Clinical trials: Depressed Mood
Depressive Disorder, Major Depressive Disorder
A Randomized Neuroimaging Trial of Psilocybin in Depression
The goal of this neuroimaging clinical trial is to test whether psilocybin produces significant immediate changes in functional brain activity in networks associated with mood regulation and depression compared to placebo in…
- Trial name
- EMBRACE (NCT06072898)
- Testing
- Psilocybin, Microcrystalline cellulose, Supportive psychotherapy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Sunnybrook Health Sciences Centre
Cognitive Impairment, Bipolar Disorder
Effects of Altitude-like Cognition Training on Neuroplasticity and Cognitive Functions
The goal of this clinical trial is to investigate the effects of a three-week altitude-like cognition training intervention in healthy individuals (substudy 1) and symptomatically stable patients with mood disorders (depression…
- Conditions
- Cognitive Impairment, Bipolar Disorder, Depression
- Trial name
- ALTIBRAIN (NCT06121206)
- Testing
- Altitude-like hypoxia (12% O2), Normoxia (20% O2), Cognitive training
- Where
- Denmark
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Depression, Anxiety
Mindfulness and Lifestyle Interventions for Depression and Anxiety: A Pilot Study
This is a quasi-experimental evaluation of psychoeducational course focusing on mindfulness and lifestyle changes for depression and anxiety; clients in active treatment group are compared to those in a treatment-as-usual…
- Conditions
- Depression, Anxiety, Major Depression
- Trial name
- NCT01230047
- Testing
- Psychoeducational course
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Arizona State University
Major Depressive Disorder
Electroencephalography (EEG) Biomarkers of Response in Depression
There are two specific aims of this project: 1. To identify physiologic indicators of venlafaxine treatment response using quantitative EEG (QEEG) cordance, and to determine if cordance changes are specifically associated with…
- Trial name
- NCT00759122
- Testing
- venlafaxine (Effexor)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of California, Los Angeles
Bipolar Disorder
Clinical Trial of Pramipexole in Bipolar Depression
The purpose of this study is to examine the safety and effectiveness of the drug pramipexole given in combination with lithium or divalproex for the short-term treatment of acute depression in patients with bipolar disorder.
- Trial name
- NCT00025792
- Testing
- Pramipexole
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Depressive Disorder, Major, Depression
The Effect of Probiotic Supplementation on the Mental Status, Inflammation, and Intestinal Barrier in Major Depressive Disorder Patients Using Gluten-free or Gluten-containing Diet
More and more evidence confirms the relationship between the gut-brain-microbiota axis and the symptoms of mood disorders. A potential pathway connecting the intestines and the brain in depression is inflammation.
- Trial name
- SANGUT (NCT03877393)
- Testing
- Probiotic supplementation + gluten-free diet, Probiotic supplementation + gluten-containing diet
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Medical University of Lublin
Mental Disorder, Substance Use Disorders
Supported Employment in Patient Aligned Care Teams
In response to the Rehabilitation Research and Development (RR\&D) Deployment Health Research, this study addresses the delivery of an evidenced-based vocational rehabilitation, specifically Individual Placement and Support…
- Conditions
- Mental Disorder, Substance Use Disorders, Posttraumatic Stress Disorder, Major Depressive Disorder
- Trial name
- NCT02400736
- Testing
- Individual Placement and Support (IPS), Treatment as Usual Vocational Rehabilitation/Transitional Work (TUA-VR)
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- VA Office of Research and Development
Major Depressive Disorder
Can Magnetic Brain Stimulation Help Prevent Relapse in Depression?
The purpose of this study is to investigate the use of repetitive transcranial magnetic stimulation (rTMS) in helping to prevent relapse in major depressive disorder.
- Trial name
- NCT02029963
- Testing
- Transcranial Magnetic Stimulation (rTMS), Treatment as Usual
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- University of Manitoba
Major Depressive Disorder (MDD), Gender Differences
Gender Differences in Depression Severity, Gender-Sensitive Symptoms, Resilience, and Stigma in Major Depressive Disorder
Depression is a common and serious mental health condition that affects mood, thoughts, behavior, and overall quality of life. It arises from a complex interaction of biological, psychological, and environmental factors.
- Conditions
- Major Depressive Disorder (MDD), Gender Differences, Resilience, Psychological, Self Stigma
- Trial name
- GD-GSS-R-S-MDD (NCT07474363)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Eskisehir Osmangazi University
Depression, Depressive Symptoms
Screening for Depression and Anxiety in Patients With Heart Disease
Depression is a risk factor for morbidity and mortality in patients with heart disease, and has a negative impact on quality of life, work capacity and treatment adherence.
