssioN and Diabetes treatmENT (INDEPENDENT) Study
To provide better care and preventive services for people with both depression and diabetes, the investigators propose to develop and test whether interventions to reduce depressive symptoms can be integrated into routine…
- Conditions
- Diabetes, Depression, Cardiovascular Risk Factor
- Trial name
- INDEPENDENT (NCT02022111)
- Testing
- Patient Education and Behavioral Activation, Supporting Self-Care (care coordinators), Psychiatrist and Diabetologist Reviews
- Where
- 4 sites in India
- Volunteers
- 404 people
- Sponsor
- Emory University
Perimenopausal Depression
Perimenopausal Effects of Estradiol on Reward Responsiveness
Using neuroimaging, the investigator will study the effects of estrogen on mood and brain function in perimenopausal women either with or without depression.
- Trial name
- PEERS (NCT02255175)
- Testing
- Estradiol, Progesterone
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Depression, Dual Diagnosis
A Randomized Double-Blind Controlled Trial of Creatine in Female Methamphetamine Users
Methamphetamine (MA) addiction is a public health concern that causes substantial harm to individual users, and imposes an economic burden in the U.S. totaling up to $48.3 billion annually.
- Conditions
- Depression, Dual Diagnosis, Drug Addiction
- Trial name
- NCT02192931
- Testing
- Creatine monohydrate
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Perry Renshaw
Perinatal Depression, HIV-1-infection
A Pilot Trial of Perinatal Depression Treatment in HIV Infected Women
This pilot study will evaluate, through quantitative and qualitative methods, whether different treatments for postpartum depression are feasible and acceptable in postpartum HIV infected women on antiretrovirals (ART).
- Trial name
- NCT04094870
- Testing
- Sertraline, Interpersonal therapy
- Where
- 2 sites in Zambia
- Volunteers
- 80 people
- Sponsor
- University of North Carolina, Chapel Hill
Depressive Disorder, Depression
A Clinical Trial of Oral Ganaxolone in Women With Postpartum Depression
A clinical study to evaluate safety, tolerability and efficacy of oral administration of ganaxolone in women with postpartum depression
- Conditions
- Depressive Disorder, Depression, Depression, Postpartum, Behavioral Symptoms
- Trial name
- NCT03460756
- Testing
- Ganaxolone
- Where
- 33 sites in United States
- Volunteers
- 84 people
- Sponsor
- Marinus Pharmaceuticals
Respiratory Depression
Single Dose Crossover Study to Compare the Respiratory Drive After Administration of Belbuca, Oxycodone and Placebo.
The purpose of this study is to explore and compare VRH after administration of Belbuca, Oxycodone HCl and Placebo in recreational opioid users.
- Trial name
- NCT03996694
- Testing
- Belbuca 300 µg, Belbuca 600 µg, Belbuca 900 µg
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- BioDelivery Sciences International
Depressive Symptoms, Depression
Feasibility & Acceptability of a Virtual Sister Circle Intervention for Black Women With Depressive Symptoms
The purpose of this study is to evaluate the feasibility and acceptability of a protocol for middle- and older-aged Black women with depressive symptoms.
- Trial name
- NCT04837573
- Testing
- Sister Circle protocol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kia Skrine Jeffers, PhD, RN, PHN
Depressive Disorder, Major, Postpartum Depression
Mommy-Baby Treatment for Perinatal Depression
Perinatal depression is a major public health problem, affecting 15% of women during pregnancy through the postpartum period, with adverse consequences for the mother, the fetus, the infant, and the family.
- Trial name
- NCT01744041
- Testing
- Dyadic Interpersonal Psychotherapy, Enhanced Treatment as Usual
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Washington University School of Medicine
Anxiety, Depression
Efficacy of CES in New Mothers During the Post Partum Period
The birth of a child is a major life event that can be filled with excitement, anticipation and joy. However, the transition and adaptation to new demands, roles, responsibilities, and changes in relationships can be stressful…
- Conditions
- Anxiety, Depression, Insomnia, Sleep Quality
- Trial name
- NCT03210155
- Testing
- Alpha-Stim AID CES (Active Comparator)
- Where
- 2 sites in United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Christina Murphey, RN, PhD
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