Clinical trials: Depression, Unipolar
Major Depressive Disorder, Drug Abuse
Ketamine IV Classic Protocol : Five Years Follow up
Patients who suffer from MDD recieved ketamnie (2014-15) in open study will be addressed and there depression mood will be evaluated using the rating scale that were used in the original research.
- Conditions
- Major Depressive Disorder, Drug Abuse, Medications, Relapse
- Trial name
- NCT04824157
- Testing
- Non
- Where
- Israel
- Volunteers
- 11 people
- Sponsor
- Sheba Medical Center
MDD, Depression
Resonant Frequency rTMS: A Novel Approach to Target Circuit Modulation in Major Depressive Disorder
The purpose of the study is to develop a more personalized brain stimulation using repetitive transcranial magnetic stimulation or rTMS approach to treat major depressive disorder (MDD).
- Trial name
- R01RF (NCT06572683)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of California, Los Angeles
Major Depressive Disorder
Effects of Intravenous (IV) Citalopram Hydrochloride During Transcranial Magnetic Stimulation in Major Depressive Disorder (MDD)
This study will recruit 30 subjects diagnosed with Major Depressive Disorder (MDD). Subjects will be recieve one infusion treatment of citalopram or placebo and 10 treatments of a form of transcranial magnetic stimulation, theta…
- Trial name
- NCT04846829
- Testing
- intermittent theta burst stimulation, intravenous citalopram hydrochloride (CIT), continuous theta burst stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Los Angeles
Depressive Disorder, Major
NMDA Modulation in Major Depressive Disorder in Late- Life
Major depressive disorder (MDD) is a complex and multi-factorial disorder. Most of the current antidepressants are based upon the monoamine hypothesis which cannot fully explain the etiology of depression.
- Trial name
- NCT03414931
- Testing
- NMDA, Sertraline
- Where
- 2 sites in Taiwan
- Volunteers
- 136 people
- Sponsor
- Chang Gung Memorial Hospital
Depressive Disorder
A Fifty-two-week Study to Evaluate the Safety of Saredutant in Adult and Elderly Patients With Depression
The purpose of the study is to evaluate the long-term safety of saredutant (or SR48968C) in adult and elderly patients with depression.The primary objective is to evaluate the long-term safety and tolerability of a 100 mg dose of…
- Trial name
- NCT00250653
- Testing
- Saredutant succinate (SR48968C)
- Where
- United States
- Volunteers
- 365 people
- Sponsor
- Sanofi
Treatment Resistant Depression, Major Depressive Disorder
Stellate Ganglion Block for Major Depressive Disorder.
This is a feasibility study, to investigate a new treatment option for major depressive disorders by performing a Stellate Ganglion Block (SGB).
- Trial name
- NCT04727229
- Testing
- Bupivacaine Hydrochloride, Normal Saline
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Unity Health Toronto
Depressive Disorder, Major Depressive Disorder
Study of Virtual Reality-based Medical Device for Patients with Depressive Disorder
This study apply a wearable visual device (HMD)-VR-based software medical device for patients with depressive disorder for 8 weeks.
- Conditions
- Depressive Disorder, Major Depressive Disorder, Depressive Episode
- Trial name
- NCT05701345
- Testing
- OMNIFIT DTx-MDD, standard treatment
- Where
- 5 sites in South Korea
- Volunteers
- 162 people
- Sponsor
- Omni C&S
Depressive Disorder, Major, Major Depressive Disorder (MDD)
Sexual Functioning Study With Antidepressants
Effects of two depression medication on sexual functioning
- Trial name
- NCT00316160
- Testing
- Bupropion Hydrochloride Extended-release, Extended-release Venlafaxine
- Where
- 45 sites in United States
- Volunteers
- 347 people
- Sponsor
- GlaxoSmithKline
Major Depressive Disorder
A Study of ALKS 5461 for the Treatment of Major Depressive Disorder (MDD) - the FORWARD-3 Study
This study will evaluate the efficacy and safety of ALKS 5461.
- Trial name
- NCT02158546
- Testing
- ALKS 5461
- Where
- 58 sites in United States, Bulgaria
- Volunteers
- 447 people
- Sponsor
- Alkermes, Inc.
Major Depressive Disorder
Escitalopram Combination Comparison Study for Adult Patients With Major Depressive Disorder
The purpose of this study is to evaluate the effectiveness, safety and tolerability of an escitalopram combination treatment compared to single treatments, and to placebo in patients with major depressive disorder.