- Conditions
- Depression, Depressive Symptoms, Depressive Disorder, Anxiety
- Trial name
- NCT03203395
- Testing
- Screening and counselling
- Volunteers
- 232 people
- Sponsor
- Diakonhjemmet Hospital
Major Depressive Disorder
Predictors of Treatment Outcome in Major Depressive Disorder
Major depressive disorder (MDD) is a common and disabling mental health condition characterized by persistent low mood, loss of interest, and disruptions in sleep, appetite, and daily functioning.
- Trial name
- NCT07853365
- Volunteers
- 100 people
- Sponsor
- Assiut University
Depression
Comparison of Two Psychotherapy Treatments for Depressed Women With a History of Sexual Abuse
This study will compare the effectiveness of individual versus interpersonal psychotherapy in treating depressed women with a history of sexual abuse.
- Trial name
- NCT00257400
- Testing
- Interpersonal Psychotherapy (IPT), Individual Psychotherapy
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Rochester
Bipolar Disorder, Manic Depression
Inositol Hexaphosphate: A Novel Treatment Strategy for Bipolar Disorder?
Inositol hexaphosphate (IP6, also called inositol hexakisphosphate, and phytic acid) is a naturally occurring phosphorylated derivative of myo-inositol.
- Trial name
- NCT02081287
- Testing
- IP6, Lamotrigine
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- San Diego Veterans Healthcare System
Major Depressive Disorder, Depression
N-methylglycine (Sarcosine) Treatment for Depression
Major depressive disorder is a complex disease and most currently available antidepressants aiming at monoamine neurotransmission exhibit limited efficacy and cognitive effects.
- Conditions
- Major Depressive Disorder, Depression, Major Depression
- Trial name
- NCT00977353
- Testing
- citalopram, sarcosine
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- China Medical University Hospital
Depressive Disorder, Major
Non-invasive Vagus Nerve Stimulation as a Tool to Modulate Stomach-Brain Coupling in Depression
The overarching goal of the project is to determine whether differences in stomach-brain coupling contribute to key symptoms of major depressive disorder (MDD) and whether transcutaneous non-invasive vagus nerve stimulation…
- Trial name
- NCT06389175
- Testing
- Transcutaneous non-invasive vagus nerve stimulation (tVNS)
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Depression
Enhancing Parenting for Depressed Caregivers
The main objective of this study is to adapt a parenting intervention for caregivers of young children who report depressive symptoms in primary care pediatric practices.
- Trial name
- EPDC (NCT01464619)
- Testing
- The Incredible Years Parenting Intervention, Delayed Intervention
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Unipolar Depression
Validation of the Spanish Version of the Clinically Useful Depression Outcome Scale (CUDOS) Scale
The Clinically Useful Depression Outcome Scale (CUDOS) is a brief, self-administered instrument that not only evaluates depressive symptoms but also both functioning and quality of life.
- Trial name
- CUDOS (NCT01360307)
- Where
- 17 sites in Spain
- Volunteers
- 330 people
- Sponsor
- AstraZeneca
Depressive Symptoms, Major Depressive Disorder
Digital Therapeutic for Adolescent Depressive Symptoms in Cardiology and Gastroenterology
The primary aim of this pilot study is to assess the feasibility, acceptability, and preliminary evidence of efficacy of a self-guided, cognitive behavioral therapy (CBT)-based mobile app intervention (SparkRx) for symptoms of…
- Conditions
- Depressive Symptoms, Major Depressive Disorder, Depression, Cardiology
- Trial name
- NCT05461599
- Testing
- SparkRx Mobile App
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Limbix Health, Inc.
Depressive Disorder, Pharmacogenomic Drug Interaction
A Single-center Randomized Controlled Study on the Effect of Pharmacogenomics Trial on Clinical Efficacy in Patients With Depression
The purpose of this clinical trial is to explore the efficacy of drug therapy under the guidance of pharmacogenomics test in the treatment of patients with depression. The main questions to be answered in this study are: 1.
- Trial name
- NCT05959187
- Testing
- pharmacogenomic testing
- Where
- China
- Volunteers
- 665 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Depressive Disorder, Depressive Symptoms
Implementation of a Psychological Online Intervention for Low to Moderate Depression in Primary Health Care
Implementation of a psychological online intervention for low to moderate depression in primary care settings.
- Conditions
- Depressive Disorder, Depressive Symptoms, Depression
- Trial name
- NCT05294614
- Testing
- "Sonreír es diveritdo" - Smiling is fun
- Where
- Spain
- Volunteers
- 420 people
- Sponsor
- Universitat Jaume I