- Trial name
- NCT00239954
- Testing
- Escitalopram
- Where
- 4 sites in United States
- Sponsor
- Pharmacology Research Institute
Depression, Anxiety
The CARE (Collaborative Adolescent Running Experience) Project
This study is being completed to see if participants activity levels may have an impact as a treatment for depression, or depressive symptoms.
- Conditions
- Depression, Anxiety, Major Depressive Disorder, Bipolar Disorder
- Trial name
- CARE (NCT05837351)
- Testing
- Exercise -Running
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Michigan
Major Depressive Disorder
Neurocognition and Work Productivity in Major Depressive Disorder (MDD)
This study will investigate the relationships between subjective cognitive complaints, neurocognitive deficits, and work productivity in participants with Major Depressive Disorder (MDD), before and after 8 weeks of treatment…
- Trial name
- NCT01468610
- Testing
- desvenlafaxine
- Where
- Canada
- Volunteers
- 47 people
- Sponsor
- University of British Columbia
Major Depressive Disorder
Transcranial Direct Current Stimulation as an Augmenting Intervention for Major Depression
Transcranial direct current stimulation (tDCS) is a noninvasive method to activate or de-activate neurons in superficial regions of the brain through the induction of weak electric currents in the brain tissue delivered by two…
- Trial name
- NCT01450150
- Testing
- Transcranial Direct Current Stimulation
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Douglas Mental Health University Institute
Major Depressive Disorder, Dysthymic Disorder
Testing a Precision Psychotherapy System for Low-income Patients
The purpose of this study is to evaluate the feasibility of an evidence-based system to recommend core interventions, before the beginning of treatment, to psychotherapists treating low-income patients with depressive or anxiety…
- Conditions
- Major Depressive Disorder, Dysthymic Disorder, Specific Phobia, Social Anxiety Disorder
- Trial name
- ML_LMIC (NCT05118594)
- Testing
- Pre-treatment psychotherapy recommendations
- Volunteers
- 111 people
- Sponsor
- National Council of Scientific and Technical Research, Argentina
Major Depressive Disorder
Aripiprazole Augmentation Versus Switching to Different Class of Antidepressants in Major Depressive Disorder
The objective of this study is to compare the efficacy and safety of aripiprazole as adjunctive therapy versus switching to different class of antidepressants for treating major depressive disorder partially or minimally…
- Trial name
- NCT01488266
- Testing
- Aripiprazole, switching to different class of antidepressant
- Where
- 2 sites in South Korea, Taiwan
- Volunteers
- 90 people
- Sponsor
- Korea University
Depression, Unipolar
Machine Learning to Predict Clinical Response to TMS
Major Depressive Disorder (MDD) is a common and debilitating illness. It affects a person's family and personal relationships, work, education, and life.
- Trial name
- LEARN (NCT03847688)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Brown University
Depressive Disorder, Major
The Antidepressant Effects Of The NMDA Antagonist, CP-101,606, In Patients With MDD
To determine if the NMDA antagonist, CP-101,606, is effective for depression
- Trial name
- NCT00163059
- Testing
- NMDA Antagonist, CP-101,606 (traxoprodil)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Pfizer
Major Depressive Disorder, Soft Tissue Discomfort Syndrome
Functional Change and Efficacy of Duloxetine in Patients With Co-Morbid Depression & Soft Tissue Discomfort Syndrome
The objective of this study is to determine the time course of duloxetine efficacy on the symptoms of Major Depressive Disorder (MDD)and on the symptoms of Soft Tissue Discomfort Syndrome(STDS) via use of 24-hour Actigraph™…
- Conditions
- Major Depressive Disorder, Soft Tissue Discomfort Syndrome, Pain
- Trial name
- NCT01035073
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Pennsylvania
Major Depression
Antidepressant Effects of Ayahuasca: a Randomized Placebo Controlled Trial in Treatment Resistant Depression
The purpose of the present trial is to test the efficacy of Ayahuasca in treatment-resistant depression. Ayahuasca is a decoction of two plants, long used by Amazonian Amerindians.
- Trial name
- NCT02914769
- Testing
- Ayahuasca
- Where
- Brazil
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio Grande do Norte
Depression - Major Depressive Disorder, Psychological Well Being
Peer-Supported E-Health Intervention for College Student Weight Management and Mental Health
This study will test whether adding peer support and online education can help college students manage their weight and improve their mood: we plan to enroll 300 full-time university students and randomly assign them to one of…
- Conditions
- Depression - Major Depressive Disorder, Psychological Well Being, Obesity Prevention
- Trial name
- NCT06966661
- Testing
- Peer Support Intervention, Peer Support and eHealth Intervention
- Where
- China
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Jinan University Guangzhou